Incidental Mutation 'R9095:Or5b107'
ID 691323
Institutional Source Beutler Lab
Gene Symbol Or5b107
Ensembl Gene ENSMUSG00000045883
Gene Name olfactory receptor family 5 subfamily B member 107
Synonyms GA_x6K02T2RE5P-3491834-3492772, Olfr1461, MOR202-35
MMRRC Submission 068910-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R9095 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 13142380-13143318 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 13143310 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 311 (S311A)
Ref Sequence ENSEMBL: ENSMUSP00000146358 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053772] [ENSMUST00000207113] [ENSMUST00000208489]
AlphaFold Q8VEV7
Predicted Effect probably benign
Transcript: ENSMUST00000053772
AA Change: S311A

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000053269
Gene: ENSMUSG00000045883
AA Change: S311A

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 6e-55 PFAM
Pfam:7TM_GPCR_Srsx 36 306 8e-6 PFAM
Pfam:7tm_1 42 291 2e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207113
AA Change: S311A

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000208489
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (75/75)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 C T 17: 24,500,370 (GRCm39) V1274M probably damaging Het
Abca4 A G 3: 121,967,556 (GRCm39) H2202R possibly damaging Het
Ablim3 A G 18: 61,953,463 (GRCm39) L350P probably benign Het
Adamts17 C T 7: 66,654,117 (GRCm39) T449I probably damaging Het
Ankrd39 T A 1: 36,586,241 (GRCm39) D9V probably benign Het
Arhgef7 T C 8: 11,835,819 (GRCm39) V192A probably damaging Het
Art4 C T 6: 136,834,269 (GRCm39) probably benign Het
Atg4a-ps A T 3: 103,553,254 (GRCm39) V29E possibly damaging Het
Ccdc180 A T 4: 45,949,466 (GRCm39) K1574* probably null Het
Cfap54 T G 10: 92,846,882 (GRCm39) T1028P probably damaging Het
Clip2 C T 5: 134,532,254 (GRCm39) R517H possibly damaging Het
Col5a1 A G 2: 27,914,665 (GRCm39) T94A probably benign Het
Cpne1 T A 2: 155,918,210 (GRCm39) probably null Het
Csnk2a1-ps3 A T 1: 156,352,213 (GRCm39) Y138F probably benign Het
Cyp2f2 T A 7: 26,830,667 (GRCm39) M346K possibly damaging Het
D130040H23Rik AAGAATATATTCTACAGAATATA AAGAATATA 8: 69,755,748 (GRCm39) probably null Het
Ddi2 T A 4: 141,419,590 (GRCm39) I387F probably benign Het
Dsg1b A G 18: 20,523,282 (GRCm39) N103S probably damaging Het
Duxf3 GCCC GCC 10: 58,066,944 (GRCm39) probably null Het
Dysf A G 6: 84,156,666 (GRCm39) I1464V probably benign Het
Epha2 A G 4: 141,044,012 (GRCm39) Y314C possibly damaging Het
Etl4 A G 2: 20,782,964 (GRCm39) E675G probably damaging Het
Fam114a1 A C 5: 65,188,733 (GRCm39) I488L probably benign Het
Fbxo31 G A 8: 122,281,136 (GRCm39) R337C probably damaging Het
Fn1 A C 1: 71,647,149 (GRCm39) I1547S probably null Het
Garre1 A T 7: 33,956,770 (GRCm39) probably null Het
Get1 T A 16: 95,954,244 (GRCm39) probably benign Het
Gm14305 T A 2: 176,413,045 (GRCm39) Y312* probably null Het
Golm2 T A 2: 121,756,096 (GRCm39) L375Q probably damaging Het
Gpihbp1 A G 15: 75,469,641 (GRCm39) T119A possibly damaging Het
Harbi1 T G 2: 91,542,980 (GRCm39) V147G probably damaging Het
Ifit1bl1 T C 19: 34,571,899 (GRCm39) Y186C probably damaging Het
Ighv13-2 C A 12: 114,321,494 (GRCm39) A82S probably benign Het
Itpr1 T A 6: 108,364,352 (GRCm39) D827E probably benign Het
Krtap4-2 C T 11: 99,525,801 (GRCm39) G17D unknown Het
Ly6a A T 15: 74,867,333 (GRCm39) probably benign Het
Mad1l1 C T 5: 140,288,741 (GRCm39) E203K probably damaging Het
Mapk14 C A 17: 28,934,413 (GRCm39) D101E probably benign Het
Meis3 G T 7: 15,917,764 (GRCm39) G306W probably damaging Het
Mixl1 T C 1: 180,524,402 (GRCm39) D59G probably benign Het
Nav2 G A 7: 49,254,293 (GRCm39) V2364M probably damaging Het
Nell1 T C 7: 50,506,150 (GRCm39) S786P possibly damaging Het
Or13a25 T G 7: 140,247,813 (GRCm39) N197K probably damaging Het
Or51e2 C A 7: 102,391,473 (GRCm39) V246L possibly damaging Het
Or51g1 A G 7: 102,633,687 (GRCm39) L228P probably damaging Het
Pcdhgb8 A T 18: 37,896,052 (GRCm39) D374V probably damaging Het
Phactr2 A G 10: 13,129,386 (GRCm39) I294T probably benign Het
Plekha4 C T 7: 45,190,492 (GRCm39) A400V probably damaging Het
Pramel21 T C 4: 143,341,760 (GRCm39) F63S probably damaging Het
Pramel4 C A 4: 143,794,928 (GRCm39) D441E probably benign Het
Prr12 G A 7: 44,695,267 (GRCm39) P1400S unknown Het
Prss3b T A 6: 41,010,038 (GRCm39) N99Y possibly damaging Het
Rbm6 G A 9: 107,669,089 (GRCm39) Q608* probably null Het
Scamp1 T A 13: 94,369,598 (GRCm39) I76F probably benign Het
Sez6 G A 11: 77,865,121 (GRCm39) E623K possibly damaging Het
Sirt1 A T 10: 63,158,077 (GRCm39) S446T probably damaging Het
Slc25a54 A G 3: 109,019,404 (GRCm39) K336R probably benign Het
Spag17 G T 3: 99,912,092 (GRCm39) V321F possibly damaging Het
Sstr1 A G 12: 58,259,620 (GRCm39) Y81C probably damaging Het
St8sia4 T C 1: 95,519,525 (GRCm39) K321R probably damaging Het
Stac3 T C 10: 127,343,584 (GRCm39) F242S probably damaging Het
Tanc2 T G 11: 105,758,104 (GRCm39) S622A probably benign Het
Tcf4 G A 18: 69,598,464 (GRCm39) D106N possibly damaging Het
Tfrc T A 16: 32,433,571 (GRCm39) I75N possibly damaging Het
Tigd2 G A 6: 59,187,509 (GRCm39) W125* probably null Het
Tjp1 T C 7: 64,952,745 (GRCm39) T1530A possibly damaging Het
Tmem132a T A 19: 10,844,412 (GRCm39) H62L probably benign Het
Tmem89 T C 9: 108,743,729 (GRCm39) S10P unknown Het
Trrap C T 5: 144,733,961 (GRCm39) P938L probably damaging Het
Unc80 C A 1: 66,545,912 (GRCm39) P488T probably damaging Het
Uri1 C A 7: 37,662,873 (GRCm39) G374C probably damaging Het
Utp20 T C 10: 88,611,180 (GRCm39) N1379S probably damaging Het
Vcan G T 13: 89,852,644 (GRCm39) T772K probably benign Het
Zbtb37 A T 1: 160,847,941 (GRCm39) Y355* probably null Het
Zfp3 A G 11: 70,662,405 (GRCm39) I121M probably benign Het
Zfp629 A T 7: 127,209,547 (GRCm39) L754Q probably damaging Het
Other mutations in Or5b107
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01088:Or5b107 APN 19 13,142,735 (GRCm39) missense probably damaging 1.00
IGL01370:Or5b107 APN 19 13,142,663 (GRCm39) missense possibly damaging 0.95
IGL01936:Or5b107 APN 19 13,142,767 (GRCm39) missense probably damaging 1.00
R0098:Or5b107 UTSW 19 13,143,026 (GRCm39) missense probably benign 0.12
R0270:Or5b107 UTSW 19 13,143,251 (GRCm39) missense probably damaging 1.00
R0575:Or5b107 UTSW 19 13,142,751 (GRCm39) nonsense probably null
R0627:Or5b107 UTSW 19 13,142,614 (GRCm39) missense probably benign 0.43
R1779:Or5b107 UTSW 19 13,142,404 (GRCm39) missense probably benign 0.00
R1956:Or5b107 UTSW 19 13,142,560 (GRCm39) missense probably damaging 1.00
R2446:Or5b107 UTSW 19 13,142,811 (GRCm39) missense probably benign 0.00
R3622:Or5b107 UTSW 19 13,143,020 (GRCm39) missense probably benign 0.06
R4485:Or5b107 UTSW 19 13,142,855 (GRCm39) missense possibly damaging 0.54
R4605:Or5b107 UTSW 19 13,142,612 (GRCm39) missense probably damaging 1.00
R4757:Or5b107 UTSW 19 13,143,277 (GRCm39) missense probably benign 0.01
R4816:Or5b107 UTSW 19 13,142,488 (GRCm39) missense probably benign 0.10
R5038:Or5b107 UTSW 19 13,142,955 (GRCm39) missense probably benign 0.39
R7026:Or5b107 UTSW 19 13,142,779 (GRCm39) missense probably benign 0.08
R8225:Or5b107 UTSW 19 13,142,507 (GRCm39) missense probably damaging 1.00
R8232:Or5b107 UTSW 19 13,142,683 (GRCm39) missense probably benign 0.28
R9127:Or5b107 UTSW 19 13,142,396 (GRCm39) missense probably damaging 1.00
R9697:Or5b107 UTSW 19 13,142,888 (GRCm39) missense possibly damaging 0.91
R9784:Or5b107 UTSW 19 13,142,813 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGAAGGCTCTTTCCACCTGTG -3'
(R):5'- CACAGAGGTGTATTTTACTGTGC -3'

Sequencing Primer
(F):5'- ACTGCTGTCTTTATTTTCTATGGAAC -3'
(R):5'- CCAGTAAGGATTACAATGATGA -3'
Posted On 2021-12-30