Incidental Mutation 'R9096:Gng2'
ID 691377
Institutional Source Beutler Lab
Gene Symbol Gng2
Ensembl Gene ENSMUSG00000043004
Gene Name guanine nucleotide binding protein (G protein), gamma 2
Synonyms 1110003P13Rik
MMRRC Submission 068911-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.112) question?
Stock # R9096 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 19922627-20027695 bp(-) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) T to A at 19941471 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000125697 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055100] [ENSMUST00000159028] [ENSMUST00000159073] [ENSMUST00000160013] [ENSMUST00000161247] [ENSMUST00000162425]
AlphaFold P63213
Predicted Effect probably benign
Transcript: ENSMUST00000055100
SMART Domains Protein: ENSMUSP00000055256
Gene: ENSMUSG00000043004

DomainStartEndE-ValueType
G_gamma 5 70 5.6e-29 SMART
GGL 9 70 4.2e-34 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000159028
SMART Domains Protein: ENSMUSP00000125141
Gene: ENSMUSG00000043004

DomainStartEndE-ValueType
G_gamma 5 70 5.6e-29 SMART
GGL 9 70 4.2e-34 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000159073
SMART Domains Protein: ENSMUSP00000125000
Gene: ENSMUSG00000043004

DomainStartEndE-ValueType
G_gamma 5 70 5.6e-29 SMART
GGL 9 70 4.2e-34 SMART
Predicted Effect probably null
Transcript: ENSMUST00000160013
SMART Domains Protein: ENSMUSP00000125697
Gene: ENSMUSG00000043004

DomainStartEndE-ValueType
G_gamma 5 70 5.7e-29 SMART
GGL 9 70 4.3e-34 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000161247
SMART Domains Protein: ENSMUSP00000124725
Gene: ENSMUSG00000043004

DomainStartEndE-ValueType
G_gamma 5 70 5.6e-29 SMART
GGL 9 70 4.2e-34 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000162425
SMART Domains Protein: ENSMUSP00000124153
Gene: ENSMUSG00000043004

DomainStartEndE-ValueType
G_gamma 5 70 5.6e-29 SMART
GGL 9 70 4.2e-34 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 98% (57/58)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced vomeronasal basal neurons, reduced posterior glomerular layer of the accessory olfactory bulb and decreased aggression towards male mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900026A02Rik A T 5: 113,339,793 (GRCm39) V73E Het
Abhd12b T A 12: 70,210,207 (GRCm39) Y128N probably damaging Het
Arhgap40 A T 2: 158,389,584 (GRCm39) M586L probably benign Het
Armt1 T C 10: 4,384,829 (GRCm39) S15P probably damaging Het
Arnt G T 3: 95,397,588 (GRCm39) S535I probably benign Het
Bmper T C 9: 23,134,988 (GRCm39) S18P possibly damaging Het
Catsperg1 G C 7: 28,884,152 (GRCm39) T987R probably damaging Het
Col9a1 A T 1: 24,224,207 (GRCm39) I130F unknown Het
Dennd1a G T 2: 37,690,077 (GRCm39) L1008I probably damaging Het
Depdc1a T A 3: 159,204,117 (GRCm39) D55E probably benign Het
Dlc1 A T 8: 37,080,721 (GRCm39) I10N probably benign Het
Dnah1 T A 14: 30,983,027 (GRCm39) I4203F probably damaging Het
Dzank1 G T 2: 144,316,882 (GRCm39) L767I possibly damaging Het
Eprs1 C A 1: 185,139,303 (GRCm39) A896E probably benign Het
Fryl T C 5: 73,265,920 (GRCm39) D467G probably benign Het
Gab3 TTC TTCCTC X: 74,043,610 (GRCm39) probably benign Het
Gimd1 T A 3: 132,340,661 (GRCm39) M59K probably benign Het
Gm3667 T C 14: 18,270,388 (GRCm39) Y139C probably damaging Het
Gpr162 A G 6: 124,836,570 (GRCm39) I367T probably benign Het
Hacd4 A G 4: 88,355,695 (GRCm39) probably null Het
Hmcn1 C T 1: 150,532,869 (GRCm39) V3105M probably benign Het
Iws1 T C 18: 32,216,373 (GRCm39) V371A probably benign Het
Kctd10 C T 5: 114,508,232 (GRCm39) R92Q probably damaging Het
Lepr T C 4: 101,631,418 (GRCm39) F643L possibly damaging Het
Lpgat1 T C 1: 191,451,569 (GRCm39) V65A possibly damaging Het
Lrrk2 C T 15: 91,557,459 (GRCm39) probably benign Het
Magel2 A G 7: 62,030,297 (GRCm39) D1067G unknown Het
Mrc2 A G 11: 105,231,398 (GRCm39) D777G probably damaging Het
Nol10 T A 12: 17,466,199 (GRCm39) D531E probably benign Het
Odf2 T A 2: 29,783,508 (GRCm39) V103D probably damaging Het
Or4f7 T A 2: 111,644,196 (GRCm39) K292* probably null Het
Pcdhb21 A G 18: 37,648,071 (GRCm39) Y400C probably damaging Het
Pkn2 C T 3: 142,515,249 (GRCm39) R695Q probably benign Het
Pld3 A G 7: 27,232,089 (GRCm39) V397A probably benign Het
Ppp1r9a A G 6: 4,906,012 (GRCm39) D189G probably damaging Het
Ppp2r1b A G 9: 50,777,856 (GRCm39) K267R probably benign Het
Prkca A G 11: 107,905,061 (GRCm39) S226P probably benign Het
Ptpru T C 4: 131,499,843 (GRCm39) N1267S probably damaging Het
Pxn T A 5: 115,686,680 (GRCm39) C391S probably benign Het
Rars1 T C 11: 35,718,256 (GRCm39) E136G probably benign Het
Rrp12 A T 19: 41,878,577 (GRCm39) D189E probably benign Het
Rsf1 GCG GCGACGGCGCCG 7: 97,229,114 (GRCm39) probably benign Het
Sdc1 T C 12: 8,841,665 (GRCm39) L265P probably damaging Het
Sycp2l A T 13: 41,300,070 (GRCm39) D428V possibly damaging Het
Tasp1 A T 2: 139,725,690 (GRCm39) probably null Het
Telo2 T C 17: 25,324,066 (GRCm39) T550A probably benign Het
Tmem131l A T 3: 83,850,122 (GRCm39) N225K probably damaging Het
Tmem260 T A 14: 48,757,803 (GRCm39) V706D unknown Het
Tnr T A 1: 159,677,804 (GRCm39) M63K probably benign Het
Ttn A G 2: 76,572,413 (GRCm39) I26160T probably damaging Het
Ubap1 T C 4: 41,379,872 (GRCm39) probably null Het
Ush2a C T 1: 188,198,333 (GRCm39) P1466S probably benign Het
Usp24 T G 4: 106,254,508 (GRCm39) M1495R probably benign Het
Utp20 T C 10: 88,611,180 (GRCm39) N1379S probably damaging Het
Vmn1r16 A T 6: 57,300,250 (GRCm39) I124N probably benign Het
Vmn1r181 A G 7: 23,684,444 (GRCm39) N303S probably benign Het
Vmn1r50 G A 6: 90,085,022 (GRCm39) V256I probably benign Het
Vps54 A G 11: 21,227,913 (GRCm39) N288S possibly damaging Het
Zfp266 A T 9: 20,416,440 (GRCm39) F50Y probably damaging Het
Other mutations in Gng2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0883:Gng2 UTSW 14 19,941,363 (GRCm39) missense probably benign 0.04
R4615:Gng2 UTSW 14 19,941,395 (GRCm39) missense possibly damaging 0.86
R4827:Gng2 UTSW 14 19,925,898 (GRCm39) missense possibly damaging 0.90
R5460:Gng2 UTSW 14 19,941,426 (GRCm39) missense probably benign 0.42
R5840:Gng2 UTSW 14 19,925,882 (GRCm39) missense probably damaging 0.97
R8711:Gng2 UTSW 14 19,941,438 (GRCm39) start codon destroyed probably null
R9303:Gng2 UTSW 14 19,925,961 (GRCm39) missense probably damaging 0.96
R9305:Gng2 UTSW 14 19,925,961 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- AGTGGAATTGTTAGAACCCTCTC -3'
(R):5'- GTAAACTCTTTGGGGCAGAGC -3'

Sequencing Primer
(F):5'- CCAATCAAATGGCAGTTGGCTG -3'
(R):5'- CAGAAATGGGAAATCAATGCCTTC -3'
Posted On 2021-12-30