Mutagenetix > Incidental Mutation

Incidental Mutation 'R9097:Or5p73'

691418

Institutional Source

Beutler Lab

Gene Symbol

Or5p73

Ensembl Gene

ENSMUSG00000096679

Gene Name

olfactory receptor family 5 subfamily P member 73

Synonyms

MOR204-36, Olfr498, GA_x6K02T2PBJ9-10795522-10796514

MMRRC Submission

068912-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R9097 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

108064533-108065525 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 108064815 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 95 (I95F)

Ref Sequence

ENSEMBL: ENSMUSP00000150971 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000217616]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000217616
AA Change: I95F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.1%

Validation Efficiency

96% (50/52)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Antxrl	G	A	14: 33,793,660 (GRCm39)	V463I	probably benign	Het
Aox1	T	A	1: 58,326,887 (GRCm39)	L162Q	possibly damaging	Het
Arhgap40	A	T	2: 158,389,584 (GRCm39)	M586L	probably benign	Het
Arnt	G	T	3: 95,397,588 (GRCm39)	S535I	probably benign	Het
Bsx	G	T	9: 40,785,636 (GRCm39)	G55C	probably damaging	Het
Ccdc168	T	C	1: 44,098,049 (GRCm39)	I1016M	possibly damaging	Het
Col9a1	A	T	1: 24,224,207 (GRCm39)	I130F	unknown	Het
Cyp51	G	T	5: 4,149,172 (GRCm39)	T235N	possibly damaging	Het
Depdc1a	T	A	3: 159,204,117 (GRCm39)	D55E	probably benign	Het
Dlc1	A	T	8: 37,080,721 (GRCm39)	I10N	probably benign	Het
Dzank1	G	T	2: 144,316,882 (GRCm39)	L767I	possibly damaging	Het
Eif3k	A	T	7: 28,671,660 (GRCm39)	*193K	probably null	Het
Eprs1	C	A	1: 185,139,303 (GRCm39)	A896E	probably benign	Het
Evc2	T	A	5: 37,550,505 (GRCm39)	F840I	possibly damaging	Het
Fut2	G	T	7: 45,300,375 (GRCm39)	H132Q	probably benign	Het
Gbp11	T	C	5: 105,474,347 (GRCm39)	*443W	probably null	Het
Gimd1	T	A	3: 132,340,661 (GRCm39)	M59K	probably benign	Het
Glis2	A	G	16: 4,429,640 (GRCm39)	T228A	probably damaging	Het
Gm21663	G	C	5: 26,147,167 (GRCm39)	C46W	probably benign	Het
Gpr162	A	G	6: 124,836,570 (GRCm39)	I367T	probably benign	Het
Grik1	G	A	16: 87,732,796 (GRCm39)	T692I		Het
Igf2r	G	T	17: 12,910,100 (GRCm39)	A2043D	probably damaging	Het
Il12b	C	A	11: 44,301,107 (GRCm39)	L208M	probably benign	Het
Il12b	T	A	11: 44,301,108 (GRCm39)	L208Q	probably damaging	Het
Lrrk2	C	T	15: 91,557,459 (GRCm39)		probably benign	Het
Map3k9	T	C	12: 81,819,855 (GRCm39)	D133G	possibly damaging	Het
Mrc2	A	G	11: 105,231,398 (GRCm39)	D777G	probably damaging	Het
Mtrr	A	G	13: 68,723,441 (GRCm39)	L157P	probably benign	Het
Nol4l	C	A	2: 153,312,630 (GRCm39)	R226L	probably damaging	Het
Nsmaf	CAAACTTTTAAACTT	CAAACTT	4: 6,416,543 (GRCm39)		probably null	Het
Or4f7	T	A	2: 111,644,196 (GRCm39)	K292*	probably null	Het
Or51f23c-ps1	A	G	7: 102,431,475 (GRCm39)	H264R	probably damaging	Het
Or6c7	T	A	10: 129,323,647 (GRCm39)	M256K	possibly damaging	Het
Or7g22	G	A	9: 19,048,670 (GRCm39)	C127Y	probably damaging	Het
Or9g8	T	A	2: 85,607,669 (GRCm39)	V247E	probably damaging	Het
Pkn2	C	T	3: 142,515,249 (GRCm39)	R695Q	probably benign	Het
Ppp1r9a	A	G	6: 4,906,012 (GRCm39)	D189G	probably damaging	Het
Prkca	A	G	11: 107,905,061 (GRCm39)	S226P	probably benign	Het
Ptpru	T	C	4: 131,499,843 (GRCm39)	N1267S	probably damaging	Het
Retnlb	T	A	16: 48,638,980 (GRCm39)		probably benign	Het
Rrp12	A	T	19: 41,878,577 (GRCm39)	D189E	probably benign	Het
Serpinb7	G	A	1: 107,377,907 (GRCm39)	C200Y	probably damaging	Het
Sez6	G	A	11: 77,865,121 (GRCm39)	E623K	possibly damaging	Het
Stk32a	A	T	18: 43,446,497 (GRCm39)	M316L	possibly damaging	Het
Supt6	G	T	11: 78,113,100 (GRCm39)	H948N	probably benign	Het
Sycp2l	A	T	13: 41,300,070 (GRCm39)	D428V	possibly damaging	Het
Tasp1	A	T	2: 139,725,690 (GRCm39)		probably null	Het
Telo2	T	C	17: 25,324,066 (GRCm39)	T550A	probably benign	Het
Tmem131l	A	T	3: 83,850,122 (GRCm39)	N225K	probably damaging	Het
Tnc	T	C	4: 63,888,622 (GRCm39)	T1724A	possibly damaging	Het
Tyk2	C	A	9: 21,020,072 (GRCm39)	E1029*	probably null	Het
Uhmk1	C	T	1: 170,042,879 (GRCm39)		probably benign	Het
Vav2	G	A	2: 27,181,850 (GRCm39)	R330W	probably damaging	Het
Vmn1r16	A	T	6: 57,300,250 (GRCm39)	I124N	probably benign	Het
Vmn1r181	A	G	7: 23,684,444 (GRCm39)	N303S	probably benign	Het
Vmn1r50	G	A	6: 90,085,022 (GRCm39)	V256I	probably benign	Het

Other mutations in Or5p73

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03232:Or5p73	APN	7	108,064,812 (GRCm39)	missense	probably benign	0.06
IGL03348:Or5p73	APN	7	108,064,615 (GRCm39)	missense	probably benign
IGL03408:Or5p73	APN	7	108,064,554 (GRCm39)	missense	probably damaging	1.00
IGL03047:Or5p73	UTSW	7	108,064,983 (GRCm39)	missense	probably damaging	0.97
R0208:Or5p73	UTSW	7	108,064,750 (GRCm39)	missense	probably damaging	1.00
R0363:Or5p73	UTSW	7	108,064,941 (GRCm39)	missense	possibly damaging	0.81
R1481:Or5p73	UTSW	7	108,065,167 (GRCm39)	missense	probably benign	0.00
R1886:Or5p73	UTSW	7	108,064,947 (GRCm39)	missense	probably benign	0.39
R2065:Or5p73	UTSW	7	108,064,875 (GRCm39)	missense	possibly damaging	0.69
R2103:Or5p73	UTSW	7	108,064,810 (GRCm39)	missense	probably benign	0.03
R3731:Or5p73	UTSW	7	108,064,633 (GRCm39)	missense	possibly damaging	0.88
R4763:Or5p73	UTSW	7	108,065,393 (GRCm39)	missense	probably benign	0.34
R4839:Or5p73	UTSW	7	108,064,938 (GRCm39)	missense	probably benign	0.03
R4997:Or5p73	UTSW	7	108,064,701 (GRCm39)	missense	probably benign	0.01
R5533:Or5p73	UTSW	7	108,065,469 (GRCm39)	missense	probably benign	0.00
R7286:Or5p73	UTSW	7	108,064,642 (GRCm39)	missense	possibly damaging	0.52
R7910:Or5p73	UTSW	7	108,064,978 (GRCm39)	missense	probably benign	0.01
R8005:Or5p73	UTSW	7	108,064,693 (GRCm39)	missense	probably benign	0.01
R8487:Or5p73	UTSW	7	108,064,784 (GRCm39)	missense	possibly damaging	0.69
R8976:Or5p73	UTSW	7	108,064,630 (GRCm39)	missense	possibly damaging	0.87
Z1088:Or5p73	UTSW	7	108,064,578 (GRCm39)	missense	probably benign
Z1176:Or5p73	UTSW	7	108,064,578 (GRCm39)	missense	probably benign
Z1177:Or5p73	UTSW	7	108,065,228 (GRCm39)	missense	probably benign	0.08
Z1177:Or5p73	UTSW	7	108,064,578 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- CATCTACCTGGTGACTGTGTCTG -3'
(R):5'- TTTGGTCCACAGAAGAACAAGG -3'

Sequencing Primer
(F):5'- CCTGGTGACTGTGTCTGGGAAC -3'
(R):5'- CCCTGTATATAAGATCCTACCACC -3'

Posted On

2021-12-30