Incidental Mutation 'R9098:Megf6'
| ID |
691467 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Megf6
|
| Ensembl Gene |
ENSMUSG00000057751 |
| Gene Name |
multiple EGF-like-domains 6 |
| Synonyms |
2600001P17Rik, Egfl3 |
| MMRRC Submission |
068913-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9098 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
154255187-154360170 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 154354160 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Arginine
at position 1355
(G1355R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000030897
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030897]
[ENSMUST00000152159]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000030897
AA Change: G1355R
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000030897
Gene: ENSMUSG00000057751
AA Change: G1355R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
EGF_CA
|
122 |
162 |
1.54e-6 |
SMART |
|
EGF_CA
|
163 |
203 |
2.08e-12 |
SMART |
|
EGF
|
207 |
245 |
5.4e-2 |
SMART |
|
EGF
|
249 |
286 |
2.39e-3 |
SMART |
|
EGF_CA
|
287 |
327 |
4.96e-10 |
SMART |
|
EGF
|
336 |
373 |
1.64e-1 |
SMART |
|
EGF
|
377 |
413 |
1.99e1 |
SMART |
|
EGF_CA
|
414 |
454 |
7.4e-9 |
SMART |
|
EGF
|
521 |
554 |
4.26e0 |
SMART |
|
EGF_Lam
|
570 |
609 |
1.19e-3 |
SMART |
|
EGF_like
|
613 |
652 |
5.29e-1 |
SMART |
|
EGF
|
642 |
685 |
2.2e1 |
SMART |
|
EGF_Lam
|
656 |
697 |
1.04e-3 |
SMART |
|
EGF
|
687 |
730 |
1.59e1 |
SMART |
|
EGF_like
|
701 |
742 |
2.27e0 |
SMART |
|
EGF_Lam
|
746 |
784 |
1.33e-1 |
SMART |
|
EGF
|
783 |
816 |
2.85e-1 |
SMART |
|
EGF_Lam
|
832 |
871 |
3.88e-3 |
SMART |
|
EGF_Lam
|
875 |
915 |
3.25e-5 |
SMART |
|
EGF
|
914 |
946 |
4.7e-2 |
SMART |
|
EGF_like
|
962 |
1001 |
1.69e-1 |
SMART |
|
EGF
|
1000 |
1032 |
7.02e-1 |
SMART |
|
EGF_Lam
|
1048 |
1087 |
3.1e-2 |
SMART |
|
EGF
|
1077 |
1118 |
7.53e-1 |
SMART |
|
EGF_like
|
1091 |
1130 |
5.59e-1 |
SMART |
|
EGF
|
1129 |
1161 |
5.04e-2 |
SMART |
|
EGF_Lam
|
1177 |
1216 |
2.94e-3 |
SMART |
|
EGF
|
1206 |
1248 |
1.87e1 |
SMART |
|
EGF_Lam
|
1220 |
1260 |
3.1e-2 |
SMART |
|
EGF
|
1259 |
1291 |
1.73e0 |
SMART |
|
EGF
|
1302 |
1334 |
6.55e-1 |
SMART |
|
EGF
|
1345 |
1377 |
4.39e-2 |
SMART |
|
EGF_Lam
|
1393 |
1432 |
7.64e-2 |
SMART |
|
EGF_Lam
|
1436 |
1475 |
2.64e-5 |
SMART |
|
EGF_like
|
1465 |
1506 |
4.2e1 |
SMART |
|
EGF_Lam
|
1479 |
1518 |
1.19e-3 |
SMART |
|
EGF
|
1517 |
1549 |
1.84e1 |
SMART |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000117277
Gene: ENSMUSG00000057751
AA Change: G222R
| Domain | Start | End | E-Value | Type |
|---|
|
EGF_Lam
|
3 |
42 |
3.1e-2 |
SMART |
|
EGF
|
32 |
73 |
7.53e-1 |
SMART |
|
EGF_like
|
46 |
85 |
8.92e-1 |
SMART |
|
EGF
|
84 |
116 |
7.13e-2 |
SMART |
|
EGF
|
127 |
159 |
1.73e0 |
SMART |
|
EGF
|
170 |
202 |
6.55e-1 |
SMART |
|
EGF
|
213 |
245 |
4.39e-2 |
SMART |
|
EGF_Lam
|
261 |
300 |
7.64e-2 |
SMART |
|
EGF
|
299 |
331 |
1.51e0 |
SMART |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000121641
Gene: ENSMUSG00000057751
AA Change: G1074R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
EGF_CA
|
55 |
95 |
2.08e-12 |
SMART |
|
EGF
|
99 |
137 |
5.4e-2 |
SMART |
|
EGF
|
141 |
178 |
2.39e-3 |
SMART |
|
EGF_CA
|
179 |
219 |
4.96e-10 |
SMART |
|
EGF
|
228 |
265 |
1.64e-1 |
SMART |
|
EGF
|
269 |
305 |
1.99e1 |
SMART |
|
EGF_CA
|
306 |
346 |
7.4e-9 |
SMART |
|
EGF
|
413 |
446 |
4.26e0 |
SMART |
|
EGF_Lam
|
462 |
501 |
1.19e-3 |
SMART |
|
EGF_like
|
505 |
544 |
5.29e-1 |
SMART |
|
EGF
|
534 |
577 |
2.2e1 |
SMART |
|
EGF_Lam
|
548 |
589 |
1.04e-3 |
SMART |
|
EGF
|
579 |
622 |
1.59e1 |
SMART |
|
EGF_like
|
593 |
634 |
2.27e0 |
SMART |
|
EGF_Lam
|
638 |
676 |
1.33e-1 |
SMART |
|
EGF
|
675 |
708 |
2.85e-1 |
SMART |
|
EGF_Lam
|
724 |
763 |
3.88e-3 |
SMART |
|
EGF_Lam
|
767 |
807 |
3.25e-5 |
SMART |
|
EGF
|
806 |
838 |
4.7e-2 |
SMART |
|
EGF_Lam
|
854 |
893 |
2.56e-3 |
SMART |
|
EGF
|
892 |
924 |
2.02e-1 |
SMART |
|
EGF
|
935 |
967 |
7.13e-2 |
SMART |
|
EGF
|
978 |
1010 |
1.73e0 |
SMART |
|
EGF
|
1021 |
1053 |
6.55e-1 |
SMART |
|
EGF
|
1064 |
1096 |
4.39e-2 |
SMART |
|
EGF
|
1107 |
1139 |
4.97e-1 |
SMART |
|
EGF
|
1159 |
1191 |
1.84e1 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
97% (72/74) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A830018L16Rik |
A |
T |
1: 11,633,211 (GRCm39) |
D168V |
probably damaging |
Het |
| Abcb4 |
A |
T |
5: 9,008,441 (GRCm39) |
D1203V |
probably damaging |
Het |
| Acat2 |
G |
A |
17: 13,178,979 (GRCm39) |
|
probably benign |
Het |
| Adam3 |
C |
T |
8: 25,179,484 (GRCm39) |
C611Y |
probably damaging |
Het |
| Adgrb1 |
A |
G |
15: 74,415,189 (GRCm39) |
D638G |
probably damaging |
Het |
| Adra1b |
T |
C |
11: 43,667,218 (GRCm39) |
N340D |
probably damaging |
Het |
| Ankrd31 |
A |
G |
13: 96,916,879 (GRCm39) |
H131R |
probably damaging |
Het |
| Aoc2 |
T |
C |
11: 101,217,164 (GRCm39) |
S416P |
possibly damaging |
Het |
| Armc8 |
G |
A |
9: 99,387,362 (GRCm39) |
R419* |
probably null |
Het |
| Atp6v1h |
T |
G |
1: 5,163,638 (GRCm39) |
V90G |
probably damaging |
Het |
| Avl9 |
T |
C |
6: 56,707,628 (GRCm39) |
V191A |
probably benign |
Het |
| Bsn |
G |
A |
9: 107,990,173 (GRCm39) |
P1860S |
possibly damaging |
Het |
| Btd |
A |
G |
14: 31,384,233 (GRCm39) |
K73R |
probably benign |
Het |
| Cd22 |
T |
C |
7: 30,567,391 (GRCm39) |
K731R |
probably benign |
Het |
| Chmp7 |
C |
A |
14: 69,956,911 (GRCm39) |
L332F |
probably damaging |
Het |
| Cirop |
T |
G |
14: 54,932,686 (GRCm39) |
S393R |
probably damaging |
Het |
| Cldn11 |
A |
G |
3: 31,217,276 (GRCm39) |
E148G |
probably damaging |
Het |
| Cmtm1 |
TCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGG |
TCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGG |
8: 105,036,334 (GRCm39) |
|
probably null |
Het |
| Cnbd1 |
A |
T |
4: 18,886,061 (GRCm39) |
Y319* |
probably null |
Het |
| Cnnm4 |
A |
G |
1: 36,511,170 (GRCm39) |
T133A |
probably benign |
Het |
| Cpeb4 |
A |
T |
11: 31,822,679 (GRCm39) |
E131V |
probably benign |
Het |
| Ctns |
A |
G |
11: 73,078,561 (GRCm39) |
|
probably null |
Het |
| Dhx36 |
C |
A |
3: 62,414,142 (GRCm39) |
Q73H |
probably benign |
Het |
| Dhx36 |
C |
A |
3: 62,414,141 (GRCm39) |
E74* |
probably null |
Het |
| Dnah5 |
A |
G |
15: 28,420,107 (GRCm39) |
T3802A |
|
Het |
| Fbxo31 |
G |
A |
8: 122,281,136 (GRCm39) |
R337C |
probably damaging |
Het |
| Flnc |
C |
T |
6: 29,455,518 (GRCm39) |
Q2056* |
probably null |
Het |
| Fmo9 |
T |
C |
1: 166,492,199 (GRCm39) |
D408G |
possibly damaging |
Het |
| Gipr |
C |
T |
7: 18,897,495 (GRCm39) |
S117N |
unknown |
Het |
| Gm14412 |
T |
A |
2: 177,006,356 (GRCm39) |
H513L |
probably damaging |
Het |
| Gm21663 |
G |
C |
5: 26,147,167 (GRCm39) |
C46W |
probably benign |
Het |
| Gucy1a2 |
A |
T |
9: 3,634,489 (GRCm39) |
I178L |
probably benign |
Het |
| Htr1b |
A |
T |
9: 81,514,481 (GRCm39) |
L42Q |
|
Het |
| Htr2b |
T |
C |
1: 86,027,481 (GRCm39) |
T342A |
probably damaging |
Het |
| Jkampl |
T |
C |
6: 73,446,517 (GRCm39) |
T11A |
probably benign |
Het |
| Jph2 |
C |
T |
2: 163,181,473 (GRCm39) |
V564M |
probably damaging |
Het |
| Kcnmb1 |
A |
G |
11: 33,914,806 (GRCm39) |
T36A |
probably damaging |
Het |
| Krit1 |
A |
C |
5: 3,863,135 (GRCm39) |
K310N |
probably benign |
Het |
| Lama1 |
C |
T |
17: 68,111,508 (GRCm39) |
T2253M |
|
Het |
| Lpar6 |
C |
T |
14: 73,476,233 (GRCm39) |
L65F |
probably damaging |
Het |
| Mmp3 |
T |
A |
9: 7,446,936 (GRCm39) |
Y39N |
probably damaging |
Het |
| Mrtfb |
A |
G |
16: 13,221,053 (GRCm39) |
H743R |
probably benign |
Het |
| Ms4a18 |
C |
A |
19: 10,990,741 (GRCm39) |
V118F |
|
Het |
| Mthfr |
G |
A |
4: 148,126,082 (GRCm39) |
S51N |
probably benign |
Het |
| Muc16 |
T |
A |
9: 18,554,975 (GRCm39) |
T3773S |
unknown |
Het |
| Mus81 |
T |
A |
19: 5,534,032 (GRCm39) |
K400* |
probably null |
Het |
| Naaladl2 |
A |
T |
3: 24,487,344 (GRCm39) |
D192E |
probably benign |
Het |
| Naip5 |
T |
C |
13: 100,366,127 (GRCm39) |
D329G |
possibly damaging |
Het |
| Nek11 |
T |
A |
9: 105,170,856 (GRCm39) |
H393L |
probably benign |
Het |
| Nmt2 |
T |
A |
2: 3,306,315 (GRCm39) |
|
probably benign |
Het |
| Nmur2 |
T |
C |
11: 55,920,408 (GRCm39) |
D279G |
possibly damaging |
Het |
| Nol4l |
C |
A |
2: 153,312,630 (GRCm39) |
R226L |
probably damaging |
Het |
| Ogfr |
GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG |
GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG |
2: 180,237,059 (GRCm39) |
|
probably benign |
Het |
| Or10d4c |
A |
G |
9: 39,558,379 (GRCm39) |
D119G |
probably damaging |
Het |
| Or1o2 |
T |
C |
17: 37,542,961 (GRCm39) |
Y100C |
probably benign |
Het |
| Or5ak22 |
T |
C |
2: 85,229,995 (GRCm39) |
N294S |
probably damaging |
Het |
| Palm |
A |
G |
10: 79,654,988 (GRCm39) |
T249A |
probably benign |
Het |
| Pramel22 |
A |
T |
4: 143,381,097 (GRCm39) |
Y309N |
probably benign |
Het |
| Rhobtb3 |
A |
G |
13: 76,087,702 (GRCm39) |
I95T |
probably damaging |
Het |
| Rnpep |
A |
T |
1: 135,206,559 (GRCm39) |
F178L |
possibly damaging |
Het |
| Rsl1d1 |
A |
G |
16: 11,019,227 (GRCm39) |
S105P |
probably damaging |
Het |
| Rxra |
C |
T |
2: 27,638,756 (GRCm39) |
T253I |
possibly damaging |
Het |
| Schip1 |
A |
G |
3: 67,972,318 (GRCm39) |
D15G |
|
Het |
| Sis |
T |
A |
3: 72,844,578 (GRCm39) |
I719F |
possibly damaging |
Het |
| Snx18 |
A |
G |
13: 113,754,310 (GRCm39) |
S208P |
probably benign |
Het |
| Srcap |
T |
C |
7: 127,151,816 (GRCm39) |
V2125A |
probably damaging |
Het |
| Stx7 |
C |
T |
10: 24,058,724 (GRCm39) |
Q199* |
probably null |
Het |
| Syt6 |
T |
C |
3: 103,492,895 (GRCm39) |
I134T |
probably damaging |
Het |
| Tlr12 |
A |
G |
4: 128,510,870 (GRCm39) |
M460T |
probably benign |
Het |
| Tnni3k |
T |
C |
3: 154,647,314 (GRCm39) |
T398A |
possibly damaging |
Het |
| Tspan4 |
T |
C |
7: 141,071,816 (GRCm39) |
S188P |
probably benign |
Het |
| Ubap2l |
A |
G |
3: 89,909,756 (GRCm39) |
S1025P |
unknown |
Het |
| Ubl7 |
A |
G |
9: 57,829,035 (GRCm39) |
D219G |
probably benign |
Het |
| Vmn2r115 |
C |
A |
17: 23,564,803 (GRCm39) |
T230K |
probably benign |
Het |
| Vmn2r95 |
T |
A |
17: 18,660,167 (GRCm39) |
M193K |
possibly damaging |
Het |
| Zfp639 |
A |
G |
3: 32,573,885 (GRCm39) |
E170G |
probably damaging |
Het |
| Zfy1 |
A |
G |
Y: 725,987 (GRCm39) |
S593P |
possibly damaging |
Het |
| Zscan4-ps1 |
T |
A |
7: 10,799,495 (GRCm39) |
T465S |
probably damaging |
Het |
|
| Other mutations in Megf6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01122:Megf6
|
APN |
4 |
154,338,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01410:Megf6
|
APN |
4 |
154,337,020 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01512:Megf6
|
APN |
4 |
154,347,040 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL01824:Megf6
|
APN |
4 |
154,336,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02172:Megf6
|
APN |
4 |
154,355,149 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02727:Megf6
|
APN |
4 |
154,337,606 (GRCm39) |
splice site |
probably null |
|
|
IGL02966:Megf6
|
APN |
4 |
154,338,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Didactic
|
UTSW |
4 |
154,339,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0118:Megf6
|
UTSW |
4 |
154,339,098 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0220:Megf6
|
UTSW |
4 |
154,342,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0347:Megf6
|
UTSW |
4 |
154,339,092 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0383:Megf6
|
UTSW |
4 |
154,349,783 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0417:Megf6
|
UTSW |
4 |
154,352,424 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0526:Megf6
|
UTSW |
4 |
154,343,398 (GRCm39) |
missense |
probably benign |
|
|
R0528:Megf6
|
UTSW |
4 |
154,343,630 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0928:Megf6
|
UTSW |
4 |
154,261,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1311:Megf6
|
UTSW |
4 |
154,348,239 (GRCm39) |
splice site |
probably null |
|
|
R1458:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1470:Megf6
|
UTSW |
4 |
154,336,876 (GRCm39) |
splice site |
probably benign |
|
|
R1476:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1479:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1624:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1626:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1638:Megf6
|
UTSW |
4 |
154,346,967 (GRCm39) |
splice site |
probably benign |
|
|
R1777:Megf6
|
UTSW |
4 |
154,355,147 (GRCm39) |
nonsense |
probably null |
|
|
R1831:Megf6
|
UTSW |
4 |
154,355,134 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1944:Megf6
|
UTSW |
4 |
154,340,523 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1984:Megf6
|
UTSW |
4 |
154,352,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2109:Megf6
|
UTSW |
4 |
154,261,578 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2448:Megf6
|
UTSW |
4 |
154,351,102 (GRCm39) |
splice site |
probably null |
|
|
R2880:Megf6
|
UTSW |
4 |
154,337,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4032:Megf6
|
UTSW |
4 |
154,261,550 (GRCm39) |
nonsense |
probably null |
|
|
R4058:Megf6
|
UTSW |
4 |
154,326,989 (GRCm39) |
splice site |
probably benign |
|
|
R4672:Megf6
|
UTSW |
4 |
154,333,909 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4688:Megf6
|
UTSW |
4 |
154,338,271 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4752:Megf6
|
UTSW |
4 |
154,336,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4863:Megf6
|
UTSW |
4 |
154,338,738 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4909:Megf6
|
UTSW |
4 |
154,349,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4942:Megf6
|
UTSW |
4 |
154,338,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4981:Megf6
|
UTSW |
4 |
154,351,907 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4990:Megf6
|
UTSW |
4 |
154,351,683 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5001:Megf6
|
UTSW |
4 |
154,352,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5189:Megf6
|
UTSW |
4 |
154,336,980 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5210:Megf6
|
UTSW |
4 |
154,354,273 (GRCm39) |
intron |
probably benign |
|
|
R5220:Megf6
|
UTSW |
4 |
154,338,295 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5250:Megf6
|
UTSW |
4 |
154,340,467 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5697:Megf6
|
UTSW |
4 |
154,342,686 (GRCm39) |
missense |
probably null |
0.15 |
|
R5808:Megf6
|
UTSW |
4 |
154,352,119 (GRCm39) |
missense |
probably benign |
|
|
R5916:Megf6
|
UTSW |
4 |
154,333,882 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6054:Megf6
|
UTSW |
4 |
154,347,636 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6075:Megf6
|
UTSW |
4 |
154,347,056 (GRCm39) |
nonsense |
probably null |
|
|
R6515:Megf6
|
UTSW |
4 |
154,343,376 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6599:Megf6
|
UTSW |
4 |
154,342,544 (GRCm39) |
splice site |
probably null |
|
|
R6811:Megf6
|
UTSW |
4 |
154,336,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6925:Megf6
|
UTSW |
4 |
154,339,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Megf6
|
UTSW |
4 |
154,338,602 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7117:Megf6
|
UTSW |
4 |
154,343,379 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7163:Megf6
|
UTSW |
4 |
154,351,898 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7345:Megf6
|
UTSW |
4 |
154,351,772 (GRCm39) |
missense |
probably benign |
|
|
R7580:Megf6
|
UTSW |
4 |
154,355,201 (GRCm39) |
nonsense |
probably null |
|
|
R7649:Megf6
|
UTSW |
4 |
154,349,542 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7702:Megf6
|
UTSW |
4 |
154,354,927 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8010:Megf6
|
UTSW |
4 |
154,354,964 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8175:Megf6
|
UTSW |
4 |
154,353,076 (GRCm39) |
nonsense |
probably null |
|
|
R8231:Megf6
|
UTSW |
4 |
154,336,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8436:Megf6
|
UTSW |
4 |
154,349,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8460:Megf6
|
UTSW |
4 |
154,350,634 (GRCm39) |
nonsense |
probably null |
|
|
R8738:Megf6
|
UTSW |
4 |
154,352,436 (GRCm39) |
missense |
probably benign |
|
|
R8854:Megf6
|
UTSW |
4 |
154,352,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Megf6
|
UTSW |
4 |
154,326,860 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9147:Megf6
|
UTSW |
4 |
154,339,130 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9148:Megf6
|
UTSW |
4 |
154,339,130 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9161:Megf6
|
UTSW |
4 |
154,352,172 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9355:Megf6
|
UTSW |
4 |
154,338,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9386:Megf6
|
UTSW |
4 |
154,340,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9404:Megf6
|
UTSW |
4 |
154,348,225 (GRCm39) |
missense |
|
|
|
R9469:Megf6
|
UTSW |
4 |
154,335,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9472:Megf6
|
UTSW |
4 |
154,333,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9777:Megf6
|
UTSW |
4 |
154,343,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Megf6
|
UTSW |
4 |
154,322,283 (GRCm39) |
missense |
probably benign |
0.12 |
|
Z1177:Megf6
|
UTSW |
4 |
154,354,198 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Megf6
|
UTSW |
4 |
154,352,204 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Megf6
|
UTSW |
4 |
154,352,139 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Megf6
|
UTSW |
4 |
154,352,138 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
Z1177:Megf6
|
UTSW |
4 |
154,335,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGGTCCCTGTTATCAGACCTG -3'
(R):5'- GGATTCTTAGTTGCTCCCTGAC -3'
Sequencing Primer
(F):5'- CTGCCCAGAATTCTGAGGGATTC -3'
(R):5'- AGTTGCTCCCTGACTCACCAC -3'
|
| Posted On |
2021-12-30 |
Incidental Mutation