Incidental Mutation 'R9098:Naip5'
ID 691501
Institutional Source Beutler Lab
Gene Symbol Naip5
Ensembl Gene ENSMUSG00000071203
Gene Name NLR family, apoptosis inhibitory protein 5
Synonyms Birc1e, Lgn1, Naip-rs3
MMRRC Submission 068913-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R9098 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 100211739-100246323 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 100229619 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 329 (D329G)
Ref Sequence ENSEMBL: ENSMUSP00000058611 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049789]
AlphaFold Q9R016
Predicted Effect possibly damaging
Transcript: ENSMUST00000049789
AA Change: D329G

PolyPhen 2 Score 0.668 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000058611
Gene: ENSMUSG00000071203
AA Change: D329G

DomainStartEndE-ValueType
low complexity region 36 51 N/A INTRINSIC
BIR 58 129 1.08e-19 SMART
BIR 157 229 1.06e-36 SMART
BIR 276 347 2.14e-32 SMART
Pfam:NACHT 464 618 1.7e-36 PFAM
low complexity region 851 862 N/A INTRINSIC
Meta Mutation Damage Score 0.1712 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 97% (72/74)
MGI Phenotype PHENOTYPE: This locus controls resistance to Legionella pneumophila, the organism responsible for Legionnaire's disease. Cultured peritoneal macrophages from A/J mice are susceptible, supporting bacterial proliferation; other strains, e.g., C57BL/6 are resistant. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931417E11Rik T C 6: 73,469,534 (GRCm38) T11A probably benign Het
A830018L16Rik A T 1: 11,562,987 (GRCm38) D168V probably damaging Het
Abcb4 A T 5: 8,958,441 (GRCm38) D1203V probably damaging Het
Acat2 G A 17: 12,960,092 (GRCm38) probably benign Het
Adam3 C T 8: 24,689,468 (GRCm38) C611Y probably damaging Het
Adgrb1 A G 15: 74,543,340 (GRCm38) D638G probably damaging Het
Adra1b T C 11: 43,776,391 (GRCm38) N340D probably damaging Het
Ankrd31 A G 13: 96,780,371 (GRCm38) H131R probably damaging Het
Aoc2 T C 11: 101,326,338 (GRCm38) S416P possibly damaging Het
Armc8 G A 9: 99,505,309 (GRCm38) R419* probably null Het
Atp6v1h T G 1: 5,093,415 (GRCm38) V90G probably damaging Het
Avl9 T C 6: 56,730,643 (GRCm38) V191A probably benign Het
Bsn G A 9: 108,112,974 (GRCm38) P1860S possibly damaging Het
Btd A G 14: 31,662,276 (GRCm38) K73R probably benign Het
Cd22 T C 7: 30,867,966 (GRCm38) K731R probably benign Het
Chmp7 C A 14: 69,719,462 (GRCm38) L332F probably damaging Het
Cldn11 A G 3: 31,163,127 (GRCm38) E148G probably damaging Het
Cmtm1 TCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGG TCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGGCTGGCTGGTGTCCCGGGTACTGAAGGTCCCTGG 8: 104,309,702 (GRCm38) probably null Het
Cnbd1 A T 4: 18,886,061 (GRCm38) Y319* probably null Het
Cnnm4 A G 1: 36,472,089 (GRCm38) T133A probably benign Het
Cpeb4 A T 11: 31,872,679 (GRCm38) E131V probably benign Het
Ctns A G 11: 73,187,735 (GRCm38) probably null Het
Dhx36 C A 3: 62,506,720 (GRCm38) E74* probably null Het
Dhx36 C A 3: 62,506,721 (GRCm38) Q73H probably benign Het
Dnah5 A G 15: 28,419,961 (GRCm38) T3802A Het
Fbxo31 G A 8: 121,554,397 (GRCm38) R337C probably damaging Het
Flnc C T 6: 29,455,519 (GRCm38) Q2056* probably null Het
Fmo9 T C 1: 166,664,630 (GRCm38) D408G possibly damaging Het
Gipr C T 7: 19,163,570 (GRCm38) S117N unknown Het
Gm13088 A T 4: 143,654,527 (GRCm38) Y309N probably benign Het
Gm14412 T A 2: 177,314,563 (GRCm38) H513L probably damaging Het
Gm21663 G C 5: 25,942,169 (GRCm38) C46W probably benign Het
Gm29776 T G 14: 54,695,229 (GRCm38) S393R probably damaging Het
Gucy1a2 A T 9: 3,634,489 (GRCm38) I178L probably benign Het
Htr1b A T 9: 81,632,428 (GRCm38) L42Q Het
Htr2b T C 1: 86,099,759 (GRCm38) T342A probably damaging Het
Jph2 C T 2: 163,339,553 (GRCm38) V564M probably damaging Het
Kcnmb1 A G 11: 33,964,806 (GRCm38) T36A probably damaging Het
Krit1 A C 5: 3,813,135 (GRCm38) K310N probably benign Het
Lama1 C T 17: 67,804,513 (GRCm38) T2253M Het
Lpar6 C T 14: 73,238,793 (GRCm38) L65F probably damaging Het
Megf6 G A 4: 154,269,703 (GRCm38) G1355R probably damaging Het
Mkl2 A G 16: 13,403,189 (GRCm38) H743R probably benign Het
Mmp3 T A 9: 7,446,936 (GRCm38) Y39N probably damaging Het
Ms4a18 C A 19: 11,013,377 (GRCm38) V118F Het
Mthfr G A 4: 148,041,625 (GRCm38) S51N probably benign Het
Muc16 T A 9: 18,643,679 (GRCm38) T3773S unknown Het
Mus81 T A 19: 5,484,004 (GRCm38) K400* probably null Het
Naaladl2 A T 3: 24,433,180 (GRCm38) D192E probably benign Het
Nek11 T A 9: 105,293,657 (GRCm38) H393L probably benign Het
Nmt2 T A 2: 3,305,278 (GRCm38) probably benign Het
Nmur2 T C 11: 56,029,582 (GRCm38) D279G possibly damaging Het
Nol4l C A 2: 153,470,710 (GRCm38) R226L probably damaging Het
Ogfr GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG 2: 180,595,266 (GRCm38) probably benign Het
Olfr961 A G 9: 39,647,083 (GRCm38) D119G probably damaging Het
Olfr97 T C 17: 37,232,070 (GRCm38) Y100C probably benign Het
Olfr992 T C 2: 85,399,651 (GRCm38) N294S probably damaging Het
Palm A G 10: 79,819,154 (GRCm38) T249A probably benign Het
Rhobtb3 A G 13: 75,939,583 (GRCm38) I95T probably damaging Het
Rnpep A T 1: 135,278,821 (GRCm38) F178L possibly damaging Het
Rsl1d1 A G 16: 11,201,363 (GRCm38) S105P probably damaging Het
Rxra C T 2: 27,748,744 (GRCm38) T253I possibly damaging Het
Schip1 A G 3: 68,064,985 (GRCm38) D15G Het
Sis T A 3: 72,937,245 (GRCm38) I719F possibly damaging Het
Snx18 A G 13: 113,617,774 (GRCm38) S208P probably benign Het
Srcap T C 7: 127,552,644 (GRCm38) V2125A probably damaging Het
Stx7 C T 10: 24,182,826 (GRCm38) Q199* probably null Het
Syt6 T C 3: 103,585,579 (GRCm38) I134T probably damaging Het
Tlr12 A G 4: 128,617,077 (GRCm38) M460T probably benign Het
Tnni3k T C 3: 154,941,677 (GRCm38) T398A possibly damaging Het
Tspan4 T C 7: 141,491,903 (GRCm38) S188P probably benign Het
Ubap2l A G 3: 90,002,449 (GRCm38) S1025P unknown Het
Ubl7 A G 9: 57,921,752 (GRCm38) D219G probably benign Het
Vmn2r115 C A 17: 23,345,829 (GRCm38) T230K probably benign Het
Vmn2r95 T A 17: 18,439,905 (GRCm38) M193K possibly damaging Het
Zfp639 A G 3: 32,519,736 (GRCm38) E170G probably damaging Het
Zfy1 A G Y: 725,987 (GRCm38) S593P possibly damaging Het
Zscan4-ps1 T A 7: 11,065,568 (GRCm38) T465S probably damaging Het
Other mutations in Naip5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00096:Naip5 APN 13 100,246,175 (GRCm38) nonsense probably null
IGL00493:Naip5 APN 13 100,230,771 (GRCm38) missense probably damaging 0.96
IGL01294:Naip5 APN 13 100,217,080 (GRCm38) missense probably damaging 0.99
IGL01405:Naip5 APN 13 100,221,945 (GRCm38) missense probably benign 0.11
IGL01568:Naip5 APN 13 100,217,101 (GRCm38) missense probably benign 0.26
IGL01804:Naip5 APN 13 100,221,584 (GRCm38) missense probably damaging 1.00
IGL02012:Naip5 APN 13 100,223,339 (GRCm38) missense probably benign 0.01
IGL02183:Naip5 APN 13 100,221,642 (GRCm38) missense probably benign 0.41
IGL02449:Naip5 APN 13 100,222,175 (GRCm38) missense probably benign 0.34
IGL02815:Naip5 APN 13 100,222,731 (GRCm38) missense probably benign
IGL02992:Naip5 APN 13 100,223,028 (GRCm38) missense probably damaging 1.00
IGL03027:Naip5 APN 13 100,223,016 (GRCm38) missense probably benign 0.00
IGL03234:Naip5 APN 13 100,212,627 (GRCm38) missense probably damaging 1.00
inwood2 UTSW 13 100,223,014 (GRCm38) nonsense probably null
inwood3 UTSW 13 100,221,903 (GRCm38) nonsense probably null
Nuchal UTSW 13 100,214,663 (GRCm38) missense possibly damaging 0.82
PIT4131001:Naip5 UTSW 13 100,219,760 (GRCm38) missense probably benign 0.00
PIT4131001:Naip5 UTSW 13 100,219,739 (GRCm38) missense probably benign
R0001:Naip5 UTSW 13 100,223,114 (GRCm38) missense probably benign
R0001:Naip5 UTSW 13 100,214,650 (GRCm38) critical splice donor site probably null
R0462:Naip5 UTSW 13 100,221,732 (GRCm38) missense probably damaging 1.00
R0636:Naip5 UTSW 13 100,219,688 (GRCm38) missense probably benign
R0674:Naip5 UTSW 13 100,223,199 (GRCm38) missense probably benign 0.04
R0764:Naip5 UTSW 13 100,217,105 (GRCm38) missense probably benign 0.03
R0837:Naip5 UTSW 13 100,230,743 (GRCm38) missense probably benign
R1179:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R1302:Naip5 UTSW 13 100,221,591 (GRCm38) missense possibly damaging 0.91
R1441:Naip5 UTSW 13 100,219,717 (GRCm38) missense possibly damaging 0.95
R1513:Naip5 UTSW 13 100,222,206 (GRCm38) missense probably benign
R1638:Naip5 UTSW 13 100,212,669 (GRCm38) missense probably damaging 1.00
R1651:Naip5 UTSW 13 100,221,911 (GRCm38) missense probably benign 0.41
R1707:Naip5 UTSW 13 100,242,855 (GRCm38) missense probably damaging 1.00
R1835:Naip5 UTSW 13 100,223,218 (GRCm38) nonsense probably null
R1836:Naip5 UTSW 13 100,219,687 (GRCm38) missense probably benign 0.18
R1972:Naip5 UTSW 13 100,212,770 (GRCm38) missense probably damaging 0.98
R2080:Naip5 UTSW 13 100,221,533 (GRCm38) missense probably damaging 1.00
R2333:Naip5 UTSW 13 100,223,171 (GRCm38) missense probably damaging 1.00
R2348:Naip5 UTSW 13 100,219,738 (GRCm38) missense probably benign 0.01
R3055:Naip5 UTSW 13 100,221,878 (GRCm38) missense probably benign 0.23
R3401:Naip5 UTSW 13 100,221,903 (GRCm38) nonsense probably null
R3723:Naip5 UTSW 13 100,223,014 (GRCm38) nonsense probably null
R3775:Naip5 UTSW 13 100,223,394 (GRCm38) missense probably benign 0.00
R3775:Naip5 UTSW 13 100,223,375 (GRCm38) missense probably benign 0.00
R4019:Naip5 UTSW 13 100,223,375 (GRCm38) missense probably benign 0.00
R4019:Naip5 UTSW 13 100,223,394 (GRCm38) missense probably benign 0.00
R4020:Naip5 UTSW 13 100,223,394 (GRCm38) missense probably benign 0.00
R4020:Naip5 UTSW 13 100,223,375 (GRCm38) missense probably benign 0.00
R4074:Naip5 UTSW 13 100,246,064 (GRCm38) missense probably damaging 1.00
R4082:Naip5 UTSW 13 100,245,830 (GRCm38) missense probably damaging 1.00
R4105:Naip5 UTSW 13 100,219,739 (GRCm38) missense probably benign
R4227:Naip5 UTSW 13 100,212,768 (GRCm38) missense probably damaging 0.99
R4639:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R4640:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R4641:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R4644:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R4645:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R4700:Naip5 UTSW 13 100,223,414 (GRCm38) missense possibly damaging 0.62
R4727:Naip5 UTSW 13 100,221,870 (GRCm38) missense possibly damaging 0.81
R4729:Naip5 UTSW 13 100,222,131 (GRCm38) missense possibly damaging 0.75
R4816:Naip5 UTSW 13 100,219,681 (GRCm38) missense probably benign 0.32
R4816:Naip5 UTSW 13 100,219,687 (GRCm38) missense probably benign 0.01
R4816:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R4869:Naip5 UTSW 13 100,245,131 (GRCm38) missense probably damaging 1.00
R5162:Naip5 UTSW 13 100,223,406 (GRCm38) missense possibly damaging 0.78
R5244:Naip5 UTSW 13 100,245,662 (GRCm38) missense probably benign 0.08
R5411:Naip5 UTSW 13 100,245,746 (GRCm38) missense possibly damaging 0.54
R5632:Naip5 UTSW 13 100,230,662 (GRCm38) splice site probably null
R5760:Naip5 UTSW 13 100,242,838 (GRCm38) missense probably damaging 1.00
R5916:Naip5 UTSW 13 100,222,701 (GRCm38) missense probably benign 0.02
R6302:Naip5 UTSW 13 100,223,166 (GRCm38) missense possibly damaging 0.76
R6304:Naip5 UTSW 13 100,223,166 (GRCm38) missense possibly damaging 0.76
R6411:Naip5 UTSW 13 100,223,405 (GRCm38) missense probably benign 0.01
R6474:Naip5 UTSW 13 100,214,663 (GRCm38) missense possibly damaging 0.82
R6499:Naip5 UTSW 13 100,221,594 (GRCm38) missense probably benign
R6544:Naip5 UTSW 13 100,223,144 (GRCm38) missense possibly damaging 0.50
R6827:Naip5 UTSW 13 100,245,929 (GRCm38) missense possibly damaging 0.48
R6954:Naip5 UTSW 13 100,223,414 (GRCm38) missense probably damaging 0.99
R7052:Naip5 UTSW 13 100,222,347 (GRCm38) missense probably benign 0.01
R7138:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R7141:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R7375:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R7375:Naip5 UTSW 13 100,219,697 (GRCm38) missense not run
R7401:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R7401:Naip5 UTSW 13 100,219,697 (GRCm38) missense not run
R7447:Naip5 UTSW 13 100,219,697 (GRCm38) missense not run
R7447:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R7466:Naip5 UTSW 13 100,221,986 (GRCm38) nonsense probably null
R7491:Naip5 UTSW 13 100,217,071 (GRCm38) missense probably benign 0.18
R7559:Naip5 UTSW 13 100,219,697 (GRCm38) missense not run
R7559:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R7562:Naip5 UTSW 13 100,219,697 (GRCm38) missense not run
R7562:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R7588:Naip5 UTSW 13 100,219,697 (GRCm38) missense not run
R7588:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R7589:Naip5 UTSW 13 100,219,697 (GRCm38) missense not run
R7589:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R7590:Naip5 UTSW 13 100,219,696 (GRCm38) missense probably benign 0.00
R7590:Naip5 UTSW 13 100,219,697 (GRCm38) missense not run
R7742:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R7886:Naip5 UTSW 13 100,246,181 (GRCm38) missense probably benign 0.28
R7996:Naip5 UTSW 13 100,221,656 (GRCm38) missense probably damaging 1.00
R8026:Naip5 UTSW 13 100,245,898 (GRCm38) missense probably damaging 1.00
R8046:Naip5 UTSW 13 100,222,233 (GRCm38) missense probably benign
R8319:Naip5 UTSW 13 100,221,659 (GRCm38) missense probably benign 0.12
R8471:Naip5 UTSW 13 100,221,645 (GRCm38) missense probably damaging 0.99
R8480:Naip5 UTSW 13 100,222,235 (GRCm38) missense probably damaging 1.00
R8496:Naip5 UTSW 13 100,212,739 (GRCm38) missense probably benign 0.00
R8500:Naip5 UTSW 13 100,222,712 (GRCm38) missense probably damaging 0.98
R8712:Naip5 UTSW 13 100,223,096 (GRCm38) missense possibly damaging 0.61
R8780:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R8781:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R8788:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R8817:Naip5 UTSW 13 100,212,699 (GRCm38) missense probably benign 0.01
R8833:Naip5 UTSW 13 100,222,934 (GRCm38) missense probably damaging 0.97
R8835:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R8958:Naip5 UTSW 13 100,217,609 (GRCm38) nonsense probably null
R9031:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R9032:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R9074:Naip5 UTSW 13 100,221,756 (GRCm38) missense possibly damaging 0.92
R9204:Naip5 UTSW 13 100,222,500 (GRCm38) missense probably damaging 1.00
R9223:Naip5 UTSW 13 100,227,676 (GRCm38) missense probably benign 0.05
R9358:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R9389:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R9403:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R9518:Naip5 UTSW 13 100,221,859 (GRCm38) missense probably benign
R9568:Naip5 UTSW 13 100,223,313 (GRCm38) missense probably benign 0.00
R9568:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R9569:Naip5 UTSW 13 100,223,313 (GRCm38) missense probably benign 0.00
R9569:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R9570:Naip5 UTSW 13 100,223,313 (GRCm38) missense probably benign 0.00
R9572:Naip5 UTSW 13 100,223,313 (GRCm38) missense probably benign 0.00
R9581:Naip5 UTSW 13 100,214,686 (GRCm38) missense probably benign 0.11
R9627:Naip5 UTSW 13 100,219,830 (GRCm38) missense probably benign
R9725:Naip5 UTSW 13 100,222,276 (GRCm38) missense possibly damaging 0.94
R9763:Naip5 UTSW 13 100,230,761 (GRCm38) missense probably damaging 0.99
R9764:Naip5 UTSW 13 100,230,761 (GRCm38) missense probably damaging 0.99
R9765:Naip5 UTSW 13 100,230,761 (GRCm38) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TTCATACTGTGGCTCTCATGTG -3'
(R):5'- TCCACCTGGAGATGAAAGTAGG -3'

Sequencing Primer
(F):5'- CTGTGGCTCTCATGTGATCTATAAAG -3'
(R):5'- GCATAACCTGGAGTTGTC -3'
Posted On 2021-12-30