Incidental Mutation 'R9099:Snx29'
ID 691577
Institutional Source Beutler Lab
Gene Symbol Snx29
Ensembl Gene ENSMUSG00000071669
Gene Name sorting nexin 29
Synonyms Rundc2a, Gm11170, LOC385605, LOC381035, 4933437K13Rik
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9099 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 11140772-11573336 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 11478435 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 322 (W322R)
Ref Sequence ENSEMBL: ENSMUSP00000093993 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096273] [ENSMUST00000122168] [ENSMUST00000150993] [ENSMUST00000180792]
AlphaFold Q9D3S3
Predicted Effect probably damaging
Transcript: ENSMUST00000096273
AA Change: W322R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000093993
Gene: ENSMUSG00000071669
AA Change: W322R

DomainStartEndE-ValueType
low complexity region 103 120 N/A INTRINSIC
coiled coil region 125 206 N/A INTRINSIC
PX 319 422 3.13e-9 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000122168
AA Change: W307R

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000113595
Gene: ENSMUSG00000071669
AA Change: W307R

DomainStartEndE-ValueType
low complexity region 88 105 N/A INTRINSIC
coiled coil region 110 191 N/A INTRINSIC
Blast:PX 301 326 1e-7 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000150993
AA Change: W220R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000117896
Gene: ENSMUSG00000071669
AA Change: W220R

DomainStartEndE-ValueType
low complexity region 1 18 N/A INTRINSIC
coiled coil region 23 104 N/A INTRINSIC
Blast:PX 217 245 3e-8 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000180792
AA Change: W664R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000138025
Gene: ENSMUSG00000071669
AA Change: W664R

DomainStartEndE-ValueType
low complexity region 64 74 N/A INTRINSIC
RUN 115 178 7.89e-26 SMART
internal_repeat_1 192 211 2.63e-5 PROSPERO
internal_repeat_1 203 222 2.63e-5 PROSPERO
low complexity region 252 262 N/A INTRINSIC
low complexity region 270 275 N/A INTRINSIC
low complexity region 314 323 N/A INTRINSIC
low complexity region 445 462 N/A INTRINSIC
coiled coil region 467 548 N/A INTRINSIC
PX 661 764 3.13e-9 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 94% (61/65)
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b A T 11: 109,871,708 (GRCm39) M90K probably damaging Het
Actn2 T C 13: 12,303,516 (GRCm39) D428G probably damaging Het
Arrb1 T C 7: 99,243,836 (GRCm39) V262A probably damaging Het
Bok A G 1: 93,622,661 (GRCm39) I102V Het
C87436 T A 6: 86,439,567 (GRCm39) F419L probably damaging Het
Capn15 A G 17: 26,192,141 (GRCm39) C34R probably benign Het
Ccdc8 T A 7: 16,728,800 (GRCm39) Y96* probably null Het
Cd274 T A 19: 29,357,771 (GRCm39) C154* probably null Het
Cfap251 A G 5: 123,418,082 (GRCm39) probably benign Het
Ckap4 A T 10: 84,369,402 (GRCm39) L110Q probably damaging Het
Col26a1 A T 5: 136,777,202 (GRCm39) D335E probably benign Het
Crybg1 C T 10: 43,874,844 (GRCm39) V755I probably benign Het
Dhx38 A T 8: 110,282,783 (GRCm39) Y628N probably damaging Het
Dnah12 A T 14: 26,492,325 (GRCm39) K1155M probably benign Het
Ei24 A G 9: 36,697,270 (GRCm39) F153L probably damaging Het
Erg T A 16: 95,178,188 (GRCm39) E246D probably benign Het
Exoc6b T C 6: 84,982,000 (GRCm39) N99D possibly damaging Het
Fam222b G T 11: 78,046,020 (GRCm39) R527L probably damaging Het
Fam83h T C 15: 75,875,135 (GRCm39) Y734C probably damaging Het
Fbxo43 T C 15: 36,162,619 (GRCm39) E196G possibly damaging Het
Gata5 G A 2: 179,976,131 (GRCm39) P11L possibly damaging Het
Gbp3 A T 3: 142,271,048 (GRCm39) S151C probably benign Het
Gli3 T C 13: 15,901,320 (GRCm39) L1569P probably damaging Het
Helz G A 11: 107,523,041 (GRCm39) V742M probably damaging Het
Ifi27l2b A T 12: 103,418,114 (GRCm39) N175K unknown Het
Itga1 A T 13: 115,185,856 (GRCm39) Y49N probably damaging Het
Kcnk2 T C 1: 188,991,072 (GRCm39) T167A probably damaging Het
Kirrel2 T A 7: 30,147,642 (GRCm39) T669S probably benign Het
Krt9 TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC 11: 100,079,903 (GRCm39) probably benign Het
Lrit2 A T 14: 36,790,812 (GRCm39) T164S possibly damaging Het
Lrriq1 A G 10: 103,051,864 (GRCm39) V296A probably damaging Het
Malsu1 C T 6: 49,050,731 (GRCm39) probably benign Het
Moxd1 G A 10: 24,155,762 (GRCm39) V289I probably damaging Het
Nfs1 C T 2: 155,968,934 (GRCm39) G380E probably damaging Het
Nol4l C A 2: 153,312,630 (GRCm39) R226L probably damaging Het
Nsmaf CAAACTTTTAAACTT CAAACTT 4: 6,416,543 (GRCm39) probably null Het
Nup98 T A 7: 101,844,173 (GRCm39) N54I probably damaging Het
Or7g21 C T 9: 19,032,890 (GRCm39) P210L probably benign Het
Or8g22 A T 9: 38,958,026 (GRCm39) C230S probably benign Het
Or8g53 A G 9: 39,683,514 (GRCm39) I194T Het
Otoa T A 7: 120,739,055 (GRCm39) F755I probably benign Het
P4htm A T 9: 108,460,911 (GRCm39) M187K probably benign Het
Phldb3 C T 7: 24,323,727 (GRCm39) R453C probably benign Het
Pkd1l1 C T 11: 8,922,986 (GRCm39) A94T Het
Pkp1 A G 1: 135,805,429 (GRCm39) F669S probably benign Het
Prl8a2 C G 13: 27,536,793 (GRCm39) Y138* probably null Het
Prl8a2 T A 13: 27,536,794 (GRCm39) Y139N probably benign Het
Rtn4r T A 16: 17,969,068 (GRCm39) N165K probably benign Het
Scaper G T 9: 55,669,616 (GRCm39) D353E probably damaging Het
Scn4a G T 11: 106,211,000 (GRCm39) D1672E probably damaging Het
She A G 3: 89,739,078 (GRCm39) S90G probably benign Het
Shmt2 A T 10: 127,355,962 (GRCm39) D130E possibly damaging Het
Slc2a12 T A 10: 22,569,923 (GRCm39) I538K possibly damaging Het
Spp1 A G 5: 104,588,387 (GRCm39) D263G probably benign Het
Srek1ip1 T C 13: 104,973,964 (GRCm39) S124P possibly damaging Het
Tcp10b C T 17: 13,280,656 (GRCm39) probably benign Het
Thap12 T C 7: 98,364,600 (GRCm39) F256S probably damaging Het
Tpte T C 8: 22,845,497 (GRCm39) Y516H Het
Trem1 C A 17: 48,544,271 (GRCm39) Q99K possibly damaging Het
Umodl1 C T 17: 31,178,147 (GRCm39) P41L probably benign Het
Upp2 T C 2: 58,457,542 (GRCm39) probably null Het
Zfand1 A T 3: 10,406,148 (GRCm39) M181K probably damaging Het
Zfp292 T C 4: 34,809,228 (GRCm39) E1277G possibly damaging Het
Zfp458 G T 13: 67,405,696 (GRCm39) P248T probably damaging Het
Zfp667 T A 7: 6,308,322 (GRCm39) M330K probably benign Het
Zfp827 A G 8: 79,917,107 (GRCm39) T561A Het
Zfp947 C T 17: 22,364,855 (GRCm39) G273D probably benign Het
Other mutations in Snx29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00733:Snx29 APN 16 11,221,366 (GRCm39) missense probably damaging 0.97
IGL02207:Snx29 APN 16 11,556,216 (GRCm39) missense probably damaging 1.00
PIT1430001:Snx29 UTSW 16 11,221,488 (GRCm39) missense probably benign 0.00
PIT4810001:Snx29 UTSW 16 11,218,845 (GRCm39) missense probably damaging 1.00
R0240:Snx29 UTSW 16 11,478,417 (GRCm39) missense probably damaging 1.00
R0240:Snx29 UTSW 16 11,478,417 (GRCm39) missense probably damaging 1.00
R0276:Snx29 UTSW 16 11,556,237 (GRCm39) missense probably benign 0.01
R0506:Snx29 UTSW 16 11,213,167 (GRCm39) missense probably benign 0.15
R0621:Snx29 UTSW 16 11,223,651 (GRCm39) splice site probably null
R0975:Snx29 UTSW 16 11,165,735 (GRCm39) missense possibly damaging 0.66
R1225:Snx29 UTSW 16 11,238,550 (GRCm39) intron probably benign
R1406:Snx29 UTSW 16 11,217,657 (GRCm39) missense probably benign 0.38
R1406:Snx29 UTSW 16 11,217,657 (GRCm39) missense probably benign 0.38
R1452:Snx29 UTSW 16 11,449,335 (GRCm39) missense probably damaging 1.00
R1515:Snx29 UTSW 16 11,217,701 (GRCm39) critical splice donor site probably null
R1874:Snx29 UTSW 16 11,185,545 (GRCm39) missense probably benign 0.01
R1953:Snx29 UTSW 16 11,217,647 (GRCm39) nonsense probably null
R1978:Snx29 UTSW 16 11,185,588 (GRCm39) missense probably benign 0.23
R2054:Snx29 UTSW 16 11,449,356 (GRCm39) missense probably damaging 1.00
R2105:Snx29 UTSW 16 11,328,898 (GRCm39) missense possibly damaging 0.72
R2128:Snx29 UTSW 16 11,218,835 (GRCm39) missense probably damaging 0.98
R2152:Snx29 UTSW 16 11,218,707 (GRCm39) missense possibly damaging 0.95
R2912:Snx29 UTSW 16 11,265,317 (GRCm39) missense probably damaging 0.99
R2913:Snx29 UTSW 16 11,265,317 (GRCm39) missense probably damaging 0.99
R2914:Snx29 UTSW 16 11,265,317 (GRCm39) missense probably damaging 0.99
R4468:Snx29 UTSW 16 11,238,565 (GRCm39) splice site probably null
R4469:Snx29 UTSW 16 11,238,565 (GRCm39) splice site probably null
R4612:Snx29 UTSW 16 11,265,359 (GRCm39) missense probably damaging 0.99
R4744:Snx29 UTSW 16 11,167,773 (GRCm39) nonsense probably null
R4798:Snx29 UTSW 16 11,238,600 (GRCm39) missense probably damaging 1.00
R5000:Snx29 UTSW 16 11,221,371 (GRCm39) missense probably damaging 0.99
R5165:Snx29 UTSW 16 11,238,639 (GRCm39) missense probably damaging 0.98
R5207:Snx29 UTSW 16 11,556,227 (GRCm39) missense probably damaging 1.00
R5235:Snx29 UTSW 16 11,231,110 (GRCm39) missense possibly damaging 0.94
R5274:Snx29 UTSW 16 11,556,268 (GRCm39) missense probably damaging 1.00
R5277:Snx29 UTSW 16 11,217,688 (GRCm39) missense possibly damaging 0.82
R5462:Snx29 UTSW 16 11,328,876 (GRCm39) missense possibly damaging 0.89
R5655:Snx29 UTSW 16 11,573,185 (GRCm39) missense probably damaging 1.00
R6036:Snx29 UTSW 16 11,556,301 (GRCm39) splice site probably null
R6036:Snx29 UTSW 16 11,556,301 (GRCm39) splice site probably null
R6326:Snx29 UTSW 16 11,221,430 (GRCm39) missense probably benign
R6576:Snx29 UTSW 16 11,532,920 (GRCm39) critical splice donor site probably null
R7406:Snx29 UTSW 16 11,573,180 (GRCm39) missense probably damaging 1.00
R7552:Snx29 UTSW 16 11,238,649 (GRCm39) critical splice donor site probably null
R7555:Snx29 UTSW 16 11,218,806 (GRCm39) missense probably benign 0.02
R7736:Snx29 UTSW 16 11,185,588 (GRCm39) missense probably benign 0.23
R7962:Snx29 UTSW 16 11,231,221 (GRCm39) critical splice donor site probably null
R8101:Snx29 UTSW 16 11,389,580 (GRCm39) missense probably benign 0.16
R8415:Snx29 UTSW 16 11,265,291 (GRCm39) missense probably damaging 1.00
R8549:Snx29 UTSW 16 11,532,920 (GRCm39) critical splice donor site probably null
R9010:Snx29 UTSW 16 11,449,391 (GRCm39) missense probably benign 0.00
R9091:Snx29 UTSW 16 11,213,155 (GRCm39) missense probably benign 0.33
R9176:Snx29 UTSW 16 11,236,728 (GRCm39) missense probably benign
R9258:Snx29 UTSW 16 11,532,799 (GRCm39) missense possibly damaging 0.78
R9270:Snx29 UTSW 16 11,213,155 (GRCm39) missense probably benign 0.33
R9672:Snx29 UTSW 16 11,478,515 (GRCm39) missense probably benign 0.00
R9778:Snx29 UTSW 16 11,223,609 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- AAGGCCACTTAGCTGGTAAGAAC -3'
(R):5'- CTGGGAAACAGCCATCAAGC -3'

Sequencing Primer
(F):5'- ATATATGTGTGTGTGTATGTGTGTG -3'
(R):5'- GGAAACAGCCATCAAGCCACAG -3'
Posted On 2021-12-30