Incidental Mutation 'R9100:Vmn1r69'
ID 691616
Institutional Source Beutler Lab
Gene Symbol Vmn1r69
Ensembl Gene ENSMUSG00000091662
Gene Name vomeronasal 1 receptor 69
Synonyms V1re9
MMRRC Submission 068914-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R9100 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 10313683-10315414 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 10314064 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 222 (R222S)
Ref Sequence ENSEMBL: ENSMUSP00000134993 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163658] [ENSMUST00000176284] [ENSMUST00000176707] [ENSMUST00000226160] [ENSMUST00000226190] [ENSMUST00000226228] [ENSMUST00000227853] [ENSMUST00000228296] [ENSMUST00000228478] [ENSMUST00000228638]
AlphaFold Q8VIC1
Predicted Effect probably damaging
Transcript: ENSMUST00000163658
AA Change: R222S

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000129646
Gene: ENSMUSG00000091662
AA Change: R222S

DomainStartEndE-ValueType
Pfam:V1R 50 307 3.3e-32 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000176284
AA Change: R222S

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000176707
AA Change: R222S

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000226160
AA Change: R222S

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000226190
AA Change: R222S

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000226228
AA Change: R222S

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227853
AA Change: R143S

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228296
AA Change: R143S

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228478
AA Change: R143S

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228638
AA Change: R143S

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 96% (75/78)
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc4 A G 14: 118,853,800 (GRCm39) V444A possibly damaging Het
Add1 T A 5: 34,770,622 (GRCm39) probably benign Het
Adgrg3 A G 8: 95,762,891 (GRCm39) probably benign Het
Adgrl3 A C 5: 81,842,299 (GRCm39) Q809P possibly damaging Het
Ankmy2 T C 12: 36,236,806 (GRCm39) C205R probably damaging Het
Atp6v1b2 A G 8: 69,541,476 (GRCm39) N11S Het
B3gnt6 T A 7: 97,843,958 (GRCm39) M1L not run Het
Bltp1 A G 3: 37,098,907 (GRCm39) K1256R Het
Ccdc88b T C 19: 6,833,213 (GRCm39) E278G probably damaging Het
Cdca8 T C 4: 124,830,238 (GRCm39) T45A probably benign Het
Ces2b C A 8: 105,558,221 (GRCm39) probably benign Het
Clip4 G A 17: 72,117,884 (GRCm39) G310R probably damaging Het
Cmklr1 G C 5: 113,752,043 (GRCm39) H319Q probably benign Het
Cnot3 A G 7: 3,661,192 (GRCm39) D567G probably benign Het
Cnot6l T C 5: 96,230,875 (GRCm39) D364G probably damaging Het
Cpped1 A G 16: 11,646,419 (GRCm39) V111A Het
Cstdc4 T A 16: 36,008,285 (GRCm39) M57K possibly damaging Het
Cyp11b2 T C 15: 74,722,995 (GRCm39) K468E probably damaging Het
Dpp4 T G 2: 62,204,733 (GRCm39) T245P possibly damaging Het
Efcab15 T C 11: 103,090,893 (GRCm39) T151A probably benign Het
Fat2 A G 11: 55,153,347 (GRCm39) W3622R probably damaging Het
Fat4 A C 3: 39,064,803 (GRCm39) K4920Q Het
Frmpd2 A G 14: 33,252,407 (GRCm39) I656M probably benign Het
Gck A G 11: 5,856,516 (GRCm39) Y214H probably damaging Het
Gde1 C T 7: 118,294,305 (GRCm39) R166H probably benign Het
Gdf7 A T 12: 8,348,652 (GRCm39) F215Y unknown Het
Gdpgp1 A G 7: 79,888,282 (GRCm39) I104M probably benign Het
Gldc A G 19: 30,077,314 (GRCm39) S953P possibly damaging Het
Golga3 C T 5: 110,337,544 (GRCm39) H411Y probably benign Het
Gpn1 G T 5: 31,655,740 (GRCm39) R101I probably damaging Het
Itgb5 T A 16: 33,740,551 (GRCm39) S554T possibly damaging Het
Klhl1 G A 14: 96,584,364 (GRCm39) L289F probably damaging Het
Klhl13 C T X: 23,113,733 (GRCm39) R95Q probably benign Het
Kmt2d G C 15: 98,747,832 (GRCm39) T3164R unknown Het
Knl1 T C 2: 118,899,469 (GRCm39) V390A probably benign Het
Krtap5-2 GCCACAGCCTCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACCACAGCCCCCACAGGAACTACA GCCACAGCCCCCACAGGAACTACA 7: 141,728,836 (GRCm39) probably benign Het
Lamtor4 G A 5: 138,254,595 (GRCm39) probably benign Het
Lonrf1 AGGCGGCGGCGGCGG AGGCGGCGGCGG 8: 36,715,919 (GRCm39) probably benign Het
Ltbp1 C T 17: 75,622,102 (GRCm39) L829F probably benign Het
Ltbp1 T A 17: 75,622,103 (GRCm39) L829H probably damaging Het
Mrgpra1 C T 7: 46,984,732 (GRCm39) E316K probably damaging Het
Muc16 T A 9: 18,556,966 (GRCm39) H3109L unknown Het
Nck1 T C 9: 100,377,561 (GRCm39) E368G probably damaging Het
Nox4 G A 7: 87,025,448 (GRCm39) R525Q probably benign Het
Nus1 A T 10: 52,305,287 (GRCm39) probably null Het
Nxph2 T C 2: 23,289,780 (GRCm39) V44A probably benign Het
Or1e30 A G 11: 73,678,687 (GRCm39) K308E probably benign Het
Or4f56 A G 2: 111,703,606 (GRCm39) M198T possibly damaging Het
Or4k35 A G 2: 111,100,094 (GRCm39) L206P probably benign Het
Or4z4 G T 19: 12,076,254 (GRCm39) H250N probably benign Het
Or5d35 T C 2: 87,855,330 (GRCm39) I88T probably benign Het
Or5m11b A G 2: 85,806,096 (GRCm39) K170E probably benign Het
Or6d13 A T 6: 116,517,990 (GRCm39) N192I possibly damaging Het
Otof T C 5: 30,539,696 (GRCm39) D1039G possibly damaging Het
Parpbp T A 10: 87,968,969 (GRCm39) Q159L possibly damaging Het
Per2 A T 1: 91,351,464 (GRCm39) L1014Q possibly damaging Het
Pik3ap1 C G 19: 41,312,924 (GRCm39) silent Het
Pik3ca A G 3: 32,514,168 (GRCm39) N885D probably damaging Het
Pip5k1c T C 10: 81,145,056 (GRCm39) V299A probably benign Het
Polr3h A T 15: 81,806,717 (GRCm39) probably benign Het
Pramel11 T A 4: 143,623,646 (GRCm39) N176I probably benign Het
Pramel23 T G 4: 143,425,727 (GRCm39) N72T probably benign Het
Pus3 C A 9: 35,476,946 (GRCm39) Q248K probably benign Het
Sectm1a T A 11: 120,960,569 (GRCm39) Q82L possibly damaging Het
Sema3e A G 5: 14,282,208 (GRCm39) Y448C probably damaging Het
Slc12a4 A T 8: 106,675,774 (GRCm39) S584T probably benign Het
Slc25a40 T C 5: 8,499,613 (GRCm39) F249L probably benign Het
St3gal6 T A 16: 58,306,793 (GRCm39) N79I Het
Stxbp4 A T 11: 90,426,320 (GRCm39) I496K possibly damaging Het
Sulf1 A G 1: 12,878,118 (GRCm39) Y202C probably damaging Het
Swt1 A G 1: 151,299,256 (GRCm39) probably null Het
Tdrd6 T C 17: 43,936,305 (GRCm39) Y1581C possibly damaging Het
Tenm4 G C 7: 96,495,061 (GRCm39) G1163A probably damaging Het
Tlr4 A G 4: 66,758,518 (GRCm39) E437G probably benign Het
Txnrd2 A T 16: 18,256,315 (GRCm39) H101L probably damaging Het
Uba3 A T 6: 97,163,671 (GRCm39) V306E probably damaging Het
Unc5b T C 10: 60,604,152 (GRCm39) Q814R probably damaging Het
Vamp5 T G 6: 72,347,304 (GRCm39) E5A possibly damaging Het
Zfp507 G A 7: 35,494,446 (GRCm39) T199I probably benign Het
Zfyve19 T G 2: 119,041,718 (GRCm39) L95R probably benign Het
Other mutations in Vmn1r69
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Vmn1r69 APN 7 10,313,879 (GRCm39) missense probably benign 0.00
IGL01972:Vmn1r69 APN 7 10,314,586 (GRCm39) nonsense probably null
IGL02339:Vmn1r69 APN 7 10,314,645 (GRCm39) nonsense probably null
IGL02424:Vmn1r69 APN 7 10,314,585 (GRCm39) missense probably benign 0.00
IGL02602:Vmn1r69 APN 7 10,313,901 (GRCm39) missense probably benign 0.14
IGL03271:Vmn1r69 APN 7 10,314,596 (GRCm39) missense probably benign 0.11
R0034:Vmn1r69 UTSW 7 10,314,738 (GRCm39) intron probably benign
R0052:Vmn1r69 UTSW 7 10,314,327 (GRCm39) missense probably benign 0.00
R0096:Vmn1r69 UTSW 7 10,313,985 (GRCm39) missense probably damaging 1.00
R0539:Vmn1r69 UTSW 7 10,314,874 (GRCm39) splice site probably benign
R0604:Vmn1r69 UTSW 7 10,314,581 (GRCm39) missense probably benign 0.00
R1681:Vmn1r69 UTSW 7 10,314,179 (GRCm39) missense probably benign 0.06
R1884:Vmn1r69 UTSW 7 10,314,678 (GRCm39) missense probably benign 0.00
R3741:Vmn1r69 UTSW 7 10,314,069 (GRCm39) missense possibly damaging 0.47
R4655:Vmn1r69 UTSW 7 10,314,026 (GRCm39) missense probably benign 0.03
R4735:Vmn1r69 UTSW 7 10,314,926 (GRCm39) utr 5 prime probably benign
R4758:Vmn1r69 UTSW 7 10,314,473 (GRCm39) missense probably benign 0.00
R5582:Vmn1r69 UTSW 7 10,314,435 (GRCm39) missense probably damaging 1.00
R5966:Vmn1r69 UTSW 7 10,314,717 (GRCm39) missense probably benign 0.00
R5977:Vmn1r69 UTSW 7 10,314,417 (GRCm39) missense probably damaging 1.00
R6458:Vmn1r69 UTSW 7 10,314,365 (GRCm39) missense probably benign
R6987:Vmn1r69 UTSW 7 10,314,491 (GRCm39) start codon destroyed probably null 0.99
R7133:Vmn1r69 UTSW 7 10,314,995 (GRCm39) intron probably benign
R7532:Vmn1r69 UTSW 7 10,314,281 (GRCm39) missense probably damaging 0.98
R7878:Vmn1r69 UTSW 7 10,314,717 (GRCm39) missense probably benign 0.00
R9558:Vmn1r69 UTSW 7 10,314,185 (GRCm39) missense probably benign
Z1176:Vmn1r69 UTSW 7 10,314,023 (GRCm39) missense possibly damaging 0.64
Predicted Primers PCR Primer
(F):5'- TGATGTTTAGGAGCCACCAATTG -3'
(R):5'- AAGTACGTTGGCTACTCCTTGTC -3'

Sequencing Primer
(F):5'- CCACCAATTGGGATTATTCTGAAGAG -3'
(R):5'- GGGTCCTGCACATTTTTATAAATTTC -3'
Posted On 2021-12-30