Incidental Mutation 'R9105:Myo19'
ID 691973
Institutional Source Beutler Lab
Gene Symbol Myo19
Ensembl Gene ENSMUSG00000020527
Gene Name myosin XIX
Synonyms Myohd1, 1110055A02Rik
MMRRC Submission 068917-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.144) question?
Stock # R9105 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 84770996-84802052 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 84794029 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 651 (I651T)
Ref Sequence ENSEMBL: ENSMUSP00000091502 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093969]
AlphaFold Q5SV80
Predicted Effect probably damaging
Transcript: ENSMUST00000093969
AA Change: I651T

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000091502
Gene: ENSMUSG00000020527
AA Change: I651T

DomainStartEndE-ValueType
MYSc 29 759 4.07e-219 SMART
IQ 760 782 1.74e1 SMART
IQ 783 804 1.97e0 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.0%
Validation Efficiency 98% (62/63)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik A T 10: 100,439,407 (GRCm39) K139* probably null Het
Acsl5 A T 19: 55,269,002 (GRCm39) K221I probably benign Het
Actrt2 G A 4: 154,751,677 (GRCm39) T153I probably damaging Het
Adam34 C T 8: 44,103,785 (GRCm39) C620Y probably damaging Het
Adgrl2 T C 3: 148,543,289 (GRCm39) K812E possibly damaging Het
Aig1 T C 10: 13,529,339 (GRCm39) T224A probably benign Het
Apbb2 G T 5: 66,460,015 (GRCm39) S694* probably null Het
Apol11b C T 15: 77,524,771 (GRCm39) E5K possibly damaging Het
Bcl3 T A 7: 19,543,175 (GRCm39) I352F probably damaging Het
Btbd19 C T 4: 116,977,961 (GRCm39) R276Q probably damaging Het
Btnl9 G A 11: 49,066,461 (GRCm39) P368S probably benign Het
Calhm5 A G 10: 33,968,144 (GRCm39) V303A probably benign Het
Ccdc97 T C 7: 25,412,537 (GRCm39) T302A probably benign Het
Cdh11 T C 8: 103,360,968 (GRCm39) D790G probably damaging Het
Cep350 T C 1: 155,835,561 (GRCm39) N45S probably damaging Het
Col5a2 T A 1: 45,419,366 (GRCm39) Y1238F probably benign Het
Ctdspl2 C T 2: 121,837,351 (GRCm39) L373F probably damaging Het
Dolpp1 A T 2: 30,289,152 (GRCm39) probably null Het
Efr3b A T 12: 4,031,782 (GRCm39) L340Q probably damaging Het
Ehd4 T C 2: 119,932,760 (GRCm39) N222S probably damaging Het
Fgf8 A C 19: 45,730,490 (GRCm39) probably benign Het
Frmd4a A G 2: 4,539,994 (GRCm39) I205V probably damaging Het
G6pc3 C T 11: 102,084,403 (GRCm39) A271V probably benign Het
Gab1 T C 8: 81,515,589 (GRCm39) D243G probably damaging Het
Gbp9 A G 5: 105,241,942 (GRCm39) I205T probably benign Het
Gtf2b T A 3: 142,489,050 (GRCm39) F304Y probably benign Het
Hps4 G A 5: 112,525,905 (GRCm39) S642N possibly damaging Het
Ip6k3 A G 17: 27,364,169 (GRCm39) L293P probably damaging Het
Itgb7 A G 15: 102,135,904 (GRCm39) S44P probably damaging Het
Klk15 C T 7: 43,587,790 (GRCm39) H73Y possibly damaging Het
Lancl1 T A 1: 67,043,962 (GRCm39) Y346F possibly damaging Het
Lca5l T G 16: 95,960,671 (GRCm39) E602A probably damaging Het
Lcor G A 19: 41,573,311 (GRCm39) A689T possibly damaging Het
Lrp1b A G 2: 41,396,803 (GRCm39) V421A Het
Lrrtm3 A G 10: 63,924,336 (GRCm39) V277A possibly damaging Het
Lypla1 T C 1: 4,911,282 (GRCm39) L189P probably damaging Het
Msantd3 A T 4: 48,560,963 (GRCm39) N180Y possibly damaging Het
Muc17 T C 5: 137,171,238 (GRCm39) Y131C Het
Ndst2 T C 14: 20,780,070 (GRCm39) S57G probably benign Het
Or12d16-ps1 C T 17: 37,705,731 (GRCm39) T100I probably benign Het
Or1j14 A G 2: 36,418,294 (GRCm39) Y290C probably damaging Het
Or4c117 C T 2: 88,955,995 (GRCm39) V27I probably benign Het
Or6p1 T A 1: 174,258,861 (GRCm39) I289N probably damaging Het
Pik3c2a T C 7: 115,972,049 (GRCm39) T794A probably benign Het
Pla2g6 T A 15: 79,183,397 (GRCm39) probably null Het
Pnrc1 C A 4: 33,246,207 (GRCm39) G251* probably null Het
Pramel14 A T 4: 143,718,595 (GRCm39) probably benign Het
Psg17 A T 7: 18,555,333 (GRCm39) V3E probably benign Het
Psmb9 A T 17: 34,401,905 (GRCm39) probably benign Het
Slc12a5 A G 2: 164,838,114 (GRCm39) T982A probably benign Het
Srrd T C 5: 112,485,465 (GRCm39) D286G possibly damaging Het
Tcp10b T C 17: 13,285,236 (GRCm39) S153P probably benign Het
Tmem131 C A 1: 36,854,591 (GRCm39) S886I probably benign Het
Ttk T A 9: 83,745,544 (GRCm39) D630E probably damaging Het
Vnn3 T C 10: 23,740,461 (GRCm39) W255R probably damaging Het
Vps13c T G 9: 67,778,081 (GRCm39) probably benign Het
Wdfy3 T C 5: 102,030,512 (GRCm39) Q2332R probably benign Het
Xkr8 A T 4: 132,459,648 (GRCm39) Y43* probably null Het
Other mutations in Myo19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00896:Myo19 APN 11 84,800,324 (GRCm39) missense probably benign 0.00
IGL01120:Myo19 APN 11 84,798,104 (GRCm39) missense probably damaging 0.96
IGL01542:Myo19 APN 11 84,800,372 (GRCm39) missense probably damaging 0.96
IGL02341:Myo19 APN 11 84,778,871 (GRCm39) splice site probably benign
IGL02708:Myo19 APN 11 84,790,222 (GRCm39) missense possibly damaging 0.89
IGL03223:Myo19 APN 11 84,801,297 (GRCm39) missense possibly damaging 0.57
BB004:Myo19 UTSW 11 84,791,046 (GRCm39) missense probably damaging 1.00
BB014:Myo19 UTSW 11 84,791,046 (GRCm39) missense probably damaging 1.00
R0009:Myo19 UTSW 11 84,778,995 (GRCm39) critical splice donor site probably null
R0125:Myo19 UTSW 11 84,779,001 (GRCm39) splice site probably benign
R0142:Myo19 UTSW 11 84,785,429 (GRCm39) missense probably damaging 1.00
R0226:Myo19 UTSW 11 84,788,558 (GRCm39) splice site probably benign
R0230:Myo19 UTSW 11 84,784,159 (GRCm39) missense possibly damaging 0.91
R0482:Myo19 UTSW 11 84,800,245 (GRCm39) missense probably benign 0.00
R1981:Myo19 UTSW 11 84,782,996 (GRCm39) missense possibly damaging 0.46
R2035:Myo19 UTSW 11 84,788,434 (GRCm39) missense probably benign
R2185:Myo19 UTSW 11 84,783,047 (GRCm39) missense probably benign 0.00
R3176:Myo19 UTSW 11 84,783,001 (GRCm39) missense probably benign 0.01
R3276:Myo19 UTSW 11 84,783,001 (GRCm39) missense probably benign 0.01
R3824:Myo19 UTSW 11 84,776,505 (GRCm39) missense probably damaging 0.98
R3914:Myo19 UTSW 11 84,785,429 (GRCm39) missense probably damaging 1.00
R4333:Myo19 UTSW 11 84,799,114 (GRCm39) missense probably benign 0.00
R4335:Myo19 UTSW 11 84,799,114 (GRCm39) missense probably benign 0.00
R4647:Myo19 UTSW 11 84,785,468 (GRCm39) missense probably damaging 1.00
R4968:Myo19 UTSW 11 84,792,328 (GRCm39) missense probably damaging 1.00
R4971:Myo19 UTSW 11 84,783,023 (GRCm39) missense probably damaging 1.00
R5083:Myo19 UTSW 11 84,794,037 (GRCm39) missense possibly damaging 0.60
R5284:Myo19 UTSW 11 84,776,098 (GRCm39) splice site probably null
R5558:Myo19 UTSW 11 84,801,274 (GRCm39) missense probably damaging 1.00
R5739:Myo19 UTSW 11 84,788,450 (GRCm39) missense probably damaging 1.00
R5982:Myo19 UTSW 11 84,790,226 (GRCm39) missense probably damaging 0.97
R6093:Myo19 UTSW 11 84,776,535 (GRCm39) missense probably damaging 1.00
R6444:Myo19 UTSW 11 84,786,134 (GRCm39) missense probably benign
R6657:Myo19 UTSW 11 84,788,022 (GRCm39) missense probably benign
R6945:Myo19 UTSW 11 84,788,386 (GRCm39) missense probably benign 0.06
R7022:Myo19 UTSW 11 84,791,373 (GRCm39) missense probably damaging 0.99
R7058:Myo19 UTSW 11 84,798,194 (GRCm39) missense possibly damaging 0.89
R7150:Myo19 UTSW 11 84,796,439 (GRCm39) missense probably benign
R7155:Myo19 UTSW 11 84,791,412 (GRCm39) missense probably damaging 1.00
R7478:Myo19 UTSW 11 84,776,626 (GRCm39) missense probably benign 0.41
R7486:Myo19 UTSW 11 84,796,463 (GRCm39) missense probably benign
R7833:Myo19 UTSW 11 84,800,093 (GRCm39) missense probably benign
R7921:Myo19 UTSW 11 84,799,064 (GRCm39) missense possibly damaging 0.55
R7923:Myo19 UTSW 11 84,776,536 (GRCm39) missense possibly damaging 0.87
R7927:Myo19 UTSW 11 84,791,046 (GRCm39) missense probably damaging 1.00
R9714:Myo19 UTSW 11 84,773,542 (GRCm39) start codon destroyed probably null 0.18
X0053:Myo19 UTSW 11 84,788,541 (GRCm39) nonsense probably null
Z1176:Myo19 UTSW 11 84,800,176 (GRCm39) frame shift probably null
Z1176:Myo19 UTSW 11 84,776,104 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- GCTATATGAGGAGCCAGGTAC -3'
(R):5'- TCCATAGGAATGTAGGCCCTAC -3'

Sequencing Primer
(F):5'- TCGGTTTCTCATGATCCCACAGAG -3'
(R):5'- CCAGGGCAGAGATTCCACACTG -3'
Posted On 2021-12-30