Incidental Mutation 'R9106:Sgo2a'
ID 691990
Institutional Source Beutler Lab
Gene Symbol Sgo2a
Ensembl Gene ENSMUSG00000026039
Gene Name shugoshin 2A
Synonyms Tripin, 5730576N04Rik, D1Ertd8e, Sgol2, Sgol2a, 1110007N04Rik
MMRRC Submission 068970-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9106 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 58035130-58065058 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 58037283 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 9 (D9E)
Ref Sequence ENSEMBL: ENSMUSP00000027202 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027202] [ENSMUST00000163061]
AlphaFold Q7TSY8
Predicted Effect possibly damaging
Transcript: ENSMUST00000027202
AA Change: D9E

PolyPhen 2 Score 0.587 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000027202
Gene: ENSMUSG00000026039
AA Change: D9E

DomainStartEndE-ValueType
coiled coil region 54 109 N/A INTRINSIC
low complexity region 182 198 N/A INTRINSIC
low complexity region 371 381 N/A INTRINSIC
low complexity region 396 431 N/A INTRINSIC
low complexity region 583 597 N/A INTRINSIC
low complexity region 718 729 N/A INTRINSIC
low complexity region 1068 1078 N/A INTRINSIC
low complexity region 1112 1125 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000163061
SMART Domains Protein: ENSMUSP00000124053
Gene: ENSMUSG00000054770

DomainStartEndE-ValueType
BTB 23 123 1.01e-2 SMART
Meta Mutation Damage Score 0.1712 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 97% (63/65)
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation display male and female infertility with abnormalities in meiosis but not in mitosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahctf1 C A 1: 179,614,601 (GRCm39) K394N probably benign Het
Banp A T 8: 122,705,372 (GRCm39) T81S possibly damaging Het
Btn2a2 T C 13: 23,662,465 (GRCm39) E495G probably benign Het
Cfap69 T C 5: 5,690,190 (GRCm39) I158M possibly damaging Het
Cgnl1 C A 9: 71,628,873 (GRCm39) probably benign Het
Clip1 T A 5: 123,753,223 (GRCm39) Q186L probably damaging Het
Clspn G A 4: 126,471,243 (GRCm39) probably benign Het
Cnst A G 1: 179,432,162 (GRCm39) E224G probably damaging Het
Ctdsp1 T C 1: 74,433,884 (GRCm39) L155P probably damaging Het
D5Ertd579e C T 5: 36,773,682 (GRCm39) A238T probably benign Het
Dnah6 T C 6: 73,121,752 (GRCm39) Y1410C probably damaging Het
Fam186a AGCCGCTGCCGCTGCCGCTGCCGC AGCCGCTGCCGCTGCCGC 15: 99,844,107 (GRCm39) probably benign Het
Farp2 T C 1: 93,488,910 (GRCm39) probably null Het
Galnt7 T G 8: 57,985,729 (GRCm39) D547A probably damaging Het
Gm1527 C A 3: 28,956,440 (GRCm39) D135E probably damaging Het
Grm5 T C 7: 87,723,747 (GRCm39) I679T probably damaging Het
Hectd4 C A 5: 121,467,619 (GRCm39) R2523S possibly damaging Het
Hps4 G A 5: 112,525,905 (GRCm39) S642N possibly damaging Het
Htr1f A T 16: 64,746,637 (GRCm39) S218R probably damaging Het
Lrit1 G A 14: 36,776,891 (GRCm39) A4T unknown Het
Ly6f G T 15: 75,141,706 (GRCm39) D50Y probably damaging Het
Mafg GGTTCTTCAGTGT GGT 11: 120,520,415 (GRCm39) probably null Het
Map2 T A 1: 66,454,522 (GRCm39) Y1137* probably null Het
Map4k3 C A 17: 81,035,257 (GRCm39) R21L possibly damaging Het
Mapk10 A T 5: 103,186,442 (GRCm39) V90D probably damaging Het
Mapkapk3 T A 9: 107,136,067 (GRCm39) E219V probably damaging Het
Mideas T C 12: 84,199,327 (GRCm39) Y1040C probably damaging Het
Mos T G 4: 3,871,457 (GRCm39) I120L probably benign Het
Mrgprb4 A G 7: 47,848,679 (GRCm39) V83A probably benign Het
Mrnip A G 11: 50,065,768 (GRCm39) Q19R probably damaging Het
Myrip T C 9: 120,261,544 (GRCm39) S386P probably benign Het
Mzt2 A G 16: 15,666,568 (GRCm39) W141R probably benign Het
Ncam1 A G 9: 49,428,856 (GRCm39) Y710H probably damaging Het
Nlrp9c G T 7: 26,081,837 (GRCm39) L630I probably benign Het
Odad2 A T 18: 7,294,527 (GRCm39) S29T probably benign Het
Oplah C A 15: 76,189,876 (GRCm39) G150C probably benign Het
Or4c11b A G 2: 88,625,016 (GRCm39) T97A probably benign Het
Or51q1 A T 7: 103,628,581 (GRCm39) M61L probably damaging Het
Or52a20 G A 7: 103,366,737 (GRCm39) C312Y probably benign Het
Or6k2 A G 1: 173,986,369 (GRCm39) Q10R probably benign Het
Patl1 A G 19: 11,908,973 (GRCm39) K460R probably damaging Het
Pdgfrb A T 18: 61,179,100 (GRCm39) probably null Het
Phldb2 T C 16: 45,680,757 (GRCm39) I17V probably benign Het
Ppp3r1 A G 11: 17,144,789 (GRCm39) D134G probably damaging Het
Ppp4r4 C T 12: 103,570,315 (GRCm39) T763I probably benign Het
Prmt9 A G 8: 78,276,358 (GRCm39) D61G probably benign Het
Ptk2 T C 15: 73,131,457 (GRCm39) M589V possibly damaging Het
Rabl6 A G 2: 25,486,446 (GRCm39) W153R probably benign Het
Rb1cc1 A G 1: 6,319,109 (GRCm39) I843V Het
Resf1 T C 6: 149,230,368 (GRCm39) V1138A possibly damaging Het
Rnf19b A G 4: 128,977,940 (GRCm39) E719G Het
Sart3 T C 5: 113,892,410 (GRCm39) D363G possibly damaging Het
Slc27a5 A G 7: 12,725,097 (GRCm39) V450A probably benign Het
Slc8b1 T A 5: 120,668,416 (GRCm39) Y483N probably damaging Het
Slco1b2 A G 6: 141,617,974 (GRCm39) T475A probably damaging Het
Slfn3 T C 11: 83,103,458 (GRCm39) F110L probably benign Het
Spata31e5 T C 1: 28,815,975 (GRCm39) I686V probably benign Het
Ssr2 T A 3: 88,495,269 (GRCm39) Y175N probably damaging Het
Tagap A T 17: 8,150,280 (GRCm39) N222Y probably damaging Het
Tecta C T 9: 42,278,479 (GRCm39) V1010M probably benign Het
Trim36 A T 18: 46,300,664 (GRCm39) I669N possibly damaging Het
Ubp1 A G 9: 113,799,319 (GRCm39) T425A probably benign Het
Usp47 T C 7: 111,681,713 (GRCm39) I508T probably damaging Het
Vit G A 17: 78,934,278 (GRCm39) D627N probably damaging Het
Vmn2r59 A T 7: 41,695,884 (GRCm39) I176N probably benign Het
Other mutations in Sgo2a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00507:Sgo2a APN 1 58,055,753 (GRCm39) missense probably damaging 1.00
IGL00534:Sgo2a APN 1 58,055,503 (GRCm39) missense probably damaging 1.00
IGL00902:Sgo2a APN 1 58,055,258 (GRCm39) missense probably benign 0.00
IGL01571:Sgo2a APN 1 58,057,133 (GRCm39) missense probably damaging 0.99
IGL02268:Sgo2a APN 1 58,056,881 (GRCm39) missense probably benign 0.10
IGL02756:Sgo2a APN 1 58,055,509 (GRCm39) missense probably damaging 1.00
IGL02887:Sgo2a APN 1 58,055,511 (GRCm39) missense probably damaging 0.99
IGL02991:Sgo2a APN 1 58,054,514 (GRCm39) intron probably benign
crazy UTSW 1 58,056,954 (GRCm39) missense probably benign 0.11
harpo UTSW 1 58,058,819 (GRCm39) nonsense probably null
mashugana UTSW 1 58,055,726 (GRCm39) missense probably damaging 1.00
meshugas UTSW 1 58,042,092 (GRCm39) nonsense probably null
R0036:Sgo2a UTSW 1 58,054,787 (GRCm39) missense probably benign 0.14
R0036:Sgo2a UTSW 1 58,054,787 (GRCm39) missense probably benign 0.14
R0095:Sgo2a UTSW 1 58,054,714 (GRCm39) missense probably benign 0.11
R0325:Sgo2a UTSW 1 58,055,856 (GRCm39) missense probably benign
R0464:Sgo2a UTSW 1 58,039,253 (GRCm39) missense probably damaging 0.98
R0699:Sgo2a UTSW 1 58,037,308 (GRCm39) nonsense probably null
R1251:Sgo2a UTSW 1 58,039,121 (GRCm39) critical splice acceptor site probably null
R1355:Sgo2a UTSW 1 58,057,124 (GRCm39) missense possibly damaging 0.91
R1457:Sgo2a UTSW 1 58,054,965 (GRCm39) missense probably benign 0.00
R2244:Sgo2a UTSW 1 58,056,213 (GRCm39) missense probably benign 0.00
R3896:Sgo2a UTSW 1 58,052,805 (GRCm39) missense probably damaging 0.99
R4919:Sgo2a UTSW 1 58,037,293 (GRCm39) missense probably damaging 0.99
R5030:Sgo2a UTSW 1 58,056,918 (GRCm39) nonsense probably null
R5123:Sgo2a UTSW 1 58,055,726 (GRCm39) missense probably damaging 1.00
R5317:Sgo2a UTSW 1 58,054,683 (GRCm39) missense probably benign
R5767:Sgo2a UTSW 1 58,058,819 (GRCm39) nonsense probably null
R5844:Sgo2a UTSW 1 58,055,556 (GRCm39) missense probably damaging 0.99
R6018:Sgo2a UTSW 1 58,056,118 (GRCm39) missense probably benign 0.01
R6039:Sgo2a UTSW 1 58,055,775 (GRCm39) missense possibly damaging 0.78
R6039:Sgo2a UTSW 1 58,055,775 (GRCm39) missense possibly damaging 0.78
R6450:Sgo2a UTSW 1 58,042,092 (GRCm39) nonsense probably null
R6998:Sgo2a UTSW 1 58,055,799 (GRCm39) missense probably damaging 0.99
R7073:Sgo2a UTSW 1 58,056,944 (GRCm39) missense possibly damaging 0.73
R7508:Sgo2a UTSW 1 58,056,954 (GRCm39) missense probably benign 0.11
R7722:Sgo2a UTSW 1 58,055,696 (GRCm39) missense probably benign 0.45
R8094:Sgo2a UTSW 1 58,056,300 (GRCm39) missense possibly damaging 0.77
R8176:Sgo2a UTSW 1 58,056,252 (GRCm39) missense possibly damaging 0.93
R8782:Sgo2a UTSW 1 58,056,616 (GRCm39) start gained probably benign
R8899:Sgo2a UTSW 1 58,058,822 (GRCm39) missense possibly damaging 0.85
R8912:Sgo2a UTSW 1 58,056,560 (GRCm39) missense probably damaging 0.99
R9256:Sgo2a UTSW 1 58,058,772 (GRCm39) missense possibly damaging 0.77
R9688:Sgo2a UTSW 1 58,056,737 (GRCm39) missense probably damaging 1.00
X0065:Sgo2a UTSW 1 58,055,517 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCTTTGCAAATACATTATGTCGAC -3'
(R):5'- AGATTGCAAAACCATTCAGCAG -3'

Sequencing Primer
(F):5'- CGACAGTGTATTGTAAGTCATGG -3'
(R):5'- GATTGCAAAACCATTCAGCAGAATAG -3'
Posted On 2021-12-30