Incidental Mutation 'R9106:Or4c11b'
ID 691998
Institutional Source Beutler Lab
Gene Symbol Or4c11b
Ensembl Gene ENSMUSG00000059023
Gene Name olfactory receptor family 4 subfamily C member 11B
Synonyms GA_x6K02T2Q125-50268830-50269753, Olfr1201, MOR230-2
MMRRC Submission 068970-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R9106 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 88624728-88625651 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 88625016 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 97 (T97A)
Ref Sequence ENSEMBL: ENSMUSP00000150454 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073458] [ENSMUST00000216213]
AlphaFold Q8VGF5
Predicted Effect probably benign
Transcript: ENSMUST00000073458
AA Change: T97A

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000073163
Gene: ENSMUSG00000059023
AA Change: T97A

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.4e-46 PFAM
Pfam:7TM_GPCR_Srsx 32 300 3.3e-5 PFAM
Pfam:7tm_1 39 285 3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216213
AA Change: T97A

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 97% (63/65)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahctf1 C A 1: 179,614,601 (GRCm39) K394N probably benign Het
Banp A T 8: 122,705,372 (GRCm39) T81S possibly damaging Het
Btn2a2 T C 13: 23,662,465 (GRCm39) E495G probably benign Het
Cfap69 T C 5: 5,690,190 (GRCm39) I158M possibly damaging Het
Cgnl1 C A 9: 71,628,873 (GRCm39) probably benign Het
Clip1 T A 5: 123,753,223 (GRCm39) Q186L probably damaging Het
Clspn G A 4: 126,471,243 (GRCm39) probably benign Het
Cnst A G 1: 179,432,162 (GRCm39) E224G probably damaging Het
Ctdsp1 T C 1: 74,433,884 (GRCm39) L155P probably damaging Het
D5Ertd579e C T 5: 36,773,682 (GRCm39) A238T probably benign Het
Dnah6 T C 6: 73,121,752 (GRCm39) Y1410C probably damaging Het
Fam186a AGCCGCTGCCGCTGCCGCTGCCGC AGCCGCTGCCGCTGCCGC 15: 99,844,107 (GRCm39) probably benign Het
Farp2 T C 1: 93,488,910 (GRCm39) probably null Het
Galnt7 T G 8: 57,985,729 (GRCm39) D547A probably damaging Het
Gm1527 C A 3: 28,956,440 (GRCm39) D135E probably damaging Het
Grm5 T C 7: 87,723,747 (GRCm39) I679T probably damaging Het
Hectd4 C A 5: 121,467,619 (GRCm39) R2523S possibly damaging Het
Hps4 G A 5: 112,525,905 (GRCm39) S642N possibly damaging Het
Htr1f A T 16: 64,746,637 (GRCm39) S218R probably damaging Het
Lrit1 G A 14: 36,776,891 (GRCm39) A4T unknown Het
Ly6f G T 15: 75,141,706 (GRCm39) D50Y probably damaging Het
Mafg GGTTCTTCAGTGT GGT 11: 120,520,415 (GRCm39) probably null Het
Map2 T A 1: 66,454,522 (GRCm39) Y1137* probably null Het
Map4k3 C A 17: 81,035,257 (GRCm39) R21L possibly damaging Het
Mapk10 A T 5: 103,186,442 (GRCm39) V90D probably damaging Het
Mapkapk3 T A 9: 107,136,067 (GRCm39) E219V probably damaging Het
Mideas T C 12: 84,199,327 (GRCm39) Y1040C probably damaging Het
Mos T G 4: 3,871,457 (GRCm39) I120L probably benign Het
Mrgprb4 A G 7: 47,848,679 (GRCm39) V83A probably benign Het
Mrnip A G 11: 50,065,768 (GRCm39) Q19R probably damaging Het
Myrip T C 9: 120,261,544 (GRCm39) S386P probably benign Het
Mzt2 A G 16: 15,666,568 (GRCm39) W141R probably benign Het
Ncam1 A G 9: 49,428,856 (GRCm39) Y710H probably damaging Het
Nlrp9c G T 7: 26,081,837 (GRCm39) L630I probably benign Het
Odad2 A T 18: 7,294,527 (GRCm39) S29T probably benign Het
Oplah C A 15: 76,189,876 (GRCm39) G150C probably benign Het
Or51q1 A T 7: 103,628,581 (GRCm39) M61L probably damaging Het
Or52a20 G A 7: 103,366,737 (GRCm39) C312Y probably benign Het
Or6k2 A G 1: 173,986,369 (GRCm39) Q10R probably benign Het
Patl1 A G 19: 11,908,973 (GRCm39) K460R probably damaging Het
Pdgfrb A T 18: 61,179,100 (GRCm39) probably null Het
Phldb2 T C 16: 45,680,757 (GRCm39) I17V probably benign Het
Ppp3r1 A G 11: 17,144,789 (GRCm39) D134G probably damaging Het
Ppp4r4 C T 12: 103,570,315 (GRCm39) T763I probably benign Het
Prmt9 A G 8: 78,276,358 (GRCm39) D61G probably benign Het
Ptk2 T C 15: 73,131,457 (GRCm39) M589V possibly damaging Het
Rabl6 A G 2: 25,486,446 (GRCm39) W153R probably benign Het
Rb1cc1 A G 1: 6,319,109 (GRCm39) I843V Het
Resf1 T C 6: 149,230,368 (GRCm39) V1138A possibly damaging Het
Rnf19b A G 4: 128,977,940 (GRCm39) E719G Het
Sart3 T C 5: 113,892,410 (GRCm39) D363G possibly damaging Het
Sgo2a C A 1: 58,037,283 (GRCm39) D9E possibly damaging Het
Slc27a5 A G 7: 12,725,097 (GRCm39) V450A probably benign Het
Slc8b1 T A 5: 120,668,416 (GRCm39) Y483N probably damaging Het
Slco1b2 A G 6: 141,617,974 (GRCm39) T475A probably damaging Het
Slfn3 T C 11: 83,103,458 (GRCm39) F110L probably benign Het
Spata31e5 T C 1: 28,815,975 (GRCm39) I686V probably benign Het
Ssr2 T A 3: 88,495,269 (GRCm39) Y175N probably damaging Het
Tagap A T 17: 8,150,280 (GRCm39) N222Y probably damaging Het
Tecta C T 9: 42,278,479 (GRCm39) V1010M probably benign Het
Trim36 A T 18: 46,300,664 (GRCm39) I669N possibly damaging Het
Ubp1 A G 9: 113,799,319 (GRCm39) T425A probably benign Het
Usp47 T C 7: 111,681,713 (GRCm39) I508T probably damaging Het
Vit G A 17: 78,934,278 (GRCm39) D627N probably damaging Het
Vmn2r59 A T 7: 41,695,884 (GRCm39) I176N probably benign Het
Other mutations in Or4c11b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01082:Or4c11b APN 2 88,625,637 (GRCm39) missense probably benign
IGL02292:Or4c11b APN 2 88,625,631 (GRCm39) missense probably benign
IGL03037:Or4c11b APN 2 88,625,299 (GRCm39) missense probably damaging 1.00
R2341:Or4c11b UTSW 2 88,624,989 (GRCm39) missense probably benign 0.16
R3900:Or4c11b UTSW 2 88,625,273 (GRCm39) missense possibly damaging 0.88
R6394:Or4c11b UTSW 2 88,625,296 (GRCm39) missense probably benign 0.22
R7276:Or4c11b UTSW 2 88,625,025 (GRCm39) missense probably damaging 1.00
R9654:Or4c11b UTSW 2 88,625,263 (GRCm39) missense probably damaging 1.00
R9802:Or4c11b UTSW 2 88,625,491 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GTGGGGAATACACTCATTATTGTGAC -3'
(R):5'- ATCAGATTGGGCCCACAGAAG -3'

Sequencing Primer
(F):5'- CAATCAAGTTCAGTCGGACACTTGG -3'
(R):5'- AAGGGCAGTCTCAAGGCC -3'
Posted On 2021-12-30