Incidental Mutation 'R9115:Vmn2r85'
| ID |
692485 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r85
|
| Ensembl Gene |
ENSMUSG00000092048 |
| Gene Name |
vomeronasal 2, receptor 85 |
| Synonyms |
EG623734 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.086)
|
| Stock # |
R9115 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
130253658-130266615 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 130254153 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 844
(Y844H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128792
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171811]
|
| AlphaFold |
G3UW56 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171811
AA Change: Y844H
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000128792
Gene: ENSMUSG00000092048
AA Change: Y844H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
425 |
9e-26 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
1.1e-18 |
PFAM |
|
Pfam:7tm_3
|
595 |
831 |
3.7e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 53 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aire |
T |
C |
10: 77,879,309 (GRCm39) |
T17A |
|
Het |
| Ankrd31 |
T |
C |
13: 96,940,773 (GRCm39) |
|
probably null |
Het |
| Brwd1 |
C |
T |
16: 95,848,314 (GRCm39) |
R569K |
probably damaging |
Het |
| Capns1 |
A |
T |
7: 29,889,978 (GRCm39) |
I177K |
probably benign |
Het |
| Ccdc182 |
A |
G |
11: 88,185,343 (GRCm39) |
N141S |
probably benign |
Het |
| Celsr1 |
A |
G |
15: 85,803,217 (GRCm39) |
W2441R |
probably damaging |
Het |
| Cftr |
A |
T |
6: 18,235,310 (GRCm39) |
R516S |
probably damaging |
Het |
| Ckap4 |
C |
T |
10: 84,363,507 (GRCm39) |
V519M |
probably damaging |
Het |
| Col27a1 |
C |
T |
4: 63,231,974 (GRCm39) |
P1277L |
unknown |
Het |
| Cspg4 |
T |
C |
9: 56,797,736 (GRCm39) |
L1400P |
probably damaging |
Het |
| Cyp4f39 |
T |
A |
17: 32,711,296 (GRCm39) |
F481Y |
probably damaging |
Het |
| Dmxl2 |
T |
C |
9: 54,309,011 (GRCm39) |
I1913M |
probably benign |
Het |
| Dock10 |
T |
C |
1: 80,490,156 (GRCm39) |
T1989A |
probably damaging |
Het |
| Eef2 |
CC |
CCC |
10: 81,014,603 (GRCm39) |
|
probably null |
Het |
| Fcgbpl1 |
G |
A |
7: 27,853,754 (GRCm39) |
V1573I |
possibly damaging |
Het |
| Fshr |
T |
A |
17: 89,292,948 (GRCm39) |
I577F |
probably damaging |
Het |
| Gfm2 |
T |
C |
13: 97,301,707 (GRCm39) |
|
probably null |
Het |
| Gm12695 |
T |
C |
4: 96,657,846 (GRCm39) |
N108D |
possibly damaging |
Het |
| Gm3285 |
T |
A |
10: 77,698,007 (GRCm39) |
L52H |
unknown |
Het |
| Gm5930 |
A |
T |
14: 44,575,006 (GRCm39) |
L95* |
probably null |
Het |
| Hjurp |
CTCTGGGAGGGCTTGCTCCGGGGGCAGTGTGTCCTGTTCTTGTGCAGCCCCT |
C |
1: 88,193,999 (GRCm39) |
|
probably benign |
Het |
| Klhl26 |
A |
G |
8: 70,904,896 (GRCm39) |
M338T |
possibly damaging |
Het |
| Lrrc4c |
T |
C |
2: 97,459,686 (GRCm39) |
I104T |
probably benign |
Het |
| Mapk10 |
A |
T |
5: 103,186,532 (GRCm39) |
V60E |
|
Het |
| Mfsd4b3-ps |
T |
A |
10: 39,824,012 (GRCm39) |
K83* |
probably null |
Het |
| Muc15 |
C |
T |
2: 110,562,089 (GRCm39) |
T175I |
probably damaging |
Het |
| Nmu |
G |
A |
5: 76,511,572 (GRCm39) |
|
probably benign |
Het |
| Nol4l |
G |
T |
2: 153,253,638 (GRCm39) |
T645K |
probably damaging |
Het |
| Nr2f1 |
A |
G |
13: 78,337,869 (GRCm39) |
S416P |
probably benign |
Het |
| Ntn4 |
A |
C |
10: 93,569,675 (GRCm39) |
I463L |
probably benign |
Het |
| Nxt2 |
C |
T |
X: 141,020,747 (GRCm39) |
A118V |
possibly damaging |
Het |
| Or12k7 |
T |
C |
2: 36,959,052 (GRCm39) |
L245P |
probably damaging |
Het |
| Or52h2 |
C |
A |
7: 103,838,931 (GRCm39) |
C161F |
possibly damaging |
Het |
| Or8h8 |
T |
A |
2: 86,752,998 (GRCm39) |
R293W |
probably damaging |
Het |
| Pccb |
T |
A |
9: 100,869,908 (GRCm39) |
N341I |
probably damaging |
Het |
| Pgm3 |
G |
A |
9: 86,447,662 (GRCm39) |
L194F |
probably damaging |
Het |
| Prkra |
T |
A |
2: 76,478,193 (GRCm39) |
H3L |
probably benign |
Het |
| Rbm12 |
TATTGCGGGACCGGGCATTGCGGGACCGGGCATTGCGGGACCGGGCATTGCGGGACCGGGCATTGCGGGACCGGGCATTGCGGGACCAGGCATTGCGGGACC |
TATTGCGGGACCGGGCATTGCGGGACCGGGCATTGCGGGACCGGGCATTGCGGGACCAGGCATTGCGGGACC |
2: 155,938,030 (GRCm39) |
|
probably benign |
Het |
| Ryr1 |
T |
A |
7: 28,803,989 (GRCm39) |
K600* |
probably null |
Het |
| Sema4d |
A |
T |
13: 51,877,596 (GRCm39) |
S79T |
probably benign |
Het |
| Slc37a1 |
T |
C |
17: 31,534,486 (GRCm39) |
C53R |
probably damaging |
Het |
| Sptbn1 |
A |
G |
11: 30,087,526 (GRCm39) |
I971T |
probably damaging |
Het |
| Tcstv1a |
T |
A |
13: 120,355,453 (GRCm39) |
I60F |
possibly damaging |
Het |
| Tdrkh |
G |
T |
3: 94,335,598 (GRCm39) |
C397F |
possibly damaging |
Het |
| Tecrl |
A |
T |
5: 83,427,906 (GRCm39) |
M314K |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,780,496 (GRCm39) |
K1131R |
unknown |
Het |
| Uimc1 |
A |
T |
13: 55,198,584 (GRCm39) |
Y531N |
possibly damaging |
Het |
| Usp5 |
A |
G |
6: 124,803,384 (GRCm39) |
S39P |
probably damaging |
Het |
| Virma |
A |
G |
4: 11,498,744 (GRCm39) |
T62A |
probably benign |
Het |
| Yars1 |
T |
C |
4: 129,109,143 (GRCm39) |
V458A |
probably benign |
Het |
| Zfp235 |
G |
A |
7: 23,841,453 (GRCm39) |
C624Y |
probably damaging |
Het |
| Zfp712 |
A |
T |
13: 67,189,241 (GRCm39) |
S429T |
probably damaging |
Het |
| Zmynd11 |
A |
T |
13: 9,743,495 (GRCm39) |
D307E |
probably damaging |
Het |
|
| Other mutations in Vmn2r85 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01160:Vmn2r85
|
APN |
10 |
130,254,690 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01298:Vmn2r85
|
APN |
10 |
130,254,690 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01361:Vmn2r85
|
APN |
10 |
130,254,690 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL02185:Vmn2r85
|
APN |
10 |
130,254,561 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02505:Vmn2r85
|
APN |
10 |
130,261,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02607:Vmn2r85
|
APN |
10 |
130,262,290 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02755:Vmn2r85
|
APN |
10 |
130,261,381 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03188:Vmn2r85
|
APN |
10 |
130,254,612 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03366:Vmn2r85
|
APN |
10 |
130,262,328 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03397:Vmn2r85
|
APN |
10 |
130,261,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4445001:Vmn2r85
|
UTSW |
10 |
130,261,572 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0066:Vmn2r85
|
UTSW |
10 |
130,261,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0128:Vmn2r85
|
UTSW |
10 |
130,255,054 (GRCm39) |
splice site |
probably benign |
|
|
R0130:Vmn2r85
|
UTSW |
10 |
130,255,054 (GRCm39) |
splice site |
probably benign |
|
|
R0503:Vmn2r85
|
UTSW |
10 |
130,258,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0827:Vmn2r85
|
UTSW |
10 |
130,265,387 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1432:Vmn2r85
|
UTSW |
10 |
130,261,155 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R1521:Vmn2r85
|
UTSW |
10 |
130,261,788 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2029:Vmn2r85
|
UTSW |
10 |
130,261,443 (GRCm39) |
nonsense |
probably null |
|
|
R2034:Vmn2r85
|
UTSW |
10 |
130,262,242 (GRCm39) |
splice site |
probably benign |
|
|
R2852:Vmn2r85
|
UTSW |
10 |
130,255,035 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2853:Vmn2r85
|
UTSW |
10 |
130,255,035 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3084:Vmn2r85
|
UTSW |
10 |
130,261,081 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3085:Vmn2r85
|
UTSW |
10 |
130,261,081 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3430:Vmn2r85
|
UTSW |
10 |
130,254,758 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3694:Vmn2r85
|
UTSW |
10 |
130,254,171 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3932:Vmn2r85
|
UTSW |
10 |
130,254,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4207:Vmn2r85
|
UTSW |
10 |
130,254,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4628:Vmn2r85
|
UTSW |
10 |
130,261,235 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4814:Vmn2r85
|
UTSW |
10 |
130,254,567 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4948:Vmn2r85
|
UTSW |
10 |
130,254,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4951:Vmn2r85
|
UTSW |
10 |
130,261,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4959:Vmn2r85
|
UTSW |
10 |
130,257,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5336:Vmn2r85
|
UTSW |
10 |
130,258,574 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5643:Vmn2r85
|
UTSW |
10 |
130,262,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6061:Vmn2r85
|
UTSW |
10 |
130,261,531 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6115:Vmn2r85
|
UTSW |
10 |
130,258,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6190:Vmn2r85
|
UTSW |
10 |
130,261,330 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6518:Vmn2r85
|
UTSW |
10 |
130,265,281 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6533:Vmn2r85
|
UTSW |
10 |
130,262,529 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6610:Vmn2r85
|
UTSW |
10 |
130,261,838 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6809:Vmn2r85
|
UTSW |
10 |
130,261,795 (GRCm39) |
missense |
probably benign |
|
|
R6962:Vmn2r85
|
UTSW |
10 |
130,261,452 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7075:Vmn2r85
|
UTSW |
10 |
130,258,557 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7104:Vmn2r85
|
UTSW |
10 |
130,262,376 (GRCm39) |
missense |
probably benign |
|
|
R7424:Vmn2r85
|
UTSW |
10 |
130,254,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7516:Vmn2r85
|
UTSW |
10 |
130,254,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7537:Vmn2r85
|
UTSW |
10 |
130,258,735 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7768:Vmn2r85
|
UTSW |
10 |
130,254,562 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7810:Vmn2r85
|
UTSW |
10 |
130,261,081 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8078:Vmn2r85
|
UTSW |
10 |
130,265,364 (GRCm39) |
nonsense |
probably null |
|
|
R8115:Vmn2r85
|
UTSW |
10 |
130,261,820 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8262:Vmn2r85
|
UTSW |
10 |
130,254,738 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8395:Vmn2r85
|
UTSW |
10 |
130,261,797 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8409:Vmn2r85
|
UTSW |
10 |
130,261,257 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8547:Vmn2r85
|
UTSW |
10 |
130,261,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8875:Vmn2r85
|
UTSW |
10 |
130,254,171 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9035:Vmn2r85
|
UTSW |
10 |
130,261,479 (GRCm39) |
missense |
probably benign |
|
|
R9040:Vmn2r85
|
UTSW |
10 |
130,254,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9182:Vmn2r85
|
UTSW |
10 |
130,265,350 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9245:Vmn2r85
|
UTSW |
10 |
130,261,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9245:Vmn2r85
|
UTSW |
10 |
130,255,033 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9405:Vmn2r85
|
UTSW |
10 |
130,261,215 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9502:Vmn2r85
|
UTSW |
10 |
130,261,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9520:Vmn2r85
|
UTSW |
10 |
130,254,993 (GRCm39) |
missense |
probably benign |
|
|
R9653:Vmn2r85
|
UTSW |
10 |
130,261,694 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Vmn2r85
|
UTSW |
10 |
130,261,713 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Vmn2r85
|
UTSW |
10 |
130,254,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTACTTAGTATAACAATGGACAGTGC -3'
(R):5'- GAACCTTCCTGACAGATTCAATGAAG -3'
Sequencing Primer
(F):5'- ACAGTGCTGTCCTGTTTGTAAG -3'
(R):5'- CTAACTTTCAGCATGCTGGTG -3'
|
| Posted On |
2021-12-30 |
Incidental Mutation