Incidental Mutation 'R9116:Cr2'
| ID |
692506 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cr2
|
| Ensembl Gene |
ENSMUSG00000026616 |
| Gene Name |
complement receptor 2 |
| Synonyms |
C3DR, CD21, Cr-2, Cr1, Cr-1, CD35 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.112)
|
| Stock # |
R9116 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
194819119-194859024 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 194840977 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 438
(Y438*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000080938
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000082321]
[ENSMUST00000193356]
[ENSMUST00000193801]
[ENSMUST00000195120]
[ENSMUST00000210219]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000082321
AA Change: Y438*
|
| SMART Domains |
Protein: ENSMUSP00000080938
Gene: ENSMUSG00000026616
AA Change: Y438*
| Domain | Start | End | E-Value | Type |
|---|
|
CCP
|
23 |
82 |
1.01e-11 |
SMART |
|
CCP
|
91 |
147 |
9.1e-14 |
SMART |
|
CCP
|
155 |
211 |
1.9e-16 |
SMART |
|
CCP
|
216 |
272 |
1.6e-9 |
SMART |
|
CCP
|
277 |
343 |
1.01e-11 |
SMART |
|
CCP
|
352 |
407 |
1.2e-13 |
SMART |
|
CCP
|
411 |
467 |
2.34e-16 |
SMART |
|
CCP
|
472 |
523 |
1.24e0 |
SMART |
|
CCP
|
528 |
594 |
4.48e-13 |
SMART |
|
CCP
|
603 |
658 |
1.95e-13 |
SMART |
|
CCP
|
718 |
778 |
1.75e-15 |
SMART |
|
CCP
|
787 |
842 |
2.06e-12 |
SMART |
|
CCP
|
850 |
906 |
7.92e-14 |
SMART |
|
CCP
|
911 |
967 |
1.29e-13 |
SMART |
|
transmembrane domain
|
975 |
997 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000193356
AA Change: Y141*
|
| SMART Domains |
Protein: ENSMUSP00000141706
Gene: ENSMUSG00000026616
AA Change: Y141*
| Domain | Start | End | E-Value | Type |
|---|
|
CCP
|
1 |
46 |
1.2e-1 |
SMART |
|
CCP
|
55 |
110 |
5.9e-16 |
SMART |
|
CCP
|
114 |
170 |
1.1e-18 |
SMART |
|
CCP
|
175 |
226 |
6.1e-3 |
SMART |
|
CCP
|
231 |
297 |
2.2e-15 |
SMART |
|
CCP
|
306 |
361 |
9.4e-16 |
SMART |
|
CCP
|
421 |
481 |
8.3e-18 |
SMART |
|
CCP
|
490 |
545 |
1e-14 |
SMART |
|
CCP
|
553 |
609 |
4e-16 |
SMART |
|
CCP
|
614 |
670 |
6.2e-16 |
SMART |
|
transmembrane domain
|
678 |
700 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193801
|
| SMART Domains |
Protein: ENSMUSP00000141276
Gene: ENSMUSG00000026616
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000195120
AA Change: Y438*
|
| SMART Domains |
Protein: ENSMUSP00000141538
Gene: ENSMUSG00000026616
AA Change: Y438*
| Domain | Start | End | E-Value | Type |
|---|
|
CCP
|
23 |
82 |
4.9e-14 |
SMART |
|
CCP
|
91 |
147 |
4.5e-16 |
SMART |
|
CCP
|
155 |
211 |
9.1e-19 |
SMART |
|
CCP
|
216 |
272 |
8e-12 |
SMART |
|
CCP
|
277 |
343 |
5e-14 |
SMART |
|
CCP
|
352 |
407 |
5.9e-16 |
SMART |
|
CCP
|
411 |
467 |
1.1e-18 |
SMART |
|
CCP
|
472 |
523 |
6.1e-3 |
SMART |
|
CCP
|
528 |
594 |
2.2e-15 |
SMART |
|
CCP
|
603 |
658 |
9.4e-16 |
SMART |
|
CCP
|
718 |
778 |
8.3e-18 |
SMART |
|
CCP
|
787 |
842 |
1e-14 |
SMART |
|
CCP
|
850 |
906 |
4e-16 |
SMART |
|
CCP
|
911 |
967 |
6.2e-16 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000210219
AA Change: Y814*
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
100% (76/76) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired humoral immune responses to T cell-dependent antigens, with limited affinity maturation, and reduced memory B cell and germinal center formation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca7 |
T |
A |
10: 79,838,973 (GRCm39) |
L689Q |
|
Het |
| Abcc2 |
G |
A |
19: 43,793,391 (GRCm39) |
V348M |
probably benign |
Het |
| Abhd5 |
T |
C |
9: 122,196,992 (GRCm39) |
S60P |
probably benign |
Het |
| Adamts10 |
C |
A |
17: 33,756,330 (GRCm39) |
H324Q |
probably benign |
Het |
| Akap1 |
A |
G |
11: 88,723,165 (GRCm39) |
L823P |
probably damaging |
Het |
| Aoc1 |
G |
A |
6: 48,885,522 (GRCm39) |
V676I |
probably damaging |
Het |
| Arhgef12 |
T |
C |
9: 42,893,241 (GRCm39) |
|
probably benign |
Het |
| Arl4d |
A |
C |
11: 101,557,620 (GRCm39) |
S49R |
possibly damaging |
Het |
| Atr |
A |
G |
9: 95,747,851 (GRCm39) |
I378V |
probably benign |
Het |
| Bicd1 |
G |
A |
6: 149,385,674 (GRCm39) |
V136I |
probably benign |
Het |
| Brd1 |
A |
T |
15: 88,585,374 (GRCm39) |
L820H |
possibly damaging |
Het |
| Cfap70 |
T |
C |
14: 20,497,590 (GRCm39) |
T55A |
probably benign |
Het |
| Cog7 |
G |
T |
7: 121,570,561 (GRCm39) |
N182K |
probably damaging |
Het |
| Col4a4 |
T |
A |
1: 82,431,752 (GRCm39) |
T1511S |
unknown |
Het |
| Ctnnbl1 |
T |
A |
2: 157,648,623 (GRCm39) |
V198E |
probably damaging |
Het |
| Fam117b |
C |
T |
1: 60,018,456 (GRCm39) |
Q58* |
probably null |
Het |
| Fam171a2 |
A |
G |
11: 102,330,519 (GRCm39) |
Y288H |
probably damaging |
Het |
| Fam186a |
A |
T |
15: 99,840,472 (GRCm39) |
I1924K |
possibly damaging |
Het |
| Fancd2 |
A |
G |
6: 113,532,180 (GRCm39) |
I498V |
probably benign |
Het |
| Fat3 |
T |
A |
9: 15,909,421 (GRCm39) |
I2194F |
probably benign |
Het |
| Flg2 |
T |
C |
3: 93,109,591 (GRCm39) |
S540P |
unknown |
Het |
| Gbp9 |
T |
C |
5: 105,231,695 (GRCm39) |
Y297C |
|
Het |
| Gck |
T |
G |
11: 5,854,377 (GRCm39) |
N283H |
possibly damaging |
Het |
| Gm13941 |
A |
T |
2: 110,935,146 (GRCm39) |
L28Q |
unknown |
Het |
| Gpr155 |
A |
G |
2: 73,204,109 (GRCm39) |
I235T |
possibly damaging |
Het |
| Junb |
A |
C |
8: 85,704,052 (GRCm39) |
L336R |
probably damaging |
Het |
| Krt14 |
A |
T |
11: 100,095,904 (GRCm39) |
M218K |
probably benign |
Het |
| Leprotl1 |
A |
G |
8: 34,604,967 (GRCm39) |
V102A |
probably benign |
Het |
| Lrrc8d |
T |
C |
5: 105,961,908 (GRCm39) |
F773L |
probably damaging |
Het |
| Mad2l1bp |
G |
A |
17: 46,458,958 (GRCm39) |
R191C |
probably damaging |
Het |
| Man1c1 |
C |
T |
4: 134,311,705 (GRCm39) |
V274M |
possibly damaging |
Het |
| Mtor |
C |
A |
4: 148,637,198 (GRCm39) |
P2466T |
probably benign |
Het |
| Mycbpap |
C |
A |
11: 94,398,032 (GRCm39) |
|
probably benign |
Het |
| Myef2l |
G |
A |
3: 10,153,593 (GRCm39) |
V121M |
probably damaging |
Het |
| Myo18b |
T |
C |
5: 112,975,862 (GRCm39) |
E1329G |
probably damaging |
Het |
| Nipbl |
A |
T |
15: 8,380,340 (GRCm39) |
D817E |
probably benign |
Het |
| Nthl1 |
C |
T |
17: 24,853,753 (GRCm39) |
Q133* |
probably null |
Het |
| Nup133 |
A |
G |
8: 124,660,155 (GRCm39) |
M381T |
probably benign |
Het |
| Or13c7 |
T |
C |
4: 43,854,602 (GRCm39) |
C98R |
probably damaging |
Het |
| Or2j3 |
T |
C |
17: 38,615,654 (GRCm39) |
T233A |
probably benign |
Het |
| Or51t4 |
T |
C |
7: 102,598,527 (GRCm39) |
I285T |
possibly damaging |
Het |
| Or7e175 |
T |
C |
9: 20,048,633 (GRCm39) |
Y74H |
probably damaging |
Het |
| Or7g20 |
T |
C |
9: 18,946,773 (GRCm39) |
M118T |
probably damaging |
Het |
| Peg10 |
GC |
GCTCC |
6: 4,756,452 (GRCm39) |
|
probably benign |
Het |
| Pmm1 |
C |
T |
15: 81,839,896 (GRCm39) |
R143H |
probably damaging |
Het |
| Pmpcb |
A |
T |
5: 21,961,608 (GRCm39) |
I422F |
probably damaging |
Het |
| Prpf8 |
T |
A |
11: 75,380,589 (GRCm39) |
H97Q |
possibly damaging |
Het |
| Psat1 |
A |
G |
19: 15,898,332 (GRCm39) |
L30P |
probably damaging |
Het |
| Rag1 |
T |
C |
2: 101,472,820 (GRCm39) |
D774G |
probably damaging |
Het |
| Rag1 |
C |
T |
2: 101,475,137 (GRCm39) |
A2T |
probably benign |
Het |
| Rccd1 |
G |
T |
7: 79,970,728 (GRCm39) |
F17L |
probably damaging |
Het |
| Rhobtb1 |
T |
A |
10: 69,106,579 (GRCm39) |
D443E |
probably damaging |
Het |
| Rnf13 |
A |
G |
3: 57,709,866 (GRCm39) |
|
probably null |
Het |
| Ryr2 |
A |
G |
13: 11,587,185 (GRCm39) |
S4699P |
possibly damaging |
Het |
| Scart1 |
A |
G |
7: 139,808,277 (GRCm39) |
T754A |
probably benign |
Het |
| Sdc3 |
T |
C |
4: 130,546,352 (GRCm39) |
V237A |
probably benign |
Het |
| Serinc5 |
T |
A |
13: 92,797,514 (GRCm39) |
|
probably benign |
Het |
| Sertad4 |
A |
G |
1: 192,528,973 (GRCm39) |
I281T |
probably benign |
Het |
| Shroom1 |
T |
C |
11: 53,354,490 (GRCm39) |
S137P |
probably damaging |
Het |
| Slurp1 |
C |
T |
15: 74,599,450 (GRCm39) |
G20D |
probably damaging |
Het |
| Sncb |
T |
A |
13: 54,910,512 (GRCm39) |
N75Y |
probably damaging |
Het |
| Spag8 |
C |
T |
4: 43,653,231 (GRCm39) |
G77S |
unknown |
Het |
| Spink14 |
A |
T |
18: 44,164,059 (GRCm39) |
I76F |
probably damaging |
Het |
| Srfbp1 |
A |
T |
18: 52,623,102 (GRCm39) |
E372D |
possibly damaging |
Het |
| Synpo |
A |
T |
18: 60,735,599 (GRCm39) |
N782K |
probably damaging |
Het |
| Syt7 |
T |
C |
19: 10,421,373 (GRCm39) |
M519T |
probably damaging |
Het |
| Tlr5 |
C |
T |
1: 182,802,160 (GRCm39) |
P488L |
probably benign |
Het |
| Tmod3 |
A |
T |
9: 75,412,202 (GRCm39) |
I315N |
probably damaging |
Het |
| Ttc12 |
T |
C |
9: 49,364,757 (GRCm39) |
M340V |
probably benign |
Het |
| Ttn |
T |
A |
2: 76,710,959 (GRCm39) |
I8392F |
unknown |
Het |
| Ttn |
A |
G |
2: 76,769,232 (GRCm39) |
V2822A |
unknown |
Het |
| Ube3b |
C |
T |
5: 114,542,837 (GRCm39) |
|
probably benign |
Het |
| Ubr4 |
C |
A |
4: 139,145,785 (GRCm39) |
N238K |
|
Het |
| Vmn2r12 |
T |
C |
5: 109,233,885 (GRCm39) |
T776A |
probably damaging |
Het |
| Vps50 |
G |
A |
6: 3,588,091 (GRCm39) |
|
probably benign |
Het |
| Vwa3a |
A |
G |
7: 120,366,470 (GRCm39) |
D165G |
|
Het |
| Wdr17 |
T |
A |
8: 55,114,605 (GRCm39) |
H644L |
probably damaging |
Het |
| Zfp628 |
T |
C |
7: 4,924,202 (GRCm39) |
V808A |
probably benign |
Het |
| Zscan21 |
T |
A |
5: 138,123,937 (GRCm39) |
D205E |
probably damaging |
Het |
|
| Other mutations in Cr2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00587:Cr2
|
APN |
1 |
194,836,559 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
IGL01326:Cr2
|
APN |
1 |
194,823,529 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL01358:Cr2
|
APN |
1 |
194,842,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01410:Cr2
|
APN |
1 |
194,845,542 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01468:Cr2
|
APN |
1 |
194,850,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01608:Cr2
|
APN |
1 |
194,837,528 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL01810:Cr2
|
APN |
1 |
194,841,903 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01843:Cr2
|
APN |
1 |
194,833,222 (GRCm39) |
splice site |
probably benign |
|
|
IGL02332:Cr2
|
APN |
1 |
194,842,630 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02934:Cr2
|
APN |
1 |
194,836,633 (GRCm39) |
splice site |
probably benign |
|
|
IGL02938:Cr2
|
APN |
1 |
194,848,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03149:Cr2
|
APN |
1 |
194,848,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03327:Cr2
|
APN |
1 |
194,852,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03346:Cr2
|
APN |
1 |
194,852,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Pillar
|
UTSW |
1 |
194,838,196 (GRCm39) |
nonsense |
probably null |
|
|
PIT4354001:Cr2
|
UTSW |
1 |
194,848,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4418001:Cr2
|
UTSW |
1 |
194,839,760 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0128:Cr2
|
UTSW |
1 |
194,848,539 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0130:Cr2
|
UTSW |
1 |
194,848,539 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0380:Cr2
|
UTSW |
1 |
194,839,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0538:Cr2
|
UTSW |
1 |
194,842,667 (GRCm39) |
splice site |
probably benign |
|
|
R0605:Cr2
|
UTSW |
1 |
194,845,904 (GRCm39) |
splice site |
probably benign |
|
|
R0626:Cr2
|
UTSW |
1 |
194,853,419 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1135:Cr2
|
UTSW |
1 |
194,839,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1396:Cr2
|
UTSW |
1 |
194,851,561 (GRCm39) |
splice site |
probably null |
|
|
R1422:Cr2
|
UTSW |
1 |
194,853,433 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1467:Cr2
|
UTSW |
1 |
194,839,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Cr2
|
UTSW |
1 |
194,839,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1511:Cr2
|
UTSW |
1 |
194,837,580 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1572:Cr2
|
UTSW |
1 |
194,845,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1714:Cr2
|
UTSW |
1 |
194,833,994 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1748:Cr2
|
UTSW |
1 |
194,838,213 (GRCm39) |
nonsense |
probably null |
|
|
R1761:Cr2
|
UTSW |
1 |
194,837,431 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1824:Cr2
|
UTSW |
1 |
194,839,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1893:Cr2
|
UTSW |
1 |
194,837,495 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1990:Cr2
|
UTSW |
1 |
194,836,458 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1991:Cr2
|
UTSW |
1 |
194,836,458 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1992:Cr2
|
UTSW |
1 |
194,836,458 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2191:Cr2
|
UTSW |
1 |
194,845,689 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2276:Cr2
|
UTSW |
1 |
194,839,676 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2277:Cr2
|
UTSW |
1 |
194,839,676 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3548:Cr2
|
UTSW |
1 |
194,838,196 (GRCm39) |
nonsense |
probably null |
|
|
R3743:Cr2
|
UTSW |
1 |
194,832,274 (GRCm39) |
splice site |
probably benign |
|
|
R3941:Cr2
|
UTSW |
1 |
194,848,122 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3963:Cr2
|
UTSW |
1 |
194,842,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4211:Cr2
|
UTSW |
1 |
194,838,636 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4484:Cr2
|
UTSW |
1 |
194,836,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4546:Cr2
|
UTSW |
1 |
194,853,349 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4791:Cr2
|
UTSW |
1 |
194,838,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Cr2
|
UTSW |
1 |
194,845,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4802:Cr2
|
UTSW |
1 |
194,845,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4874:Cr2
|
UTSW |
1 |
194,858,878 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4885:Cr2
|
UTSW |
1 |
194,841,039 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4889:Cr2
|
UTSW |
1 |
194,858,893 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R5154:Cr2
|
UTSW |
1 |
194,841,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5574:Cr2
|
UTSW |
1 |
194,823,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5594:Cr2
|
UTSW |
1 |
194,839,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5645:Cr2
|
UTSW |
1 |
194,836,581 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5700:Cr2
|
UTSW |
1 |
194,842,065 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5929:Cr2
|
UTSW |
1 |
194,853,419 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6237:Cr2
|
UTSW |
1 |
194,839,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6299:Cr2
|
UTSW |
1 |
194,850,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6368:Cr2
|
UTSW |
1 |
194,850,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6406:Cr2
|
UTSW |
1 |
194,852,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6618:Cr2
|
UTSW |
1 |
194,839,687 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6684:Cr2
|
UTSW |
1 |
194,853,329 (GRCm39) |
nonsense |
probably null |
|
|
R6720:Cr2
|
UTSW |
1 |
194,837,508 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6866:Cr2
|
UTSW |
1 |
194,833,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6915:Cr2
|
UTSW |
1 |
194,853,454 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7057:Cr2
|
UTSW |
1 |
194,833,918 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7117:Cr2
|
UTSW |
1 |
194,842,909 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7200:Cr2
|
UTSW |
1 |
194,845,557 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7209:Cr2
|
UTSW |
1 |
194,851,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7350:Cr2
|
UTSW |
1 |
194,837,594 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7414:Cr2
|
UTSW |
1 |
194,832,344 (GRCm39) |
missense |
probably benign |
|
|
R7453:Cr2
|
UTSW |
1 |
194,847,565 (GRCm39) |
splice site |
probably null |
|
|
R7479:Cr2
|
UTSW |
1 |
194,840,718 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7480:Cr2
|
UTSW |
1 |
194,836,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7570:Cr2
|
UTSW |
1 |
194,851,648 (GRCm39) |
nonsense |
probably null |
|
|
R7666:Cr2
|
UTSW |
1 |
194,836,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7921:Cr2
|
UTSW |
1 |
194,833,975 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7923:Cr2
|
UTSW |
1 |
194,850,995 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8396:Cr2
|
UTSW |
1 |
194,840,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8503:Cr2
|
UTSW |
1 |
194,845,850 (GRCm39) |
missense |
probably benign |
|
|
R8517:Cr2
|
UTSW |
1 |
194,838,207 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8773:Cr2
|
UTSW |
1 |
194,840,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8849:Cr2
|
UTSW |
1 |
194,839,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Cr2
|
UTSW |
1 |
194,851,581 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8938:Cr2
|
UTSW |
1 |
194,853,424 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9027:Cr2
|
UTSW |
1 |
194,834,029 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9045:Cr2
|
UTSW |
1 |
194,837,680 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9137:Cr2
|
UTSW |
1 |
194,850,640 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9476:Cr2
|
UTSW |
1 |
194,840,416 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9497:Cr2
|
UTSW |
1 |
194,850,743 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9510:Cr2
|
UTSW |
1 |
194,840,416 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9752:Cr2
|
UTSW |
1 |
194,823,575 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9799:Cr2
|
UTSW |
1 |
194,842,988 (GRCm39) |
missense |
probably benign |
0.02 |
|
X0028:Cr2
|
UTSW |
1 |
194,832,290 (GRCm39) |
missense |
probably benign |
0.09 |
|
X0066:Cr2
|
UTSW |
1 |
194,848,629 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Cr2
|
UTSW |
1 |
194,836,461 (GRCm39) |
missense |
probably benign |
0.23 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGATTCTGAGGCCTCTTAAAGAG -3'
(R):5'- GACAACTGCCATGCAAATGG -3'
Sequencing Primer
(F):5'- AAAGAGATGTGGTCCTACTGGCTTAC -3'
(R):5'- CAACTGCCATGCAAATGGTATTATC -3'
|
| Posted On |
2021-12-30 |
Incidental Mutation