Incidental Mutation 'R9116:Vmn2r12'
| ID |
692526 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r12
|
| Ensembl Gene |
ENSMUSG00000090688 |
| Gene Name |
vomeronasal 2, receptor 12 |
| Synonyms |
Gm6769 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.070)
|
| Stock # |
R9116 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
109233715-109245730 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 109233885 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 776
(T776A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000093612
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000095922]
|
| AlphaFold |
L7N217 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000095922
AA Change: T776A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000093612
Gene: ENSMUSG00000090688
AA Change: T776A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
466 |
8.8e-30 |
PFAM |
|
Pfam:NCD3G
|
505 |
559 |
1.7e-18 |
PFAM |
|
Pfam:7tm_3
|
591 |
827 |
3.9e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
100% (76/76) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca7 |
T |
A |
10: 79,838,973 (GRCm39) |
L689Q |
|
Het |
| Abcc2 |
G |
A |
19: 43,793,391 (GRCm39) |
V348M |
probably benign |
Het |
| Abhd5 |
T |
C |
9: 122,196,992 (GRCm39) |
S60P |
probably benign |
Het |
| Adamts10 |
C |
A |
17: 33,756,330 (GRCm39) |
H324Q |
probably benign |
Het |
| Akap1 |
A |
G |
11: 88,723,165 (GRCm39) |
L823P |
probably damaging |
Het |
| Aoc1 |
G |
A |
6: 48,885,522 (GRCm39) |
V676I |
probably damaging |
Het |
| Arhgef12 |
T |
C |
9: 42,893,241 (GRCm39) |
|
probably benign |
Het |
| Arl4d |
A |
C |
11: 101,557,620 (GRCm39) |
S49R |
possibly damaging |
Het |
| Atr |
A |
G |
9: 95,747,851 (GRCm39) |
I378V |
probably benign |
Het |
| Bicd1 |
G |
A |
6: 149,385,674 (GRCm39) |
V136I |
probably benign |
Het |
| Brd1 |
A |
T |
15: 88,585,374 (GRCm39) |
L820H |
possibly damaging |
Het |
| Cfap70 |
T |
C |
14: 20,497,590 (GRCm39) |
T55A |
probably benign |
Het |
| Cog7 |
G |
T |
7: 121,570,561 (GRCm39) |
N182K |
probably damaging |
Het |
| Col4a4 |
T |
A |
1: 82,431,752 (GRCm39) |
T1511S |
unknown |
Het |
| Cr2 |
A |
T |
1: 194,840,977 (GRCm39) |
Y438* |
probably null |
Het |
| Ctnnbl1 |
T |
A |
2: 157,648,623 (GRCm39) |
V198E |
probably damaging |
Het |
| Fam117b |
C |
T |
1: 60,018,456 (GRCm39) |
Q58* |
probably null |
Het |
| Fam171a2 |
A |
G |
11: 102,330,519 (GRCm39) |
Y288H |
probably damaging |
Het |
| Fam186a |
A |
T |
15: 99,840,472 (GRCm39) |
I1924K |
possibly damaging |
Het |
| Fancd2 |
A |
G |
6: 113,532,180 (GRCm39) |
I498V |
probably benign |
Het |
| Fat3 |
T |
A |
9: 15,909,421 (GRCm39) |
I2194F |
probably benign |
Het |
| Flg2 |
T |
C |
3: 93,109,591 (GRCm39) |
S540P |
unknown |
Het |
| Gbp9 |
T |
C |
5: 105,231,695 (GRCm39) |
Y297C |
|
Het |
| Gck |
T |
G |
11: 5,854,377 (GRCm39) |
N283H |
possibly damaging |
Het |
| Gm13941 |
A |
T |
2: 110,935,146 (GRCm39) |
L28Q |
unknown |
Het |
| Gpr155 |
A |
G |
2: 73,204,109 (GRCm39) |
I235T |
possibly damaging |
Het |
| Junb |
A |
C |
8: 85,704,052 (GRCm39) |
L336R |
probably damaging |
Het |
| Krt14 |
A |
T |
11: 100,095,904 (GRCm39) |
M218K |
probably benign |
Het |
| Leprotl1 |
A |
G |
8: 34,604,967 (GRCm39) |
V102A |
probably benign |
Het |
| Lrrc8d |
T |
C |
5: 105,961,908 (GRCm39) |
F773L |
probably damaging |
Het |
| Mad2l1bp |
G |
A |
17: 46,458,958 (GRCm39) |
R191C |
probably damaging |
Het |
| Man1c1 |
C |
T |
4: 134,311,705 (GRCm39) |
V274M |
possibly damaging |
Het |
| Mtor |
C |
A |
4: 148,637,198 (GRCm39) |
P2466T |
probably benign |
Het |
| Mycbpap |
C |
A |
11: 94,398,032 (GRCm39) |
|
probably benign |
Het |
| Myef2l |
G |
A |
3: 10,153,593 (GRCm39) |
V121M |
probably damaging |
Het |
| Myo18b |
T |
C |
5: 112,975,862 (GRCm39) |
E1329G |
probably damaging |
Het |
| Nipbl |
A |
T |
15: 8,380,340 (GRCm39) |
D817E |
probably benign |
Het |
| Nthl1 |
C |
T |
17: 24,853,753 (GRCm39) |
Q133* |
probably null |
Het |
| Nup133 |
A |
G |
8: 124,660,155 (GRCm39) |
M381T |
probably benign |
Het |
| Or13c7 |
T |
C |
4: 43,854,602 (GRCm39) |
C98R |
probably damaging |
Het |
| Or2j3 |
T |
C |
17: 38,615,654 (GRCm39) |
T233A |
probably benign |
Het |
| Or51t4 |
T |
C |
7: 102,598,527 (GRCm39) |
I285T |
possibly damaging |
Het |
| Or7e175 |
T |
C |
9: 20,048,633 (GRCm39) |
Y74H |
probably damaging |
Het |
| Or7g20 |
T |
C |
9: 18,946,773 (GRCm39) |
M118T |
probably damaging |
Het |
| Peg10 |
GC |
GCTCC |
6: 4,756,452 (GRCm39) |
|
probably benign |
Het |
| Pmm1 |
C |
T |
15: 81,839,896 (GRCm39) |
R143H |
probably damaging |
Het |
| Pmpcb |
A |
T |
5: 21,961,608 (GRCm39) |
I422F |
probably damaging |
Het |
| Prpf8 |
T |
A |
11: 75,380,589 (GRCm39) |
H97Q |
possibly damaging |
Het |
| Psat1 |
A |
G |
19: 15,898,332 (GRCm39) |
L30P |
probably damaging |
Het |
| Rag1 |
T |
C |
2: 101,472,820 (GRCm39) |
D774G |
probably damaging |
Het |
| Rag1 |
C |
T |
2: 101,475,137 (GRCm39) |
A2T |
probably benign |
Het |
| Rccd1 |
G |
T |
7: 79,970,728 (GRCm39) |
F17L |
probably damaging |
Het |
| Rhobtb1 |
T |
A |
10: 69,106,579 (GRCm39) |
D443E |
probably damaging |
Het |
| Rnf13 |
A |
G |
3: 57,709,866 (GRCm39) |
|
probably null |
Het |
| Ryr2 |
A |
G |
13: 11,587,185 (GRCm39) |
S4699P |
possibly damaging |
Het |
| Scart1 |
A |
G |
7: 139,808,277 (GRCm39) |
T754A |
probably benign |
Het |
| Sdc3 |
T |
C |
4: 130,546,352 (GRCm39) |
V237A |
probably benign |
Het |
| Serinc5 |
T |
A |
13: 92,797,514 (GRCm39) |
|
probably benign |
Het |
| Sertad4 |
A |
G |
1: 192,528,973 (GRCm39) |
I281T |
probably benign |
Het |
| Shroom1 |
T |
C |
11: 53,354,490 (GRCm39) |
S137P |
probably damaging |
Het |
| Slurp1 |
C |
T |
15: 74,599,450 (GRCm39) |
G20D |
probably damaging |
Het |
| Sncb |
T |
A |
13: 54,910,512 (GRCm39) |
N75Y |
probably damaging |
Het |
| Spag8 |
C |
T |
4: 43,653,231 (GRCm39) |
G77S |
unknown |
Het |
| Spink14 |
A |
T |
18: 44,164,059 (GRCm39) |
I76F |
probably damaging |
Het |
| Srfbp1 |
A |
T |
18: 52,623,102 (GRCm39) |
E372D |
possibly damaging |
Het |
| Synpo |
A |
T |
18: 60,735,599 (GRCm39) |
N782K |
probably damaging |
Het |
| Syt7 |
T |
C |
19: 10,421,373 (GRCm39) |
M519T |
probably damaging |
Het |
| Tlr5 |
C |
T |
1: 182,802,160 (GRCm39) |
P488L |
probably benign |
Het |
| Tmod3 |
A |
T |
9: 75,412,202 (GRCm39) |
I315N |
probably damaging |
Het |
| Ttc12 |
T |
C |
9: 49,364,757 (GRCm39) |
M340V |
probably benign |
Het |
| Ttn |
T |
A |
2: 76,710,959 (GRCm39) |
I8392F |
unknown |
Het |
| Ttn |
A |
G |
2: 76,769,232 (GRCm39) |
V2822A |
unknown |
Het |
| Ube3b |
C |
T |
5: 114,542,837 (GRCm39) |
|
probably benign |
Het |
| Ubr4 |
C |
A |
4: 139,145,785 (GRCm39) |
N238K |
|
Het |
| Vps50 |
G |
A |
6: 3,588,091 (GRCm39) |
|
probably benign |
Het |
| Vwa3a |
A |
G |
7: 120,366,470 (GRCm39) |
D165G |
|
Het |
| Wdr17 |
T |
A |
8: 55,114,605 (GRCm39) |
H644L |
probably damaging |
Het |
| Zfp628 |
T |
C |
7: 4,924,202 (GRCm39) |
V808A |
probably benign |
Het |
| Zscan21 |
T |
A |
5: 138,123,937 (GRCm39) |
D205E |
probably damaging |
Het |
|
| Other mutations in Vmn2r12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00948:Vmn2r12
|
APN |
5 |
109,245,541 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL01096:Vmn2r12
|
APN |
5 |
109,234,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01538:Vmn2r12
|
APN |
5 |
109,239,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01548:Vmn2r12
|
APN |
5 |
109,240,893 (GRCm39) |
nonsense |
probably null |
|
|
IGL01762:Vmn2r12
|
APN |
5 |
109,234,430 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01860:Vmn2r12
|
APN |
5 |
109,240,025 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02269:Vmn2r12
|
APN |
5 |
109,234,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02530:Vmn2r12
|
APN |
5 |
109,233,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02887:Vmn2r12
|
APN |
5 |
109,238,351 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03265:Vmn2r12
|
APN |
5 |
109,239,936 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0396:Vmn2r12
|
UTSW |
5 |
109,240,765 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0497:Vmn2r12
|
UTSW |
5 |
109,239,755 (GRCm39) |
nonsense |
probably null |
|
|
R0529:Vmn2r12
|
UTSW |
5 |
109,240,714 (GRCm39) |
missense |
probably benign |
|
|
R0715:Vmn2r12
|
UTSW |
5 |
109,238,373 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0742:Vmn2r12
|
UTSW |
5 |
109,234,281 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R0894:Vmn2r12
|
UTSW |
5 |
109,235,716 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1173:Vmn2r12
|
UTSW |
5 |
109,240,720 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1174:Vmn2r12
|
UTSW |
5 |
109,240,720 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1259:Vmn2r12
|
UTSW |
5 |
109,239,763 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1349:Vmn2r12
|
UTSW |
5 |
109,234,452 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1388:Vmn2r12
|
UTSW |
5 |
109,240,840 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R1549:Vmn2r12
|
UTSW |
5 |
109,240,696 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1766:Vmn2r12
|
UTSW |
5 |
109,239,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1781:Vmn2r12
|
UTSW |
5 |
109,239,594 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1885:Vmn2r12
|
UTSW |
5 |
109,239,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2159:Vmn2r12
|
UTSW |
5 |
109,239,340 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2420:Vmn2r12
|
UTSW |
5 |
109,234,398 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2421:Vmn2r12
|
UTSW |
5 |
109,234,398 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2422:Vmn2r12
|
UTSW |
5 |
109,234,398 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2937:Vmn2r12
|
UTSW |
5 |
109,239,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2938:Vmn2r12
|
UTSW |
5 |
109,239,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3898:Vmn2r12
|
UTSW |
5 |
109,238,370 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4061:Vmn2r12
|
UTSW |
5 |
109,240,058 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4063:Vmn2r12
|
UTSW |
5 |
109,240,058 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4090:Vmn2r12
|
UTSW |
5 |
109,239,412 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4297:Vmn2r12
|
UTSW |
5 |
109,239,830 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4298:Vmn2r12
|
UTSW |
5 |
109,239,830 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4299:Vmn2r12
|
UTSW |
5 |
109,239,830 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4304:Vmn2r12
|
UTSW |
5 |
109,233,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4306:Vmn2r12
|
UTSW |
5 |
109,233,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4307:Vmn2r12
|
UTSW |
5 |
109,233,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4308:Vmn2r12
|
UTSW |
5 |
109,233,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4594:Vmn2r12
|
UTSW |
5 |
109,234,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4783:Vmn2r12
|
UTSW |
5 |
109,234,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4900:Vmn2r12
|
UTSW |
5 |
109,240,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4929:Vmn2r12
|
UTSW |
5 |
109,239,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4974:Vmn2r12
|
UTSW |
5 |
109,239,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5389:Vmn2r12
|
UTSW |
5 |
109,238,261 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5431:Vmn2r12
|
UTSW |
5 |
109,239,684 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5527:Vmn2r12
|
UTSW |
5 |
109,234,483 (GRCm39) |
nonsense |
probably null |
|
|
R5639:Vmn2r12
|
UTSW |
5 |
109,240,666 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5753:Vmn2r12
|
UTSW |
5 |
109,239,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5797:Vmn2r12
|
UTSW |
5 |
109,233,736 (GRCm39) |
nonsense |
probably null |
|
|
R6142:Vmn2r12
|
UTSW |
5 |
109,240,763 (GRCm39) |
missense |
probably benign |
|
|
R6162:Vmn2r12
|
UTSW |
5 |
109,234,430 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6176:Vmn2r12
|
UTSW |
5 |
109,233,866 (GRCm39) |
missense |
probably benign |
0.43 |
|
R6853:Vmn2r12
|
UTSW |
5 |
109,240,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7238:Vmn2r12
|
UTSW |
5 |
109,245,655 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7341:Vmn2r12
|
UTSW |
5 |
109,239,811 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7341:Vmn2r12
|
UTSW |
5 |
109,234,113 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7383:Vmn2r12
|
UTSW |
5 |
109,240,684 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7740:Vmn2r12
|
UTSW |
5 |
109,239,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7749:Vmn2r12
|
UTSW |
5 |
109,233,920 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7861:Vmn2r12
|
UTSW |
5 |
109,235,829 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7908:Vmn2r12
|
UTSW |
5 |
109,234,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8128:Vmn2r12
|
UTSW |
5 |
109,239,747 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8175:Vmn2r12
|
UTSW |
5 |
109,238,349 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8234:Vmn2r12
|
UTSW |
5 |
109,234,074 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8771:Vmn2r12
|
UTSW |
5 |
109,239,952 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8947:Vmn2r12
|
UTSW |
5 |
109,234,522 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8991:Vmn2r12
|
UTSW |
5 |
109,234,033 (GRCm39) |
nonsense |
probably null |
|
|
R9122:Vmn2r12
|
UTSW |
5 |
109,240,910 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9153:Vmn2r12
|
UTSW |
5 |
109,234,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9371:Vmn2r12
|
UTSW |
5 |
109,234,452 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9375:Vmn2r12
|
UTSW |
5 |
109,233,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9524:Vmn2r12
|
UTSW |
5 |
109,239,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9587:Vmn2r12
|
UTSW |
5 |
109,239,322 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r12
|
UTSW |
5 |
109,240,646 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Vmn2r12
|
UTSW |
5 |
109,239,303 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCATGTTATCTTTGTACTTCTGCAG -3'
(R):5'- CCTCTGTGGAATCTGGTTGGTAAC -3'
Sequencing Primer
(F):5'- GTACTTCTGCAGATTTGAATCTAGTC -3'
(R):5'- CCTCCCTTTATTGACAGAGATACAC -3'
|
| Posted On |
2021-12-30 |
Incidental Mutation