Incidental Mutation 'R9122:Trgv1'
ID 692834
Institutional Source Beutler Lab
Gene Symbol Trgv1
Ensembl Gene ENSMUSG00000076755
Gene Name T cell receptor gamma, variable 1
Synonyms Tcrg-V1, Gm16602
MMRRC Submission 068924-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.123) question?
Stock # R9122 (G1)
Quality Score 86.0076
Status Validated
Chromosome 13
Chromosomal Location 19524186-19524624 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 19524330 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Glutamic Acid at position 18 (G18E)
Ref Sequence ENSEMBL: ENSMUSP00000100342 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103563] [ENSMUST00000103564] [ENSMUST00000184430]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000103563
SMART Domains Protein: ENSMUSP00000100341
Gene: ENSMUSG00000076754

DomainStartEndE-ValueType
IGv 34 114 1.66e-9 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000103564
AA Change: G18E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000100342
Gene: ENSMUSG00000076755
AA Change: G18E

DomainStartEndE-ValueType
IGv 34 113 8.44e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000179181
Predicted Effect probably benign
Transcript: ENSMUST00000184430
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.9%
  • 20x: 99.7%
Validation Efficiency 100% (42/42)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310061I04Rik C G 17: 36,203,963 (GRCm39) S185T probably benign Het
Armh4 A T 14: 50,011,459 (GRCm39) Y83N possibly damaging Het
Bean1 CT C 8: 104,908,664 (GRCm39) probably null Het
Cacna1d C A 14: 29,845,402 (GRCm39) R611L probably damaging Het
Cacna1d G A 14: 29,852,125 (GRCm39) T498I probably benign Het
Cc2d2a T A 5: 43,831,081 (GRCm39) D57E probably null Het
Cd180 C A 13: 102,841,517 (GRCm39) L188M probably damaging Het
Chd7 A G 4: 8,840,510 (GRCm39) K1426R possibly damaging Het
Cntnap5c A T 17: 58,411,601 (GRCm39) D495V probably benign Het
Col11a1 T A 3: 113,907,249 (GRCm39) M630K unknown Het
Cxxc1 T G 18: 74,350,246 (GRCm39) D4E probably benign Het
Ddx31 G A 2: 28,748,753 (GRCm39) R227Q probably damaging Het
Ddx60 A G 8: 62,442,898 (GRCm39) M1109V probably benign Het
Dennd5b T C 6: 148,908,240 (GRCm39) T1018A Het
Efcab3 A T 11: 104,856,605 (GRCm39) D3840V unknown Het
Ggta1 A T 2: 35,303,336 (GRCm39) probably null Het
Gm40460 CACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG CACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG 7: 141,794,554 (GRCm39) probably benign Het
Gpr37l1 C T 1: 135,095,209 (GRCm39) V12I probably benign Het
Grin2a A T 16: 9,397,186 (GRCm39) V967E possibly damaging Het
H2ac25 T C 11: 58,845,667 (GRCm39) L35P probably damaging Het
Helz A G 11: 107,556,830 (GRCm39) T1283A probably benign Het
Ints1 A G 5: 139,745,930 (GRCm39) M1315T possibly damaging Het
Klri1 T A 6: 129,693,995 (GRCm39) R31* probably null Het
Nadk T A 4: 155,671,275 (GRCm39) N226K probably benign Het
Ncapg T C 5: 45,846,015 (GRCm39) F624S possibly damaging Het
Nxn A T 11: 76,169,317 (GRCm39) I154N probably damaging Het
Pclo T C 5: 14,729,998 (GRCm39) V2952A unknown Het
Poc1a T C 9: 106,162,242 (GRCm39) V89A probably benign Het
Pou2f2 T A 7: 24,792,302 (GRCm39) T518S probably benign Het
Pou5f1 C T 17: 35,819,953 (GRCm39) T7I probably benign Het
Prss44 T C 9: 110,646,362 (GRCm39) V363A probably damaging Het
Rhobtb1 T C 10: 69,106,653 (GRCm39) V468A probably damaging Het
Slc24a1 C A 9: 64,834,478 (GRCm39) M981I probably benign Het
Tacc1 G T 8: 25,659,255 (GRCm39) S570R probably damaging Het
Tle3 C T 9: 61,314,755 (GRCm39) probably benign Het
Tmem135 G C 7: 88,797,186 (GRCm39) L357V probably benign Het
Trim23 A G 13: 104,317,681 (GRCm39) T61A probably benign Het
Tshr C A 12: 91,478,737 (GRCm39) H195N probably benign Het
Ttn A G 2: 76,712,151 (GRCm39) S8202P unknown Het
Ufsp2 A T 8: 46,438,441 (GRCm39) Y248F probably benign Het
Vmn2r12 T A 5: 109,240,910 (GRCm39) I68L probably benign Het
Wdfy3 C A 5: 102,091,831 (GRCm39) V503L probably damaging Het
Zfp788 A T 7: 41,299,919 (GRCm39) K852* probably null Het
Zfp980 A C 4: 145,428,834 (GRCm39) H521P probably damaging Het
Other mutations in Trgv1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01538:Trgv1 APN 13 19,520,740 (GRCm39) unclassified probably benign
R4662:Trgv1 UTSW 13 19,524,503 (GRCm39) missense possibly damaging 0.64
R5022:Trgv1 UTSW 13 19,524,401 (GRCm39) missense probably benign 0.07
R5987:Trgv1 UTSW 13 19,524,474 (GRCm39) missense probably benign 0.02
R6902:Trgv1 UTSW 13 19,524,190 (GRCm39) missense probably benign 0.00
R6946:Trgv1 UTSW 13 19,524,190 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GACTCTGCGTTTTCCTGAGAC -3'
(R):5'- CCTCCTAAGGGTCGTTGATTG -3'

Sequencing Primer
(F):5'- TGGTGACCTGAAATTCCAGC -3'
(R):5'- CCTAAGGGTCGTTGATTGTAGTTTG -3'
Posted On 2021-12-30