Mutagenetix > Incidental Mutation

Incidental Mutation 'R9124:Vmn2r23'

693086

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r23

Ensembl Gene

ENSMUSG00000091620

Gene Name

vomeronasal 2, receptor 23

Synonyms

EG435916

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R9124 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

123702821-123742291 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 123742079 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 797 (I797T)

Ref Sequence

ENSEMBL: ENSMUSP00000126682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172391]

AlphaFold

E9PXI5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000172391
AA Change: I797T

PolyPhen 2 Score 0.573 (Sensitivity: 0.88; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: I797T

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	79	461	1.7e-31	PFAM
Pfam:NCD3G	513	566	1.2e-23	PFAM
Pfam:7tm_3	596	834	1.5e-55	PFAM

Meta Mutation Damage Score

0.1712

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (91/91)

Allele List at MGI

Other mutations in this stock

Total: 95 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A1bg	G	T	15: 60,920,830 (GRCm38)	N89K	possibly damaging	Het
Abca5	A	T	11: 110,298,179 (GRCm38)	D817E	possibly damaging	Het
Abca8b	G	A	11: 109,937,767 (GRCm38)	S1435F	probably damaging	Het
Akap9	T	C	5: 4,061,284 (GRCm38)	L3115P	probably damaging	Het
Arhgap39	G	A	15: 76,735,267 (GRCm38)	R706W	probably damaging	Het
BC048403	C	T	10: 121,750,511 (GRCm38)	Q244*	probably null	Het
BC061237	A	T	14: 44,503,394 (GRCm38)	I84F	possibly damaging	Het
Bhlhe22	T	C	3: 18,055,178 (GRCm38)	S131P	probably damaging	Het
Brinp1	C	A	4: 68,829,345 (GRCm38)	D174Y	probably damaging	Het
Bsdc1	A	G	4: 129,465,275 (GRCm38)	T40A	probably benign	Het
Ccdc65	A	T	15: 98,720,982 (GRCm38)	K281*	probably null	Het
Cd22	T	C	7: 30,873,237 (GRCm38)	I316V	probably benign	Het
Cfap100	A	C	6: 90,409,348 (GRCm38)	I275S		Het
Chd3	T	G	11: 69,369,336 (GRCm38)	E19A	unknown	Het
Chrnb1	T	C	11: 69,794,231 (GRCm38)	D91G	probably benign	Het
Cr1l	A	G	1: 195,117,617 (GRCm38)	S250P	possibly damaging	Het
Csmd1	A	G	8: 15,984,806 (GRCm38)	V2455A	probably damaging	Het
Dbp	C	T	7: 45,708,394 (GRCm38)	R229C	probably damaging	Het
Dmxl1	C	G	18: 49,939,572 (GRCm38)	N2744K	probably damaging	Het
Dnah6	C	A	6: 73,121,899 (GRCm38)	V2058F	possibly damaging	Het
Dsp	T	A	13: 38,193,300 (GRCm38)	V1687D	probably benign	Het
Dtd1	T	A	2: 144,603,878 (GRCm38)	M45K	possibly damaging	Het
Fat1	T	A	8: 45,025,027 (GRCm38)	V2370E	possibly damaging	Het
Fat1	T	A	8: 44,950,326 (GRCm38)	F38Y	probably benign	Het
Fgfr1	T	A	8: 25,570,169 (GRCm38)	D438E	probably damaging	Het
Fsip2	A	T	2: 82,985,759 (GRCm38)	K3945N	probably benign	Het
Galc	C	A	12: 98,254,164 (GRCm38)		probably null	Het
Git1	C	A	11: 77,504,672 (GRCm38)	D398E	possibly damaging	Het
Gm12569	T	C	11: 51,234,654 (GRCm38)	S135P	probably benign	Het
Gm281	A	G	14: 13,864,354 (GRCm38)	F324S		Het
Gm4924	A	G	10: 82,379,041 (GRCm38)	Q891R	unknown	Het
Gm5724	A	G	6: 141,723,104 (GRCm38)	V534A	possibly damaging	Het
Gm765	T	A	6: 98,341,938 (GRCm38)	N22I	possibly damaging	Het
Gm884	T	C	11: 103,618,895 (GRCm38)	Y749C	unknown	Het
Gpc2	T	C	5: 138,276,522 (GRCm38)		probably benign	Het
Havcr2	C	T	11: 46,469,561 (GRCm38)	T205I	probably benign	Het
Herc2	A	G	7: 56,184,308 (GRCm38)	N3087S	probably damaging	Het
Ifi204	C	T	1: 173,751,627 (GRCm38)		probably null	Het
Imp4	C	T	1: 34,440,047 (GRCm38)	R4W	unknown	Het
Itfg2	A	G	6: 128,424,807 (GRCm38)	S3P	probably damaging	Het
Kcnn3	C	T	3: 89,521,229 (GRCm38)	T254I	possibly damaging	Het
Kpna1	A	G	16: 36,033,274 (GRCm38)	I425V	probably benign	Het
Krt23	A	T	11: 99,492,929 (GRCm38)	S46T	probably damaging	Het
Loxl4	C	A	19: 42,607,660 (GRCm38)	W118L	probably damaging	Het
Lysmd2	T	A	9: 75,625,793 (GRCm38)	L10Q	probably damaging	Het
Mcm5	T	A	8: 75,124,790 (GRCm38)		probably benign	Het
Mctp2	T	A	7: 72,259,430 (GRCm38)	D45V	probably damaging	Het
Mfsd10	T	C	5: 34,634,596 (GRCm38)	T341A	probably benign	Het
Micu1	T	A	10: 59,750,513 (GRCm38)	L170Q	probably damaging	Het
Muc5ac	T	C	7: 141,809,792 (GRCm38)	I2280T	unknown	Het
Myo15	A	T	11: 60,479,126 (GRCm38)	Q904L	probably benign	Het
Myo6	G	A	9: 80,288,071 (GRCm38)	D908N	unknown	Het
Nlrp4e	A	T	7: 23,320,978 (GRCm38)	M297L	probably benign	Het
Nptn	A	G	9: 58,651,215 (GRCm38)		probably benign	Het
Oas3	A	C	5: 120,774,105 (GRCm38)	D73E	probably damaging	Het
Olfr213	A	T	6: 116,540,455 (GRCm38)	M1L	probably null	Het
Olfr429	T	C	1: 174,089,775 (GRCm38)	L245P	probably damaging	Het
Olfr536	T	A	7: 140,504,309 (GRCm38)	H50L	probably benign	Het
Olfr619	A	T	7: 103,603,656 (GRCm38)	M1L	probably benign	Het
Papd4	A	T	13: 93,147,652 (GRCm38)	L465*	probably null	Het
Pck1	C	G	2: 173,155,225 (GRCm38)	A220G	probably benign	Het
Pigq	G	A	17: 25,937,259 (GRCm38)	T65I	probably damaging	Het
Pld2	T	C	11: 70,540,870 (GRCm38)	F9L	probably damaging	Het
Plk3	ACACTCAC	ACAC	4: 117,131,893 (GRCm38)		probably benign	Het
Pnkd	A	G	1: 74,347,443 (GRCm38)	R138G	possibly damaging	Het
Ralgapa1	A	T	12: 55,735,096 (GRCm38)	I781N	probably damaging	Het
Ranbp2	A	G	10: 58,492,897 (GRCm38)	I2873V	probably benign	Het
Rpn2	C	A	2: 157,297,538 (GRCm38)	Q283K	probably benign	Het
Shmt2	A	G	10: 127,519,692 (GRCm38)	S178P	possibly damaging	Het
Shroom3	A	G	5: 92,964,542 (GRCm38)	K1921E	probably benign	Het
Slc20a1	A	G	2: 129,209,222 (GRCm38)	S600G	probably damaging	Het
Slit1	C	T	19: 41,606,512 (GRCm38)	V1140I	probably benign	Het
Sncg	T	C	14: 34,373,683 (GRCm38)	S51G	possibly damaging	Het
Spon2	C	A	5: 33,215,591 (GRCm38)	D256Y	possibly damaging	Het
Srcap	G	T	7: 127,560,702 (GRCm38)	R3250L	unknown	Het
Sun1	T	G	5: 139,245,366 (GRCm38)	Y763*	probably null	Het
Synj1	A	T	16: 90,938,625 (GRCm38)	F1480Y	probably benign	Het
Tbc1d30	T	A	10: 121,296,811 (GRCm38)	N216I	probably damaging	Het
Tgfb1	A	T	7: 25,689,155 (GRCm38)	K39*	probably null	Het
Tmem87a	A	G	2: 120,394,360 (GRCm38)		probably null	Het
Tmem8b	C	A	4: 43,681,982 (GRCm38)	R452S	probably benign	Het
Tnfsf13b	A	G	8: 10,006,966 (GRCm38)	I42V	probably benign	Het
Trpc2	A	G	7: 102,095,883 (GRCm38)	T769A	possibly damaging	Het
Ttc3	A	G	16: 94,435,530 (GRCm38)	T1033A	probably benign	Het
Ttll13	C	T	7: 80,257,003 (GRCm38)	A473V	probably damaging	Het
U2surp	G	A	9: 95,464,415 (GRCm38)	R908*	probably null	Het
Ube2s	A	G	7: 4,811,511 (GRCm38)	Y17H	probably damaging	Het
Usmg5	T	C	19: 47,086,139 (GRCm38)	M28V	probably benign	Het
Vmn1r94	A	T	7: 20,167,584 (GRCm38)	M265K	probably benign	Het
Yipf3	A	T	17: 46,248,969 (GRCm38)	E70D	probably benign	Het
Zcchc14	G	A	8: 121,605,230 (GRCm38)	P465S	unknown	Het
Zfp169	T	C	13: 48,491,081 (GRCm38)	E190G	unknown	Het
Zfp707	T	C	15: 75,973,619 (GRCm38)	S111P		Het
Zfp738	T	C	13: 67,671,338 (GRCm38)	E178G	possibly damaging	Het
Zfr	A	T	15: 12,136,671 (GRCm38)	N138I	unknown	Het

Other mutations in Vmn2r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Vmn2r23	APN	6	123,729,725 (GRCm38)	missense	possibly damaging	0.89
IGL01012:Vmn2r23	APN	6	123,729,596 (GRCm38)	missense	probably benign
IGL01073:Vmn2r23	APN	6	123,712,800 (GRCm38)	missense	possibly damaging	0.82
IGL01547:Vmn2r23	APN	6	123,704,424 (GRCm38)	missense	possibly damaging	0.88
IGL01571:Vmn2r23	APN	6	123,704,407 (GRCm38)	missense	probably damaging	1.00
IGL01950:Vmn2r23	APN	6	123,741,886 (GRCm38)	missense	possibly damaging	0.80
IGL02028:Vmn2r23	APN	6	123,741,860 (GRCm38)	missense	probably damaging	1.00
IGL02248:Vmn2r23	APN	6	123,741,744 (GRCm38)	missense	probably damaging	0.96
IGL02318:Vmn2r23	APN	6	123,741,836 (GRCm38)	missense	probably benign	0.10
IGL02649:Vmn2r23	APN	6	123,704,478 (GRCm38)	missense	probably benign
IGL02831:Vmn2r23	APN	6	123,704,385 (GRCm38)	missense	probably benign	0.22
IGL02832:Vmn2r23	APN	6	123,704,396 (GRCm38)	missense	probably benign	0.00
IGL02865:Vmn2r23	APN	6	123,741,619 (GRCm38)	missense	probably damaging	1.00
IGL02964:Vmn2r23	APN	6	123,741,782 (GRCm38)	missense	possibly damaging	0.93
IGL03347:Vmn2r23	APN	6	123,704,374 (GRCm38)	missense	probably benign	0.01
IGL03396:Vmn2r23	APN	6	123,729,626 (GRCm38)	missense	probably damaging	1.00
PIT4472001:Vmn2r23	UTSW	6	123,712,977 (GRCm38)	missense	possibly damaging	0.62
R0597:Vmn2r23	UTSW	6	123,729,721 (GRCm38)	missense	probably benign	0.08
R0677:Vmn2r23	UTSW	6	123,713,451 (GRCm38)	missense	probably benign	0.00
R0904:Vmn2r23	UTSW	6	123,742,135 (GRCm38)	missense	probably damaging	1.00
R1330:Vmn2r23	UTSW	6	123,742,004 (GRCm38)	missense	probably damaging	1.00
R1424:Vmn2r23	UTSW	6	123,713,270 (GRCm38)	nonsense	probably null
R1629:Vmn2r23	UTSW	6	123,713,427 (GRCm38)	missense	probably benign	0.05
R1842:Vmn2r23	UTSW	6	123,729,690 (GRCm38)	missense	possibly damaging	0.77
R1867:Vmn2r23	UTSW	6	123,702,915 (GRCm38)	missense	probably damaging	1.00
R1919:Vmn2r23	UTSW	6	123,713,010 (GRCm38)	missense	possibly damaging	0.94
R2087:Vmn2r23	UTSW	6	123,741,499 (GRCm38)	missense	probably benign	0.00
R2338:Vmn2r23	UTSW	6	123,704,425 (GRCm38)	missense	possibly damaging	0.88
R2568:Vmn2r23	UTSW	6	123,742,188 (GRCm38)	nonsense	probably null
R2867:Vmn2r23	UTSW	6	123,713,164 (GRCm38)	missense	possibly damaging	0.94
R2867:Vmn2r23	UTSW	6	123,713,164 (GRCm38)	missense	possibly damaging	0.94
R3500:Vmn2r23	UTSW	6	123,713,170 (GRCm38)	missense	possibly damaging	0.81
R3789:Vmn2r23	UTSW	6	123,741,389 (GRCm38)	missense	probably damaging	1.00
R4164:Vmn2r23	UTSW	6	123,729,738 (GRCm38)	missense	probably benign
R4506:Vmn2r23	UTSW	6	123,702,925 (GRCm38)	missense	probably damaging	1.00
R4652:Vmn2r23	UTSW	6	123,741,730 (GRCm38)	missense	probably damaging	1.00
R4697:Vmn2r23	UTSW	6	123,741,826 (GRCm38)	missense	probably damaging	1.00
R4840:Vmn2r23	UTSW	6	123,713,074 (GRCm38)	missense	probably damaging	1.00
R4983:Vmn2r23	UTSW	6	123,733,349 (GRCm38)	missense	probably damaging	1.00
R5276:Vmn2r23	UTSW	6	123,712,977 (GRCm38)	missense	possibly damaging	0.62
R5392:Vmn2r23	UTSW	6	123,704,364 (GRCm38)	missense	probably benign	0.36
R5528:Vmn2r23	UTSW	6	123,713,002 (GRCm38)	missense	probably damaging	1.00
R5529:Vmn2r23	UTSW	6	123,713,451 (GRCm38)	missense	probably benign	0.00
R5664:Vmn2r23	UTSW	6	123,713,074 (GRCm38)	missense	probably damaging	1.00
R5749:Vmn2r23	UTSW	6	123,733,273 (GRCm38)	missense	probably benign
R5761:Vmn2r23	UTSW	6	123,712,759 (GRCm38)	missense	probably benign	0.39
R5762:Vmn2r23	UTSW	6	123,733,393 (GRCm38)	missense	probably damaging	1.00
R5868:Vmn2r23	UTSW	6	123,712,942 (GRCm38)	missense	probably benign	0.12
R5935:Vmn2r23	UTSW	6	123,741,895 (GRCm38)	missense	possibly damaging	0.94
R6242:Vmn2r23	UTSW	6	123,704,400 (GRCm38)	missense	possibly damaging	0.82
R6416:Vmn2r23	UTSW	6	123,712,902 (GRCm38)	missense	probably damaging	1.00
R6524:Vmn2r23	UTSW	6	123,713,425 (GRCm38)	missense	probably damaging	1.00
R6576:Vmn2r23	UTSW	6	123,733,273 (GRCm38)	missense	probably benign
R6925:Vmn2r23	UTSW	6	123,704,553 (GRCm38)	missense	probably damaging	1.00
R7148:Vmn2r23	UTSW	6	123,713,022 (GRCm38)	missense	probably benign
R7215:Vmn2r23	UTSW	6	123,704,364 (GRCm38)	missense	probably benign	0.36
R7252:Vmn2r23	UTSW	6	123,741,581 (GRCm38)	missense	probably damaging	0.97
R7403:Vmn2r23	UTSW	6	123,704,579 (GRCm38)	missense	probably benign	0.01
R8015:Vmn2r23	UTSW	6	123,704,541 (GRCm38)	missense	probably benign	0.00
R8143:Vmn2r23	UTSW	6	123,741,353 (GRCm38)	missense	probably damaging	0.99
R8474:Vmn2r23	UTSW	6	123,704,640 (GRCm38)	missense	probably benign	0.36
R8520:Vmn2r23	UTSW	6	123,741,656 (GRCm38)	missense	probably damaging	0.99
R8679:Vmn2r23	UTSW	6	123,713,472 (GRCm38)	missense	probably damaging	0.99
R8713:Vmn2r23	UTSW	6	123,703,032 (GRCm38)	missense
R8966:Vmn2r23	UTSW	6	123,742,120 (GRCm38)	missense	possibly damaging	0.94
R9163:Vmn2r23	UTSW	6	123,741,823 (GRCm38)	missense	probably damaging	1.00
R9189:Vmn2r23	UTSW	6	123,704,364 (GRCm38)	missense	probably benign	0.36
R9451:Vmn2r23	UTSW	6	123,733,393 (GRCm38)	missense	probably damaging	1.00
R9495:Vmn2r23	UTSW	6	123,712,713 (GRCm38)	missense	probably benign	0.30
R9514:Vmn2r23	UTSW	6	123,712,713 (GRCm38)	missense	probably benign	0.30
RF018:Vmn2r23	UTSW	6	123,713,116 (GRCm38)	missense	probably benign	0.00
T0975:Vmn2r23	UTSW	6	123,713,161 (GRCm38)	missense	probably benign	0.00
Z1088:Vmn2r23	UTSW	6	123,742,108 (GRCm38)	missense	probably damaging	0.98
Z1177:Vmn2r23	UTSW	6	123,729,725 (GRCm38)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- TGTTGTAATGAGGGGTCCACC -3'
(R):5'- GGATTGCAGAGTCAGATGCC -3'

Sequencing Primer
(F):5'- GGTCCACCCTTGCATTCTATTGTG -3'
(R):5'- CAGAGTCAGATGCCATTGTTTAG -3'

Posted On

2022-01-20