Incidental Mutation 'R9124:Cd22'
| ID |
693092 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cd22
|
| Ensembl Gene |
ENSMUSG00000030577 |
| Gene Name |
CD22 antigen |
| Synonyms |
Lyb8, Lyb-8 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9124 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
30564829-30579767 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 30572662 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 316
(I316V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000019248
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000019248]
[ENSMUST00000108125]
[ENSMUST00000186154]
[ENSMUST00000187989]
[ENSMUST00000188157]
[ENSMUST00000189718]
[ENSMUST00000190617]
[ENSMUST00000190646]
[ENSMUST00000190753]
[ENSMUST00000214289]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000019248
AA Change: I316V
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000019248
Gene: ENSMUSG00000030577
AA Change: I316V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IG
|
31 |
147 |
2.75e-1 |
SMART |
|
IG_like
|
156 |
254 |
4.07e1 |
SMART |
|
IGc2
|
269 |
337 |
2.68e-4 |
SMART |
|
IGc2
|
365 |
424 |
4.52e-11 |
SMART |
|
IG
|
448 |
523 |
1.21e-2 |
SMART |
|
IGc2
|
541 |
599 |
6.75e-10 |
SMART |
|
IGc2
|
628 |
687 |
2.68e-4 |
SMART |
|
transmembrane domain
|
709 |
726 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108125
AA Change: I316V
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000103760
Gene: ENSMUSG00000030577
AA Change: I316V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IG
|
31 |
147 |
2.75e-1 |
SMART |
|
IG_like
|
156 |
254 |
4.07e1 |
SMART |
|
IGc2
|
269 |
337 |
2.68e-4 |
SMART |
|
IGc2
|
365 |
424 |
4.52e-11 |
SMART |
|
IG
|
448 |
523 |
1.21e-2 |
SMART |
|
IGc2
|
541 |
599 |
6.75e-10 |
SMART |
|
IGc2
|
628 |
687 |
2.68e-4 |
SMART |
|
transmembrane domain
|
709 |
726 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000186154
AA Change: I316V
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000139685
Gene: ENSMUSG00000030577
AA Change: I316V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IG
|
31 |
147 |
2.75e-1 |
SMART |
|
IG_like
|
156 |
254 |
4.07e1 |
SMART |
|
IGc2
|
269 |
337 |
2.68e-4 |
SMART |
|
IGc2
|
365 |
424 |
4.52e-11 |
SMART |
|
IG
|
448 |
523 |
1.21e-2 |
SMART |
|
IGc2
|
541 |
599 |
6.75e-10 |
SMART |
|
IGc2
|
628 |
687 |
2.68e-4 |
SMART |
|
transmembrane domain
|
709 |
726 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000187989
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188157
|
| SMART Domains |
Protein: ENSMUSP00000140450
Gene: ENSMUSG00000030577
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IG
|
31 |
147 |
1.1e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189718
AA Change: I316V
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000140521
Gene: ENSMUSG00000030577
AA Change: I316V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IG
|
31 |
147 |
2.75e-1 |
SMART |
|
IG_like
|
156 |
254 |
4.07e1 |
SMART |
|
IGc2
|
269 |
337 |
2.68e-4 |
SMART |
|
IGc2
|
365 |
424 |
4.52e-11 |
SMART |
|
IG
|
448 |
523 |
1.21e-2 |
SMART |
|
IGc2
|
541 |
599 |
6.75e-10 |
SMART |
|
IGc2
|
628 |
687 |
2.68e-4 |
SMART |
|
transmembrane domain
|
709 |
726 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190617
AA Change: I316V
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000139871
Gene: ENSMUSG00000030577
AA Change: I316V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IG
|
31 |
147 |
2.75e-1 |
SMART |
|
IG_like
|
156 |
254 |
4.07e1 |
SMART |
|
IGc2
|
269 |
337 |
2.68e-4 |
SMART |
|
IGc2
|
365 |
424 |
4.52e-11 |
SMART |
|
IG
|
448 |
523 |
1.21e-2 |
SMART |
|
IGc2
|
541 |
599 |
6.75e-10 |
SMART |
|
IGc2
|
628 |
687 |
2.68e-4 |
SMART |
|
transmembrane domain
|
709 |
726 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190646
AA Change: I316V
PolyPhen 2
Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000140528
Gene: ENSMUSG00000030577
AA Change: I316V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
IG
|
31 |
147 |
1.1e-3 |
SMART |
|
IG_like
|
166 |
245 |
1.6e-2 |
SMART |
|
IGc2
|
269 |
337 |
1.1e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190753
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000214289
AA Change: I316V
PolyPhen 2
Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (91/91) |
| MGI Phenotype |
PHENOTYPE: Homozygous null mice have reduced mature B cell numbers with altered proliferation kinetics and reduced antibody production to T cell independent antigens. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A1bg |
G |
T |
15: 60,792,679 (GRCm39) |
N89K |
possibly damaging |
Het |
| Abca5 |
A |
T |
11: 110,189,005 (GRCm39) |
D817E |
possibly damaging |
Het |
| Abca8b |
G |
A |
11: 109,828,593 (GRCm39) |
S1435F |
probably damaging |
Het |
| Akap9 |
T |
C |
5: 4,111,284 (GRCm39) |
L3115P |
probably damaging |
Het |
| Arhgap39 |
G |
A |
15: 76,619,467 (GRCm39) |
R706W |
probably damaging |
Het |
| Atp5mk |
T |
C |
19: 47,074,578 (GRCm39) |
M28V |
probably benign |
Het |
| BC061237 |
A |
T |
14: 44,740,851 (GRCm39) |
I84F |
possibly damaging |
Het |
| Bhlhe22 |
T |
C |
3: 18,109,342 (GRCm39) |
S131P |
probably damaging |
Het |
| Brinp1 |
C |
A |
4: 68,747,582 (GRCm39) |
D174Y |
probably damaging |
Het |
| Bsdc1 |
A |
G |
4: 129,359,068 (GRCm39) |
T40A |
probably benign |
Het |
| Ccdc65 |
A |
T |
15: 98,618,863 (GRCm39) |
K281* |
probably null |
Het |
| Cdhr18 |
A |
G |
14: 13,864,354 (GRCm38) |
F324S |
|
Het |
| Cfap100 |
A |
C |
6: 90,386,330 (GRCm39) |
I275S |
|
Het |
| Chd3 |
T |
G |
11: 69,260,162 (GRCm39) |
E19A |
unknown |
Het |
| Chrnb1 |
T |
C |
11: 69,685,057 (GRCm39) |
D91G |
probably benign |
Het |
| Cr1l |
A |
G |
1: 194,799,925 (GRCm39) |
S250P |
possibly damaging |
Het |
| Csmd1 |
A |
G |
8: 16,034,806 (GRCm39) |
V2455A |
probably damaging |
Het |
| Dbp |
C |
T |
7: 45,357,818 (GRCm39) |
R229C |
probably damaging |
Het |
| Dmxl1 |
C |
G |
18: 50,072,639 (GRCm39) |
N2744K |
probably damaging |
Het |
| Dnah6 |
C |
A |
6: 73,098,882 (GRCm39) |
V2058F |
possibly damaging |
Het |
| Dsp |
T |
A |
13: 38,377,276 (GRCm39) |
V1687D |
probably benign |
Het |
| Dtd1 |
T |
A |
2: 144,445,798 (GRCm39) |
M45K |
possibly damaging |
Het |
| Fat1 |
T |
A |
8: 45,478,064 (GRCm39) |
V2370E |
possibly damaging |
Het |
| Fat1 |
T |
A |
8: 45,403,363 (GRCm39) |
F38Y |
probably benign |
Het |
| Fgfr1 |
T |
A |
8: 26,060,185 (GRCm39) |
D438E |
probably damaging |
Het |
| Fsip2 |
A |
T |
2: 82,816,103 (GRCm39) |
K3945N |
probably benign |
Het |
| Galc |
C |
A |
12: 98,220,423 (GRCm39) |
|
probably null |
Het |
| Git1 |
C |
A |
11: 77,395,498 (GRCm39) |
D398E |
possibly damaging |
Het |
| Gm4924 |
A |
G |
10: 82,214,875 (GRCm39) |
Q891R |
unknown |
Het |
| Gpc2 |
T |
C |
5: 138,274,784 (GRCm39) |
|
probably benign |
Het |
| Havcr2 |
C |
T |
11: 46,360,388 (GRCm39) |
T205I |
probably benign |
Het |
| Herc2 |
A |
G |
7: 55,834,056 (GRCm39) |
N3087S |
probably damaging |
Het |
| Ifi204 |
C |
T |
1: 173,579,193 (GRCm39) |
|
probably null |
Het |
| Imp4 |
C |
T |
1: 34,479,128 (GRCm39) |
R4W |
unknown |
Het |
| Itfg2 |
A |
G |
6: 128,401,770 (GRCm39) |
S3P |
probably damaging |
Het |
| Kcnn3 |
C |
T |
3: 89,428,536 (GRCm39) |
T254I |
possibly damaging |
Het |
| Kics2 |
C |
T |
10: 121,586,416 (GRCm39) |
Q244* |
probably null |
Het |
| Kpna1 |
A |
G |
16: 35,853,644 (GRCm39) |
I425V |
probably benign |
Het |
| Krt23 |
A |
T |
11: 99,383,755 (GRCm39) |
S46T |
probably damaging |
Het |
| Loxl4 |
C |
A |
19: 42,596,099 (GRCm39) |
W118L |
probably damaging |
Het |
| Lrrc37 |
T |
C |
11: 103,509,721 (GRCm39) |
Y749C |
unknown |
Het |
| Lysmd2 |
T |
A |
9: 75,533,075 (GRCm39) |
L10Q |
probably damaging |
Het |
| Mcm5 |
T |
A |
8: 75,851,418 (GRCm39) |
|
probably benign |
Het |
| Mctp2 |
T |
A |
7: 71,909,178 (GRCm39) |
D45V |
probably damaging |
Het |
| Mdfic2 |
T |
A |
6: 98,318,899 (GRCm39) |
N22I |
possibly damaging |
Het |
| Mfsd10 |
T |
C |
5: 34,791,940 (GRCm39) |
T341A |
probably benign |
Het |
| Micu1 |
T |
A |
10: 59,586,335 (GRCm39) |
L170Q |
probably damaging |
Het |
| Msantd5 |
T |
C |
11: 51,125,481 (GRCm39) |
S135P |
probably benign |
Het |
| Muc5ac |
T |
C |
7: 141,363,529 (GRCm39) |
I2280T |
unknown |
Het |
| Myo15a |
A |
T |
11: 60,369,952 (GRCm39) |
Q904L |
probably benign |
Het |
| Myo6 |
G |
A |
9: 80,195,353 (GRCm39) |
D908N |
unknown |
Het |
| Nlrp4e |
A |
T |
7: 23,020,403 (GRCm39) |
M297L |
probably benign |
Het |
| Nptn |
A |
G |
9: 58,558,498 (GRCm39) |
|
probably benign |
Het |
| Oas3 |
A |
C |
5: 120,912,170 (GRCm39) |
D73E |
probably damaging |
Het |
| Or12j5 |
T |
A |
7: 140,084,222 (GRCm39) |
H50L |
probably benign |
Het |
| Or52z14 |
A |
T |
7: 103,252,863 (GRCm39) |
M1L |
probably benign |
Het |
| Or6d13 |
A |
T |
6: 116,517,416 (GRCm39) |
M1L |
probably null |
Het |
| Or6n1 |
T |
C |
1: 173,917,341 (GRCm39) |
L245P |
probably damaging |
Het |
| Pck1 |
C |
G |
2: 172,997,018 (GRCm39) |
A220G |
probably benign |
Het |
| Pigq |
G |
A |
17: 26,156,233 (GRCm39) |
T65I |
probably damaging |
Het |
| Pld2 |
T |
C |
11: 70,431,696 (GRCm39) |
F9L |
probably damaging |
Het |
| Plk3 |
ACACTCAC |
ACAC |
4: 116,989,090 (GRCm39) |
|
probably benign |
Het |
| Pnkd |
A |
G |
1: 74,386,602 (GRCm39) |
R138G |
possibly damaging |
Het |
| Ralgapa1 |
A |
T |
12: 55,781,881 (GRCm39) |
I781N |
probably damaging |
Het |
| Ranbp2 |
A |
G |
10: 58,328,719 (GRCm39) |
I2873V |
probably benign |
Het |
| Rpn2 |
C |
A |
2: 157,139,458 (GRCm39) |
Q283K |
probably benign |
Het |
| Shmt2 |
A |
G |
10: 127,355,561 (GRCm39) |
S178P |
possibly damaging |
Het |
| Shroom3 |
A |
G |
5: 93,112,401 (GRCm39) |
K1921E |
probably benign |
Het |
| Slc20a1 |
A |
G |
2: 129,051,142 (GRCm39) |
S600G |
probably damaging |
Het |
| Slco1a7 |
A |
G |
6: 141,668,830 (GRCm39) |
V534A |
possibly damaging |
Het |
| Slit1 |
C |
T |
19: 41,594,951 (GRCm39) |
V1140I |
probably benign |
Het |
| Sncg |
T |
C |
14: 34,095,640 (GRCm39) |
S51G |
possibly damaging |
Het |
| Spon2 |
C |
A |
5: 33,372,935 (GRCm39) |
D256Y |
possibly damaging |
Het |
| Srcap |
G |
T |
7: 127,159,874 (GRCm39) |
R3250L |
unknown |
Het |
| Sun1 |
T |
G |
5: 139,231,121 (GRCm39) |
Y763* |
probably null |
Het |
| Synj1 |
A |
T |
16: 90,735,513 (GRCm39) |
F1480Y |
probably benign |
Het |
| Tbc1d30 |
T |
A |
10: 121,132,716 (GRCm39) |
N216I |
probably damaging |
Het |
| Tent2 |
A |
T |
13: 93,284,160 (GRCm39) |
L465* |
probably null |
Het |
| Tgfb1 |
A |
T |
7: 25,388,580 (GRCm39) |
K39* |
probably null |
Het |
| Tmem87a |
A |
G |
2: 120,224,841 (GRCm39) |
|
probably null |
Het |
| Tmem8b |
C |
A |
4: 43,681,982 (GRCm39) |
R452S |
probably benign |
Het |
| Tnfsf13b |
A |
G |
8: 10,056,966 (GRCm39) |
I42V |
probably benign |
Het |
| Trpc2 |
A |
G |
7: 101,745,090 (GRCm39) |
T769A |
possibly damaging |
Het |
| Ttc3 |
A |
G |
16: 94,236,389 (GRCm39) |
T1033A |
probably benign |
Het |
| Ttll13 |
C |
T |
7: 79,906,751 (GRCm39) |
A473V |
probably damaging |
Het |
| U2surp |
G |
A |
9: 95,346,468 (GRCm39) |
R908* |
probably null |
Het |
| Ube2s |
A |
G |
7: 4,814,510 (GRCm39) |
Y17H |
probably damaging |
Het |
| Vmn1r94 |
A |
T |
7: 19,901,509 (GRCm39) |
M265K |
probably benign |
Het |
| Vmn2r23 |
T |
C |
6: 123,719,038 (GRCm39) |
I797T |
possibly damaging |
Het |
| Yipf3 |
A |
T |
17: 46,559,895 (GRCm39) |
E70D |
probably benign |
Het |
| Zcchc14 |
G |
A |
8: 122,331,969 (GRCm39) |
P465S |
unknown |
Het |
| Zfp169 |
T |
C |
13: 48,644,557 (GRCm39) |
E190G |
unknown |
Het |
| Zfp707 |
T |
C |
15: 75,845,468 (GRCm39) |
S111P |
|
Het |
| Zfp738 |
T |
C |
13: 67,819,457 (GRCm39) |
E178G |
possibly damaging |
Het |
| Zfr |
A |
T |
15: 12,136,757 (GRCm39) |
N138I |
unknown |
Het |
|
| Other mutations in Cd22 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00714:Cd22
|
APN |
7 |
30,575,572 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02236:Cd22
|
APN |
7 |
30,566,893 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL02321:Cd22
|
APN |
7 |
30,569,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02335:Cd22
|
APN |
7 |
30,575,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02397:Cd22
|
APN |
7 |
30,577,050 (GRCm39) |
missense |
probably benign |
|
|
IGL02402:Cd22
|
APN |
7 |
30,576,955 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02538:Cd22
|
APN |
7 |
30,576,985 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL02736:Cd22
|
APN |
7 |
30,577,470 (GRCm39) |
splice site |
probably null |
|
|
blitz
|
UTSW |
7 |
30,569,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
crullers
|
UTSW |
7 |
30,569,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
gansu
|
UTSW |
7 |
30,569,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
lacrima
|
UTSW |
7 |
30,575,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Lluvia
|
UTSW |
7 |
30,569,912 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
Mist
|
UTSW |
7 |
30,566,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
rain
|
UTSW |
7 |
30,576,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
well
|
UTSW |
7 |
30,577,212 (GRCm39) |
nonsense |
probably null |
|
|
Yosemite
|
UTSW |
7 |
30,568,934 (GRCm39) |
critical splice donor site |
probably null |
|
|
FR4304:Cd22
|
UTSW |
7 |
30,577,507 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
FR4340:Cd22
|
UTSW |
7 |
30,577,507 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
FR4342:Cd22
|
UTSW |
7 |
30,577,507 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
FR4589:Cd22
|
UTSW |
7 |
30,577,507 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
LCD18:Cd22
|
UTSW |
7 |
30,577,507 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
PIT4142001:Cd22
|
UTSW |
7 |
30,577,224 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0123:Cd22
|
UTSW |
7 |
30,566,533 (GRCm39) |
splice site |
probably benign |
|
|
R0130:Cd22
|
UTSW |
7 |
30,569,389 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0926:Cd22
|
UTSW |
7 |
30,568,934 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1245:Cd22
|
UTSW |
7 |
30,569,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1332:Cd22
|
UTSW |
7 |
30,569,912 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1457:Cd22
|
UTSW |
7 |
30,572,595 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1716:Cd22
|
UTSW |
7 |
30,577,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1980:Cd22
|
UTSW |
7 |
30,572,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Cd22
|
UTSW |
7 |
30,572,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2061:Cd22
|
UTSW |
7 |
30,575,581 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2061:Cd22
|
UTSW |
7 |
30,569,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2075:Cd22
|
UTSW |
7 |
30,569,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2216:Cd22
|
UTSW |
7 |
30,566,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3886:Cd22
|
UTSW |
7 |
30,569,532 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R4599:Cd22
|
UTSW |
7 |
30,575,325 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4701:Cd22
|
UTSW |
7 |
30,575,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4796:Cd22
|
UTSW |
7 |
30,572,381 (GRCm39) |
splice site |
probably null |
|
|
R5179:Cd22
|
UTSW |
7 |
30,575,299 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5233:Cd22
|
UTSW |
7 |
30,576,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5456:Cd22
|
UTSW |
7 |
30,575,464 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5511:Cd22
|
UTSW |
7 |
30,569,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5513:Cd22
|
UTSW |
7 |
30,566,450 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5611:Cd22
|
UTSW |
7 |
30,577,575 (GRCm39) |
unclassified |
probably benign |
|
|
R5656:Cd22
|
UTSW |
7 |
30,569,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5966:Cd22
|
UTSW |
7 |
30,566,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6329:Cd22
|
UTSW |
7 |
30,577,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6356:Cd22
|
UTSW |
7 |
30,577,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6455:Cd22
|
UTSW |
7 |
30,575,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6550:Cd22
|
UTSW |
7 |
30,576,977 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6656:Cd22
|
UTSW |
7 |
30,577,182 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6688:Cd22
|
UTSW |
7 |
30,572,389 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6844:Cd22
|
UTSW |
7 |
30,572,856 (GRCm39) |
splice site |
probably null |
|
|
R6957:Cd22
|
UTSW |
7 |
30,566,999 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7068:Cd22
|
UTSW |
7 |
30,577,504 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7083:Cd22
|
UTSW |
7 |
30,567,473 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7225:Cd22
|
UTSW |
7 |
30,577,059 (GRCm39) |
missense |
not run |
|
|
R7732:Cd22
|
UTSW |
7 |
30,569,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8686:Cd22
|
UTSW |
7 |
30,569,494 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8851:Cd22
|
UTSW |
7 |
30,577,084 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8987:Cd22
|
UTSW |
7 |
30,577,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9051:Cd22
|
UTSW |
7 |
30,575,449 (GRCm39) |
missense |
probably benign |
|
|
R9098:Cd22
|
UTSW |
7 |
30,567,391 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9167:Cd22
|
UTSW |
7 |
30,575,430 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9319:Cd22
|
UTSW |
7 |
30,569,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9369:Cd22
|
UTSW |
7 |
30,576,999 (GRCm39) |
missense |
probably benign |
0.09 |
|
X0025:Cd22
|
UTSW |
7 |
30,572,844 (GRCm39) |
splice site |
probably null |
|
|
Z1176:Cd22
|
UTSW |
7 |
30,568,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Cd22
|
UTSW |
7 |
30,567,388 (GRCm39) |
missense |
probably benign |
0.03 |
|
Z1186:Cd22
|
UTSW |
7 |
30,566,891 (GRCm39) |
missense |
probably benign |
|
|
Z1186:Cd22
|
UTSW |
7 |
30,566,478 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1186:Cd22
|
UTSW |
7 |
30,575,292 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGAATGTATGGCCACAGGAC -3'
(R):5'- GAGATCAAGGTCAATCCCACAG -3'
Sequencing Primer
(F):5'- AGAGCCTGCTAATGTGGGC -3'
(R):5'- TCAAGGTCAATCCCACAGAGGTG -3'
|
| Posted On |
2022-01-20 |
Incidental Mutation