Mutagenetix > Incidental Mutation

Incidental Mutation 'R9124:Myo15a'

693119

Institutional Source

Beutler Lab

Gene Symbol

Myo15a

Ensembl Gene

ENSMUSG00000042678

Gene Name

myosin XVA

Synonyms

Myo15

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9124 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

60360165-60419195 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 60369952 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 904 (Q904L)

Ref Sequence

ENSEMBL: ENSMUSP00000071777 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071880] [ENSMUST00000081823] [ENSMUST00000094135]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000071880
AA Change: Q904L

PolyPhen 2 Score 0.372 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000071777
Gene: ENSMUSG00000042678
AA Change: Q904L

Domain	Start	End	E-Value	Type
low complexity region	4	24	N/A	INTRINSIC
low complexity region	87	100	N/A	INTRINSIC
low complexity region	107	120	N/A	INTRINSIC
low complexity region	269	292	N/A	INTRINSIC
low complexity region	295	306	N/A	INTRINSIC
low complexity region	311	325	N/A	INTRINSIC
low complexity region	349	384	N/A	INTRINSIC
low complexity region	425	435	N/A	INTRINSIC
low complexity region	487	498	N/A	INTRINSIC
low complexity region	502	509	N/A	INTRINSIC
low complexity region	653	681	N/A	INTRINSIC
low complexity region	692	705	N/A	INTRINSIC
low complexity region	737	747	N/A	INTRINSIC
low complexity region	758	775	N/A	INTRINSIC
low complexity region	781	792	N/A	INTRINSIC
low complexity region	796	809	N/A	INTRINSIC
low complexity region	825	849	N/A	INTRINSIC
low complexity region	883	897	N/A	INTRINSIC
low complexity region	1067	1082	N/A	INTRINSIC
low complexity region	1115	1130	N/A	INTRINSIC
MYSc	1200	1884	N/A	SMART
IQ	1885	1907	1.63e-1	SMART
IQ	1908	1930	1.77e-2	SMART
IQ	1931	1953	2.97e2	SMART
low complexity region	1955	1974	N/A	INTRINSIC
low complexity region	1992	2006	N/A	INTRINSIC
MyTH4	2049	2195	1.8e-42	SMART
low complexity region	2396	2405	N/A	INTRINSIC
low complexity region	2451	2461	N/A	INTRINSIC
Blast:MYSc	2665	2848	2e-14	BLAST
SH3	2851	2933	1.55e-4	SMART
low complexity region	2949	2962	N/A	INTRINSIC
MyTH4	3031	3185	5.59e-48	SMART
B41	3188	3400	6.94e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000081823

SMART Domains

Protein: ENSMUSP00000080507
Gene: ENSMUSG00000042678

Domain	Start	End	E-Value	Type
MYSc	13	697	N/A	SMART
IQ	698	720	1.63e-1	SMART
IQ	721	743	1.77e-2	SMART
IQ	744	766	2.97e2	SMART
low complexity region	787	801	N/A	INTRINSIC
MyTH4	844	990	1.8e-42	SMART
low complexity region	1191	1200	N/A	INTRINSIC
low complexity region	1246	1256	N/A	INTRINSIC
Blast:MYSc	1460	1643	7e-15	BLAST
SH3	1646	1728	1.55e-4	SMART
low complexity region	1744	1757	N/A	INTRINSIC
MyTH4	1826	1980	5.59e-48	SMART
B41	1983	2195	6.94e-3	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000094135
AA Change: Q904L

PolyPhen 2 Score 0.505 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000091686
Gene: ENSMUSG00000042678
AA Change: Q904L

Domain	Start	End	E-Value	Type
low complexity region	4	24	N/A	INTRINSIC
low complexity region	87	100	N/A	INTRINSIC
low complexity region	107	120	N/A	INTRINSIC
low complexity region	269	292	N/A	INTRINSIC
low complexity region	295	306	N/A	INTRINSIC
low complexity region	311	325	N/A	INTRINSIC
low complexity region	349	384	N/A	INTRINSIC
low complexity region	425	435	N/A	INTRINSIC
low complexity region	487	498	N/A	INTRINSIC
low complexity region	502	509	N/A	INTRINSIC
low complexity region	653	681	N/A	INTRINSIC
low complexity region	692	705	N/A	INTRINSIC
low complexity region	737	747	N/A	INTRINSIC
low complexity region	758	775	N/A	INTRINSIC
low complexity region	781	792	N/A	INTRINSIC
low complexity region	796	809	N/A	INTRINSIC
low complexity region	825	849	N/A	INTRINSIC
low complexity region	883	897	N/A	INTRINSIC
low complexity region	1067	1082	N/A	INTRINSIC
low complexity region	1115	1130	N/A	INTRINSIC
MYSc	1200	1884	N/A	SMART
IQ	1885	1907	1.63e-1	SMART
IQ	1908	1930	1.77e-2	SMART
IQ	1931	1953	2.97e2	SMART
low complexity region	1974	1988	N/A	INTRINSIC
MyTH4	2031	2177	1.8e-42	SMART
low complexity region	2378	2387	N/A	INTRINSIC
low complexity region	2433	2443	N/A	INTRINSIC
Blast:MYSc	2647	2830	2e-14	BLAST
SH3	2833	2915	1.55e-4	SMART
low complexity region	2931	2944	N/A	INTRINSIC
MyTH4	3013	3167	5.59e-48	SMART
B41	3170	3382	6.94e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000126522

SMART Domains

Protein: ENSMUSP00000120839
Gene: ENSMUSG00000042678

Domain	Start	End	E-Value	Type
MYSc	34	716	N/A	SMART
IQ	717	739	1.63e-1	SMART
IQ	740	762	1.77e-2	SMART
IQ	763	785	2.97e2	SMART
low complexity region	806	820	N/A	INTRINSIC
MyTH4	863	1009	1.8e-42	SMART
low complexity region	1210	1219	N/A	INTRINSIC
low complexity region	1265	1275	N/A	INTRINSIC
Blast:MYSc	1479	1662	5e-15	BLAST
SH3	1665	1747	1.55e-4	SMART
low complexity region	1763	1776	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (91/91)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutations in this gene result in profound deafness and neurological behavior. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 95 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A1bg	G	T	15: 60,792,679 (GRCm39)	N89K	possibly damaging	Het
Abca5	A	T	11: 110,189,005 (GRCm39)	D817E	possibly damaging	Het
Abca8b	G	A	11: 109,828,593 (GRCm39)	S1435F	probably damaging	Het
Akap9	T	C	5: 4,111,284 (GRCm39)	L3115P	probably damaging	Het
Arhgap39	G	A	15: 76,619,467 (GRCm39)	R706W	probably damaging	Het
Atp5mk	T	C	19: 47,074,578 (GRCm39)	M28V	probably benign	Het
BC061237	A	T	14: 44,740,851 (GRCm39)	I84F	possibly damaging	Het
Bhlhe22	T	C	3: 18,109,342 (GRCm39)	S131P	probably damaging	Het
Brinp1	C	A	4: 68,747,582 (GRCm39)	D174Y	probably damaging	Het
Bsdc1	A	G	4: 129,359,068 (GRCm39)	T40A	probably benign	Het
Ccdc65	A	T	15: 98,618,863 (GRCm39)	K281*	probably null	Het
Cd22	T	C	7: 30,572,662 (GRCm39)	I316V	probably benign	Het
Cdhr18	A	G	14: 13,864,354 (GRCm38)	F324S		Het
Cfap100	A	C	6: 90,386,330 (GRCm39)	I275S		Het
Chd3	T	G	11: 69,260,162 (GRCm39)	E19A	unknown	Het
Chrnb1	T	C	11: 69,685,057 (GRCm39)	D91G	probably benign	Het
Cr1l	A	G	1: 194,799,925 (GRCm39)	S250P	possibly damaging	Het
Csmd1	A	G	8: 16,034,806 (GRCm39)	V2455A	probably damaging	Het
Dbp	C	T	7: 45,357,818 (GRCm39)	R229C	probably damaging	Het
Dmxl1	C	G	18: 50,072,639 (GRCm39)	N2744K	probably damaging	Het
Dnah6	C	A	6: 73,098,882 (GRCm39)	V2058F	possibly damaging	Het
Dsp	T	A	13: 38,377,276 (GRCm39)	V1687D	probably benign	Het
Dtd1	T	A	2: 144,445,798 (GRCm39)	M45K	possibly damaging	Het
Fat1	T	A	8: 45,403,363 (GRCm39)	F38Y	probably benign	Het
Fat1	T	A	8: 45,478,064 (GRCm39)	V2370E	possibly damaging	Het
Fgfr1	T	A	8: 26,060,185 (GRCm39)	D438E	probably damaging	Het
Fsip2	A	T	2: 82,816,103 (GRCm39)	K3945N	probably benign	Het
Galc	C	A	12: 98,220,423 (GRCm39)		probably null	Het
Git1	C	A	11: 77,395,498 (GRCm39)	D398E	possibly damaging	Het
Gm4924	A	G	10: 82,214,875 (GRCm39)	Q891R	unknown	Het
Gpc2	T	C	5: 138,274,784 (GRCm39)		probably benign	Het
Havcr2	C	T	11: 46,360,388 (GRCm39)	T205I	probably benign	Het
Herc2	A	G	7: 55,834,056 (GRCm39)	N3087S	probably damaging	Het
Ifi204	C	T	1: 173,579,193 (GRCm39)		probably null	Het
Imp4	C	T	1: 34,479,128 (GRCm39)	R4W	unknown	Het
Itfg2	A	G	6: 128,401,770 (GRCm39)	S3P	probably damaging	Het
Kcnn3	C	T	3: 89,428,536 (GRCm39)	T254I	possibly damaging	Het
Kics2	C	T	10: 121,586,416 (GRCm39)	Q244*	probably null	Het
Kpna1	A	G	16: 35,853,644 (GRCm39)	I425V	probably benign	Het
Krt23	A	T	11: 99,383,755 (GRCm39)	S46T	probably damaging	Het
Loxl4	C	A	19: 42,596,099 (GRCm39)	W118L	probably damaging	Het
Lrrc37	T	C	11: 103,509,721 (GRCm39)	Y749C	unknown	Het
Lysmd2	T	A	9: 75,533,075 (GRCm39)	L10Q	probably damaging	Het
Mcm5	T	A	8: 75,851,418 (GRCm39)		probably benign	Het
Mctp2	T	A	7: 71,909,178 (GRCm39)	D45V	probably damaging	Het
Mdfic2	T	A	6: 98,318,899 (GRCm39)	N22I	possibly damaging	Het
Mfsd10	T	C	5: 34,791,940 (GRCm39)	T341A	probably benign	Het
Micu1	T	A	10: 59,586,335 (GRCm39)	L170Q	probably damaging	Het
Msantd5	T	C	11: 51,125,481 (GRCm39)	S135P	probably benign	Het
Muc5ac	T	C	7: 141,363,529 (GRCm39)	I2280T	unknown	Het
Myo6	G	A	9: 80,195,353 (GRCm39)	D908N	unknown	Het
Nlrp4e	A	T	7: 23,020,403 (GRCm39)	M297L	probably benign	Het
Nptn	A	G	9: 58,558,498 (GRCm39)		probably benign	Het
Oas3	A	C	5: 120,912,170 (GRCm39)	D73E	probably damaging	Het
Or12j5	T	A	7: 140,084,222 (GRCm39)	H50L	probably benign	Het
Or52z14	A	T	7: 103,252,863 (GRCm39)	M1L	probably benign	Het
Or6d13	A	T	6: 116,517,416 (GRCm39)	M1L	probably null	Het
Or6n1	T	C	1: 173,917,341 (GRCm39)	L245P	probably damaging	Het
Pck1	C	G	2: 172,997,018 (GRCm39)	A220G	probably benign	Het
Pigq	G	A	17: 26,156,233 (GRCm39)	T65I	probably damaging	Het
Pld2	T	C	11: 70,431,696 (GRCm39)	F9L	probably damaging	Het
Plk3	ACACTCAC	ACAC	4: 116,989,090 (GRCm39)		probably benign	Het
Pnkd	A	G	1: 74,386,602 (GRCm39)	R138G	possibly damaging	Het
Ralgapa1	A	T	12: 55,781,881 (GRCm39)	I781N	probably damaging	Het
Ranbp2	A	G	10: 58,328,719 (GRCm39)	I2873V	probably benign	Het
Rpn2	C	A	2: 157,139,458 (GRCm39)	Q283K	probably benign	Het
Shmt2	A	G	10: 127,355,561 (GRCm39)	S178P	possibly damaging	Het
Shroom3	A	G	5: 93,112,401 (GRCm39)	K1921E	probably benign	Het
Slc20a1	A	G	2: 129,051,142 (GRCm39)	S600G	probably damaging	Het
Slco1a7	A	G	6: 141,668,830 (GRCm39)	V534A	possibly damaging	Het
Slit1	C	T	19: 41,594,951 (GRCm39)	V1140I	probably benign	Het
Sncg	T	C	14: 34,095,640 (GRCm39)	S51G	possibly damaging	Het
Spon2	C	A	5: 33,372,935 (GRCm39)	D256Y	possibly damaging	Het
Srcap	G	T	7: 127,159,874 (GRCm39)	R3250L	unknown	Het
Sun1	T	G	5: 139,231,121 (GRCm39)	Y763*	probably null	Het
Synj1	A	T	16: 90,735,513 (GRCm39)	F1480Y	probably benign	Het
Tbc1d30	T	A	10: 121,132,716 (GRCm39)	N216I	probably damaging	Het
Tent2	A	T	13: 93,284,160 (GRCm39)	L465*	probably null	Het
Tgfb1	A	T	7: 25,388,580 (GRCm39)	K39*	probably null	Het
Tmem87a	A	G	2: 120,224,841 (GRCm39)		probably null	Het
Tmem8b	C	A	4: 43,681,982 (GRCm39)	R452S	probably benign	Het
Tnfsf13b	A	G	8: 10,056,966 (GRCm39)	I42V	probably benign	Het
Trpc2	A	G	7: 101,745,090 (GRCm39)	T769A	possibly damaging	Het
Ttc3	A	G	16: 94,236,389 (GRCm39)	T1033A	probably benign	Het
Ttll13	C	T	7: 79,906,751 (GRCm39)	A473V	probably damaging	Het
U2surp	G	A	9: 95,346,468 (GRCm39)	R908*	probably null	Het
Ube2s	A	G	7: 4,814,510 (GRCm39)	Y17H	probably damaging	Het
Vmn1r94	A	T	7: 19,901,509 (GRCm39)	M265K	probably benign	Het
Vmn2r23	T	C	6: 123,719,038 (GRCm39)	I797T	possibly damaging	Het
Yipf3	A	T	17: 46,559,895 (GRCm39)	E70D	probably benign	Het
Zcchc14	G	A	8: 122,331,969 (GRCm39)	P465S	unknown	Het
Zfp169	T	C	13: 48,644,557 (GRCm39)	E190G	unknown	Het
Zfp707	T	C	15: 75,845,468 (GRCm39)	S111P		Het
Zfp738	T	C	13: 67,819,457 (GRCm39)	E178G	possibly damaging	Het
Zfr	A	T	15: 12,136,757 (GRCm39)	N138I	unknown	Het

Other mutations in Myo15a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00845:Myo15a	APN	11	60,368,605 (GRCm39)	missense	probably damaging	1.00
IGL01011:Myo15a	APN	11	60,367,818 (GRCm39)	missense	probably benign	0.33
IGL01100:Myo15a	APN	11	60,401,984 (GRCm39)	missense	probably damaging	1.00
IGL01357:Myo15a	APN	11	60,393,115 (GRCm39)	splice site	probably benign
IGL01634:Myo15a	APN	11	60,386,298 (GRCm39)	missense	probably damaging	1.00
IGL01763:Myo15a	APN	11	60,412,564 (GRCm39)	missense	probably benign	0.07
IGL01901:Myo15a	APN	11	60,418,260 (GRCm39)	utr 3 prime	probably benign
IGL01931:Myo15a	APN	11	60,386,964 (GRCm39)	missense	probably damaging	1.00
IGL02006:Myo15a	APN	11	60,401,954 (GRCm39)	missense	probably damaging	1.00
IGL02041:Myo15a	APN	11	60,397,689 (GRCm39)	missense	probably damaging	0.99
IGL02094:Myo15a	APN	11	60,401,473 (GRCm39)	unclassified	probably benign
IGL02122:Myo15a	APN	11	60,374,292 (GRCm39)	missense	probably benign	0.23
IGL02153:Myo15a	APN	11	60,389,223 (GRCm39)	missense	probably damaging	1.00
IGL02328:Myo15a	APN	11	60,417,433 (GRCm39)	missense	probably benign	0.13
IGL02330:Myo15a	APN	11	60,367,987 (GRCm39)	missense	possibly damaging	0.94
IGL02431:Myo15a	APN	11	60,401,465 (GRCm39)	missense	possibly damaging	0.73
IGL02639:Myo15a	APN	11	60,369,447 (GRCm39)	missense	probably benign
IGL02659:Myo15a	APN	11	60,382,609 (GRCm39)	splice site	probably benign
IGL02800:Myo15a	APN	11	60,393,195 (GRCm39)	missense	probably damaging	1.00
IGL02812:Myo15a	APN	11	60,368,005 (GRCm39)	missense	probably benign	0.15
IGL02863:Myo15a	APN	11	60,368,953 (GRCm39)	missense	probably damaging	1.00
IGL02873:Myo15a	APN	11	60,374,308 (GRCm39)	missense	probably damaging	1.00
IGL02990:Myo15a	APN	11	60,370,266 (GRCm39)	missense	probably benign	0.02
IGL03011:Myo15a	APN	11	60,400,357 (GRCm39)	splice site	probably benign
IGL03243:Myo15a	APN	11	60,387,344 (GRCm39)	missense	probably damaging	1.00
IGL03297:Myo15a	APN	11	60,369,967 (GRCm39)	missense	probably damaging	1.00
novichok	UTSW	11	60,372,566 (GRCm39)	critical splice donor site	probably null
parker	UTSW	11	60,411,740 (GRCm39)	critical splice donor site	probably null
Typhoon	UTSW	11	60,378,251 (GRCm39)	critical splice donor site	probably null
PIT4131001:Myo15a	UTSW	11	60,386,280 (GRCm39)	missense	probably damaging	1.00
PIT4131001:Myo15a	UTSW	11	60,373,953 (GRCm39)	missense	probably damaging	1.00
R0133:Myo15a	UTSW	11	60,368,676 (GRCm39)	missense	possibly damaging	0.94
R0265:Myo15a	UTSW	11	60,405,723 (GRCm39)	critical splice acceptor site	probably null
R0389:Myo15a	UTSW	11	60,369,364 (GRCm39)	missense	probably benign
R0416:Myo15a	UTSW	11	60,402,000 (GRCm39)	missense	probably damaging	1.00
R0449:Myo15a	UTSW	11	60,400,422 (GRCm39)	missense	possibly damaging	0.92
R0477:Myo15a	UTSW	11	60,411,740 (GRCm39)	critical splice donor site	probably null
R0543:Myo15a	UTSW	11	60,369,877 (GRCm39)	missense	probably benign
R0546:Myo15a	UTSW	11	60,397,139 (GRCm39)	missense	probably damaging	1.00
R0555:Myo15a	UTSW	11	60,412,464 (GRCm39)	missense	probably damaging	1.00
R0639:Myo15a	UTSW	11	60,370,162 (GRCm39)	missense	probably benign	0.12
R0723:Myo15a	UTSW	11	60,369,803 (GRCm39)	missense	possibly damaging	0.94
R0837:Myo15a	UTSW	11	60,378,077 (GRCm39)	missense	probably damaging	0.98
R0865:Myo15a	UTSW	11	60,382,514 (GRCm39)	missense	probably damaging	1.00
R0899:Myo15a	UTSW	11	60,368,011 (GRCm39)	missense	possibly damaging	0.87
R1022:Myo15a	UTSW	11	60,370,442 (GRCm39)	missense	probably benign	0.00
R1024:Myo15a	UTSW	11	60,370,442 (GRCm39)	missense	probably benign	0.00
R1035:Myo15a	UTSW	11	60,401,384 (GRCm39)	unclassified	probably benign
R1109:Myo15a	UTSW	11	60,383,892 (GRCm39)	missense	probably damaging	1.00
R1170:Myo15a	UTSW	11	60,370,233 (GRCm39)	missense	probably benign	0.04
R1241:Myo15a	UTSW	11	60,390,256 (GRCm39)	missense	possibly damaging	0.58
R1392:Myo15a	UTSW	11	60,368,800 (GRCm39)	missense	possibly damaging	0.95
R1392:Myo15a	UTSW	11	60,368,800 (GRCm39)	missense	possibly damaging	0.95
R1434:Myo15a	UTSW	11	60,395,157 (GRCm39)	missense	probably benign	0.00
R1450:Myo15a	UTSW	11	60,386,308 (GRCm39)	missense	probably damaging	1.00
R1456:Myo15a	UTSW	11	60,399,028 (GRCm39)	missense	probably damaging	1.00
R1468:Myo15a	UTSW	11	60,396,832 (GRCm39)	missense	probably damaging	1.00
R1468:Myo15a	UTSW	11	60,396,832 (GRCm39)	missense	probably damaging	1.00
R1548:Myo15a	UTSW	11	60,379,064 (GRCm39)	missense	probably damaging	1.00
R1551:Myo15a	UTSW	11	60,383,791 (GRCm39)	missense	possibly damaging	0.70
R1571:Myo15a	UTSW	11	60,409,290 (GRCm39)	missense	probably damaging	1.00
R1662:Myo15a	UTSW	11	60,392,527 (GRCm39)	missense	probably damaging	1.00
R1777:Myo15a	UTSW	11	60,405,762 (GRCm39)	missense	probably benign
R1778:Myo15a	UTSW	11	60,369,238 (GRCm39)	missense	possibly damaging	0.57
R1847:Myo15a	UTSW	11	60,390,321 (GRCm39)	nonsense	probably null
R1875:Myo15a	UTSW	11	60,398,354 (GRCm39)	missense	probably damaging	0.99
R1944:Myo15a	UTSW	11	60,392,909 (GRCm39)	missense	probably damaging	0.99
R1945:Myo15a	UTSW	11	60,392,909 (GRCm39)	missense	probably damaging	0.99
R2013:Myo15a	UTSW	11	60,385,057 (GRCm39)	missense	probably damaging	1.00
R2107:Myo15a	UTSW	11	60,382,636 (GRCm39)	missense	probably damaging	1.00
R2108:Myo15a	UTSW	11	60,382,636 (GRCm39)	missense	probably damaging	1.00
R2112:Myo15a	UTSW	11	60,384,994 (GRCm39)	missense	probably damaging	0.99
R2147:Myo15a	UTSW	11	60,401,055 (GRCm39)	missense	possibly damaging	0.66
R2196:Myo15a	UTSW	11	60,400,847 (GRCm39)	nonsense	probably null
R2207:Myo15a	UTSW	11	60,396,860 (GRCm39)	missense	probably benign	0.01
R2245:Myo15a	UTSW	11	60,399,925 (GRCm39)	missense	probably damaging	1.00
R2367:Myo15a	UTSW	11	60,408,064 (GRCm39)	missense	probably damaging	0.99
R2374:Myo15a	UTSW	11	60,369,669 (GRCm39)	missense	possibly damaging	0.88
R2438:Myo15a	UTSW	11	60,373,878 (GRCm39)	missense	probably damaging	1.00
R3154:Myo15a	UTSW	11	60,370,186 (GRCm39)	splice site	probably null
R3423:Myo15a	UTSW	11	60,401,126 (GRCm39)	critical splice donor site	probably null
R3551:Myo15a	UTSW	11	60,400,489 (GRCm39)	missense	possibly damaging	0.93
R3552:Myo15a	UTSW	11	60,400,489 (GRCm39)	missense	possibly damaging	0.93
R3612:Myo15a	UTSW	11	60,368,505 (GRCm39)	missense	probably damaging	1.00
R3620:Myo15a	UTSW	11	60,369,468 (GRCm39)	missense	possibly damaging	0.63
R3713:Myo15a	UTSW	11	60,370,057 (GRCm39)	missense	possibly damaging	0.55
R3714:Myo15a	UTSW	11	60,370,057 (GRCm39)	missense	possibly damaging	0.55
R3715:Myo15a	UTSW	11	60,370,057 (GRCm39)	missense	possibly damaging	0.55
R3783:Myo15a	UTSW	11	60,368,398 (GRCm39)	missense	probably damaging	0.97
R3784:Myo15a	UTSW	11	60,368,398 (GRCm39)	missense	probably damaging	0.97
R3785:Myo15a	UTSW	11	60,368,398 (GRCm39)	missense	probably damaging	0.97
R3786:Myo15a	UTSW	11	60,368,398 (GRCm39)	missense	probably damaging	0.97
R3787:Myo15a	UTSW	11	60,368,398 (GRCm39)	missense	probably damaging	0.97
R3894:Myo15a	UTSW	11	60,395,145 (GRCm39)	missense	probably benign	0.00
R3962:Myo15a	UTSW	11	60,370,654 (GRCm39)	missense	probably benign	0.00
R4082:Myo15a	UTSW	11	60,378,022 (GRCm39)	missense	possibly damaging	0.92
R4555:Myo15a	UTSW	11	60,387,763 (GRCm39)	missense	probably damaging	1.00
R4641:Myo15a	UTSW	11	60,393,867 (GRCm39)	missense	probably damaging	1.00
R4665:Myo15a	UTSW	11	60,395,705 (GRCm39)	critical splice acceptor site	probably null
R4713:Myo15a	UTSW	11	60,370,756 (GRCm39)	missense	probably benign	0.21
R4820:Myo15a	UTSW	11	60,367,741 (GRCm39)	missense	probably damaging	0.98
R5013:Myo15a	UTSW	11	60,382,493 (GRCm39)	missense	probably damaging	1.00
R5051:Myo15a	UTSW	11	60,378,251 (GRCm39)	critical splice donor site	probably null
R5187:Myo15a	UTSW	11	60,394,440 (GRCm39)	missense	probably damaging	1.00
R5230:Myo15a	UTSW	11	60,393,674 (GRCm39)	missense	possibly damaging	0.68
R5277:Myo15a	UTSW	11	60,367,940 (GRCm39)	nonsense	probably null
R5345:Myo15a	UTSW	11	60,388,364 (GRCm39)	missense	probably damaging	0.99
R5349:Myo15a	UTSW	11	60,384,409 (GRCm39)	missense	probably damaging	1.00
R5356:Myo15a	UTSW	11	60,389,192 (GRCm39)	missense	probably damaging	1.00
R5445:Myo15a	UTSW	11	60,411,603 (GRCm39)	nonsense	probably null
R5477:Myo15a	UTSW	11	60,368,503 (GRCm39)	missense	probably damaging	1.00
R5629:Myo15a	UTSW	11	60,370,578 (GRCm39)	missense	probably benign
R5728:Myo15a	UTSW	11	60,379,722 (GRCm39)	missense	probably damaging	1.00
R5818:Myo15a	UTSW	11	60,388,777 (GRCm39)	missense	probably benign	0.06
R5952:Myo15a	UTSW	11	60,370,246 (GRCm39)	missense	possibly damaging	0.50
R6338:Myo15a	UTSW	11	60,368,959 (GRCm39)	missense	probably damaging	0.99
R6467:Myo15a	UTSW	11	60,417,487 (GRCm39)	critical splice donor site	probably null
R6488:Myo15a	UTSW	11	60,369,313 (GRCm39)	missense	possibly damaging	0.86
R6521:Myo15a	UTSW	11	60,393,195 (GRCm39)	missense	probably damaging	1.00
R6645:Myo15a	UTSW	11	60,368,118 (GRCm39)	missense	probably benign	0.00
R6702:Myo15a	UTSW	11	60,383,818 (GRCm39)	missense	probably benign	0.16
R6703:Myo15a	UTSW	11	60,383,818 (GRCm39)	missense	probably benign	0.16
R6821:Myo15a	UTSW	11	60,415,301 (GRCm39)	missense	probably damaging	1.00
R6882:Myo15a	UTSW	11	60,414,832 (GRCm39)	missense	probably damaging	1.00
R6908:Myo15a	UTSW	11	60,396,832 (GRCm39)	missense	probably damaging	1.00
R6932:Myo15a	UTSW	11	60,390,320 (GRCm39)	missense	probably damaging	1.00
R6958:Myo15a	UTSW	11	60,394,451 (GRCm39)	missense	probably benign	0.07
R7041:Myo15a	UTSW	11	60,396,832 (GRCm39)	missense	probably damaging	1.00
R7149:Myo15a	UTSW	11	60,400,836 (GRCm39)	missense	possibly damaging	0.56
R7163:Myo15a	UTSW	11	60,389,195 (GRCm39)	missense
R7229:Myo15a	UTSW	11	60,387,321 (GRCm39)	missense	probably benign	0.08
R7347:Myo15a	UTSW	11	60,368,787 (GRCm39)	missense	probably benign
R7368:Myo15a	UTSW	11	60,381,741 (GRCm39)	splice site	probably null
R7392:Myo15a	UTSW	11	60,396,802 (GRCm39)	missense
R7414:Myo15a	UTSW	11	60,374,309 (GRCm39)	missense
R7461:Myo15a	UTSW	11	60,395,978 (GRCm39)	missense
R7609:Myo15a	UTSW	11	60,379,637 (GRCm39)	missense
R7613:Myo15a	UTSW	11	60,395,978 (GRCm39)	missense
R7734:Myo15a	UTSW	11	60,401,108 (GRCm39)	missense	probably benign
R7748:Myo15a	UTSW	11	60,395,727 (GRCm39)	missense
R7767:Myo15a	UTSW	11	60,392,922 (GRCm39)	missense
R7769:Myo15a	UTSW	11	60,399,975 (GRCm39)	missense
R7894:Myo15a	UTSW	11	60,381,963 (GRCm39)	missense
R7919:Myo15a	UTSW	11	60,417,356 (GRCm39)	missense	probably damaging	1.00
R8100:Myo15a	UTSW	11	60,408,016 (GRCm39)	missense	probably damaging	1.00
R8124:Myo15a	UTSW	11	60,398,279 (GRCm39)	missense
R8129:Myo15a	UTSW	11	60,399,026 (GRCm39)	missense
R8428:Myo15a	UTSW	11	60,387,241 (GRCm39)	missense	probably damaging	1.00
R8706:Myo15a	UTSW	11	60,370,443 (GRCm39)	missense	probably benign
R8735:Myo15a	UTSW	11	60,401,679 (GRCm39)	critical splice acceptor site	probably null
R8739:Myo15a	UTSW	11	60,368,088 (GRCm39)	missense	probably benign	0.06
R8790:Myo15a	UTSW	11	60,378,047 (GRCm39)	missense
R8790:Myo15a	UTSW	11	60,367,362 (GRCm39)	missense	possibly damaging	0.73
R8822:Myo15a	UTSW	11	60,367,740 (GRCm39)	missense	probably damaging	0.99
R8907:Myo15a	UTSW	11	60,417,434 (GRCm39)	missense
R8931:Myo15a	UTSW	11	60,368,020 (GRCm39)	missense	probably benign
R9061:Myo15a	UTSW	11	60,393,692 (GRCm39)	missense
R9297:Myo15a	UTSW	11	60,385,899 (GRCm39)	missense	probably null
R9347:Myo15a	UTSW	11	60,374,555 (GRCm39)	missense
R9417:Myo15a	UTSW	11	60,378,243 (GRCm39)	missense
R9456:Myo15a	UTSW	11	60,392,668 (GRCm39)	missense
R9460:Myo15a	UTSW	11	60,372,566 (GRCm39)	critical splice donor site	probably null
R9615:Myo15a	UTSW	11	60,374,320 (GRCm39)	missense
R9630:Myo15a	UTSW	11	60,407,988 (GRCm39)	missense	probably damaging	1.00
R9746:Myo15a	UTSW	11	60,378,234 (GRCm39)	nonsense	probably null
X0021:Myo15a	UTSW	11	60,373,185 (GRCm39)	nonsense	probably null
X0066:Myo15a	UTSW	11	60,369,046 (GRCm39)	missense	probably damaging	1.00
X0067:Myo15a	UTSW	11	60,369,444 (GRCm39)	missense	possibly damaging	0.88
Z1176:Myo15a	UTSW	11	60,389,229 (GRCm39)	missense
Z1176:Myo15a	UTSW	11	60,379,084 (GRCm39)	missense
Z1176:Myo15a	UTSW	11	60,415,267 (GRCm39)	missense	probably damaging	1.00
Z1177:Myo15a	UTSW	11	60,386,301 (GRCm39)	missense
Z1177:Myo15a	UTSW	11	60,379,663 (GRCm39)	missense
Z1177:Myo15a	UTSW	11	60,368,349 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCACCAGTGCTAGGTTCTCC -3'
(R):5'- AAGGGCTTGTGTGCTCAAG -3'

Sequencing Primer
(F):5'- AGTGCTAGGTTCTCCCCGAC -3'
(R):5'- GCTCAAGCAATGGATTTTCAGGC -3'

Posted On

2022-01-20