Incidental Mutation 'R9124:Ttc3'
| ID |
693144 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ttc3
|
| Ensembl Gene |
ENSMUSG00000040785 |
| Gene Name |
tetratricopeptide repeat domain 3 |
| Synonyms |
D16Ium21e, TPRD, 2610202A04Rik, D16Ium21 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.574)
|
| Stock # |
R9124 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
94171479-94270081 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 94236389 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 1033
(T1033A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000116097
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000117648]
[ENSMUST00000122895]
[ENSMUST00000143145]
[ENSMUST00000147352]
[ENSMUST00000150346]
[ENSMUST00000151770]
[ENSMUST00000152117]
[ENSMUST00000155692]
[ENSMUST00000231569]
[ENSMUST00000231915]
[ENSMUST00000232395]
[ENSMUST00000232660]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117648
AA Change: T1051A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000112801
Gene: ENSMUSG00000040785
AA Change: T1051A
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
231 |
264 |
3.61e-2 |
SMART |
|
TPR
|
265 |
298 |
3.32e-1 |
SMART |
|
Blast:TPR
|
300 |
332 |
2e-12 |
BLAST |
|
low complexity region
|
444 |
459 |
N/A |
INTRINSIC |
|
TPR
|
576 |
609 |
2.55e-2 |
SMART |
|
low complexity region
|
720 |
732 |
N/A |
INTRINSIC |
|
coiled coil region
|
765 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1170 |
1190 |
N/A |
INTRINSIC |
|
low complexity region
|
1248 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1278 |
1291 |
N/A |
INTRINSIC |
|
coiled coil region
|
1472 |
1570 |
N/A |
INTRINSIC |
|
low complexity region
|
1876 |
1887 |
N/A |
INTRINSIC |
|
RING
|
1931 |
1970 |
7e-9 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000122895
AA Change: T1033A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000123037
Gene: ENSMUSG00000040785
AA Change: T1033A
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
213 |
246 |
3.61e-2 |
SMART |
|
TPR
|
247 |
280 |
3.32e-1 |
SMART |
|
Blast:TPR
|
282 |
314 |
3e-12 |
BLAST |
|
low complexity region
|
426 |
441 |
N/A |
INTRINSIC |
|
TPR
|
558 |
591 |
2.55e-2 |
SMART |
|
low complexity region
|
702 |
714 |
N/A |
INTRINSIC |
|
coiled coil region
|
747 |
778 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141176
|
| SMART Domains |
Protein: ENSMUSP00000114483
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
28 |
40 |
N/A |
INTRINSIC |
|
coiled coil region
|
72 |
103 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143145
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147352
AA Change: T1033A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000116097
Gene: ENSMUSG00000040785
AA Change: T1033A
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
213 |
246 |
3.61e-2 |
SMART |
|
TPR
|
247 |
280 |
3.32e-1 |
SMART |
|
Blast:TPR
|
282 |
314 |
3e-12 |
BLAST |
|
low complexity region
|
426 |
441 |
N/A |
INTRINSIC |
|
TPR
|
558 |
591 |
2.55e-2 |
SMART |
|
low complexity region
|
702 |
714 |
N/A |
INTRINSIC |
|
coiled coil region
|
747 |
778 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150346
|
| SMART Domains |
Protein: ENSMUSP00000122726
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
Pfam:TPR_1
|
175 |
206 |
9.6e-6 |
PFAM |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
364 |
395 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000151770
AA Change: T1051A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000121349
Gene: ENSMUSG00000040785
AA Change: T1051A
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
231 |
264 |
3.61e-2 |
SMART |
|
TPR
|
265 |
298 |
3.32e-1 |
SMART |
|
Blast:TPR
|
300 |
332 |
3e-12 |
BLAST |
|
low complexity region
|
444 |
459 |
N/A |
INTRINSIC |
|
TPR
|
576 |
609 |
2.55e-2 |
SMART |
|
low complexity region
|
720 |
732 |
N/A |
INTRINSIC |
|
coiled coil region
|
765 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1050 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000152117
AA Change: T650A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000116896
Gene: ENSMUSG00000040785
AA Change: T650A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
SCOP:d1ihga1
|
69 |
201 |
6e-8 |
SMART |
|
Blast:TPR
|
175 |
208 |
1e-14 |
BLAST |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
364 |
395 |
N/A |
INTRINSIC |
|
low complexity region
|
617 |
631 |
N/A |
INTRINSIC |
|
low complexity region
|
635 |
649 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000155692
AA Change: T1070A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000122724
Gene: ENSMUSG00000040785
AA Change: T1070A
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
250 |
283 |
3.61e-2 |
SMART |
|
TPR
|
284 |
317 |
3.32e-1 |
SMART |
|
Blast:TPR
|
319 |
351 |
3e-12 |
BLAST |
|
low complexity region
|
463 |
478 |
N/A |
INTRINSIC |
|
TPR
|
595 |
628 |
2.55e-2 |
SMART |
|
low complexity region
|
739 |
751 |
N/A |
INTRINSIC |
|
coiled coil region
|
784 |
815 |
N/A |
INTRINSIC |
|
low complexity region
|
1037 |
1051 |
N/A |
INTRINSIC |
|
low complexity region
|
1055 |
1069 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231569
AA Change: T696A
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231915
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232395
AA Change: T1051A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232660
AA Change: T1051A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| Meta Mutation Damage Score |
0.1195 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (91/91) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A1bg |
G |
T |
15: 60,792,679 (GRCm39) |
N89K |
possibly damaging |
Het |
| Abca5 |
A |
T |
11: 110,189,005 (GRCm39) |
D817E |
possibly damaging |
Het |
| Abca8b |
G |
A |
11: 109,828,593 (GRCm39) |
S1435F |
probably damaging |
Het |
| Akap9 |
T |
C |
5: 4,111,284 (GRCm39) |
L3115P |
probably damaging |
Het |
| Arhgap39 |
G |
A |
15: 76,619,467 (GRCm39) |
R706W |
probably damaging |
Het |
| Atp5mk |
T |
C |
19: 47,074,578 (GRCm39) |
M28V |
probably benign |
Het |
| BC061237 |
A |
T |
14: 44,740,851 (GRCm39) |
I84F |
possibly damaging |
Het |
| Bhlhe22 |
T |
C |
3: 18,109,342 (GRCm39) |
S131P |
probably damaging |
Het |
| Brinp1 |
C |
A |
4: 68,747,582 (GRCm39) |
D174Y |
probably damaging |
Het |
| Bsdc1 |
A |
G |
4: 129,359,068 (GRCm39) |
T40A |
probably benign |
Het |
| Ccdc65 |
A |
T |
15: 98,618,863 (GRCm39) |
K281* |
probably null |
Het |
| Cd22 |
T |
C |
7: 30,572,662 (GRCm39) |
I316V |
probably benign |
Het |
| Cdhr18 |
A |
G |
14: 13,864,354 (GRCm38) |
F324S |
|
Het |
| Cfap100 |
A |
C |
6: 90,386,330 (GRCm39) |
I275S |
|
Het |
| Chd3 |
T |
G |
11: 69,260,162 (GRCm39) |
E19A |
unknown |
Het |
| Chrnb1 |
T |
C |
11: 69,685,057 (GRCm39) |
D91G |
probably benign |
Het |
| Cr1l |
A |
G |
1: 194,799,925 (GRCm39) |
S250P |
possibly damaging |
Het |
| Csmd1 |
A |
G |
8: 16,034,806 (GRCm39) |
V2455A |
probably damaging |
Het |
| Dbp |
C |
T |
7: 45,357,818 (GRCm39) |
R229C |
probably damaging |
Het |
| Dmxl1 |
C |
G |
18: 50,072,639 (GRCm39) |
N2744K |
probably damaging |
Het |
| Dnah6 |
C |
A |
6: 73,098,882 (GRCm39) |
V2058F |
possibly damaging |
Het |
| Dsp |
T |
A |
13: 38,377,276 (GRCm39) |
V1687D |
probably benign |
Het |
| Dtd1 |
T |
A |
2: 144,445,798 (GRCm39) |
M45K |
possibly damaging |
Het |
| Fat1 |
T |
A |
8: 45,403,363 (GRCm39) |
F38Y |
probably benign |
Het |
| Fat1 |
T |
A |
8: 45,478,064 (GRCm39) |
V2370E |
possibly damaging |
Het |
| Fgfr1 |
T |
A |
8: 26,060,185 (GRCm39) |
D438E |
probably damaging |
Het |
| Fsip2 |
A |
T |
2: 82,816,103 (GRCm39) |
K3945N |
probably benign |
Het |
| Galc |
C |
A |
12: 98,220,423 (GRCm39) |
|
probably null |
Het |
| Git1 |
C |
A |
11: 77,395,498 (GRCm39) |
D398E |
possibly damaging |
Het |
| Gm4924 |
A |
G |
10: 82,214,875 (GRCm39) |
Q891R |
unknown |
Het |
| Gpc2 |
T |
C |
5: 138,274,784 (GRCm39) |
|
probably benign |
Het |
| Havcr2 |
C |
T |
11: 46,360,388 (GRCm39) |
T205I |
probably benign |
Het |
| Herc2 |
A |
G |
7: 55,834,056 (GRCm39) |
N3087S |
probably damaging |
Het |
| Ifi204 |
C |
T |
1: 173,579,193 (GRCm39) |
|
probably null |
Het |
| Imp4 |
C |
T |
1: 34,479,128 (GRCm39) |
R4W |
unknown |
Het |
| Itfg2 |
A |
G |
6: 128,401,770 (GRCm39) |
S3P |
probably damaging |
Het |
| Kcnn3 |
C |
T |
3: 89,428,536 (GRCm39) |
T254I |
possibly damaging |
Het |
| Kics2 |
C |
T |
10: 121,586,416 (GRCm39) |
Q244* |
probably null |
Het |
| Kpna1 |
A |
G |
16: 35,853,644 (GRCm39) |
I425V |
probably benign |
Het |
| Krt23 |
A |
T |
11: 99,383,755 (GRCm39) |
S46T |
probably damaging |
Het |
| Loxl4 |
C |
A |
19: 42,596,099 (GRCm39) |
W118L |
probably damaging |
Het |
| Lrrc37 |
T |
C |
11: 103,509,721 (GRCm39) |
Y749C |
unknown |
Het |
| Lysmd2 |
T |
A |
9: 75,533,075 (GRCm39) |
L10Q |
probably damaging |
Het |
| Mcm5 |
T |
A |
8: 75,851,418 (GRCm39) |
|
probably benign |
Het |
| Mctp2 |
T |
A |
7: 71,909,178 (GRCm39) |
D45V |
probably damaging |
Het |
| Mdfic2 |
T |
A |
6: 98,318,899 (GRCm39) |
N22I |
possibly damaging |
Het |
| Mfsd10 |
T |
C |
5: 34,791,940 (GRCm39) |
T341A |
probably benign |
Het |
| Micu1 |
T |
A |
10: 59,586,335 (GRCm39) |
L170Q |
probably damaging |
Het |
| Msantd5 |
T |
C |
11: 51,125,481 (GRCm39) |
S135P |
probably benign |
Het |
| Muc5ac |
T |
C |
7: 141,363,529 (GRCm39) |
I2280T |
unknown |
Het |
| Myo15a |
A |
T |
11: 60,369,952 (GRCm39) |
Q904L |
probably benign |
Het |
| Myo6 |
G |
A |
9: 80,195,353 (GRCm39) |
D908N |
unknown |
Het |
| Nlrp4e |
A |
T |
7: 23,020,403 (GRCm39) |
M297L |
probably benign |
Het |
| Nptn |
A |
G |
9: 58,558,498 (GRCm39) |
|
probably benign |
Het |
| Oas3 |
A |
C |
5: 120,912,170 (GRCm39) |
D73E |
probably damaging |
Het |
| Or12j5 |
T |
A |
7: 140,084,222 (GRCm39) |
H50L |
probably benign |
Het |
| Or52z14 |
A |
T |
7: 103,252,863 (GRCm39) |
M1L |
probably benign |
Het |
| Or6d13 |
A |
T |
6: 116,517,416 (GRCm39) |
M1L |
probably null |
Het |
| Or6n1 |
T |
C |
1: 173,917,341 (GRCm39) |
L245P |
probably damaging |
Het |
| Pck1 |
C |
G |
2: 172,997,018 (GRCm39) |
A220G |
probably benign |
Het |
| Pigq |
G |
A |
17: 26,156,233 (GRCm39) |
T65I |
probably damaging |
Het |
| Pld2 |
T |
C |
11: 70,431,696 (GRCm39) |
F9L |
probably damaging |
Het |
| Plk3 |
ACACTCAC |
ACAC |
4: 116,989,090 (GRCm39) |
|
probably benign |
Het |
| Pnkd |
A |
G |
1: 74,386,602 (GRCm39) |
R138G |
possibly damaging |
Het |
| Ralgapa1 |
A |
T |
12: 55,781,881 (GRCm39) |
I781N |
probably damaging |
Het |
| Ranbp2 |
A |
G |
10: 58,328,719 (GRCm39) |
I2873V |
probably benign |
Het |
| Rpn2 |
C |
A |
2: 157,139,458 (GRCm39) |
Q283K |
probably benign |
Het |
| Shmt2 |
A |
G |
10: 127,355,561 (GRCm39) |
S178P |
possibly damaging |
Het |
| Shroom3 |
A |
G |
5: 93,112,401 (GRCm39) |
K1921E |
probably benign |
Het |
| Slc20a1 |
A |
G |
2: 129,051,142 (GRCm39) |
S600G |
probably damaging |
Het |
| Slco1a7 |
A |
G |
6: 141,668,830 (GRCm39) |
V534A |
possibly damaging |
Het |
| Slit1 |
C |
T |
19: 41,594,951 (GRCm39) |
V1140I |
probably benign |
Het |
| Sncg |
T |
C |
14: 34,095,640 (GRCm39) |
S51G |
possibly damaging |
Het |
| Spon2 |
C |
A |
5: 33,372,935 (GRCm39) |
D256Y |
possibly damaging |
Het |
| Srcap |
G |
T |
7: 127,159,874 (GRCm39) |
R3250L |
unknown |
Het |
| Sun1 |
T |
G |
5: 139,231,121 (GRCm39) |
Y763* |
probably null |
Het |
| Synj1 |
A |
T |
16: 90,735,513 (GRCm39) |
F1480Y |
probably benign |
Het |
| Tbc1d30 |
T |
A |
10: 121,132,716 (GRCm39) |
N216I |
probably damaging |
Het |
| Tent2 |
A |
T |
13: 93,284,160 (GRCm39) |
L465* |
probably null |
Het |
| Tgfb1 |
A |
T |
7: 25,388,580 (GRCm39) |
K39* |
probably null |
Het |
| Tmem87a |
A |
G |
2: 120,224,841 (GRCm39) |
|
probably null |
Het |
| Tmem8b |
C |
A |
4: 43,681,982 (GRCm39) |
R452S |
probably benign |
Het |
| Tnfsf13b |
A |
G |
8: 10,056,966 (GRCm39) |
I42V |
probably benign |
Het |
| Trpc2 |
A |
G |
7: 101,745,090 (GRCm39) |
T769A |
possibly damaging |
Het |
| Ttll13 |
C |
T |
7: 79,906,751 (GRCm39) |
A473V |
probably damaging |
Het |
| U2surp |
G |
A |
9: 95,346,468 (GRCm39) |
R908* |
probably null |
Het |
| Ube2s |
A |
G |
7: 4,814,510 (GRCm39) |
Y17H |
probably damaging |
Het |
| Vmn1r94 |
A |
T |
7: 19,901,509 (GRCm39) |
M265K |
probably benign |
Het |
| Vmn2r23 |
T |
C |
6: 123,719,038 (GRCm39) |
I797T |
possibly damaging |
Het |
| Yipf3 |
A |
T |
17: 46,559,895 (GRCm39) |
E70D |
probably benign |
Het |
| Zcchc14 |
G |
A |
8: 122,331,969 (GRCm39) |
P465S |
unknown |
Het |
| Zfp169 |
T |
C |
13: 48,644,557 (GRCm39) |
E190G |
unknown |
Het |
| Zfp707 |
T |
C |
15: 75,845,468 (GRCm39) |
S111P |
|
Het |
| Zfp738 |
T |
C |
13: 67,819,457 (GRCm39) |
E178G |
possibly damaging |
Het |
| Zfr |
A |
T |
15: 12,136,757 (GRCm39) |
N138I |
unknown |
Het |
|
| Other mutations in Ttc3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Ttc3
|
APN |
16 |
94,227,620 (GRCm39) |
splice site |
probably null |
|
|
IGL00979:Ttc3
|
APN |
16 |
94,257,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01520:Ttc3
|
APN |
16 |
94,191,066 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01663:Ttc3
|
APN |
16 |
94,210,590 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01720:Ttc3
|
APN |
16 |
94,186,228 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01736:Ttc3
|
APN |
16 |
94,243,386 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02045:Ttc3
|
APN |
16 |
94,210,540 (GRCm39) |
splice site |
probably benign |
|
|
IGL02203:Ttc3
|
APN |
16 |
94,219,457 (GRCm39) |
splice site |
probably benign |
|
|
IGL02327:Ttc3
|
APN |
16 |
94,248,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02794:Ttc3
|
APN |
16 |
94,268,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02898:Ttc3
|
APN |
16 |
94,220,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4378001:Ttc3
|
UTSW |
16 |
94,211,765 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0064:Ttc3
|
UTSW |
16 |
94,223,106 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0098:Ttc3
|
UTSW |
16 |
94,191,124 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0112:Ttc3
|
UTSW |
16 |
94,186,181 (GRCm39) |
splice site |
probably benign |
|
|
R0135:Ttc3
|
UTSW |
16 |
94,263,127 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0480:Ttc3
|
UTSW |
16 |
94,232,863 (GRCm39) |
nonsense |
probably null |
|
|
R0513:Ttc3
|
UTSW |
16 |
94,227,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0532:Ttc3
|
UTSW |
16 |
94,188,189 (GRCm39) |
splice site |
probably benign |
|
|
R0607:Ttc3
|
UTSW |
16 |
94,257,644 (GRCm39) |
nonsense |
probably null |
|
|
R0742:Ttc3
|
UTSW |
16 |
94,260,739 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0905:Ttc3
|
UTSW |
16 |
94,257,648 (GRCm39) |
nonsense |
probably null |
|
|
R1118:Ttc3
|
UTSW |
16 |
94,217,127 (GRCm39) |
splice site |
probably benign |
|
|
R1355:Ttc3
|
UTSW |
16 |
94,219,496 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1370:Ttc3
|
UTSW |
16 |
94,219,496 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1486:Ttc3
|
UTSW |
16 |
94,248,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1598:Ttc3
|
UTSW |
16 |
94,223,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1641:Ttc3
|
UTSW |
16 |
94,244,176 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2092:Ttc3
|
UTSW |
16 |
94,243,691 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2232:Ttc3
|
UTSW |
16 |
94,260,831 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2339:Ttc3
|
UTSW |
16 |
94,232,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2342:Ttc3
|
UTSW |
16 |
94,232,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2842:Ttc3
|
UTSW |
16 |
94,232,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3117:Ttc3
|
UTSW |
16 |
94,243,422 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4194:Ttc3
|
UTSW |
16 |
94,223,136 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4329:Ttc3
|
UTSW |
16 |
94,267,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4431:Ttc3
|
UTSW |
16 |
94,211,817 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4530:Ttc3
|
UTSW |
16 |
94,267,736 (GRCm39) |
intron |
probably benign |
|
|
R4531:Ttc3
|
UTSW |
16 |
94,267,736 (GRCm39) |
intron |
probably benign |
|
|
R4532:Ttc3
|
UTSW |
16 |
94,267,736 (GRCm39) |
intron |
probably benign |
|
|
R4533:Ttc3
|
UTSW |
16 |
94,267,736 (GRCm39) |
intron |
probably benign |
|
|
R4588:Ttc3
|
UTSW |
16 |
94,243,760 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4625:Ttc3
|
UTSW |
16 |
94,189,131 (GRCm39) |
nonsense |
probably null |
|
|
R4676:Ttc3
|
UTSW |
16 |
94,243,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4700:Ttc3
|
UTSW |
16 |
94,240,100 (GRCm39) |
splice site |
probably null |
|
|
R4856:Ttc3
|
UTSW |
16 |
94,191,142 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4867:Ttc3
|
UTSW |
16 |
94,255,374 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4885:Ttc3
|
UTSW |
16 |
94,227,690 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4885:Ttc3
|
UTSW |
16 |
94,220,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4899:Ttc3
|
UTSW |
16 |
94,230,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4997:Ttc3
|
UTSW |
16 |
94,253,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5023:Ttc3
|
UTSW |
16 |
94,230,218 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5105:Ttc3
|
UTSW |
16 |
94,267,793 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5205:Ttc3
|
UTSW |
16 |
94,248,918 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5287:Ttc3
|
UTSW |
16 |
94,260,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5338:Ttc3
|
UTSW |
16 |
94,184,900 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5347:Ttc3
|
UTSW |
16 |
94,230,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5403:Ttc3
|
UTSW |
16 |
94,260,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5460:Ttc3
|
UTSW |
16 |
94,258,241 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5739:Ttc3
|
UTSW |
16 |
94,240,183 (GRCm39) |
nonsense |
probably null |
|
|
R6242:Ttc3
|
UTSW |
16 |
94,243,554 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6253:Ttc3
|
UTSW |
16 |
94,258,272 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6455:Ttc3
|
UTSW |
16 |
94,219,482 (GRCm39) |
start codon destroyed |
probably null |
0.83 |
|
R6559:Ttc3
|
UTSW |
16 |
94,223,208 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6564:Ttc3
|
UTSW |
16 |
94,243,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6932:Ttc3
|
UTSW |
16 |
94,244,312 (GRCm39) |
missense |
probably benign |
|
|
R7331:Ttc3
|
UTSW |
16 |
94,195,218 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7497:Ttc3
|
UTSW |
16 |
94,219,541 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7610:Ttc3
|
UTSW |
16 |
94,228,697 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7738:Ttc3
|
UTSW |
16 |
94,188,241 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7970:Ttc3
|
UTSW |
16 |
94,258,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8052:Ttc3
|
UTSW |
16 |
94,268,848 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8087:Ttc3
|
UTSW |
16 |
94,243,812 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8309:Ttc3
|
UTSW |
16 |
94,267,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8320:Ttc3
|
UTSW |
16 |
94,219,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8322:Ttc3
|
UTSW |
16 |
94,255,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8518:Ttc3
|
UTSW |
16 |
94,258,238 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8670:Ttc3
|
UTSW |
16 |
94,191,067 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8826:Ttc3
|
UTSW |
16 |
94,232,829 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8868:Ttc3
|
UTSW |
16 |
94,252,002 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8873:Ttc3
|
UTSW |
16 |
94,243,842 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8940:Ttc3
|
UTSW |
16 |
94,230,358 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8993:Ttc3
|
UTSW |
16 |
94,228,667 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9068:Ttc3
|
UTSW |
16 |
94,204,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9119:Ttc3
|
UTSW |
16 |
94,192,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9129:Ttc3
|
UTSW |
16 |
94,185,208 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9189:Ttc3
|
UTSW |
16 |
94,268,831 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R9217:Ttc3
|
UTSW |
16 |
94,230,467 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9490:Ttc3
|
UTSW |
16 |
94,245,360 (GRCm39) |
missense |
probably benign |
|
|
R9564:Ttc3
|
UTSW |
16 |
94,248,918 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9631:Ttc3
|
UTSW |
16 |
94,171,581 (GRCm39) |
intron |
probably benign |
|
|
X0022:Ttc3
|
UTSW |
16 |
94,243,384 (GRCm39) |
missense |
probably benign |
0.00 |
|
Y5378:Ttc3
|
UTSW |
16 |
94,212,988 (GRCm39) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TTCTCATTAAATCCAGTGGTGGG -3'
(R):5'- ACATGGCTGAACTGAATTCTTAAGC -3'
Sequencing Primer
(F):5'- TTTTCTTCCATGGCATTTTAGAGTAG -3'
(R):5'- GCTTTTAATTCCTACAGTCATAGCAC -3'
|
| Posted On |
2022-01-20 |
Incidental Mutation