Incidental Mutation 'R9127:Abcb1a'
| ID |
693315 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Abcb1a
|
| Ensembl Gene |
ENSMUSG00000040584 |
| Gene Name |
ATP-binding cassette, sub-family B member 1A |
| Synonyms |
Evi32, multiple drug resistant 1a, Pgp, MDR3, Pgy-3, Mdr1a, P-glycoprotein, P-gp, Pgy3, mdr-3 |
| MMRRC Submission |
068926-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.172)
|
| Stock # |
R9127 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
8710077-8798575 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 8724707 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Tryptophan
at position 47
(R47W)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000041204
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047753]
|
| AlphaFold |
P21447 |
| PDB Structure |
Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding [X-RAY DIFFRACTION]
Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding [X-RAY DIFFRACTION]
Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding [X-RAY DIFFRACTION]
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain [X-RAY DIFFRACTION]
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain [X-RAY DIFFRACTION]
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain [X-RAY DIFFRACTION]
Structure of Mouse P-Glycoprotein [X-RAY DIFFRACTION]
Corrected Structure of Mouse P-glycoprotein [X-RAY DIFFRACTION]
Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR [X-RAY DIFFRACTION]
Corrected Structure of Mouse P-glycoprotein bound to QZ59-SSS [X-RAY DIFFRACTION]
>> 5 additional structures at PDB <<
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000047753
AA Change: R47W
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000041204
Gene: ENSMUSG00000040584
AA Change: R47W
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
30 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
50 |
339 |
8.3e-97 |
PFAM |
|
AAA
|
415 |
607 |
1.22e-20 |
SMART |
|
Pfam:ABC_membrane
|
707 |
982 |
4.8e-79 |
PFAM |
|
AAA
|
1058 |
1246 |
8.85e-18 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
100% (82/82) |
| MGI Phenotype |
FUNCTION: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutations in this gene result in increased sensitivity to various drugs, including avermectins and vinblastine. Mice with a null allele develop spontanous colitis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
T |
G |
11: 9,242,080 (GRCm39) |
D1314E |
probably benign |
Het |
| Abcc6 |
T |
C |
7: 45,629,184 (GRCm39) |
N1354S |
probably damaging |
Het |
| Abracl |
T |
C |
10: 17,887,444 (GRCm39) |
Y61C |
probably damaging |
Het |
| Adamtsl1 |
A |
G |
4: 86,208,027 (GRCm39) |
T633A |
probably benign |
Het |
| Agap3 |
G |
A |
5: 24,681,439 (GRCm39) |
|
probably benign |
Het |
| Ago4 |
A |
T |
4: 126,400,904 (GRCm39) |
M647K |
probably damaging |
Het |
| Akap7 |
G |
T |
10: 25,155,676 (GRCm39) |
S72R |
unknown |
Het |
| Arhgef12 |
A |
G |
9: 42,885,870 (GRCm39) |
L1251S |
possibly damaging |
Het |
| Astn2 |
A |
T |
4: 66,322,164 (GRCm39) |
V145E |
unknown |
Het |
| Atxn2l |
A |
T |
7: 126,097,393 (GRCm39) |
S304R |
probably damaging |
Het |
| Cd226 |
A |
T |
18: 89,287,155 (GRCm39) |
I318F |
probably damaging |
Het |
| Cep250 |
C |
T |
2: 155,812,042 (GRCm39) |
A446V |
unknown |
Het |
| Cfap65 |
A |
T |
1: 74,958,510 (GRCm39) |
|
probably benign |
Het |
| Cfap96 |
T |
G |
8: 46,415,403 (GRCm39) |
D201A |
probably benign |
Het |
| Chtf8 |
A |
G |
8: 107,613,640 (GRCm39) |
V18A |
probably benign |
Het |
| Cit |
G |
T |
5: 116,074,896 (GRCm39) |
E683* |
probably null |
Het |
| Ckmt2 |
T |
C |
13: 92,007,337 (GRCm39) |
R286G |
probably damaging |
Het |
| Clec4a2 |
T |
A |
6: 123,116,218 (GRCm39) |
W128R |
probably damaging |
Het |
| Clec4n |
T |
G |
6: 123,212,447 (GRCm39) |
S88A |
probably damaging |
Het |
| Cndp2 |
G |
A |
18: 84,699,121 (GRCm39) |
A48V |
probably benign |
Het |
| Csmd1 |
T |
C |
8: 16,273,286 (GRCm39) |
T849A |
probably benign |
Het |
| Cts3 |
A |
T |
13: 61,715,235 (GRCm39) |
Y199* |
probably null |
Het |
| Dag1 |
A |
T |
9: 108,085,734 (GRCm39) |
L469* |
probably null |
Het |
| Dclre1c |
T |
C |
2: 3,439,125 (GRCm39) |
V225A |
|
Het |
| Dedd |
A |
G |
1: 171,166,409 (GRCm39) |
D115G |
probably damaging |
Het |
| Efcab3 |
T |
A |
11: 104,741,407 (GRCm39) |
V2166D |
probably benign |
Het |
| Eif2ak3 |
T |
A |
6: 70,860,704 (GRCm39) |
W427R |
probably damaging |
Het |
| Fbln2 |
T |
A |
6: 91,210,473 (GRCm39) |
V139D |
probably damaging |
Het |
| Fbn1 |
A |
T |
2: 125,223,985 (GRCm39) |
M588K |
possibly damaging |
Het |
| Gm17019 |
A |
T |
5: 15,081,113 (GRCm39) |
Y109* |
probably null |
Het |
| Gm32742 |
T |
A |
9: 51,056,015 (GRCm39) |
N1255Y |
probably damaging |
Het |
| Gm5431 |
T |
A |
11: 48,779,600 (GRCm39) |
K441* |
probably null |
Het |
| Golga2 |
A |
G |
2: 32,196,079 (GRCm39) |
D898G |
|
Het |
| Gramd4 |
G |
A |
15: 85,975,525 (GRCm39) |
R39H |
probably benign |
Het |
| Gucy1a2 |
A |
G |
9: 3,634,553 (GRCm39) |
N199S |
probably damaging |
Het |
| Heyl |
G |
A |
4: 123,139,885 (GRCm39) |
R148H |
probably damaging |
Het |
| Ifi208 |
A |
T |
1: 173,523,400 (GRCm39) |
M557L |
probably benign |
Het |
| Igf2r |
A |
G |
17: 12,958,238 (GRCm39) |
V145A |
probably damaging |
Het |
| Ighv1-4 |
A |
T |
12: 114,450,879 (GRCm39) |
Y76* |
probably null |
Het |
| Ikzf4 |
T |
C |
10: 128,468,487 (GRCm39) |
D664G |
unknown |
Het |
| Il1a |
T |
A |
2: 129,146,715 (GRCm39) |
Y126F |
possibly damaging |
Het |
| Lmf2 |
C |
A |
15: 89,239,771 (GRCm39) |
|
probably benign |
Het |
| Lyst |
T |
C |
13: 13,808,827 (GRCm39) |
S166P |
probably damaging |
Het |
| Mgat5 |
A |
C |
1: 127,294,197 (GRCm39) |
T180P |
probably benign |
Het |
| Mical2 |
A |
C |
7: 111,870,589 (GRCm39) |
K26T |
possibly damaging |
Het |
| Mov10 |
G |
T |
3: 104,711,659 (GRCm39) |
Y209* |
probably null |
Het |
| Nol8 |
T |
C |
13: 49,815,475 (GRCm39) |
Y528H |
probably benign |
Het |
| Numa1 |
T |
A |
7: 101,641,869 (GRCm39) |
S106T |
possibly damaging |
Het |
| Or1e1d-ps1 |
A |
T |
11: 73,819,167 (GRCm39) |
E39V |
probably damaging |
Het |
| Or4c124 |
G |
A |
2: 89,156,474 (GRCm39) |
Q17* |
probably null |
Het |
| Or5b107 |
A |
G |
19: 13,142,396 (GRCm39) |
N6S |
probably damaging |
Het |
| Or7g27 |
A |
G |
9: 19,250,026 (GRCm39) |
H90R |
probably benign |
Het |
| Pcdhb14 |
A |
G |
18: 37,582,091 (GRCm39) |
N399S |
probably damaging |
Het |
| Plcl2 |
T |
A |
17: 50,918,032 (GRCm39) |
S944T |
probably benign |
Het |
| Pml |
A |
T |
9: 58,127,660 (GRCm39) |
I695N |
probably benign |
Het |
| Ppard |
G |
T |
17: 28,505,349 (GRCm39) |
R12L |
unknown |
Het |
| Ppip5k1 |
C |
T |
2: 121,158,125 (GRCm39) |
|
probably null |
Het |
| Ppp1r3g |
T |
C |
13: 36,152,621 (GRCm39) |
S14P |
probably benign |
Het |
| Pramel55 |
A |
G |
5: 95,951,623 (GRCm39) |
Y470C |
probably damaging |
Het |
| Prrc2b |
C |
A |
2: 32,103,764 (GRCm39) |
R1081S |
probably damaging |
Het |
| Rasgrp2 |
A |
T |
19: 6,454,438 (GRCm39) |
E160D |
possibly damaging |
Het |
| Rb1cc1 |
G |
A |
1: 6,333,073 (GRCm39) |
V1331I |
probably damaging |
Het |
| Rnd3 |
A |
T |
2: 51,022,413 (GRCm39) |
S210T |
probably benign |
Het |
| Scaf11 |
T |
C |
15: 96,312,764 (GRCm39) |
T1426A |
probably benign |
Het |
| Sin3b |
C |
T |
8: 73,460,034 (GRCm39) |
T207I |
possibly damaging |
Het |
| Slc26a7 |
A |
T |
4: 14,593,873 (GRCm39) |
Y81N |
probably damaging |
Het |
| Slc28a3 |
C |
T |
13: 58,724,581 (GRCm39) |
M224I |
probably benign |
Het |
| Slc30a1 |
T |
C |
1: 191,639,342 (GRCm39) |
I75T |
probably damaging |
Het |
| Slc6a21 |
T |
A |
7: 44,929,674 (GRCm39) |
|
probably benign |
Het |
| Slco2a1 |
T |
A |
9: 102,945,243 (GRCm39) |
L206Q |
probably damaging |
Het |
| Spata31d1e |
A |
G |
13: 59,890,828 (GRCm39) |
S331P |
probably benign |
Het |
| Sptbn1 |
A |
G |
11: 30,104,356 (GRCm39) |
V116A |
probably damaging |
Het |
| Syngap1 |
G |
A |
17: 27,181,095 (GRCm39) |
D1008N |
probably damaging |
Het |
| Syt11 |
T |
C |
3: 88,669,643 (GRCm39) |
D83G |
probably benign |
Het |
| Syt14 |
G |
A |
1: 192,584,131 (GRCm39) |
T428I |
probably damaging |
Het |
| Taf15 |
T |
A |
11: 83,395,085 (GRCm39) |
Y338* |
probably null |
Het |
| Tfap4 |
A |
T |
16: 4,365,183 (GRCm39) |
M253K |
possibly damaging |
Het |
| Tnr |
T |
C |
1: 159,713,680 (GRCm39) |
S703P |
possibly damaging |
Het |
| Trrap |
G |
A |
5: 144,767,830 (GRCm39) |
D2577N |
probably benign |
Het |
| Uqcc6 |
A |
T |
10: 82,458,588 (GRCm39) |
M21K |
probably benign |
Het |
| Wdr20 |
C |
T |
12: 110,759,597 (GRCm39) |
S161L |
possibly damaging |
Het |
| Zfp503 |
C |
A |
14: 22,037,418 (GRCm39) |
V62L |
probably benign |
Het |
|
| Other mutations in Abcb1a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00704:Abcb1a
|
APN |
5 |
8,736,257 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00898:Abcb1a
|
APN |
5 |
8,783,690 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01064:Abcb1a
|
APN |
5 |
8,782,388 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL01118:Abcb1a
|
APN |
5 |
8,724,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01150:Abcb1a
|
APN |
5 |
8,752,550 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01584:Abcb1a
|
APN |
5 |
8,748,637 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01654:Abcb1a
|
APN |
5 |
8,765,065 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01820:Abcb1a
|
APN |
5 |
8,765,896 (GRCm39) |
splice site |
probably benign |
|
|
IGL02499:Abcb1a
|
APN |
5 |
8,776,807 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02711:Abcb1a
|
APN |
5 |
8,773,245 (GRCm39) |
splice site |
probably null |
|
|
IGL02954:Abcb1a
|
APN |
5 |
8,782,341 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03018:Abcb1a
|
APN |
5 |
8,752,451 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03119:Abcb1a
|
APN |
5 |
8,764,887 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03292:Abcb1a
|
APN |
5 |
8,765,827 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03338:Abcb1a
|
APN |
5 |
8,744,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0418:Abcb1a
|
UTSW |
5 |
8,763,281 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0559:Abcb1a
|
UTSW |
5 |
8,748,535 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0595:Abcb1a
|
UTSW |
5 |
8,790,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0599:Abcb1a
|
UTSW |
5 |
8,748,539 (GRCm39) |
missense |
probably benign |
0.13 |
|
R0811:Abcb1a
|
UTSW |
5 |
8,763,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0812:Abcb1a
|
UTSW |
5 |
8,763,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0894:Abcb1a
|
UTSW |
5 |
8,724,856 (GRCm39) |
splice site |
probably benign |
|
|
R0948:Abcb1a
|
UTSW |
5 |
8,790,621 (GRCm39) |
splice site |
probably null |
|
|
R1292:Abcb1a
|
UTSW |
5 |
8,763,343 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1318:Abcb1a
|
UTSW |
5 |
8,751,621 (GRCm39) |
missense |
probably benign |
0.31 |
|
R1459:Abcb1a
|
UTSW |
5 |
8,752,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1489:Abcb1a
|
UTSW |
5 |
8,736,300 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1514:Abcb1a
|
UTSW |
5 |
8,724,791 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2100:Abcb1a
|
UTSW |
5 |
8,763,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2409:Abcb1a
|
UTSW |
5 |
8,788,747 (GRCm39) |
missense |
probably benign |
0.30 |
|
R2844:Abcb1a
|
UTSW |
5 |
8,736,164 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3709:Abcb1a
|
UTSW |
5 |
8,788,738 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3755:Abcb1a
|
UTSW |
5 |
8,797,403 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4193:Abcb1a
|
UTSW |
5 |
8,765,068 (GRCm39) |
splice site |
probably null |
|
|
R4401:Abcb1a
|
UTSW |
5 |
8,752,390 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R4463:Abcb1a
|
UTSW |
5 |
8,769,981 (GRCm39) |
splice site |
probably benign |
|
|
R4539:Abcb1a
|
UTSW |
5 |
8,765,793 (GRCm39) |
missense |
probably benign |
|
|
R4635:Abcb1a
|
UTSW |
5 |
8,764,927 (GRCm39) |
missense |
probably benign |
|
|
R4740:Abcb1a
|
UTSW |
5 |
8,752,280 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4757:Abcb1a
|
UTSW |
5 |
8,787,632 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4764:Abcb1a
|
UTSW |
5 |
8,765,732 (GRCm39) |
splice site |
probably null |
|
|
R4792:Abcb1a
|
UTSW |
5 |
8,796,657 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4829:Abcb1a
|
UTSW |
5 |
8,773,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4935:Abcb1a
|
UTSW |
5 |
8,787,773 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5140:Abcb1a
|
UTSW |
5 |
8,752,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5181:Abcb1a
|
UTSW |
5 |
8,764,937 (GRCm39) |
missense |
probably benign |
|
|
R5355:Abcb1a
|
UTSW |
5 |
8,776,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5406:Abcb1a
|
UTSW |
5 |
8,752,946 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5496:Abcb1a
|
UTSW |
5 |
8,724,818 (GRCm39) |
missense |
probably benign |
|
|
R5557:Abcb1a
|
UTSW |
5 |
8,764,949 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5572:Abcb1a
|
UTSW |
5 |
8,765,108 (GRCm39) |
splice site |
probably null |
|
|
R5702:Abcb1a
|
UTSW |
5 |
8,787,752 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5753:Abcb1a
|
UTSW |
5 |
8,773,160 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5769:Abcb1a
|
UTSW |
5 |
8,733,426 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5895:Abcb1a
|
UTSW |
5 |
8,752,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6536:Abcb1a
|
UTSW |
5 |
8,769,030 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6555:Abcb1a
|
UTSW |
5 |
8,752,468 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6798:Abcb1a
|
UTSW |
5 |
8,782,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6875:Abcb1a
|
UTSW |
5 |
8,751,628 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7000:Abcb1a
|
UTSW |
5 |
8,752,823 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7102:Abcb1a
|
UTSW |
5 |
8,744,072 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7172:Abcb1a
|
UTSW |
5 |
8,752,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7313:Abcb1a
|
UTSW |
5 |
8,773,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7513:Abcb1a
|
UTSW |
5 |
8,765,771 (GRCm39) |
nonsense |
probably null |
|
|
R7718:Abcb1a
|
UTSW |
5 |
8,765,788 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7816:Abcb1a
|
UTSW |
5 |
8,736,132 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7829:Abcb1a
|
UTSW |
5 |
8,748,623 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7943:Abcb1a
|
UTSW |
5 |
8,736,222 (GRCm39) |
missense |
probably benign |
|
|
R8040:Abcb1a
|
UTSW |
5 |
8,765,035 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8086:Abcb1a
|
UTSW |
5 |
8,724,833 (GRCm39) |
missense |
probably benign |
|
|
R8271:Abcb1a
|
UTSW |
5 |
8,736,212 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8367:Abcb1a
|
UTSW |
5 |
8,736,221 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8520:Abcb1a
|
UTSW |
5 |
8,735,346 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8680:Abcb1a
|
UTSW |
5 |
8,735,371 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8820:Abcb1a
|
UTSW |
5 |
8,773,204 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8996:Abcb1a
|
UTSW |
5 |
8,769,069 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9114:Abcb1a
|
UTSW |
5 |
8,788,702 (GRCm39) |
nonsense |
probably null |
|
|
R9187:Abcb1a
|
UTSW |
5 |
8,765,016 (GRCm39) |
missense |
probably benign |
|
|
R9294:Abcb1a
|
UTSW |
5 |
8,736,171 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9459:Abcb1a
|
UTSW |
5 |
8,735,414 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9581:Abcb1a
|
UTSW |
5 |
8,790,428 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9617:Abcb1a
|
UTSW |
5 |
8,797,353 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9676:Abcb1a
|
UTSW |
5 |
8,714,548 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9682:Abcb1a
|
UTSW |
5 |
8,752,507 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9790:Abcb1a
|
UTSW |
5 |
8,748,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9791:Abcb1a
|
UTSW |
5 |
8,748,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Abcb1a
|
UTSW |
5 |
8,796,544 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAAATGAGTCAAACGCCCATTC -3'
(R):5'- GTGTATCCTTTTAAGGCCCCAC -3'
Sequencing Primer
(F):5'- AATGAGTCAAACGCCCATTCTTTTTC -3'
(R):5'- GGCCCCACAAATAATTACTCTAGATG -3'
|
| Posted On |
2022-01-20 |
Incidental Mutation