Mutagenetix > Incidental Mutation

Incidental Mutation 'R9128:Vwf'

693398

Institutional Source

Beutler Lab

Gene Symbol

Vwf

Ensembl Gene

ENSMUSG00000001930

Gene Name

Von Willebrand factor

Synonyms

6820430P06Rik, B130011O06Rik

MMRRC Submission

068927-MU

Accession Numbers

Genbank: NM_011708; MGI: 98941

Essential gene?

Probably non essential (E-score: 0.165) question?

Stock #

R9128 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

125546774-125686679 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 125642730 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 1457 (L1457P)

Ref Sequence

ENSEMBL: ENSMUSP00000107873 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000112254]

AlphaFold

no structure available at present

Predicted Effect

SMART Domains

Protein: ENSMUSP00000107873
Gene: ENSMUSG00000001930
AA Change: L1457P

Domain	Start	End	E-Value	Type
VWD	23	181	3.43e-35	SMART
C8	221	295	1.11e-21	SMART
Pfam:TIL	298	351	6.9e-15	PFAM
VWC	353	413	8.71e-1	SMART
VWD	380	543	2.93e-52	SMART
C8	580	652	3.82e-25	SMART
Pfam:TIL	655	710	4.1e-14	PFAM
EGF_like	790	825	4.37e1	SMART
VWC	832	901	3.29e-3	SMART
VWD	859	1015	5.15e-39	SMART
C8	1056	1130	1.01e-33	SMART
Pfam:TIL	1144	1199	1.3e-9	PFAM
VWA	1278	1461	1.81e-20	SMART
low complexity region	1464	1477	N/A	INTRINSIC
VWA	1499	1672	8.43e-39	SMART
VWA	1692	1875	2.83e-31	SMART
VWC	1882	1949	2.99e0	SMART
VWD	1941	2104	5.03e-42	SMART
C8	2135	2203	1.29e-13	SMART
Pfam:TIL	2206	2257	8.3e-8	PFAM
VWC	2260	2328	3.16e-16	SMART
low complexity region	2417	2428	N/A	INTRINSIC
VWC	2434	2497	2.61e-17	SMART
VWC	2513	2577	3.37e0	SMART
VWC	2585	2647	2.55e-11	SMART
CT	2730	2815	1.37e-31	SMART

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015]
PHENOTYPE: Homozygous null mutants exhibit hemostatic and thrombotic defects similar to human von Willebrand disease. Mutants have prolonged bleeding time, newborns occasionally show fatal intra-abdominal bleeding and some adults have detectable fecal occult blood. [provided by MGI curators]

Allele List at MGI

All alleles(33) : Targeted, knock-out(1) Gene trapped(32)

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca7	T	C	10: 80,002,518 (GRCm38)	V542A	possibly damaging	Het
Abhd8	G	T	8: 71,461,745 (GRCm38)	R80S	probably benign	Het
Actc1	T	C	2: 114,050,465 (GRCm38)	Y93C	possibly damaging	Het
Actn4	G	T	7: 28,894,504 (GRCm38)	D859E	possibly damaging	Het
Adcy2	C	T	13: 68,625,808 (GRCm38)	G1039R	probably damaging	Het
Als2	A	G	1: 59,180,550 (GRCm38)	M1202T	probably benign	Het
Aste1	T	A	9: 105,396,709 (GRCm38)	Y49*	probably null	Het
Atp8b4	T	C	2: 126,392,830 (GRCm38)	D422G	probably benign	Het
Bag6	T	A	17: 35,144,712 (GRCm38)	S791T	probably damaging	Het
Bivm	T	A	1: 44,128,789 (GRCm38)	W222R	probably null	Het
Bod1l	A	C	5: 41,788,923 (GRCm38)	V3003G	probably benign	Het
Bsn	T	C	9: 108,116,150 (GRCm38)	D801G	probably benign	Het
Ccdc14	G	A	16: 34,706,789 (GRCm38)	D403N	probably damaging	Het
Cenpj	T	A	14: 56,542,862 (GRCm38)	E964V	probably damaging	Het
Cep250	C	T	2: 155,970,122 (GRCm38)	A446V	unknown	Het
Clca3a1	G	A	3: 144,758,034 (GRCm38)	R161W	probably damaging	Het
Dcxr	A	T	11: 120,726,546 (GRCm38)	V57E		Het
Dnah17	T	G	11: 118,046,178 (GRCm38)	N3400T	possibly damaging	Het
Dnaja3	C	T	16: 4,702,300 (GRCm38)	T444I	possibly damaging	Het
Dopey1	T	C	9: 86,513,155 (GRCm38)	S772P	probably benign	Het
Ednrb	T	C	14: 103,843,092 (GRCm38)	N129D	probably damaging	Het
Ep300	T	A	15: 81,649,745 (GRCm38)	M2001K	unknown	Het
Fam3b	A	G	16: 97,501,000 (GRCm38)	I8T	probably benign	Het
Fam98c	A	T	7: 29,154,690 (GRCm38)	S85T		Het
Fat1	G	A	8: 45,009,841 (GRCm38)	V1232I	probably benign	Het
Fzd3	T	A	14: 65,212,177 (GRCm38)	Y484F	probably damaging	Het
Gm13023	T	A	4: 143,793,608 (GRCm38)	S141T	probably benign	Het
H3f3a	T	C	1: 180,803,095 (GRCm38)	I131M	possibly damaging	Het
Ifi206	A	T	1: 173,471,456 (GRCm38)	D861E	unknown	Het
Ihh	T	C	1: 74,946,339 (GRCm38)	Y329C	probably damaging	Het
Jak2	A	G	19: 29,301,062 (GRCm38)	N909D	probably damaging	Het
Krtap12-1	C	A	10: 77,720,789 (GRCm38)	C55*	probably null	Het
Mical2	A	C	7: 112,271,382 (GRCm38)	K26T	possibly damaging	Het
Mpp5	A	G	12: 78,797,058 (GRCm38)	E12G	probably benign	Het
Mreg	T	C	1: 72,192,057 (GRCm38)	T81A	probably benign	Het
Muc16	T	C	9: 18,647,582 (GRCm38)	T2472A	unknown	Het
Nanos3	A	T	8: 84,176,451 (GRCm38)	D27E	probably benign	Het
Nox3	T	G	17: 3,669,861 (GRCm38)	S350R	probably damaging	Het
Olfr1049	T	A	2: 86,255,678 (GRCm38)	N5I	probably damaging	Het
Olfr734	A	G	14: 50,320,757 (GRCm38)	V26A	probably benign	Het
Pafah2	C	T	4: 134,419,970 (GRCm38)	T310M	probably damaging	Het
Pianp	A	G	6: 125,000,695 (GRCm38)	I185V	probably benign	Het
Pja2	T	C	17: 64,309,475 (GRCm38)	T142A	probably benign	Het
Poln	G	A	5: 34,014,314 (GRCm38)	P747L	probably damaging	Het
Rdx	T	A	9: 52,064,879 (GRCm38)	L39*	probably null	Het
Rnf146	A	G	10: 29,347,543 (GRCm38)	W116R	probably damaging	Het
Rsf1	G	GACGGCGGCT	7: 97,579,909 (GRCm38)		probably benign	Het
Sec24d	A	G	3: 123,294,161 (GRCm38)	T224A	probably benign	Het
Serpinb9	T	A	13: 33,006,703 (GRCm38)	I54K	possibly damaging	Het
Slc25a13	A	T	6: 6,109,987 (GRCm38)	L324Q	probably null	Het
Slc9c1	T	C	16: 45,580,127 (GRCm38)	L700P	probably benign	Het
Snta1	T	C	2: 154,380,936 (GRCm38)	K289R	probably benign	Het
Sppl2a	A	G	2: 126,923,473 (GRCm38)	F243S	probably damaging	Het
Syne1	T	C	10: 5,108,556 (GRCm38)	E7319G	probably benign	Het
Taf5l	G	A	8: 124,003,275 (GRCm38)	P225L	probably benign	Het
Tet2	A	T	3: 133,469,613 (GRCm38)	N1324K	possibly damaging	Het
Usp5	A	T	6: 124,823,451 (GRCm38)		probably null	Het
Vmn2r124	G	T	17: 18,074,177 (GRCm38)	R842L	probably benign	Het
Vps16	A	G	2: 130,424,399 (GRCm38)	D2G	possibly damaging	Het
Xpo1	A	G	11: 23,285,058 (GRCm38)	T576A	probably damaging	Het
Zdhhc6	A	T	19: 55,313,248 (GRCm38)	Y100*	probably null	Het
Zfp534	T	A	4: 147,675,625 (GRCm38)	R196*	probably null	Het
Zfp710	C	T	7: 80,081,374 (GRCm38)	R100W	probably damaging	Het
Zfp750	T	C	11: 121,513,848 (GRCm38)	K67R	probably benign	Het
Zmynd10	T	C	9: 107,549,127 (GRCm38)	S158P		Het
Zmynd8	A	T	2: 165,858,138 (GRCm38)	M1K	probably null	Het

Other mutations in Vwf

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00489:Vwf	APN	6	125,658,872 (GRCm38)	missense	unknown
IGL00561:Vwf	APN	6	125,642,721 (GRCm38)	missense	possibly damaging	0.88
IGL01104:Vwf	APN	6	125,683,556 (GRCm38)	missense	probably damaging	1.00
IGL01404:Vwf	APN	6	125,677,970 (GRCm38)	missense	probably damaging	1.00
IGL01539:Vwf	APN	6	125,590,262 (GRCm38)	missense	possibly damaging	0.85
IGL01550:Vwf	APN	6	125,679,289 (GRCm38)	missense	probably benign	0.00
IGL01563:Vwf	APN	6	125,591,165 (GRCm38)	missense	probably damaging	1.00
IGL01637:Vwf	APN	6	125,645,736 (GRCm38)	missense	probably damaging	1.00
IGL01720:Vwf	APN	6	125,642,835 (GRCm38)	missense	possibly damaging	0.69
IGL01834:Vwf	APN	6	125,590,170 (GRCm38)	splice site	probably benign
IGL02103:Vwf	APN	6	125,646,355 (GRCm38)	missense	probably damaging	1.00
IGL02120:Vwf	APN	6	125,616,034 (GRCm38)	missense	probably benign	0.26
IGL02174:Vwf	APN	6	125,555,395 (GRCm38)	missense	probably damaging	1.00
IGL02203:Vwf	APN	6	125,642,406 (GRCm38)	missense	probably damaging	1.00
IGL02420:Vwf	APN	6	125,677,916 (GRCm38)	missense	probably benign	0.00
IGL02723:Vwf	APN	6	125,642,930 (GRCm38)	missense	possibly damaging	0.85
IGL02818:Vwf	APN	6	125,663,548 (GRCm38)	missense	probably benign
IGL02931:Vwf	APN	6	125,615,968 (GRCm38)	missense	possibly damaging	0.68
IGL03015:Vwf	APN	6	125,684,138 (GRCm38)	splice site	probably benign
IGL03038:Vwf	APN	6	125,604,157 (GRCm38)	missense	possibly damaging	0.92
IGL03060:Vwf	APN	6	125,663,560 (GRCm38)	missense	probably damaging	1.00
IGL03114:Vwf	APN	6	125,599,363 (GRCm38)	nonsense	probably null
IGL03266:Vwf	APN	6	125,678,077 (GRCm38)	splice site	probably benign
gingerman	UTSW	6	125,662,963 (GRCm38)	critical splice acceptor site	probably null
R0605_vwf_644	UTSW	6	125,685,837 (GRCm38)	missense	probably benign	0.02
R1575_Vwf_091	UTSW	6	125,663,571 (GRCm38)	nonsense	probably null
R1628_Vwf_608	UTSW	6	125,647,738 (GRCm38)	unclassified	probably benign
R1669_Vwf_448	UTSW	6	125,647,906 (GRCm38)	missense	possibly damaging	0.92
R1833_Vwf_948	UTSW	6	125,642,037 (GRCm38)	missense	probably benign	0.14
R2130_vwf_946	UTSW	6	125,657,057 (GRCm38)	missense	probably damaging	1.00
R6360_Vwf_065	UTSW	6	125,683,526 (GRCm38)	missense	probably benign	0.13
R7900_Vwf_938	UTSW	6	125,628,476 (GRCm38)	critical splice donor site	probably null
Russiahouse	UTSW	6	125,639,341 (GRCm38)	nonsense	probably null
B5639:Vwf	UTSW	6	125,642,984 (GRCm38)	missense	probably damaging	1.00
R0025:Vwf	UTSW	6	125,682,812 (GRCm38)	missense	probably benign	0.05
R0025:Vwf	UTSW	6	125,682,812 (GRCm38)	missense	probably benign	0.05
R0087:Vwf	UTSW	6	125,645,954 (GRCm38)	missense	probably benign	0.03
R0194:Vwf	UTSW	6	125,643,297 (GRCm38)	missense	probably benign
R0206:Vwf	UTSW	6	125,637,456 (GRCm38)	missense	probably damaging	1.00
R0233:Vwf	UTSW	6	125,686,510 (GRCm38)	missense	possibly damaging	0.91
R0233:Vwf	UTSW	6	125,686,510 (GRCm38)	missense	possibly damaging	0.91
R0390:Vwf	UTSW	6	125,626,361 (GRCm38)	nonsense	probably null
R0427:Vwf	UTSW	6	125,673,939 (GRCm38)	missense	probably benign
R0437:Vwf	UTSW	6	125,566,318 (GRCm38)	missense	probably damaging	1.00
R0470:Vwf	UTSW	6	125,628,428 (GRCm38)	missense	possibly damaging	0.70
R0499:Vwf	UTSW	6	125,638,114 (GRCm38)	missense	probably benign	0.10
R0554:Vwf	UTSW	6	125,642,781 (GRCm38)	missense	probably benign	0.13
R0605:Vwf	UTSW	6	125,685,837 (GRCm38)	missense	probably benign	0.02
R0711:Vwf	UTSW	6	125,626,271 (GRCm38)	missense	probably benign	0.01
R0723:Vwf	UTSW	6	125,566,262 (GRCm38)	missense	probably benign	0.01
R0973:Vwf	UTSW	6	125,643,006 (GRCm38)	missense	probably damaging	1.00
R1054:Vwf	UTSW	6	125,590,227 (GRCm38)	missense	probably damaging	1.00
R1115:Vwf	UTSW	6	125,655,065 (GRCm38)	missense	unknown
R1156:Vwf	UTSW	6	125,637,488 (GRCm38)	missense	probably damaging	1.00
R1191:Vwf	UTSW	6	125,599,252 (GRCm38)	missense	probably damaging	1.00
R1240:Vwf	UTSW	6	125,603,308 (GRCm38)	splice site	probably null
R1398:Vwf	UTSW	6	125,603,457 (GRCm38)	missense	probably benign	0.02
R1435:Vwf	UTSW	6	125,642,249 (GRCm38)	nonsense	probably null
R1528:Vwf	UTSW	6	125,608,291 (GRCm38)	missense	possibly damaging	0.69
R1575:Vwf	UTSW	6	125,663,571 (GRCm38)	nonsense	probably null
R1575:Vwf	UTSW	6	125,655,251 (GRCm38)	missense	unknown
R1628:Vwf	UTSW	6	125,647,738 (GRCm38)	unclassified	probably benign
R1669:Vwf	UTSW	6	125,647,906 (GRCm38)	missense	possibly damaging	0.92
R1699:Vwf	UTSW	6	125,685,900 (GRCm38)	missense	possibly damaging	0.74
R1699:Vwf	UTSW	6	125,643,069 (GRCm38)	missense	probably damaging	1.00
R1725:Vwf	UTSW	6	125,646,282 (GRCm38)	missense	probably benign	0.05
R1742:Vwf	UTSW	6	125,667,550 (GRCm38)	missense	probably benign	0.02
R1809:Vwf	UTSW	6	125,590,175 (GRCm38)	splice site	probably benign
R1833:Vwf	UTSW	6	125,642,037 (GRCm38)	missense	probably benign	0.14
R1866:Vwf	UTSW	6	125,667,529 (GRCm38)	missense	possibly damaging	0.62
R1870:Vwf	UTSW	6	125,642,939 (GRCm38)	missense	probably damaging	1.00
R1874:Vwf	UTSW	6	125,628,372 (GRCm38)	missense	probably benign	0.00
R1941:Vwf	UTSW	6	125,639,279 (GRCm38)	missense	possibly damaging	0.64
R2061:Vwf	UTSW	6	125,591,188 (GRCm38)	missense	probably damaging	0.98
R2103:Vwf	UTSW	6	125,646,330 (GRCm38)	missense	probably benign	0.31
R2104:Vwf	UTSW	6	125,646,330 (GRCm38)	missense	probably benign	0.31
R2130:Vwf	UTSW	6	125,657,057 (GRCm38)	missense	probably damaging	1.00
R2159:Vwf	UTSW	6	125,626,341 (GRCm38)	missense	probably damaging	0.99
R2178:Vwf	UTSW	6	125,642,132 (GRCm38)	missense	possibly damaging	0.90
R2656:Vwf	UTSW	6	125,555,361 (GRCm38)	missense	probably benign	0.00
R2913:Vwf	UTSW	6	125,685,846 (GRCm38)	missense	probably benign	0.08
R2917:Vwf	UTSW	6	125,608,143 (GRCm38)	missense	probably benign	0.07
R3726:Vwf	UTSW	6	125,677,948 (GRCm38)	utr 3 prime	probably benign
R3735:Vwf	UTSW	6	125,588,613 (GRCm38)	missense	probably damaging	1.00
R3774:Vwf	UTSW	6	125,649,099 (GRCm38)	splice site	probably null
R3934:Vwf	UTSW	6	125,555,499 (GRCm38)	missense	probably damaging	1.00
R4291:Vwf	UTSW	6	125,642,322 (GRCm38)	missense	probably damaging	1.00
R4384:Vwf	UTSW	6	125,655,116 (GRCm38)	missense	unknown
R4743:Vwf	UTSW	6	125,684,091 (GRCm38)	critical splice acceptor site	probably null
R4760:Vwf	UTSW	6	125,570,604 (GRCm38)	missense	probably damaging	1.00
R4776:Vwf	UTSW	6	125,566,305 (GRCm38)	missense	possibly damaging	0.53
R4791:Vwf	UTSW	6	125,643,363 (GRCm38)	missense
R4871:Vwf	UTSW	6	125,686,462 (GRCm38)	missense	probably benign	0.25
R4894:Vwf	UTSW	6	125,645,934 (GRCm38)	nonsense	probably null
R4963:Vwf	UTSW	6	125,667,483 (GRCm38)	nonsense	probably null
R5010:Vwf	UTSW	6	125,566,257 (GRCm38)	missense	probably benign	0.15
R5289:Vwf	UTSW	6	125,667,510 (GRCm38)	utr 3 prime	probably benign
R5512:Vwf	UTSW	6	125,673,887 (GRCm38)	utr 3 prime	probably benign
R5523:Vwf	UTSW	6	125,643,042 (GRCm38)	missense
R5642:Vwf	UTSW	6	125,603,418 (GRCm38)	missense
R5860:Vwf	UTSW	6	125,679,265 (GRCm38)	utr 3 prime	probably benign
R5860:Vwf	UTSW	6	125,643,090 (GRCm38)	missense
R5896:Vwf	UTSW	6	125,678,762 (GRCm38)	critical splice acceptor site	probably null
R5926:Vwf	UTSW	6	125,604,174 (GRCm38)	missense	probably damaging	1.00
R5976:Vwf	UTSW	6	125,603,463 (GRCm38)	missense
R6053:Vwf	UTSW	6	125,600,665 (GRCm38)	missense	probably benign	0.21
R6151:Vwf	UTSW	6	125,657,065 (GRCm38)	missense	unknown
R6179:Vwf	UTSW	6	125,649,289 (GRCm38)	missense	unknown
R6181:Vwf	UTSW	6	125,566,146 (GRCm38)	missense	probably damaging	0.98
R6234:Vwf	UTSW	6	125,657,165 (GRCm38)	missense	unknown
R6360:Vwf	UTSW	6	125,683,526 (GRCm38)	missense	probably benign	0.13
R6412:Vwf	UTSW	6	125,679,316 (GRCm38)	missense	probably benign	0.00
R6464:Vwf	UTSW	6	125,639,400 (GRCm38)	critical splice donor site	probably null
R6522:Vwf	UTSW	6	125,662,963 (GRCm38)	critical splice acceptor site	probably null
R6766:Vwf	UTSW	6	125,639,376 (GRCm38)	missense	unknown
R6856:Vwf	UTSW	6	125,642,150 (GRCm38)	nonsense	probably null
R6877:Vwf	UTSW	6	125,657,201 (GRCm38)	missense	possibly damaging	0.48
R6896:Vwf	UTSW	6	125,566,194 (GRCm38)	missense	probably damaging	1.00
R7113:Vwf	UTSW	6	125,655,044 (GRCm38)	missense
R7287:Vwf	UTSW	6	125,637,467 (GRCm38)	missense
R7359:Vwf	UTSW	6	125,566,257 (GRCm38)	missense
R7509:Vwf	UTSW	6	125,642,169 (GRCm38)	missense
R7519:Vwf	UTSW	6	125,667,543 (GRCm38)	missense
R7545:Vwf	UTSW	6	125,614,097 (GRCm38)	missense
R7549:Vwf	UTSW	6	125,626,267 (GRCm38)	missense
R7593:Vwf	UTSW	6	125,647,768 (GRCm38)	missense
R7635:Vwf	UTSW	6	125,682,734 (GRCm38)	missense
R7793:Vwf	UTSW	6	125,686,520 (GRCm38)	missense
R7802:Vwf	UTSW	6	125,666,677 (GRCm38)	missense
R7824:Vwf	UTSW	6	125,658,815 (GRCm38)	missense
R7849:Vwf	UTSW	6	125,656,803 (GRCm38)	missense
R7900:Vwf	UTSW	6	125,628,476 (GRCm38)	critical splice donor site	probably null
R7919:Vwf	UTSW	6	125,647,859 (GRCm38)	missense
R7966:Vwf	UTSW	6	125,639,341 (GRCm38)	nonsense	probably null
R8101:Vwf	UTSW	6	125,570,559 (GRCm38)	nonsense	probably null
R8162:Vwf	UTSW	6	125,645,836 (GRCm38)	splice site	probably null
R8345:Vwf	UTSW	6	125,679,302 (GRCm38)	missense
R8853:Vwf	UTSW	6	125,657,264 (GRCm38)	missense
R9027:Vwf	UTSW	6	125,666,663 (GRCm38)	missense
R9065:Vwf	UTSW	6	125,646,299 (GRCm38)	missense
R9068:Vwf	UTSW	6	125,648,829 (GRCm38)	unclassified	probably benign
R9136:Vwf	UTSW	6	125,599,393 (GRCm38)	splice site	probably benign
R9164:Vwf	UTSW	6	125,565,843 (GRCm38)	missense
R9177:Vwf	UTSW	6	125,604,291 (GRCm38)	missense
R9334:Vwf	UTSW	6	125,677,946 (GRCm38)	missense
R9508:Vwf	UTSW	6	125,555,508 (GRCm38)	missense
R9553:Vwf	UTSW	6	125,600,699 (GRCm38)	missense
R9660:Vwf	UTSW	6	125,591,707 (GRCm38)	missense	possibly damaging	0.61
R9706:Vwf	UTSW	6	125,624,573 (GRCm38)	missense
R9708:Vwf	UTSW	6	125,657,090 (GRCm38)	missense
R9712:Vwf	UTSW	6	125,624,573 (GRCm38)	missense
R9714:Vwf	UTSW	6	125,624,573 (GRCm38)	missense
R9728:Vwf	UTSW	6	125,591,707 (GRCm38)	missense	possibly damaging	0.61
R9758:Vwf	UTSW	6	125,626,267 (GRCm38)	missense
X0021:Vwf	UTSW	6	125,646,331 (GRCm38)	missense	probably damaging	1.00
X0065:Vwf	UTSW	6	125,603,433 (GRCm38)	missense	probably null	0.05
Z1176:Vwf	UTSW	6	125,603,308 (GRCm38)	splice site	probably null
Z1176:Vwf	UTSW	6	125,591,231 (GRCm38)	missense

Predicted Primers

PCR Primer
(F):5'- GATGGCTAGGAATTTGGTCCGC -3'
(R):5'- GGATTACCTCCTCCACGAAC -3'

Sequencing Primer
(F):5'- TCCGCTATGTCCAAGGTCTGAAG -3'
(R):5'- ACGAACTCCTTGCTCTTATTGAAG -3'

Posted On

2022-01-20