Mutagenetix > Incidental Mutation

Incidental Mutation 'R9128:Vmn2r124'

693435

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r124

Ensembl Gene

ENSMUSG00000094396

Gene Name

vomeronasal 2, receptor 124

Synonyms

Vmn2r-ps113, Gm7196

MMRRC Submission

068927-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.270) question?

Stock #

R9128 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

18269746-18294482 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 18294439 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Leucine at position 842 (R842L)

Ref Sequence

ENSEMBL: ENSMUSP00000135613 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000176802] [ENSMUST00000231546]

AlphaFold

K7N789

Predicted Effect

probably benign
Transcript: ENSMUST00000176802
AA Change: R842L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000135613
Gene: ENSMUSG00000094396
AA Change: R842L

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	84	449	2.2e-37	PFAM
Pfam:NCD3G	510	563	9.3e-21	PFAM
Pfam:7tm_3	596	831	1.6e-52	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000231546

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca7	T	C	10: 79,838,352 (GRCm39)	V542A	possibly damaging	Het
Abhd8	G	T	8: 71,914,389 (GRCm39)	R80S	probably benign	Het
Actc1	T	C	2: 113,880,946 (GRCm39)	Y93C	possibly damaging	Het
Actn4	G	T	7: 28,593,929 (GRCm39)	D859E	possibly damaging	Het
Adcy2	C	T	13: 68,773,927 (GRCm39)	G1039R	probably damaging	Het
Als2	A	G	1: 59,219,709 (GRCm39)	M1202T	probably benign	Het
Aste1	T	A	9: 105,273,908 (GRCm39)	Y49*	probably null	Het
Atp8b4	T	C	2: 126,234,750 (GRCm39)	D422G	probably benign	Het
Bag6	T	A	17: 35,363,688 (GRCm39)	S791T	probably damaging	Het
Bivm	T	A	1: 44,167,949 (GRCm39)	W222R	probably null	Het
Bod1l	A	C	5: 41,946,266 (GRCm39)	V3003G	probably benign	Het
Bsn	T	C	9: 107,993,349 (GRCm39)	D801G	probably benign	Het
Ccdc14	G	A	16: 34,527,159 (GRCm39)	D403N	probably damaging	Het
Cenpj	T	A	14: 56,780,319 (GRCm39)	E964V	probably damaging	Het
Cep250	C	T	2: 155,812,042 (GRCm39)	A446V	unknown	Het
Clca3a1	G	A	3: 144,463,795 (GRCm39)	R161W	probably damaging	Het
Dcxr	A	T	11: 120,617,372 (GRCm39)	V57E		Het
Dnah17	T	G	11: 117,937,004 (GRCm39)	N3400T	possibly damaging	Het
Dnaja3	C	T	16: 4,520,164 (GRCm39)	T444I	possibly damaging	Het
Dop1a	T	C	9: 86,395,208 (GRCm39)	S772P	probably benign	Het
Ednrb	T	C	14: 104,080,528 (GRCm39)	N129D	probably damaging	Het
Ep300	T	A	15: 81,533,946 (GRCm39)	M2001K	unknown	Het
Fam3b	A	G	16: 97,302,200 (GRCm39)	I8T	probably benign	Het
Fam98c	A	T	7: 28,854,115 (GRCm39)	S85T		Het
Fat1	G	A	8: 45,462,878 (GRCm39)	V1232I	probably benign	Het
Fzd3	T	A	14: 65,449,626 (GRCm39)	Y484F	probably damaging	Het
H3f3a	T	C	1: 180,630,660 (GRCm39)	I131M	possibly damaging	Het
Ifi206	A	T	1: 173,299,022 (GRCm39)	D861E	unknown	Het
Ihh	T	C	1: 74,985,498 (GRCm39)	Y329C	probably damaging	Het
Jak2	A	G	19: 29,278,462 (GRCm39)	N909D	probably damaging	Het
Krtap12-1	C	A	10: 77,556,623 (GRCm39)	C55*	probably null	Het
Mical2	A	C	7: 111,870,589 (GRCm39)	K26T	possibly damaging	Het
Mreg	T	C	1: 72,231,216 (GRCm39)	T81A	probably benign	Het
Muc16	T	C	9: 18,558,878 (GRCm39)	T2472A	unknown	Het
Nanos3	A	T	8: 84,903,080 (GRCm39)	D27E	probably benign	Het
Nox3	T	G	17: 3,720,136 (GRCm39)	S350R	probably damaging	Het
Or4m1	A	G	14: 50,558,214 (GRCm39)	V26A	probably benign	Het
Or8k18	T	A	2: 86,086,022 (GRCm39)	N5I	probably damaging	Het
Pafah2	C	T	4: 134,147,281 (GRCm39)	T310M	probably damaging	Het
Pals1	A	G	12: 78,843,832 (GRCm39)	E12G	probably benign	Het
Pianp	A	G	6: 124,977,658 (GRCm39)	I185V	probably benign	Het
Pja2	T	C	17: 64,616,470 (GRCm39)	T142A	probably benign	Het
Poln	G	A	5: 34,171,658 (GRCm39)	P747L	probably damaging	Het
Pramel25	T	A	4: 143,520,178 (GRCm39)	S141T	probably benign	Het
Rdx	T	A	9: 51,976,179 (GRCm39)	L39*	probably null	Het
Rnf146	A	G	10: 29,223,539 (GRCm39)	W116R	probably damaging	Het
Rsf1	G	GACGGCGGCT	7: 97,229,116 (GRCm39)		probably benign	Het
Sec24d	A	G	3: 123,087,810 (GRCm39)	T224A	probably benign	Het
Serpinb9	T	A	13: 33,190,686 (GRCm39)	I54K	possibly damaging	Het
Slc25a13	A	T	6: 6,109,987 (GRCm39)	L324Q	probably null	Het
Slc9c1	T	C	16: 45,400,490 (GRCm39)	L700P	probably benign	Het
Snta1	T	C	2: 154,222,856 (GRCm39)	K289R	probably benign	Het
Sppl2a	A	G	2: 126,765,393 (GRCm39)	F243S	probably damaging	Het
Syne1	T	C	10: 5,058,556 (GRCm39)	E7319G	probably benign	Het
Taf5l	G	A	8: 124,730,014 (GRCm39)	P225L	probably benign	Het
Tet2	A	T	3: 133,175,374 (GRCm39)	N1324K	possibly damaging	Het
Usp5	A	T	6: 124,800,414 (GRCm39)		probably null	Het
Vps16	A	G	2: 130,266,319 (GRCm39)	D2G	possibly damaging	Het
Vwf	T	C	6: 125,619,693 (GRCm39)	L1457P		Het
Xpo1	A	G	11: 23,235,058 (GRCm39)	T576A	probably damaging	Het
Zdhhc6	A	T	19: 55,301,680 (GRCm39)	Y100*	probably null	Het
Zfp534	T	A	4: 147,760,082 (GRCm39)	R196*	probably null	Het
Zfp710	C	T	7: 79,731,122 (GRCm39)	R100W	probably damaging	Het
Zfp750	T	C	11: 121,404,674 (GRCm39)	K67R	probably benign	Het
Zmynd10	T	C	9: 107,426,326 (GRCm39)	S158P		Het
Zmynd8	A	T	2: 165,700,058 (GRCm39)	M1K	probably null	Het

Other mutations in Vmn2r124

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00988:Vmn2r124	APN	17	18,282,932 (GRCm39)	missense	probably benign	0.04
IGL01356:Vmn2r124	APN	17	18,293,733 (GRCm39)	missense	probably benign	0.08
IGL01387:Vmn2r124	APN	17	18,283,188 (GRCm39)	missense	probably damaging	0.98
IGL01413:Vmn2r124	APN	17	18,282,827 (GRCm39)	missense	probably benign	0.41
IGL01550:Vmn2r124	APN	17	18,283,617 (GRCm39)	critical splice donor site	probably null
IGL01759:Vmn2r124	APN	17	18,284,330 (GRCm39)	missense	probably benign	0.00
IGL01762:Vmn2r124	APN	17	18,283,434 (GRCm39)	missense	possibly damaging	0.51
IGL02132:Vmn2r124	APN	17	18,284,491 (GRCm39)	splice site	probably benign
IGL02290:Vmn2r124	APN	17	18,293,597 (GRCm39)	missense	probably benign	0.09
IGL02370:Vmn2r124	APN	17	18,284,453 (GRCm39)	missense	probably benign	0.14
IGL02527:Vmn2r124	APN	17	18,286,764 (GRCm39)	critical splice acceptor site	probably null
PIT4280001:Vmn2r124	UTSW	17	18,283,487 (GRCm39)	missense	probably benign	0.22
PIT4514001:Vmn2r124	UTSW	17	18,293,974 (GRCm39)	missense	probably benign	0.01
R0362:Vmn2r124	UTSW	17	18,284,486 (GRCm39)	critical splice donor site	probably null
R0401:Vmn2r124	UTSW	17	18,284,407 (GRCm39)	missense	probably damaging	0.99
R0513:Vmn2r124	UTSW	17	18,293,991 (GRCm39)	missense	possibly damaging	0.89
R1139:Vmn2r124	UTSW	17	18,294,052 (GRCm39)	missense	possibly damaging	0.56
R1513:Vmn2r124	UTSW	17	18,283,535 (GRCm39)	missense	probably damaging	1.00
R1669:Vmn2r124	UTSW	17	18,283,206 (GRCm39)	missense	possibly damaging	0.94
R1710:Vmn2r124	UTSW	17	18,282,187 (GRCm39)	splice site	probably benign
R1852:Vmn2r124	UTSW	17	18,283,436 (GRCm39)	missense	probably benign
R1860:Vmn2r124	UTSW	17	18,269,759 (GRCm39)	missense	probably benign	0.11
R1953:Vmn2r124	UTSW	17	18,283,122 (GRCm39)	missense	probably benign	0.08
R2233:Vmn2r124	UTSW	17	18,269,927 (GRCm39)	missense	possibly damaging	0.95
R2234:Vmn2r124	UTSW	17	18,269,927 (GRCm39)	missense	possibly damaging	0.95
R2235:Vmn2r124	UTSW	17	18,269,927 (GRCm39)	missense	possibly damaging	0.95
R2397:Vmn2r124	UTSW	17	18,269,859 (GRCm39)	missense	possibly damaging	0.95
R2519:Vmn2r124	UTSW	17	18,294,280 (GRCm39)	missense	probably damaging	1.00
R3845:Vmn2r124	UTSW	17	18,293,953 (GRCm39)	missense	possibly damaging	0.90
R3846:Vmn2r124	UTSW	17	18,293,953 (GRCm39)	missense	possibly damaging	0.90
R4594:Vmn2r124	UTSW	17	18,294,231 (GRCm39)	missense	probably damaging	1.00
R4612:Vmn2r124	UTSW	17	18,283,284 (GRCm39)	missense	probably benign	0.12
R4790:Vmn2r124	UTSW	17	18,269,855 (GRCm39)	missense	probably damaging	1.00
R4809:Vmn2r124	UTSW	17	18,294,007 (GRCm39)	missense	probably benign	0.00
R5227:Vmn2r124	UTSW	17	18,269,819 (GRCm39)	missense	possibly damaging	0.95
R5254:Vmn2r124	UTSW	17	18,283,339 (GRCm39)	missense	probably benign	0.00
R5609:Vmn2r124	UTSW	17	18,294,102 (GRCm39)	missense	probably benign
R6145:Vmn2r124	UTSW	17	18,283,113 (GRCm39)	missense	probably benign	0.05
R6181:Vmn2r124	UTSW	17	18,294,019 (GRCm39)	missense	possibly damaging	0.93
R6271:Vmn2r124	UTSW	17	18,283,145 (GRCm39)	missense	probably benign	0.01
R7297:Vmn2r124	UTSW	17	18,293,835 (GRCm39)	missense	probably damaging	1.00
R7397:Vmn2r124	UTSW	17	18,282,947 (GRCm39)	missense	probably damaging	1.00
R7406:Vmn2r124	UTSW	17	18,282,306 (GRCm39)	missense	unknown
R7699:Vmn2r124	UTSW	17	18,293,985 (GRCm39)	missense	probably benign	0.00
R7859:Vmn2r124	UTSW	17	18,282,212 (GRCm39)	missense	probably damaging	1.00
R8121:Vmn2r124	UTSW	17	18,282,433 (GRCm39)	missense	probably benign
R8138:Vmn2r124	UTSW	17	18,283,610 (GRCm39)	missense	probably damaging	0.99
R8756:Vmn2r124	UTSW	17	18,294,094 (GRCm39)	missense	probably benign	0.08
R8796:Vmn2r124	UTSW	17	18,282,933 (GRCm39)	missense	possibly damaging	0.95
R8841:Vmn2r124	UTSW	17	18,283,299 (GRCm39)	missense
R8960:Vmn2r124	UTSW	17	18,283,291 (GRCm39)	nonsense	probably null
R8970:Vmn2r124	UTSW	17	18,294,439 (GRCm39)	missense	probably benign
R9566:Vmn2r124	UTSW	17	18,293,581 (GRCm39)	missense	probably benign	0.14
R9680:Vmn2r124	UTSW	17	18,293,758 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACGAATCCAAGTTTCTGTCATTCAG -3'
(R):5'- ACATGATCCAGGAATGGAGCC -3'

Sequencing Primer
(F):5'- CAAGTTTCTGTCATTCAGTATGCTG -3'
(R):5'- TCCAGGAATGGAGCCATCTG -3'

Posted On

2022-01-20