Mutagenetix > Incidental Mutation

Incidental Mutation 'R9131:Muc5ac'

693634

Institutional Source

Beutler Lab

Gene Symbol

Muc5ac

Ensembl Gene

ENSMUSG00000037974

Gene Name

mucin 5, subtypes A and C, tracheobronchial/gastric

Synonyms

MGM, 2210005L13Rik

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9131 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

141342709-141372968 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 141363529 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 2280 (I2280T)

Ref Sequence

ENSEMBL: ENSMUSP00000122353 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041924] [ENSMUST00000155534] [ENSMUST00000163321]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000041924

SMART Domains

Protein: ENSMUSP00000039699
Gene: ENSMUSG00000037974

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
VWD	69	226	4.19e-30	SMART
C8	258	334	1.34e-11	SMART
Pfam:TIL	337	393	1.6e-14	PFAM
VWC	395	462	8.6e-18	SMART
VWD	421	585	1.55e-33	SMART
C8	622	696	8.42e-36	SMART
Pfam:TIL	702	759	6.1e-9	PFAM
VWC	761	825	6.75e-1	SMART
VWC	863	905	4.06e-1	SMART
VWD	890	1050	1.51e-45	SMART
C8	1086	1160	2.78e-36	SMART
low complexity region	1315	1330	N/A	INTRINSIC
low complexity region	1333	1366	N/A	INTRINSIC
low complexity region	1371	1387	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1394	1482	2.3e-25	PFAM
low complexity region	1521	1532	N/A	INTRINSIC
low complexity region	1536	1563	N/A	INTRINSIC
low complexity region	1578	1595	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1604	1692	2.2e-27	PFAM
Pfam:Mucin2_WxxW	1765	1857	8.6e-27	PFAM
low complexity region	1875	1895	N/A	INTRINSIC
low complexity region	1949	1968	N/A	INTRINSIC
VWD	2030	2199	4.17e-48	SMART
C8	2242	2311	3.95e-9	SMART
VWC	2376	2439	1.04e-11	SMART
VWC	2479	2543	9.31e-5	SMART
CT	2625	2711	3.43e-32	SMART
low complexity region	2720	2733	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000155534
AA Change: I2280T

SMART Domains

Protein: ENSMUSP00000122353
Gene: ENSMUSG00000037974
AA Change: I2280T

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
VWD	69	226	4.19e-30	SMART
C8	258	334	1.34e-11	SMART
Pfam:TIL	337	393	9.6e-15	PFAM
VWC	395	437	3.54e-1	SMART
VWD	422	586	2.35e-33	SMART
C8	623	697	8.42e-36	SMART
Pfam:TIL	703	760	3.6e-9	PFAM
VWC	762	826	6.75e-1	SMART
VWC	864	906	4.06e-1	SMART
VWD	891	1051	1.51e-45	SMART
C8	1087	1161	2.78e-36	SMART
low complexity region	1316	1331	N/A	INTRINSIC
low complexity region	1334	1367	N/A	INTRINSIC
low complexity region	1372	1388	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1395	1483	1.3e-25	PFAM
low complexity region	1522	1533	N/A	INTRINSIC
low complexity region	1537	1564	N/A	INTRINSIC
low complexity region	1579	1596	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1605	1693	1.3e-27	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000163321

SMART Domains

Protein: ENSMUSP00000131681
Gene: ENSMUSG00000037974

Domain	Start	End	E-Value	Type
signal peptide	1	27	N/A	INTRINSIC
VWD	69	226	4.19e-30	SMART
C8	258	334	1.34e-11	SMART
Pfam:TIL	337	393	7.9e-15	PFAM
VWC	395	462	8.6e-18	SMART
VWD	421	585	1.55e-33	SMART
C8	622	696	8.42e-36	SMART
Pfam:TIL	702	759	1.9e-9	PFAM
VWC	761	825	6.75e-1	SMART
VWC	863	905	4.06e-1	SMART
VWD	890	1050	1.51e-45	SMART
C8	1086	1160	2.78e-36	SMART
low complexity region	1315	1330	N/A	INTRINSIC
low complexity region	1333	1366	N/A	INTRINSIC
low complexity region	1371	1387	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1394	1481	1.1e-23	PFAM
low complexity region	1521	1532	N/A	INTRINSIC
low complexity region	1536	1563	N/A	INTRINSIC
low complexity region	1578	1595	N/A	INTRINSIC
Pfam:Mucin2_WxxW	1604	1691	1.1e-25	PFAM
Pfam:Mucin2_WxxW	1765	1856	6.3e-24	PFAM
low complexity region	1875	1895	N/A	INTRINSIC
low complexity region	1949	1968	N/A	INTRINSIC
VWD	2030	2199	4.17e-48	SMART
C8	2242	2311	3.95e-9	SMART
VWC	2376	2439	1.04e-11	SMART
VWC	2479	2543	9.31e-5	SMART
CT	2625	2711	3.43e-32	SMART
low complexity region	2720	2733	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to T. muris infection with persistent worm burden, goblet cell hyperplasia, and increased serum IFN-gamma despite a normal TH2-type immune response. A portion of mice show corneal opacity and poor tear quality. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 91 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ackr1	T	A	1: 173,160,075 (GRCm39)	Y148F	possibly damaging	Het
Adamtsl3	A	G	7: 82,244,722 (GRCm39)	T1393A	probably benign	Het
Adgrf4	G	T	17: 42,978,258 (GRCm39)	Q362K	probably benign	Het
Akr1d1	A	G	6: 37,531,451 (GRCm39)	K163R	probably benign	Het
Arhgap42	A	G	9: 9,011,364 (GRCm39)	L474P	probably damaging	Het
Arhgef18	G	A	8: 3,487,007 (GRCm39)	R242Q	possibly damaging	Het
Asah1	A	G	8: 41,807,049 (GRCm39)		probably null	Het
Atm	A	T	9: 53,445,044 (GRCm39)	I34N	probably benign	Het
Brms1l	A	G	12: 55,906,913 (GRCm39)	E160G	possibly damaging	Het
Camk2a	C	T	18: 61,076,327 (GRCm39)	H102Y	unknown	Het
Cd300lb	A	G	11: 114,819,134 (GRCm39)	V165A	probably damaging	Het
Cela1	G	A	15: 100,579,038 (GRCm39)	R207C	probably benign	Het
Chd7	T	C	4: 8,785,642 (GRCm39)	S649P		Het
Cilk1	A	T	9: 78,074,230 (GRCm39)	S551C	possibly damaging	Het
Clic3	A	G	2: 25,348,325 (GRCm39)	Q130R	probably benign	Het
Clns1a	G	A	7: 97,363,125 (GRCm39)	G166R	probably damaging	Het
Cngb1	A	T	8: 95,979,893 (GRCm39)	H1002Q	probably benign	Het
Cnnm1	C	A	19: 43,429,839 (GRCm39)	A319E	probably benign	Het
Cntnap5b	C	T	1: 99,978,368 (GRCm39)	T128I	probably benign	Het
Csf3r	G	A	4: 125,923,813 (GRCm39)	D108N	probably benign	Het
Ctsc	G	A	7: 87,959,016 (GRCm39)	W432*	probably null	Het
Dapk1	G	A	13: 60,909,208 (GRCm39)	G1274R	probably damaging	Het
Dennd2c	C	A	3: 103,065,031 (GRCm39)	P718Q	probably damaging	Het
Dmxl1	C	G	18: 50,072,639 (GRCm39)	N2744K	probably damaging	Het
Dnah7b	C	T	1: 46,266,180 (GRCm39)	R2250C	probably damaging	Het
Dnmt3a	A	T	12: 3,916,136 (GRCm39)	Q107L	probably benign	Het
Eml2	A	G	7: 18,918,751 (GRCm39)	D67G		Het
Eml5	A	T	12: 98,825,099 (GRCm39)	V706E	probably damaging	Het
Eps8l1	A	G	7: 4,480,573 (GRCm39)	D509G		Het
Farsb	T	C	1: 78,459,951 (GRCm39)	K43E	probably benign	Het
Fbxw20	A	G	9: 109,052,514 (GRCm39)	F273S	probably damaging	Het
Fig4	A	T	10: 41,141,407 (GRCm39)	F284Y	possibly damaging	Het
Fsd1l	C	A	4: 53,694,756 (GRCm39)	N403K	probably damaging	Het
Fsip2	A	T	2: 82,813,170 (GRCm39)	H3163L	probably benign	Het
Gm38119	C	A	3: 92,645,403 (GRCm39)	G64*	probably null	Het
Gpr18	A	G	14: 122,149,173 (GRCm39)	V284A	probably benign	Het
Hacd3	A	G	9: 64,908,286 (GRCm39)	V170A	probably damaging	Het
Hps3	T	C	3: 20,083,350 (GRCm39)	E281G	probably damaging	Het
Ighv12-3	A	C	12: 114,330,546 (GRCm39)	V10G	probably benign	Het
Lrp1b	G	A	2: 40,589,590 (GRCm39)	R3862*	probably null	Het
Ltbp4	A	G	7: 27,036,976 (GRCm39)	L6P	unknown	Het
Ly6h	T	A	15: 75,437,522 (GRCm39)	T53S	probably damaging	Het
Ly6i	A	G	15: 74,855,006 (GRCm39)		probably benign	Het
Mat2a	G	A	6: 72,413,227 (GRCm39)	R168C	probably damaging	Het
Mdn1	T	A	4: 32,762,275 (GRCm39)	D5066E	possibly damaging	Het
Med23	T	A	10: 24,780,279 (GRCm39)	F976I		Het
Mylk	G	T	16: 34,776,835 (GRCm39)	C1336F	probably benign	Het
Myo9a	G	C	9: 59,768,772 (GRCm39)	R918P	probably damaging	Het
Naglu	T	A	11: 100,967,731 (GRCm39)	D560E	probably damaging	Het
Nrg2	C	T	18: 36,157,396 (GRCm39)	V430M	probably damaging	Het
Oit3	T	C	10: 59,271,751 (GRCm39)	N202S	probably benign	Het
Or13a1	A	G	6: 116,470,881 (GRCm39)	T104A	probably benign	Het
Or1e29	A	T	11: 73,668,150 (GRCm39)	M1K	probably null	Het
Or52r1	T	C	7: 102,537,186 (GRCm39)	H58R	probably benign	Het
Or5b101	T	A	19: 13,005,360 (GRCm39)	Y111F	probably benign	Het
Or6c63-ps1	C	A	10: 128,899,097 (GRCm39)	V260F	probably damaging	Het
Otog	T	A	7: 45,952,597 (GRCm39)	C423*	probably null	Het
Pcolce	T	A	5: 137,603,770 (GRCm39)	T401S	probably benign	Het
Pcsk2	T	C	2: 143,655,583 (GRCm39)	M589T	possibly damaging	Het
Pik3r5	T	C	11: 68,383,099 (GRCm39)	L306P	possibly damaging	Het
Pikfyve	T	A	1: 65,285,239 (GRCm39)	M826K	probably damaging	Het
Ppp1r9a	A	G	6: 5,134,106 (GRCm39)	R898G	possibly damaging	Het
Prl7b1	A	G	13: 27,790,968 (GRCm39)	V39A	probably benign	Het
Pros1	T	A	16: 62,748,397 (GRCm39)	D623E	probably damaging	Het
Psg16	A	G	7: 16,832,024 (GRCm39)	D320G	probably benign	Het
Ptpre	T	A	7: 135,280,875 (GRCm39)	H612Q	probably damaging	Het
Rbm34	A	G	8: 127,679,928 (GRCm39)	S283P	probably damaging	Het
Rc3h2	A	T	2: 37,304,702 (GRCm39)	N19K	possibly damaging	Het
Sacm1l	T	A	9: 123,381,827 (GRCm39)	L143*	probably null	Het
Septin9	T	A	11: 117,181,460 (GRCm39)	S105T	probably damaging	Het
Shprh	T	C	10: 11,038,589 (GRCm39)	M448T	possibly damaging	Het
Slc6a20a	A	C	9: 123,466,063 (GRCm39)	*593E	probably null	Het
Smarcc1	A	G	9: 109,964,710 (GRCm39)	D89G	possibly damaging	Het
Svep1	T	A	4: 58,087,778 (GRCm39)	Y1767F	possibly damaging	Het
Tanc2	T	C	11: 105,689,603 (GRCm39)	V255A	probably benign	Het
Tiam1	A	G	16: 89,657,155 (GRCm39)	S694P	probably damaging	Het
Tmem130	T	C	5: 144,680,529 (GRCm39)	T292A		Het
Tob1	ACAGCAGCAGCAGCAGCAGCAGC	ACAGCAGCAGCAGCAGCAGC	11: 94,105,203 (GRCm39)		probably benign	Het
Tpcn2	A	G	7: 144,814,662 (GRCm39)	Y480H	probably damaging	Het
Trf	G	T	9: 103,089,087 (GRCm39)	A600D	probably damaging	Het
Ttc16	A	T	2: 32,659,232 (GRCm39)	L346Q	probably damaging	Het
Vars1	A	C	17: 35,223,773 (GRCm39)	K229N	possibly damaging	Het
Vmn1r113	G	T	7: 20,521,342 (GRCm39)	G45C	probably damaging	Het
Vmn1r32	A	G	6: 66,530,020 (GRCm39)	V252A	probably benign	Het
Vmn2r93	A	G	17: 18,546,143 (GRCm39)	T672A	probably damaging	Het
Wdfy4	T	A	14: 32,819,807 (GRCm39)	T1466S		Het
Zcwpw1	T	C	5: 137,809,182 (GRCm39)	Y317H	probably damaging	Het
Zfp169	T	C	13: 48,644,557 (GRCm39)	E190G	unknown	Het
Zfp273	A	T	13: 67,973,685 (GRCm39)	H271L	probably damaging	Het
Zfp764	C	A	7: 127,005,719 (GRCm39)	E20*	probably null	Het
Znfx1	A	T	2: 166,892,298 (GRCm39)	N639K	probably benign	Het

Other mutations in Muc5ac

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00899:Muc5ac	APN	7	141,366,440 (GRCm39)	missense	possibly damaging	0.93
IGL01064:Muc5ac	APN	7	141,361,210 (GRCm39)	missense	probably benign	0.12
IGL01155:Muc5ac	APN	7	141,360,680 (GRCm39)	splice site	probably benign
IGL01452:Muc5ac	APN	7	141,371,292 (GRCm39)	missense	probably benign	0.00
IGL01590:Muc5ac	APN	7	141,352,630 (GRCm39)	missense	probably benign	0.02
IGL02104:Muc5ac	APN	7	141,364,815 (GRCm39)	missense	probably damaging	0.98
IGL02152:Muc5ac	APN	7	141,353,914 (GRCm39)	missense	possibly damaging	0.86
IGL02153:Muc5ac	APN	7	141,372,537 (GRCm39)	nonsense	probably null
IGL02178:Muc5ac	APN	7	141,359,184 (GRCm39)	splice site	probably benign
IGL02403:Muc5ac	APN	7	141,357,187 (GRCm39)	missense	possibly damaging	0.71
IGL02576:Muc5ac	APN	7	141,370,781 (GRCm39)	missense	probably benign	0.01
IGL02665:Muc5ac	APN	7	141,344,823 (GRCm39)	missense	possibly damaging	0.71
IGL02704:Muc5ac	APN	7	141,349,000 (GRCm39)	missense	possibly damaging	0.71
IGL02808:Muc5ac	APN	7	141,359,512 (GRCm39)	missense	possibly damaging	0.72
IGL03283:Muc5ac	APN	7	141,367,518 (GRCm39)	missense	probably benign	0.34
IGL03384:Muc5ac	APN	7	141,366,140 (GRCm39)	missense	possibly damaging	0.71
IGL03046:Muc5ac	UTSW	7	141,348,950 (GRCm39)	missense	probably benign	0.27
PIT4515001:Muc5ac	UTSW	7	141,361,153 (GRCm39)	missense	probably damaging	0.99
R0092:Muc5ac	UTSW	7	141,372,367 (GRCm39)	missense	possibly damaging	0.72
R0145:Muc5ac	UTSW	7	141,349,012 (GRCm39)	missense	possibly damaging	0.71
R0147:Muc5ac	UTSW	7	141,364,776 (GRCm39)	missense	probably benign	0.08
R0363:Muc5ac	UTSW	7	141,354,697 (GRCm39)	missense	probably benign	0.01
R0384:Muc5ac	UTSW	7	141,365,988 (GRCm39)	missense	possibly damaging	0.71
R0440:Muc5ac	UTSW	7	141,345,771 (GRCm39)	nonsense	probably null
R0583:Muc5ac	UTSW	7	141,361,345 (GRCm39)	missense	probably damaging	0.99
R0616:Muc5ac	UTSW	7	141,349,981 (GRCm39)	missense	probably benign	0.02
R0682:Muc5ac	UTSW	7	141,359,406 (GRCm39)	missense	possibly damaging	0.53
R0685:Muc5ac	UTSW	7	141,361,446 (GRCm39)	missense	probably benign	0.03
R0883:Muc5ac	UTSW	7	141,350,002 (GRCm39)	missense	possibly damaging	0.71
R0924:Muc5ac	UTSW	7	141,361,252 (GRCm39)	missense	possibly damaging	0.68
R1300:Muc5ac	UTSW	7	141,370,666 (GRCm39)	missense	possibly damaging	0.73
R1315:Muc5ac	UTSW	7	141,361,060 (GRCm39)	missense	probably damaging	0.99
R1354:Muc5ac	UTSW	7	141,361,114 (GRCm39)	missense	probably damaging	0.99
R1484:Muc5ac	UTSW	7	141,367,629 (GRCm39)	splice site	probably null
R1599:Muc5ac	UTSW	7	141,352,640 (GRCm39)	missense	possibly damaging	0.52
R1758:Muc5ac	UTSW	7	141,355,268 (GRCm39)	missense	possibly damaging	0.86
R1837:Muc5ac	UTSW	7	141,360,823 (GRCm39)	missense	probably benign	0.00
R1911:Muc5ac	UTSW	7	141,350,041 (GRCm39)	missense	probably benign	0.18
R1922:Muc5ac	UTSW	7	141,347,426 (GRCm39)	missense	probably benign	0.03
R1966:Muc5ac	UTSW	7	141,357,113 (GRCm39)	missense	possibly damaging	0.92
R1994:Muc5ac	UTSW	7	141,366,889 (GRCm39)	missense	possibly damaging	0.93
R2056:Muc5ac	UTSW	7	141,345,772 (GRCm39)	missense	probably benign	0.01
R2126:Muc5ac	UTSW	7	141,364,479 (GRCm39)	missense	possibly damaging	0.84
R2170:Muc5ac	UTSW	7	141,366,084 (GRCm39)	missense	possibly damaging	0.93
R2258:Muc5ac	UTSW	7	141,344,745 (GRCm39)	missense	probably benign	0.41
R2259:Muc5ac	UTSW	7	141,344,745 (GRCm39)	missense	probably benign	0.41
R2293:Muc5ac	UTSW	7	141,360,936 (GRCm39)	missense	probably damaging	0.99
R2435:Muc5ac	UTSW	7	141,371,841 (GRCm39)	missense	possibly damaging	0.53
R2895:Muc5ac	UTSW	7	141,344,877 (GRCm39)	missense	possibly damaging	0.92
R2910:Muc5ac	UTSW	7	141,361,378 (GRCm39)	missense	probably damaging	0.99
R3154:Muc5ac	UTSW	7	141,346,473 (GRCm39)	splice site	probably null
R3762:Muc5ac	UTSW	7	141,361,212 (GRCm39)	missense	possibly damaging	0.53
R3791:Muc5ac	UTSW	7	141,352,238 (GRCm39)	missense	probably benign	0.32
R3806:Muc5ac	UTSW	7	141,367,471 (GRCm39)	missense	possibly damaging	0.91
R3825:Muc5ac	UTSW	7	141,368,460 (GRCm39)	missense	possibly damaging	0.92
R3888:Muc5ac	UTSW	7	141,344,961 (GRCm39)	missense	possibly damaging	0.51
R3929:Muc5ac	UTSW	7	141,356,629 (GRCm39)	missense	probably benign
R3981:Muc5ac	UTSW	7	141,367,512 (GRCm39)	missense	possibly damaging	0.86
R4034:Muc5ac	UTSW	7	141,353,581 (GRCm39)	critical splice donor site	probably null
R4043:Muc5ac	UTSW	7	141,361,215 (GRCm39)	missense	possibly damaging	0.53
R4061:Muc5ac	UTSW	7	141,364,867 (GRCm39)	missense	possibly damaging	0.85
R4106:Muc5ac	UTSW	7	141,356,572 (GRCm39)	missense	possibly damaging	0.86
R4206:Muc5ac	UTSW	7	141,370,847 (GRCm39)	missense	possibly damaging	0.73
R4613:Muc5ac	UTSW	7	141,344,840 (GRCm39)	missense	possibly damaging	0.93
R4719:Muc5ac	UTSW	7	141,343,500 (GRCm39)	missense	possibly damaging	0.83
R4751:Muc5ac	UTSW	7	141,371,338 (GRCm39)	missense	probably benign	0.00
R4789:Muc5ac	UTSW	7	141,352,619 (GRCm39)	missense	possibly damaging	0.86
R4928:Muc5ac	UTSW	7	141,371,639 (GRCm39)	nonsense	probably null
R4971:Muc5ac	UTSW	7	141,370,015 (GRCm39)	missense	possibly damaging	0.68
R4982:Muc5ac	UTSW	7	141,363,193 (GRCm39)	intron	probably benign
R5088:Muc5ac	UTSW	7	141,350,056 (GRCm39)	missense	possibly damaging	0.53
R5141:Muc5ac	UTSW	7	141,368,479 (GRCm39)	missense	possibly damaging	0.72
R5224:Muc5ac	UTSW	7	141,347,708 (GRCm39)	missense	probably benign	0.32
R5366:Muc5ac	UTSW	7	141,361,287 (GRCm39)	missense	probably benign	0.01
R5497:Muc5ac	UTSW	7	141,361,380 (GRCm39)	missense	probably damaging	0.99
R5507:Muc5ac	UTSW	7	141,361,569 (GRCm39)	missense	possibly damaging	0.72
R5643:Muc5ac	UTSW	7	141,347,452 (GRCm39)	critical splice donor site	probably null
R5811:Muc5ac	UTSW	7	141,352,721 (GRCm39)	missense	possibly damaging	0.51
R5946:Muc5ac	UTSW	7	141,371,644 (GRCm39)	missense	possibly damaging	0.73
R5970:Muc5ac	UTSW	7	141,344,406 (GRCm39)	nonsense	probably null
R5977:Muc5ac	UTSW	7	141,350,104 (GRCm39)	missense	possibly damaging	0.73
R6051:Muc5ac	UTSW	7	141,365,594 (GRCm39)	missense	possibly damaging	0.53
R6126:Muc5ac	UTSW	7	141,354,969 (GRCm39)	missense	possibly damaging	0.71
R6159:Muc5ac	UTSW	7	141,369,323 (GRCm39)	missense	possibly damaging	0.53
R6256:Muc5ac	UTSW	7	141,343,532 (GRCm39)	missense	possibly damaging	0.53
R6283:Muc5ac	UTSW	7	141,370,601 (GRCm39)	nonsense	probably null
R6341:Muc5ac	UTSW	7	141,355,229 (GRCm39)	missense	probably damaging	0.99
R6356:Muc5ac	UTSW	7	141,366,416 (GRCm39)	missense	probably benign	0.05
R6481:Muc5ac	UTSW	7	141,362,808 (GRCm39)	intron	probably benign
R6483:Muc5ac	UTSW	7	141,356,591 (GRCm39)	missense	probably benign	0.18
R6627:Muc5ac	UTSW	7	141,362,427 (GRCm39)	intron	probably benign
R6636:Muc5ac	UTSW	7	141,372,342 (GRCm39)	missense	possibly damaging	0.86
R6637:Muc5ac	UTSW	7	141,372,342 (GRCm39)	missense	possibly damaging	0.86
R6656:Muc5ac	UTSW	7	141,357,065 (GRCm39)	missense	probably damaging	0.98
R6721:Muc5ac	UTSW	7	141,352,729 (GRCm39)	missense	possibly damaging	0.71
R6794:Muc5ac	UTSW	7	141,363,289 (GRCm39)	intron	probably benign
R6844:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6847:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6852:Muc5ac	UTSW	7	141,370,644 (GRCm39)	missense	probably benign	0.03
R6862:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6863:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6864:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6865:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6874:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6875:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6876:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6877:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6889:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R6920:Muc5ac	UTSW	7	141,347,035 (GRCm39)	missense	possibly damaging	0.86
R6998:Muc5ac	UTSW	7	141,372,451 (GRCm39)	missense	possibly damaging	0.92
R7017:Muc5ac	UTSW	7	141,363,424 (GRCm39)	intron	probably benign
R7091:Muc5ac	UTSW	7	141,363,424 (GRCm39)	intron	probably benign
R7092:Muc5ac	UTSW	7	141,363,424 (GRCm39)	intron	probably benign
R7092:Muc5ac	UTSW	7	141,363,385 (GRCm39)	intron	probably benign
R7110:Muc5ac	UTSW	7	141,353,559 (GRCm39)	missense	possibly damaging	0.95
R7117:Muc5ac	UTSW	7	141,367,559 (GRCm39)	nonsense	probably null
R7238:Muc5ac	UTSW	7	141,363,424 (GRCm39)	intron	probably benign
R7238:Muc5ac	UTSW	7	141,363,254 (GRCm39)	missense	unknown
R7396:Muc5ac	UTSW	7	141,362,152 (GRCm39)	missense	unknown
R7456:Muc5ac	UTSW	7	141,346,904 (GRCm39)	missense	probably benign	0.32
R7477:Muc5ac	UTSW	7	141,370,019 (GRCm39)	missense	possibly damaging	0.72
R7530:Muc5ac	UTSW	7	141,367,536 (GRCm39)	missense	possibly damaging	0.51
R7545:Muc5ac	UTSW	7	141,362,405 (GRCm39)	missense	unknown
R7604:Muc5ac	UTSW	7	141,363,446 (GRCm39)	missense	unknown
R7635:Muc5ac	UTSW	7	141,359,413 (GRCm39)	missense	probably damaging	0.98
R7635:Muc5ac	UTSW	7	141,359,490 (GRCm39)	missense	possibly damaging	0.53
R7650:Muc5ac	UTSW	7	141,363,159 (GRCm39)	missense	unknown
R7651:Muc5ac	UTSW	7	141,349,991 (GRCm39)	missense	possibly damaging	0.92
R7685:Muc5ac	UTSW	7	141,363,120 (GRCm39)	missense	unknown
R7720:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7749:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7750:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7751:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7754:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7798:Muc5ac	UTSW	7	141,347,778 (GRCm39)	critical splice donor site	probably null
R7835:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7837:Muc5ac	UTSW	7	141,369,700 (GRCm39)	missense	possibly damaging	0.53
R7858:Muc5ac	UTSW	7	141,357,166 (GRCm39)	missense	possibly damaging	0.51
R7866:Muc5ac	UTSW	7	141,349,589 (GRCm39)	missense	probably benign	0.00
R7874:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7876:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7877:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7881:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7884:Muc5ac	UTSW	7	141,363,040 (GRCm39)	missense	unknown
R7921:Muc5ac	UTSW	7	141,363,424 (GRCm39)	intron	probably benign
R7976:Muc5ac	UTSW	7	141,363,528 (GRCm39)	missense	unknown
R8104:Muc5ac	UTSW	7	141,358,520 (GRCm39)	missense	possibly damaging	0.96
R8177:Muc5ac	UTSW	7	141,361,068 (GRCm39)	missense	probably damaging	1.00
R8214:Muc5ac	UTSW	7	141,356,685 (GRCm39)	missense	possibly damaging	0.53
R8292:Muc5ac	UTSW	7	141,363,000 (GRCm39)	missense	unknown
R8386:Muc5ac	UTSW	7	141,361,371 (GRCm39)	missense	possibly damaging	0.93
R8400:Muc5ac	UTSW	7	141,364,213 (GRCm39)	missense	probably damaging	0.99
R8504:Muc5ac	UTSW	7	141,360,892 (GRCm39)	missense	probably damaging	1.00
R8709:Muc5ac	UTSW	7	141,370,663 (GRCm39)	missense	possibly damaging	0.96
R8725:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R8727:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
R8754:Muc5ac	UTSW	7	141,354,008 (GRCm39)	missense	possibly damaging	0.85
R8769:Muc5ac	UTSW	7	141,372,609 (GRCm39)	missense	probably damaging	1.00
R8933:Muc5ac	UTSW	7	141,343,493 (GRCm39)	missense	possibly damaging	0.59
R8939:Muc5ac	UTSW	7	141,347,091 (GRCm39)	missense	probably damaging	0.98
R9049:Muc5ac	UTSW	7	141,362,712 (GRCm39)	missense	unknown
R9124:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9132:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9135:Muc5ac	UTSW	7	141,352,218 (GRCm39)	missense	probably damaging	0.99
R9156:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9157:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9159:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9160:Muc5ac	UTSW	7	141,363,529 (GRCm39)	missense	unknown
R9161:Muc5ac	UTSW	7	141,353,026 (GRCm39)	missense	possibly damaging	0.53
R9175:Muc5ac	UTSW	7	141,366,093 (GRCm39)	missense	possibly damaging	0.92
R9183:Muc5ac	UTSW	7	141,352,637 (GRCm39)	missense	possibly damaging	0.71
R9218:Muc5ac	UTSW	7	141,361,098 (GRCm39)	missense	probably damaging	0.99
R9219:Muc5ac	UTSW	7	141,370,800 (GRCm39)	nonsense	probably null
R9239:Muc5ac	UTSW	7	141,353,954 (GRCm39)	missense	probably damaging	0.99
R9246:Muc5ac	UTSW	7	141,364,215 (GRCm39)	missense	probably benign	0.11
R9287:Muc5ac	UTSW	7	141,361,626 (GRCm39)	missense	probably damaging	0.99
R9320:Muc5ac	UTSW	7	141,369,255 (GRCm39)	missense	probably benign	0.01
R9327:Muc5ac	UTSW	7	141,365,429 (GRCm39)	missense	possibly damaging	0.86
R9428:Muc5ac	UTSW	7	141,362,559 (GRCm39)	missense	unknown
R9430:Muc5ac	UTSW	7	141,362,569 (GRCm39)	missense	unknown
R9454:Muc5ac	UTSW	7	141,362,431 (GRCm39)	missense	unknown
R9483:Muc5ac	UTSW	7	141,365,465 (GRCm39)	nonsense	probably null
R9581:Muc5ac	UTSW	7	141,363,799 (GRCm39)	missense	unknown
R9610:Muc5ac	UTSW	7	141,350,078 (GRCm39)	missense	possibly damaging	0.86
R9642:Muc5ac	UTSW	7	141,349,601 (GRCm39)	missense	possibly damaging	0.71
R9684:Muc5ac	UTSW	7	141,364,798 (GRCm39)	missense	probably benign	0.41
R9760:Muc5ac	UTSW	7	141,360,985 (GRCm39)	missense	probably benign	0.05
R9778:Muc5ac	UTSW	7	141,349,021 (GRCm39)	nonsense	probably null
X0060:Muc5ac	UTSW	7	141,357,070 (GRCm39)	missense	possibly damaging	0.71
Z1088:Muc5ac	UTSW	7	141,365,429 (GRCm39)	missense	possibly damaging	0.86
Z1088:Muc5ac	UTSW	7	141,363,481 (GRCm39)	intron	probably benign
Z1177:Muc5ac	UTSW	7	141,371,777 (GRCm39)	missense	probably benign	0.33
Z1177:Muc5ac	UTSW	7	141,362,961 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- TACAGGAAAGGCCAGCACC -3'
(R):5'- CGTGGCTTCTCACAGAACTTG -3'

Sequencing Primer
(F):5'- GAAAGGCCAGCACCCCATC -3'
(R):5'- AGAACTTGTATCCTTTGGATCTCAGG -3'

Posted On

2022-01-20