Incidental Mutation 'R9132:Wars1'
ID 693728
Institutional Source Beutler Lab
Gene Symbol Wars1
Ensembl Gene ENSMUSG00000021266
Gene Name tryptophanyl-tRNA synthetase1
Synonyms Wars
MMRRC Submission 068929-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9132 (G1)
Quality Score 225.009
Status Validated
Chromosome 12
Chromosomal Location 108825956-108860095 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 108827199 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 474 (F474L)
Ref Sequence ENSEMBL: ENSMUSP00000124625 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057026] [ENSMUST00000109848] [ENSMUST00000160477] [ENSMUST00000161154] [ENSMUST00000161410] [ENSMUST00000221080]
AlphaFold P32921
Predicted Effect probably benign
Transcript: ENSMUST00000057026
SMART Domains Protein: ENSMUSP00000050329
Gene: ENSMUSG00000048856

DomainStartEndE-ValueType
Pfam:Mito_carr 1 84 1.2e-19 PFAM
Pfam:Mito_carr 94 212 1.5e-19 PFAM
Pfam:Mito_carr 215 308 6.1e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000109848
AA Change: F474L

PolyPhen 2 Score 0.412 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000105474
Gene: ENSMUSG00000021266
AA Change: F474L

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 447 5.8e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000160477
Predicted Effect probably benign
Transcript: ENSMUST00000161154
AA Change: F474L

PolyPhen 2 Score 0.412 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000124625
Gene: ENSMUSG00000021266
AA Change: F474L

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 446 1.4e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000161410
AA Change: F474L

PolyPhen 2 Score 0.412 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000125320
Gene: ENSMUSG00000021266
AA Change: F474L

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 447 5.8e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000221080
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 97% (65/67)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AC133488.1 A T 16: 18,440,075 (GRCm39) V363E probably benign Het
Adamts16 A G 13: 70,901,408 (GRCm39) S890P probably benign Het
Amd1 A G 10: 40,169,158 (GRCm39) probably null Het
Apcs A G 1: 172,722,061 (GRCm39) I95T probably damaging Het
Arhgap18 A G 10: 26,730,886 (GRCm39) D188G probably benign Het
Arhgap42 C T 9: 9,011,419 (GRCm39) V456M probably damaging Het
Atp2a2 T C 5: 122,599,633 (GRCm39) Y586C probably damaging Het
Cbr1 G C 16: 93,406,794 (GRCm39) G170A probably benign Het
Cdh23 T A 10: 60,270,283 (GRCm39) probably benign Het
Cfap53 T A 18: 74,416,272 (GRCm39) Y2N probably damaging Het
Clcn3 A G 8: 61,382,136 (GRCm39) I511T probably damaging Het
Col28a1 T A 6: 8,014,993 (GRCm39) D804V probably damaging Het
Csmd2 A G 4: 128,443,007 (GRCm39) T3253A Het
Csta3 G A 16: 36,038,069 (GRCm39) V69I probably benign Het
Cyp2c40 A T 19: 39,762,317 (GRCm39) D443E probably damaging Het
Cyp7b1 A G 3: 18,151,476 (GRCm39) C246R probably benign Het
Dmxl1 C G 18: 50,072,639 (GRCm39) N2744K probably damaging Het
Dnai4 A G 4: 102,916,930 (GRCm39) M592T probably damaging Het
Dpyd T A 3: 118,710,897 (GRCm39) I435N probably damaging Het
Fat2 A T 11: 55,189,436 (GRCm39) L1194Q possibly damaging Het
Firrm A G 1: 163,814,514 (GRCm39) I143T probably damaging Het
Gabrg1 A T 5: 70,939,622 (GRCm39) I170N possibly damaging Het
Gon4l C T 3: 88,815,484 (GRCm39) P2016S probably benign Het
Hax1 T C 3: 89,903,127 (GRCm39) R251G probably damaging Het
Hbq1b A T 11: 32,237,228 (GRCm39) K41* probably null Het
Ido2 G A 8: 25,023,933 (GRCm39) P302S probably damaging Het
Igf2bp2 G A 16: 21,900,502 (GRCm39) T213I probably damaging Het
Itga2 A T 13: 115,014,298 (GRCm39) L210* probably null Het
Kdm1b G A 13: 47,225,458 (GRCm39) S547N probably benign Het
Ltbp2 G A 12: 84,837,864 (GRCm39) P1192L probably benign Het
Lyz2 A T 10: 117,116,562 (GRCm39) C95* probably null Het
Mafa A T 15: 75,619,048 (GRCm39) S242T possibly damaging Het
Mapk1 T C 16: 16,856,300 (GRCm39) probably null Het
Mta1 T A 12: 113,100,025 (GRCm39) V645E probably damaging Het
Muc5ac T C 7: 141,363,529 (GRCm39) I2280T unknown Het
Naa35 T C 13: 59,772,341 (GRCm39) I438T possibly damaging Het
Necab2 T C 8: 120,189,303 (GRCm39) Y158H probably damaging Het
Nphp3 T A 9: 103,897,980 (GRCm39) L523Q probably damaging Het
Ogdh A T 11: 6,290,488 (GRCm39) I369F probably benign Het
Pglyrp4 C T 3: 90,635,238 (GRCm39) Q28* probably null Het
Pla2g4a C T 1: 149,747,230 (GRCm39) V319I probably benign Het
Plk3 ACACTCAC ACAC 4: 116,989,090 (GRCm39) probably benign Het
Prdm6 C A 18: 53,598,019 (GRCm39) A127D unknown Het
Prop1 T G 11: 50,843,037 (GRCm39) E50A Het
Ripk1 A G 13: 34,212,184 (GRCm39) N498S probably benign Het
Rnf213 A G 11: 119,374,742 (GRCm39) N5069S Het
Saa3 T C 7: 46,362,121 (GRCm39) D41G probably damaging Het
Setd2 T C 9: 110,374,385 (GRCm39) probably null Het
Shbg G A 11: 69,506,430 (GRCm39) L327F probably benign Het
Slc12a5 G A 2: 164,835,876 (GRCm39) probably benign Het
Slc1a4 C T 11: 20,258,527 (GRCm39) G304D probably damaging Het
Slf1 T C 13: 77,249,073 (GRCm39) K372E probably benign Het
Smad2 T A 18: 76,395,573 (GRCm39) I4N possibly damaging Het
Smad6 A C 9: 63,914,870 (GRCm39) S300A probably benign Het
Spata31h1 T C 10: 82,127,896 (GRCm39) T1705A possibly damaging Het
Spem2 T A 11: 69,707,414 (GRCm39) probably benign Het
Syde1 T C 10: 78,425,340 (GRCm39) S224G probably benign Het
Tacc1 A T 8: 25,672,151 (GRCm39) V359E possibly damaging Het
Tex15 T G 8: 34,067,554 (GRCm39) V2328G possibly damaging Het
Tmem43 A C 6: 91,459,291 (GRCm39) D254A probably benign Het
Trav6d-3 T A 14: 52,964,210 (GRCm39) Y58N possibly damaging Het
Trrap A G 5: 144,726,362 (GRCm39) E437G probably benign Het
Zfp169 T C 13: 48,644,557 (GRCm39) E190G unknown Het
Zfp541 T A 7: 15,816,966 (GRCm39) V918D probably benign Het
Zfp747 T C 7: 126,974,922 (GRCm39) D26G probably damaging Het
Other mutations in Wars1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01961:Wars1 APN 12 108,832,096 (GRCm39) missense probably damaging 1.00
IGL02327:Wars1 APN 12 108,832,227 (GRCm39) critical splice acceptor site probably null
IGL02864:Wars1 APN 12 108,848,791 (GRCm39) missense probably benign
IGL02962:Wars1 APN 12 108,841,706 (GRCm39) missense probably damaging 0.99
R0271:Wars1 UTSW 12 108,841,119 (GRCm39) missense probably benign
R0485:Wars1 UTSW 12 108,841,083 (GRCm39) missense probably damaging 1.00
R0669:Wars1 UTSW 12 108,831,944 (GRCm39) missense probably benign 0.00
R1144:Wars1 UTSW 12 108,854,291 (GRCm39) nonsense probably null
R1581:Wars1 UTSW 12 108,841,635 (GRCm39) nonsense probably null
R1730:Wars1 UTSW 12 108,841,667 (GRCm39) missense probably damaging 1.00
R1783:Wars1 UTSW 12 108,841,667 (GRCm39) missense probably damaging 1.00
R1990:Wars1 UTSW 12 108,854,359 (GRCm39) missense possibly damaging 0.94
R5382:Wars1 UTSW 12 108,848,706 (GRCm39) missense probably benign
R5703:Wars1 UTSW 12 108,841,047 (GRCm39) missense probably damaging 1.00
R6299:Wars1 UTSW 12 108,827,309 (GRCm39) missense probably benign 0.00
R7186:Wars1 UTSW 12 108,846,982 (GRCm39) missense probably damaging 0.99
R7508:Wars1 UTSW 12 108,848,801 (GRCm39) missense probably benign 0.01
R7919:Wars1 UTSW 12 108,847,030 (GRCm39) missense probably benign 0.11
R8530:Wars1 UTSW 12 108,848,818 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CTCTTTGTGGGAGAGACTGC -3'
(R):5'- GCTCACAGTATCAGCCTTCTAC -3'

Sequencing Primer
(F):5'- TGGGGTTCTATCTGACCACACAAC -3'
(R):5'- TTCTACAGGATTACACCAGCGGAG -3'
Posted On 2022-01-20