Incidental Mutation 'R9133:Ksr2'
ID 693764
Institutional Source Beutler Lab
Gene Symbol Ksr2
Ensembl Gene ENSMUSG00000061578
Gene Name kinase suppressor of ras 2
Synonyms
MMRRC Submission 068930-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R9133 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 117552067-117906061 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 117841319 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 598 (T598A)
Ref Sequence ENSEMBL: ENSMUSP00000137670 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000180430]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000180430
AA Change: T598A

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000137670
Gene: ENSMUSG00000061578
AA Change: T598A

DomainStartEndE-ValueType
Pfam:KSR1-SAM 24 152 1.1e-45 PFAM
low complexity region 258 282 N/A INTRINSIC
low complexity region 326 341 N/A INTRINSIC
low complexity region 357 368 N/A INTRINSIC
C1 412 457 2.74e-8 SMART
low complexity region 518 551 N/A INTRINSIC
low complexity region 617 637 N/A INTRINSIC
Pfam:Pkinase 667 929 1.1e-41 PFAM
Pfam:Pkinase_Tyr 667 929 1.8e-46 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (65/65)
MGI Phenotype PHENOTYPE: Homozygous mice exhibit increased body fat and obesity, resulting from hyperphagia. Mice are also glucose intolerant and have high serum cholesterol, ALT, serum lipids and show hepatic steatosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acat3 T A 17: 13,159,176 (GRCm39) R4S probably benign Het
Adamdec1 A T 14: 68,814,547 (GRCm39) C143* probably null Het
Adck5 A G 15: 76,460,612 (GRCm39) probably benign Het
Aebp2 A G 6: 140,579,441 (GRCm39) D226G probably damaging Het
Ascc3 A G 10: 50,630,175 (GRCm39) I1755V possibly damaging Het
Aspm C T 1: 139,419,266 (GRCm39) T2977M probably damaging Het
Cacna1a A G 8: 85,276,152 (GRCm39) S582G probably damaging Het
Card14 T C 11: 119,231,835 (GRCm39) F801S probably damaging Het
Casp16 T A 17: 23,771,003 (GRCm39) D134V probably damaging Het
Cmya5 A G 13: 93,234,108 (GRCm39) S327P possibly damaging Het
Cutc A T 19: 43,755,727 (GRCm39) D229V possibly damaging Het
Cyp21a1 C A 17: 35,023,419 (GRCm39) probably benign Het
Dnah10 A G 5: 124,859,423 (GRCm39) K2130R probably damaging Het
Dsc1 C T 18: 20,234,904 (GRCm39) S250N probably benign Het
Edc4 T C 8: 106,611,778 (GRCm39) probably null Het
Efcab8 G C 2: 153,646,861 (GRCm39) V397L unknown Het
Ehmt1 A T 2: 24,729,635 (GRCm39) I642K possibly damaging Het
Gjd2 T C 2: 113,842,039 (GRCm39) Q146R probably benign Het
Gm26661 A G 14: 7,791,936 (GRCm38) H117R unknown Het
H2-Oa T A 17: 34,313,505 (GRCm39) D185E probably damaging Het
Hjurp A T 1: 88,202,772 (GRCm39) Y71N possibly damaging Het
Hyal6 A G 6: 24,734,585 (GRCm39) R173G possibly damaging Het
Ica1 A T 6: 8,659,921 (GRCm39) V125D probably benign Het
Ift172 T C 5: 31,442,867 (GRCm39) T140A probably benign Het
Ighv9-4 T A 12: 114,263,883 (GRCm39) I17F probably benign Het
Igkv4-92 G T 6: 68,732,248 (GRCm39) T42N probably damaging Het
Kctd16 C A 18: 40,392,069 (GRCm39) P219Q probably damaging Het
Kdm5b A T 1: 134,530,323 (GRCm39) I445F probably benign Het
Lrrn1 C T 6: 107,544,568 (GRCm39) T122I probably damaging Het
Mars2 A G 1: 55,276,721 (GRCm39) D108G possibly damaging Het
Ms4a14 A G 19: 11,281,038 (GRCm39) W507R Het
Ncoa3 A G 2: 165,910,381 (GRCm39) T1266A possibly damaging Het
Neb T C 2: 52,083,256 (GRCm39) K5650E possibly damaging Het
Nlrp4f T A 13: 65,332,883 (GRCm39) K92* probably null Het
Nme4 G T 17: 26,314,389 (GRCm39) A13E probably benign Het
Nova1 G T 12: 46,865,524 (GRCm39) A4E unknown Het
Nphs1 G T 7: 30,160,092 (GRCm39) E124* probably null Het
Or10d4 T A 9: 39,580,974 (GRCm39) I207N possibly damaging Het
Or10d4b T A 9: 39,534,809 (GRCm39) L128* probably null Het
Or5d14 T C 2: 87,880,782 (GRCm39) Y62C probably damaging Het
Pde8a C T 7: 80,982,619 (GRCm39) T746I probably damaging Het
Peg3 GTGGGGCTCCTGGCCATGGGGCTTATCATCATGGGGCTCCTGGCCATGGGGCTTATCATCATGGGGCTCCTGGCCATGGGGCTTATCATCATGGGGCTC GTGGGGCTCCTGGCCATGGGGCTTATCATCATGGGGCTCCTGGCCATGGGGCTTATCATCATGGGGCTC 7: 6,712,167 (GRCm39) probably benign Het
Ranbp2 T C 10: 58,313,050 (GRCm39) S1257P probably damaging Het
Ranbp3 T C 17: 57,003,791 (GRCm39) probably null Het
Rasgrf1 A G 9: 89,793,600 (GRCm39) T126A probably benign Het
Rexo5 T G 7: 119,444,667 (GRCm39) L714R probably damaging Het
Rhobtb3 A G 13: 76,020,512 (GRCm39) Y597H probably damaging Het
Riox1 C G 12: 83,998,221 (GRCm39) Y252* probably null Het
Sh2d3c T C 2: 32,634,778 (GRCm39) Y186H possibly damaging Het
Slc16a7 T A 10: 125,066,536 (GRCm39) T368S probably benign Het
Slc25a26 G A 6: 94,511,143 (GRCm39) V107I Het
Slc4a5 A T 6: 83,203,217 (GRCm39) Y39F possibly damaging Het
Smarcad1 A G 6: 65,049,035 (GRCm39) K254E probably damaging Het
Sspo G T 6: 48,434,747 (GRCm39) V1080L possibly damaging Het
Thsd7b A T 1: 129,843,382 (GRCm39) T865S probably benign Het
Top1 C T 2: 160,545,591 (GRCm39) Q320* probably null Het
Trank1 T A 9: 111,220,770 (GRCm39) N2502K possibly damaging Het
Urad T C 5: 147,252,251 (GRCm39) H67R probably damaging Het
Vamp5 A C 6: 72,357,362 (GRCm39) probably null Het
Vmn1r62 A G 7: 5,679,062 (GRCm39) I248V probably benign Het
Wwc2 G T 8: 48,305,007 (GRCm39) Q873K unknown Het
Zcchc2 C A 1: 105,958,535 (GRCm39) S1002Y probably damaging Het
Zdhhc14 G A 17: 5,803,283 (GRCm39) R462H probably benign Het
Zfp788 A G 7: 41,299,484 (GRCm39) N707D Het
Zfp964 A G 8: 70,115,783 (GRCm39) T128A probably benign Het
Zkscan16 T C 4: 58,957,722 (GRCm39) L668S possibly damaging Het
Other mutations in Ksr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02136:Ksr2 APN 5 117,754,959 (GRCm39) missense possibly damaging 0.52
IGL02231:Ksr2 APN 5 117,638,841 (GRCm39) missense probably damaging 1.00
IGL02634:Ksr2 APN 5 117,901,394 (GRCm39) splice site probably benign
IGL02669:Ksr2 APN 5 117,693,446 (GRCm39) missense probably damaging 1.00
IGL03116:Ksr2 APN 5 117,846,022 (GRCm39) missense probably benign 0.20
IGL03168:Ksr2 APN 5 117,886,846 (GRCm39) missense probably damaging 1.00
IGL03372:Ksr2 APN 5 117,840,783 (GRCm39) missense possibly damaging 0.93
float UTSW 5 117,809,523 (GRCm39) missense probably damaging 1.00
gigante UTSW 5 117,809,514 (GRCm39) missense probably damaging 0.99
loft UTSW 5 117,638,857 (GRCm39) missense probably benign 0.10
R0133:Ksr2 UTSW 5 117,693,359 (GRCm39) missense possibly damaging 0.95
R0811:Ksr2 UTSW 5 117,693,290 (GRCm39) missense probably damaging 1.00
R0812:Ksr2 UTSW 5 117,693,290 (GRCm39) missense probably damaging 1.00
R1162:Ksr2 UTSW 5 117,693,020 (GRCm39) splice site probably benign
R1420:Ksr2 UTSW 5 117,552,904 (GRCm39) missense probably benign 0.10
R1717:Ksr2 UTSW 5 117,809,514 (GRCm39) missense probably damaging 0.99
R1809:Ksr2 UTSW 5 117,693,535 (GRCm39) missense probably damaging 1.00
R1859:Ksr2 UTSW 5 117,553,006 (GRCm39) missense probably damaging 1.00
R1867:Ksr2 UTSW 5 117,643,594 (GRCm39) missense probably benign 0.32
R1868:Ksr2 UTSW 5 117,643,594 (GRCm39) missense probably benign 0.32
R3024:Ksr2 UTSW 5 117,693,125 (GRCm39) missense possibly damaging 0.52
R3499:Ksr2 UTSW 5 117,827,640 (GRCm39) missense probably damaging 1.00
R3687:Ksr2 UTSW 5 117,693,044 (GRCm39) missense probably damaging 0.98
R3688:Ksr2 UTSW 5 117,693,044 (GRCm39) missense probably damaging 0.98
R4044:Ksr2 UTSW 5 117,693,127 (GRCm39) nonsense probably null
R4579:Ksr2 UTSW 5 117,894,335 (GRCm39) missense probably damaging 0.99
R4697:Ksr2 UTSW 5 117,846,212 (GRCm39) missense probably damaging 1.00
R4834:Ksr2 UTSW 5 117,806,392 (GRCm39) missense probably benign 0.37
R5016:Ksr2 UTSW 5 117,638,857 (GRCm39) missense probably benign 0.10
R5107:Ksr2 UTSW 5 117,827,673 (GRCm39) missense probably benign 0.01
R5150:Ksr2 UTSW 5 117,693,074 (GRCm39) missense probably damaging 0.97
R5326:Ksr2 UTSW 5 117,846,305 (GRCm39) missense probably damaging 1.00
R5493:Ksr2 UTSW 5 117,846,175 (GRCm39) missense probably damaging 1.00
R5738:Ksr2 UTSW 5 117,886,864 (GRCm39) missense probably damaging 0.97
R6257:Ksr2 UTSW 5 117,552,909 (GRCm39) missense probably benign 0.01
R6316:Ksr2 UTSW 5 117,823,567 (GRCm39) missense probably damaging 1.00
R6389:Ksr2 UTSW 5 117,552,907 (GRCm39) missense probably benign 0.09
R6460:Ksr2 UTSW 5 117,894,449 (GRCm39) critical splice donor site probably null
R6874:Ksr2 UTSW 5 117,894,401 (GRCm39) nonsense probably null
R6939:Ksr2 UTSW 5 117,903,626 (GRCm39) makesense probably null
R7352:Ksr2 UTSW 5 117,827,706 (GRCm39) missense probably benign 0.00
R7594:Ksr2 UTSW 5 117,693,131 (GRCm39) missense possibly damaging 0.89
R7840:Ksr2 UTSW 5 117,693,329 (GRCm39) missense probably benign 0.00
R7919:Ksr2 UTSW 5 117,899,418 (GRCm39) missense possibly damaging 0.86
R8152:Ksr2 UTSW 5 117,809,523 (GRCm39) missense probably damaging 1.00
R8949:Ksr2 UTSW 5 117,823,560 (GRCm39) missense possibly damaging 0.68
R9299:Ksr2 UTSW 5 117,885,399 (GRCm39) critical splice acceptor site probably null
R9356:Ksr2 UTSW 5 117,827,706 (GRCm39) missense probably benign 0.40
R9592:Ksr2 UTSW 5 117,894,344 (GRCm39) missense probably damaging 1.00
R9658:Ksr2 UTSW 5 117,885,425 (GRCm39) missense probably damaging 1.00
RF020:Ksr2 UTSW 5 117,693,283 (GRCm39) missense probably benign
Z1088:Ksr2 UTSW 5 117,885,467 (GRCm39) missense probably damaging 1.00
Z1177:Ksr2 UTSW 5 117,885,473 (GRCm39) missense probably damaging 0.99
Z1177:Ksr2 UTSW 5 117,846,265 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTTGGCCAATATTGAAACCC -3'
(R):5'- ACGCTACCATTGCCACAGAG -3'

Sequencing Primer
(F):5'- TATTGAAACCCACGTCAATAGGG -3'
(R):5'- GGGCTAACACTGCTTCCTG -3'
Posted On 2022-01-20