Incidental Mutation 'R9133:Peg3'
ID 693778
Institutional Source Beutler Lab
Gene Symbol Peg3
Ensembl Gene ENSMUSG00000002265
Gene Name paternally expressed 3
Synonyms Zfp102, Gcap4, End4, Pw1
MMRRC Submission 068930-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9133 (G1)
Quality Score 105.723
Status Validated
Chromosome 7
Chromosomal Location 6706891-6733430 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) GTGGGGCTCCTGGCCATGGGGCTTATCATCATGGGGCTCCTGGCCATGGGGCTTATCATCATGGGGCTCCTGGCCATGGGGCTTATCATCATGGGGCTC to GTGGGGCTCCTGGCCATGGGGCTTATCATCATGGGGCTCCTGGCCATGGGGCTTATCATCATGGGGCTC at 6712167 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000116161 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051209] [ENSMUST00000143703] [ENSMUST00000150182]
AlphaFold Q3URU2
Predicted Effect probably benign
Transcript: ENSMUST00000051209
SMART Domains Protein: ENSMUSP00000050750
Gene: ENSMUSG00000002265

DomainStartEndE-ValueType
low complexity region 6 19 N/A INTRINSIC
low complexity region 213 221 N/A INTRINSIC
ZnF_C2H2 325 347 7.26e-3 SMART
ZnF_C2H2 378 400 6.88e-4 SMART
ZnF_C2H2 436 458 2.95e-3 SMART
low complexity region 464 496 N/A INTRINSIC
ZnF_C2H2 520 542 5.99e-4 SMART
low complexity region 691 698 N/A INTRINSIC
ZnF_C2H2 850 872 2.99e-4 SMART
ZnF_C2H2 1091 1113 2.05e-2 SMART
ZnF_C2H2 1147 1169 1.04e-3 SMART
ZnF_C2H2 1209 1231 1.38e-3 SMART
ZnF_C2H2 1266 1289 1.89e-1 SMART
ZnF_C2H2 1317 1339 1.57e2 SMART
low complexity region 1373 1419 N/A INTRINSIC
low complexity region 1440 1486 N/A INTRINSIC
ZnF_C2H2 1488 1510 2.2e-2 SMART
ZnF_C2H2 1547 1569 1.38e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000143703
SMART Domains Protein: ENSMUSP00000122423
Gene: ENSMUSG00000002265

DomainStartEndE-ValueType
low complexity region 6 19 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000150182
SMART Domains Protein: ENSMUSP00000116161
Gene: ENSMUSG00000002265

DomainStartEndE-ValueType
low complexity region 6 19 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (65/65)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
PHENOTYPE: Heterozygous mutant females exhibit growth retardation, impaired maternal behavior and diminished milk ejection, and fewer oxytocin neurons. [provided by MGI curators]
Allele List at MGI

All alleles(4) : Targeted, knock-out(1) Gene trapped(3)

Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acat3 T A 17: 13,159,176 (GRCm39) R4S probably benign Het
Adamdec1 A T 14: 68,814,547 (GRCm39) C143* probably null Het
Adck5 A G 15: 76,460,612 (GRCm39) probably benign Het
Aebp2 A G 6: 140,579,441 (GRCm39) D226G probably damaging Het
Ascc3 A G 10: 50,630,175 (GRCm39) I1755V possibly damaging Het
Aspm C T 1: 139,419,266 (GRCm39) T2977M probably damaging Het
Cacna1a A G 8: 85,276,152 (GRCm39) S582G probably damaging Het
Card14 T C 11: 119,231,835 (GRCm39) F801S probably damaging Het
Casp16 T A 17: 23,771,003 (GRCm39) D134V probably damaging Het
Cmya5 A G 13: 93,234,108 (GRCm39) S327P possibly damaging Het
Cutc A T 19: 43,755,727 (GRCm39) D229V possibly damaging Het
Cyp21a1 C A 17: 35,023,419 (GRCm39) probably benign Het
Dnah10 A G 5: 124,859,423 (GRCm39) K2130R probably damaging Het
Dsc1 C T 18: 20,234,904 (GRCm39) S250N probably benign Het
Edc4 T C 8: 106,611,778 (GRCm39) probably null Het
Efcab8 G C 2: 153,646,861 (GRCm39) V397L unknown Het
Ehmt1 A T 2: 24,729,635 (GRCm39) I642K possibly damaging Het
Gjd2 T C 2: 113,842,039 (GRCm39) Q146R probably benign Het
Gm26661 A G 14: 7,791,936 (GRCm38) H117R unknown Het
H2-Oa T A 17: 34,313,505 (GRCm39) D185E probably damaging Het
Hjurp A T 1: 88,202,772 (GRCm39) Y71N possibly damaging Het
Hyal6 A G 6: 24,734,585 (GRCm39) R173G possibly damaging Het
Ica1 A T 6: 8,659,921 (GRCm39) V125D probably benign Het
Ift172 T C 5: 31,442,867 (GRCm39) T140A probably benign Het
Ighv9-4 T A 12: 114,263,883 (GRCm39) I17F probably benign Het
Igkv4-92 G T 6: 68,732,248 (GRCm39) T42N probably damaging Het
Kctd16 C A 18: 40,392,069 (GRCm39) P219Q probably damaging Het
Kdm5b A T 1: 134,530,323 (GRCm39) I445F probably benign Het
Ksr2 A G 5: 117,841,319 (GRCm39) T598A probably benign Het
Lrrn1 C T 6: 107,544,568 (GRCm39) T122I probably damaging Het
Mars2 A G 1: 55,276,721 (GRCm39) D108G possibly damaging Het
Ms4a14 A G 19: 11,281,038 (GRCm39) W507R Het
Ncoa3 A G 2: 165,910,381 (GRCm39) T1266A possibly damaging Het
Neb T C 2: 52,083,256 (GRCm39) K5650E possibly damaging Het
Nlrp4f T A 13: 65,332,883 (GRCm39) K92* probably null Het
Nme4 G T 17: 26,314,389 (GRCm39) A13E probably benign Het
Nova1 G T 12: 46,865,524 (GRCm39) A4E unknown Het
Nphs1 G T 7: 30,160,092 (GRCm39) E124* probably null Het
Or10d4 T A 9: 39,580,974 (GRCm39) I207N possibly damaging Het
Or10d4b T A 9: 39,534,809 (GRCm39) L128* probably null Het
Or5d14 T C 2: 87,880,782 (GRCm39) Y62C probably damaging Het
Pde8a C T 7: 80,982,619 (GRCm39) T746I probably damaging Het
Ranbp2 T C 10: 58,313,050 (GRCm39) S1257P probably damaging Het
Ranbp3 T C 17: 57,003,791 (GRCm39) probably null Het
Rasgrf1 A G 9: 89,793,600 (GRCm39) T126A probably benign Het
Rexo5 T G 7: 119,444,667 (GRCm39) L714R probably damaging Het
Rhobtb3 A G 13: 76,020,512 (GRCm39) Y597H probably damaging Het
Riox1 C G 12: 83,998,221 (GRCm39) Y252* probably null Het
Sh2d3c T C 2: 32,634,778 (GRCm39) Y186H possibly damaging Het
Slc16a7 T A 10: 125,066,536 (GRCm39) T368S probably benign Het
Slc25a26 G A 6: 94,511,143 (GRCm39) V107I Het
Slc4a5 A T 6: 83,203,217 (GRCm39) Y39F possibly damaging Het
Smarcad1 A G 6: 65,049,035 (GRCm39) K254E probably damaging Het
Sspo G T 6: 48,434,747 (GRCm39) V1080L possibly damaging Het
Thsd7b A T 1: 129,843,382 (GRCm39) T865S probably benign Het
Top1 C T 2: 160,545,591 (GRCm39) Q320* probably null Het
Trank1 T A 9: 111,220,770 (GRCm39) N2502K possibly damaging Het
Urad T C 5: 147,252,251 (GRCm39) H67R probably damaging Het
Vamp5 A C 6: 72,357,362 (GRCm39) probably null Het
Vmn1r62 A G 7: 5,679,062 (GRCm39) I248V probably benign Het
Wwc2 G T 8: 48,305,007 (GRCm39) Q873K unknown Het
Zcchc2 C A 1: 105,958,535 (GRCm39) S1002Y probably damaging Het
Zdhhc14 G A 17: 5,803,283 (GRCm39) R462H probably benign Het
Zfp788 A G 7: 41,299,484 (GRCm39) N707D Het
Zfp964 A G 8: 70,115,783 (GRCm39) T128A probably benign Het
Zkscan16 T C 4: 58,957,722 (GRCm39) L668S possibly damaging Het
Other mutations in Peg3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00158:Peg3 APN 7 6,713,273 (GRCm39) missense probably benign 0.09
IGL01410:Peg3 APN 7 6,710,624 (GRCm39) missense probably benign 0.04
IGL01415:Peg3 APN 7 6,714,652 (GRCm39) missense probably damaging 0.99
IGL02073:Peg3 APN 7 6,714,001 (GRCm39) missense probably damaging 1.00
IGL02193:Peg3 APN 7 6,714,927 (GRCm39) missense probably damaging 1.00
IGL02212:Peg3 APN 7 6,714,415 (GRCm39) missense probably benign 0.41
IGL02215:Peg3 APN 7 6,712,010 (GRCm39) missense probably benign 0.00
IGL02407:Peg3 APN 7 6,710,635 (GRCm39) missense probably damaging 0.99
IGL02586:Peg3 APN 7 6,713,068 (GRCm39) missense probably benign
IGL02673:Peg3 APN 7 6,713,413 (GRCm39) missense probably damaging 1.00
IGL02935:Peg3 APN 7 6,714,128 (GRCm39) missense probably damaging 1.00
IGL03277:Peg3 APN 7 6,714,673 (GRCm39) missense probably damaging 1.00
IGL03330:Peg3 APN 7 6,713,412 (GRCm39) missense probably damaging 1.00
IGL03393:Peg3 APN 7 6,710,648 (GRCm39) missense probably damaging 0.99
R0049:Peg3 UTSW 7 6,714,672 (GRCm39) missense possibly damaging 0.85
R0049:Peg3 UTSW 7 6,714,672 (GRCm39) missense possibly damaging 0.85
R0518:Peg3 UTSW 7 6,714,427 (GRCm39) missense probably damaging 1.00
R0521:Peg3 UTSW 7 6,714,427 (GRCm39) missense probably damaging 1.00
R1477:Peg3 UTSW 7 6,719,141 (GRCm39) missense probably damaging 1.00
R1716:Peg3 UTSW 7 6,710,780 (GRCm39) missense possibly damaging 0.93
R1721:Peg3 UTSW 7 6,712,900 (GRCm39) missense possibly damaging 0.92
R1732:Peg3 UTSW 7 6,712,084 (GRCm39) missense possibly damaging 0.72
R2051:Peg3 UTSW 7 6,715,720 (GRCm39) missense probably damaging 0.96
R2288:Peg3 UTSW 7 6,712,114 (GRCm39) missense probably damaging 0.96
R3606:Peg3 UTSW 7 6,711,508 (GRCm39) missense probably damaging 1.00
R5075:Peg3 UTSW 7 6,711,419 (GRCm39) missense probably damaging 1.00
R5076:Peg3 UTSW 7 6,711,419 (GRCm39) missense probably damaging 1.00
R5084:Peg3 UTSW 7 6,710,848 (GRCm39) missense probably damaging 1.00
R5097:Peg3 UTSW 7 6,713,026 (GRCm39) missense probably damaging 0.99
R5121:Peg3 UTSW 7 6,713,288 (GRCm39) missense probably benign 0.20
R5141:Peg3 UTSW 7 6,712,381 (GRCm39) missense probably benign 0.03
R5292:Peg3 UTSW 7 6,711,259 (GRCm39) missense probably damaging 1.00
R5294:Peg3 UTSW 7 6,720,848 (GRCm39) missense possibly damaging 0.88
R5342:Peg3 UTSW 7 6,712,969 (GRCm39) missense probably damaging 1.00
R5415:Peg3 UTSW 7 6,711,628 (GRCm39) missense probably benign
R5906:Peg3 UTSW 7 6,720,854 (GRCm39) missense probably damaging 0.99
R6056:Peg3 UTSW 7 6,712,570 (GRCm39) missense probably damaging 1.00
R6259:Peg3 UTSW 7 6,712,810 (GRCm39) missense probably damaging 0.99
R6529:Peg3 UTSW 7 6,711,071 (GRCm39) missense probably damaging 1.00
R6631:Peg3 UTSW 7 6,712,069 (GRCm39) missense possibly damaging 0.72
R6855:Peg3 UTSW 7 6,711,797 (GRCm39) missense probably benign 0.13
R6861:Peg3 UTSW 7 6,714,385 (GRCm39) nonsense probably null
R6864:Peg3 UTSW 7 6,715,761 (GRCm39) missense probably damaging 1.00
R6892:Peg3 UTSW 7 6,711,898 (GRCm39) missense possibly damaging 0.58
R7018:Peg3 UTSW 7 6,711,838 (GRCm39) missense possibly damaging 0.72
R7039:Peg3 UTSW 7 6,720,858 (GRCm39) missense probably damaging 0.99
R7066:Peg3 UTSW 7 6,711,856 (GRCm39) missense probably damaging 1.00
R7117:Peg3 UTSW 7 6,712,167 (GRCm39) unclassified probably benign
R7133:Peg3 UTSW 7 6,711,944 (GRCm39) missense probably damaging 1.00
R7493:Peg3 UTSW 7 6,712,723 (GRCm39) missense probably damaging 1.00
R7539:Peg3 UTSW 7 6,711,167 (GRCm39) missense probably benign 0.00
R7642:Peg3 UTSW 7 6,712,167 (GRCm39) unclassified probably benign
R7646:Peg3 UTSW 7 6,712,221 (GRCm39) missense probably benign
R7658:Peg3 UTSW 7 6,712,609 (GRCm39) missense probably damaging 1.00
R7846:Peg3 UTSW 7 6,713,650 (GRCm39) missense probably damaging 1.00
R7853:Peg3 UTSW 7 6,711,839 (GRCm39) missense possibly damaging 0.72
R7903:Peg3 UTSW 7 6,712,167 (GRCm39) unclassified probably benign
R7913:Peg3 UTSW 7 6,712,167 (GRCm39) unclassified probably benign
R7948:Peg3 UTSW 7 6,711,781 (GRCm39) missense probably damaging 1.00
R8219:Peg3 UTSW 7 6,711,364 (GRCm39) missense probably benign 0.00
R8385:Peg3 UTSW 7 6,711,082 (GRCm39) missense probably damaging 1.00
R8672:Peg3 UTSW 7 6,711,523 (GRCm39) missense possibly damaging 0.62
R9209:Peg3 UTSW 7 6,711,226 (GRCm39) missense possibly damaging 0.48
R9457:Peg3 UTSW 7 6,710,998 (GRCm39) missense probably damaging 0.99
R9518:Peg3 UTSW 7 6,714,280 (GRCm39) missense probably benign 0.00
R9519:Peg3 UTSW 7 6,714,394 (GRCm39) missense probably benign 0.00
R9599:Peg3 UTSW 7 6,714,723 (GRCm39) missense probably damaging 0.97
RF039:Peg3 UTSW 7 6,712,167 (GRCm39) unclassified probably benign
YA93:Peg3 UTSW 7 6,714,646 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGCATCACCAGCGTCATC -3'
(R):5'- CCATATGGTAAGGAGCCCAGTG -3'

Sequencing Primer
(F):5'- TGCTCTTCAGAAACTGAGGC -3'
(R):5'- AGCCCCATGATGATAAGC -3'
Posted On 2022-01-20