Mutagenetix > Incidental Mutation

Incidental Mutation 'R9134:Fpr-rs7'

693869

Institutional Source

Beutler Lab

Gene Symbol

Fpr-rs7

Ensembl Gene

ENSMUSG00000071276

Gene Name

formyl peptide receptor, related sequence 7

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.110) question?

Stock #

R9134 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

20113210-20114226 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 20114063 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 55 (M55K)

Ref Sequence

ENSEMBL: ENSMUSP00000093297 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095637]

AlphaFold

Q71MR7

Predicted Effect

probably damaging
Transcript: ENSMUST00000095637
AA Change: M55K

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000093297
Gene: ENSMUSG00000071276
AA Change: M55K

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	1.2e-38	PFAM

Meta Mutation Damage Score

0.4700

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

95% (54/57)

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410089E03Rik	T	C	15: 8,199,232	V929A	probably damaging	Het
Ap1m1	A	G	8: 72,240,069		probably benign	Het
Arhgdia	A	T	11: 120,579,566	I122N	probably damaging	Het
Atad2b	T	A	12: 5,010,351	H915Q	probably benign	Het
Atad5	G	A	11: 80,133,105	R1681K	probably benign	Het
Bpifb9b	T	C	2: 154,309,521	V54A	probably benign	Het
Cby3	A	C	11: 50,359,326	T25P	probably damaging	Het
Ccdc138	T	G	10: 58,538,280	L374R	probably damaging	Het
Cd84	T	A	1: 171,851,846	N30K	probably damaging	Het
Cdk20	T	A	13: 64,433,092		probably null	Het
Chd9	A	G	8: 90,933,126	H238R	unknown	Het
Csl	T	A	10: 99,758,375	H276L	probably damaging	Het
Dchs1	A	G	7: 105,755,703	L2544P	probably damaging	Het
Dnah17	T	C	11: 118,088,146	T1807A	probably damaging	Het
Dph7	C	T	2: 24,971,708	H378Y	probably benign	Het
Enkur	T	C	2: 21,180,968	I249V	probably benign	Het
Fam117a	C	A	11: 95,380,919	S439*	probably null	Het
Fam184a	T	G	10: 53,697,248	K345N	probably damaging	Het
Fam228a	T	C	12: 4,715,686	R255G	probably benign	Het
Frem2	A	G	3: 53,654,900	Y729H	probably damaging	Het
Gm15448	T	C	7: 3,822,183	S487G		Het
Herc2	A	G	7: 56,182,429	T2989A	probably damaging	Het
Hspb8	A	G	5: 116,409,488	L145P	probably damaging	Het
Iars	T	A	13: 49,701,847	V250E	probably benign	Het
Ide	G	T	19: 37,296,162		probably benign	Het
Ino80c	T	C	18: 24,121,708	S32G	probably benign	Het
Insr	G	A	8: 3,258,413	R208W	probably damaging	Het
Ints1	G	A	5: 139,757,596	R1674W	probably benign	Het
Itsn1	G	A	16: 91,869,626	V1153M	unknown	Het
Krt1	AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC	AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC	15: 101,850,378		probably benign	Het
Lrrc41	C	A	4: 116,088,585	Q166K	possibly damaging	Het
Lrriq3	T	C	3: 155,114,546		probably null	Het
Mndal	T	C	1: 173,871,530	I190V	unknown	Het
Nisch	TCTGCTGC	TCTGCTGCTGC	14: 31,174,680		probably benign	Het
Nme4	G	T	17: 26,095,415	A13E	probably benign	Het
Olfr1468-ps1	G	T	19: 13,375,249	A96S	probably damaging	Het
Olfr292	C	A	7: 86,695,380	S308*	probably null	Het
Olfr410	A	G	11: 74,334,844	I129T	probably damaging	Het
Pcmt1	A	T	10: 7,644,443		probably benign	Het
Pde4c	G	T	8: 70,748,511	V493F	probably damaging	Het
Pde8a	C	T	7: 81,332,871	T746I	probably damaging	Het
Pkd1l3	GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA	GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA	8: 109,624,195		probably benign	Het
Prr23a1	T	C	9: 98,842,882	L99P		Het
Rex2	C	G	4: 147,058,186	T377S	probably benign	Het
Robo2	A	G	16: 73,906,850	F50L		Het
Srgap1	A	G	10: 122,047,222		probably benign	Het
Syt3	A	G	7: 44,393,367	N358D	possibly damaging	Het
Tfec	T	A	6: 16,835,327	T151S	probably damaging	Het
Tll1	A	T	8: 64,016,167	I974N	possibly damaging	Het
Tmc2	T	C	2: 130,232,401	V338A	probably benign	Het
Trappc6b	T	A	12: 59,050,374	D54V	probably damaging	Het
Trav6-2	T	A	14: 52,667,652	C43*	probably null	Het
Ubr4	T	A	4: 139,400,444		probably null	Het
Vmn1r2	T	A	4: 3,172,884	W268R	probably damaging	Het
Vmn2r120	A	G	17: 57,525,093	L232S	probably damaging	Het
Vps26b	T	C	9: 27,009,929	T325A	probably benign	Het
Vwa3a	T	C	7: 120,778,436	V438A	probably damaging	Het
Wdcp	C	A	12: 4,851,533	S463*	probably null	Het
Xkr4	C	T	1: 3,670,637	G238S	probably benign	Het
Zranb1	A	G	7: 132,950,157	N179S	probably benign	Het

Other mutations in Fpr-rs7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00332:Fpr-rs7	APN	17	20113218	nonsense	probably null
IGL01386:Fpr-rs7	APN	17	20114192	missense	probably damaging	0.98
IGL02293:Fpr-rs7	APN	17	20113970	missense	probably benign	0.01
IGL03303:Fpr-rs7	APN	17	20113739	missense	possibly damaging	0.55
R0731:Fpr-rs7	UTSW	17	20113854	missense	probably benign	0.00
R0826:Fpr-rs7	UTSW	17	20113626	missense	probably benign	0.01
R1439:Fpr-rs7	UTSW	17	20113607	missense	probably benign	0.10
R1590:Fpr-rs7	UTSW	17	20113416	missense	probably benign	0.05
R1778:Fpr-rs7	UTSW	17	20114015	missense	probably damaging	1.00
R4715:Fpr-rs7	UTSW	17	20113428	missense	probably benign	0.00
R4744:Fpr-rs7	UTSW	17	20114003	missense	probably benign	0.17
R4921:Fpr-rs7	UTSW	17	20113820	missense	possibly damaging	0.70
R5540:Fpr-rs7	UTSW	17	20114094	missense	probably damaging	1.00
R5677:Fpr-rs7	UTSW	17	20114103	missense	probably benign
R5959:Fpr-rs7	UTSW	17	20113749	missense	probably benign	0.01
R6042:Fpr-rs7	UTSW	17	20113215	missense	probably benign	0.00
R7921:Fpr-rs7	UTSW	17	20113405	missense	probably benign	0.03
R7984:Fpr-rs7	UTSW	17	20113409	missense	probably benign	0.01
R8137:Fpr-rs7	UTSW	17	20113793	missense	possibly damaging	0.49
R8172:Fpr-rs7	UTSW	17	20114181	missense	probably benign	0.04
R8762:Fpr-rs7	UTSW	17	20113527	missense	probably benign	0.07
Z1176:Fpr-rs7	UTSW	17	20113393	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- GCCCATACTGGATGCAGAAC -3'
(R):5'- TGCTGACAAAATGGAAGCCAAC -3'

Sequencing Primer
(F):5'- TACAGCGATCCATGGCAATG -3'
(R):5'- CTTCTCCATACCTCAGAATGGATCAG -3'

Posted On

2022-01-20