Incidental Mutation 'R9134:Nme4'
ID 693870
Institutional Source Beutler Lab
Gene Symbol Nme4
Ensembl Gene ENSMUSG00000024177
Gene Name NME/NM23 nucleoside diphosphate kinase 4
Synonyms 5730493H09Rik, 2610027N22Rik, 2810024O08Rik, non-metastatic cells 4, protein expressed in, NM23-M4
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9134 (G1)
Quality Score 199.009
Status Validated
Chromosome 17
Chromosomal Location 26310708-26314576 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 26314389 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Glutamic Acid at position 13 (A13E)
Ref Sequence ENSEMBL: ENSMUSP00000025007 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025007] [ENSMUST00000053575]
AlphaFold Q9WV84
Predicted Effect probably benign
Transcript: ENSMUST00000025007
AA Change: A13E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000025007
Gene: ENSMUSG00000024177
AA Change: A13E

DomainStartEndE-ValueType
NDK 36 173 4.09e-83 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000053575
SMART Domains Protein: ENSMUSP00000137416
Gene: ENSMUSG00000049124

DomainStartEndE-ValueType
Sm 7 72 3.7e-24 SMART
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 95% (54/57)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ap1m1 A G 8: 72,993,913 (GRCm39) probably benign Het
Arhgdia A T 11: 120,470,392 (GRCm39) I122N probably damaging Het
Atad2b T A 12: 5,060,351 (GRCm39) H915Q probably benign Het
Atad5 G A 11: 80,023,931 (GRCm39) R1681K probably benign Het
Bpifb9b T C 2: 154,151,441 (GRCm39) V54A probably benign Het
Cby3 A C 11: 50,250,153 (GRCm39) T25P probably damaging Het
Ccdc138 T G 10: 58,374,102 (GRCm39) L374R probably damaging Het
Cd84 T A 1: 171,679,413 (GRCm39) N30K probably damaging Het
Cdk20 T A 13: 64,580,906 (GRCm39) probably null Het
Chd9 A G 8: 91,659,754 (GRCm39) H238R unknown Het
Cplane1 T C 15: 8,228,716 (GRCm39) V929A probably damaging Het
Csl T A 10: 99,594,237 (GRCm39) H276L probably damaging Het
Dchs1 A G 7: 105,404,910 (GRCm39) L2544P probably damaging Het
Dnah17 T C 11: 117,978,972 (GRCm39) T1807A probably damaging Het
Dph7 C T 2: 24,861,720 (GRCm39) H378Y probably benign Het
Enkur T C 2: 21,185,779 (GRCm39) I249V probably benign Het
Fam117a C A 11: 95,271,745 (GRCm39) S439* probably null Het
Fam184a T G 10: 53,573,344 (GRCm39) K345N probably damaging Het
Fam228a T C 12: 4,765,686 (GRCm39) R255G probably benign Het
Fpr-rs7 A T 17: 20,334,325 (GRCm39) M55K probably damaging Het
Frem2 A G 3: 53,562,321 (GRCm39) Y729H probably damaging Het
Herc2 A G 7: 55,832,177 (GRCm39) T2989A probably damaging Het
Hspb8 A G 5: 116,547,547 (GRCm39) L145P probably damaging Het
Iars1 T A 13: 49,855,323 (GRCm39) V250E probably benign Het
Ide G T 19: 37,273,561 (GRCm39) probably benign Het
Ino80c T C 18: 24,254,765 (GRCm39) S32G probably benign Het
Insr G A 8: 3,308,413 (GRCm39) R208W probably damaging Het
Ints1 G A 5: 139,743,351 (GRCm39) R1674W probably benign Het
Itsn1 G A 16: 91,666,514 (GRCm39) V1153M unknown Het
Krt1 AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC 15: 101,758,813 (GRCm39) probably benign Het
Lrrc41 C A 4: 115,945,782 (GRCm39) Q166K possibly damaging Het
Lrriq3 T C 3: 154,820,183 (GRCm39) probably null Het
Mndal T C 1: 173,699,096 (GRCm39) I190V unknown Het
Nisch TCTGCTGC TCTGCTGCTGC 14: 30,896,637 (GRCm39) probably benign Het
Or14c39 C A 7: 86,344,588 (GRCm39) S308* probably null Het
Or3a1 A G 11: 74,225,670 (GRCm39) I129T probably damaging Het
Or5b114-ps1 G T 19: 13,352,613 (GRCm39) A96S probably damaging Het
Pcmt1 A T 10: 7,520,207 (GRCm39) probably benign Het
Pde4c G T 8: 71,201,160 (GRCm39) V493F probably damaging Het
Pde8a C T 7: 80,982,619 (GRCm39) T746I probably damaging Het
Pira13 T C 7: 3,825,182 (GRCm39) S487G Het
Pkd1l3 GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA 8: 110,350,827 (GRCm39) probably benign Het
Prr23a1 T C 9: 98,724,935 (GRCm39) L99P Het
Rex2 C G 4: 147,142,643 (GRCm39) T377S probably benign Het
Robo2 A G 16: 73,703,738 (GRCm39) F50L Het
Srgap1 A G 10: 121,883,127 (GRCm39) probably benign Het
Syt3 A G 7: 44,042,791 (GRCm39) N358D possibly damaging Het
Tfec T A 6: 16,835,326 (GRCm39) T151S probably damaging Het
Tll1 A T 8: 64,469,201 (GRCm39) I974N possibly damaging Het
Tmc2 T C 2: 130,074,321 (GRCm39) V338A probably benign Het
Trappc6b T A 12: 59,097,160 (GRCm39) D54V probably damaging Het
Trav6-2 T A 14: 52,905,109 (GRCm39) C43* probably null Het
Ubr4 T A 4: 139,127,755 (GRCm39) probably null Het
Vmn1r2 T A 4: 3,172,884 (GRCm39) W268R probably damaging Het
Vmn2r120 A G 17: 57,832,093 (GRCm39) L232S probably damaging Het
Vps26b T C 9: 26,921,225 (GRCm39) T325A probably benign Het
Vwa3a T C 7: 120,377,659 (GRCm39) V438A probably damaging Het
Wdcp C A 12: 4,901,533 (GRCm39) S463* probably null Het
Xkr4 C T 1: 3,740,860 (GRCm39) G238S probably benign Het
Zranb1 A G 7: 132,551,886 (GRCm39) N179S probably benign Het
Other mutations in Nme4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01455:Nme4 APN 17 26,311,036 (GRCm39) missense probably benign 0.00
IGL01725:Nme4 APN 17 26,311,040 (GRCm39) missense probably benign 0.05
IGL02217:Nme4 APN 17 26,312,834 (GRCm39) missense probably damaging 0.99
R0153:Nme4 UTSW 17 26,312,831 (GRCm39) critical splice donor site probably null
R1839:Nme4 UTSW 17 26,311,071 (GRCm39) missense probably damaging 1.00
R2205:Nme4 UTSW 17 26,311,114 (GRCm39) missense possibly damaging 0.95
R4027:Nme4 UTSW 17 26,313,196 (GRCm39) splice site probably null
R4029:Nme4 UTSW 17 26,313,196 (GRCm39) splice site probably null
R5023:Nme4 UTSW 17 26,312,642 (GRCm39) missense probably benign 0.11
R5044:Nme4 UTSW 17 26,312,807 (GRCm39) unclassified probably benign
R5635:Nme4 UTSW 17 26,313,205 (GRCm39) missense probably damaging 1.00
R7873:Nme4 UTSW 17 26,312,862 (GRCm39) missense probably damaging 1.00
R9133:Nme4 UTSW 17 26,314,389 (GRCm39) missense probably benign
R9168:Nme4 UTSW 17 26,314,389 (GRCm39) missense probably benign
R9170:Nme4 UTSW 17 26,314,389 (GRCm39) missense probably benign
R9776:Nme4 UTSW 17 26,314,410 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- ATAGCGTCTGGTAGTCTCCC -3'
(R):5'- GAAGGCTATCAGCTCCAGAAGAC -3'

Sequencing Primer
(F):5'- ACTGCTAAAAGCTCTGTCCCGG -3'
(R):5'- TATCAGCTCCAGAAGACAAGAATGTG -3'
Posted On 2022-01-20