Incidental Mutation 'R9135:Asxl3'
| ID |
693980 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Asxl3
|
| Ensembl Gene |
ENSMUSG00000045215 |
| Gene Name |
ASXL transcriptional regulator 3 |
| Synonyms |
D430002O22Rik, C230079D11Rik, LOC381127, D930044O18Rik |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.339)
|
| Stock # |
R9135 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
22477303-22663284 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 22657481 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 1830
(N1830K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000095260
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000097655]
[ENSMUST00000120223]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000097655
AA Change: N1830K
PolyPhen 2
Score 0.888 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000095260
Gene: ENSMUSG00000045215
AA Change: N1830K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
98 |
112 |
N/A |
INTRINSIC |
|
Pfam:ASXH
|
173 |
305 |
5.6e-50 |
PFAM |
|
low complexity region
|
391 |
404 |
N/A |
INTRINSIC |
|
low complexity region
|
667 |
686 |
N/A |
INTRINSIC |
|
low complexity region
|
939 |
954 |
N/A |
INTRINSIC |
|
low complexity region
|
978 |
988 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1023 |
N/A |
INTRINSIC |
|
low complexity region
|
1160 |
1168 |
N/A |
INTRINSIC |
|
low complexity region
|
1424 |
1436 |
N/A |
INTRINSIC |
|
low complexity region
|
1681 |
1691 |
N/A |
INTRINSIC |
|
SCOP:d1dnpa2
|
1946 |
1995 |
6e-3 |
SMART |
|
low complexity region
|
2035 |
2050 |
N/A |
INTRINSIC |
|
Pfam:PHD_3
|
2139 |
2202 |
9.8e-28 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000120223
AA Change: N1830K
PolyPhen 2
Score 0.888 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000112793
Gene: ENSMUSG00000045215
AA Change: N1830K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
98 |
112 |
N/A |
INTRINSIC |
|
Pfam:ASXH
|
179 |
304 |
1.3e-36 |
PFAM |
|
low complexity region
|
391 |
404 |
N/A |
INTRINSIC |
|
low complexity region
|
667 |
686 |
N/A |
INTRINSIC |
|
low complexity region
|
939 |
954 |
N/A |
INTRINSIC |
|
low complexity region
|
978 |
988 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1023 |
N/A |
INTRINSIC |
|
low complexity region
|
1160 |
1168 |
N/A |
INTRINSIC |
|
low complexity region
|
1424 |
1436 |
N/A |
INTRINSIC |
|
low complexity region
|
1681 |
1691 |
N/A |
INTRINSIC |
|
SCOP:d1dnpa2
|
1946 |
1995 |
6e-3 |
SMART |
|
low complexity region
|
2035 |
2050 |
N/A |
INTRINSIC |
|
Pfam:PHD_3
|
2138 |
2202 |
1.9e-24 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 115 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb9 |
T |
C |
5: 124,228,176 (GRCm39) |
T22A |
possibly damaging |
Het |
| Abi3bp |
A |
G |
16: 56,417,173 (GRCm39) |
D419G |
probably benign |
Het |
| Acoxl |
A |
T |
2: 127,696,691 (GRCm39) |
|
probably benign |
Het |
| Acvr1 |
T |
C |
2: 58,352,983 (GRCm39) |
T326A |
possibly damaging |
Het |
| Adgra2 |
T |
C |
8: 27,610,979 (GRCm39) |
L976P |
probably damaging |
Het |
| Adora2b |
A |
G |
11: 62,155,886 (GRCm39) |
|
probably null |
Het |
| Ak1 |
A |
T |
2: 32,521,182 (GRCm39) |
Q117L |
probably damaging |
Het |
| Akr1c14 |
T |
A |
13: 4,128,029 (GRCm39) |
D143E |
probably damaging |
Het |
| Ap4e1 |
A |
T |
2: 126,861,242 (GRCm39) |
H127L |
probably damaging |
Het |
| Atp11a |
G |
A |
8: 12,863,144 (GRCm39) |
A108T |
probably damaging |
Het |
| Bag6 |
A |
G |
17: 35,362,437 (GRCm39) |
T582A |
unknown |
Het |
| Bbs9 |
T |
C |
9: 22,490,005 (GRCm39) |
S259P |
probably damaging |
Het |
| Bean1 |
CT |
C |
8: 104,908,664 (GRCm39) |
|
probably null |
Het |
| Bltp3a |
T |
A |
17: 28,104,902 (GRCm39) |
L532* |
probably null |
Het |
| Blvrb |
T |
C |
7: 27,165,210 (GRCm39) |
S177P |
probably damaging |
Het |
| C1s2 |
T |
A |
6: 124,602,642 (GRCm39) |
D523V |
probably benign |
Het |
| Cacna2d1 |
C |
T |
5: 16,558,850 (GRCm39) |
T736I |
probably damaging |
Het |
| Card9 |
T |
C |
2: 26,242,397 (GRCm39) |
N513S |
probably benign |
Het |
| Casp2 |
A |
G |
6: 42,245,882 (GRCm39) |
T180A |
probably benign |
Het |
| Cenpf |
A |
T |
1: 189,404,746 (GRCm39) |
L361Q |
probably damaging |
Het |
| Cnbd2 |
T |
C |
2: 156,217,488 (GRCm39) |
I659T |
probably damaging |
Het |
| Cped1 |
A |
T |
6: 21,987,012 (GRCm39) |
D68V |
probably damaging |
Het |
| Cxcr1 |
T |
C |
1: 74,231,099 (GRCm39) |
I308V |
probably benign |
Het |
| Dad1 |
A |
G |
14: 54,491,163 (GRCm39) |
L46P |
probably damaging |
Het |
| Defb23 |
G |
A |
2: 152,301,422 (GRCm39) |
A50V |
probably benign |
Het |
| Dhx33 |
C |
T |
11: 70,877,992 (GRCm39) |
A684T |
probably damaging |
Het |
| Dnai3 |
T |
C |
3: 145,772,589 (GRCm39) |
T486A |
probably benign |
Het |
| Epb41l4a |
T |
A |
18: 33,965,729 (GRCm39) |
N366I |
probably benign |
Het |
| Erich3 |
A |
G |
3: 154,467,912 (GRCm39) |
E788G |
|
Het |
| Fam241b |
T |
C |
10: 61,944,892 (GRCm39) |
N35S |
probably benign |
Het |
| Fbxo24 |
T |
A |
5: 137,622,526 (GRCm39) |
Q80L |
probably benign |
Het |
| Foxk1 |
T |
G |
5: 142,434,497 (GRCm39) |
F254V |
probably benign |
Het |
| Gm10801 |
C |
CGTG |
2: 98,494,152 (GRCm39) |
|
probably null |
Het |
| Gm12886 |
T |
C |
4: 121,274,743 (GRCm39) |
I46V |
probably benign |
Het |
| Gm20834 |
G |
T |
Y: 10,323,354 (GRCm39) |
H27Q |
probably damaging |
Het |
| Gm2888 |
A |
G |
14: 3,032,106 (GRCm38) |
N138S |
probably damaging |
Het |
| Gm5773 |
T |
C |
3: 93,681,179 (GRCm39) |
C284R |
possibly damaging |
Het |
| Gprin3 |
A |
T |
6: 59,330,273 (GRCm39) |
M678K |
probably benign |
Het |
| Grm7 |
T |
C |
6: 111,472,729 (GRCm39) |
V856A |
probably benign |
Het |
| Il18rap |
C |
T |
1: 40,582,177 (GRCm39) |
T366M |
probably benign |
Het |
| Immt |
C |
T |
6: 71,851,403 (GRCm39) |
T588I |
probably damaging |
Het |
| Ints1 |
G |
C |
5: 139,737,701 (GRCm39) |
N2145K |
possibly damaging |
Het |
| Jade2 |
T |
C |
11: 51,715,951 (GRCm39) |
D418G |
probably benign |
Het |
| Kdf1 |
T |
C |
4: 133,256,140 (GRCm39) |
Y286H |
probably damaging |
Het |
| Kif18a |
A |
G |
2: 109,171,506 (GRCm39) |
Y861C |
possibly damaging |
Het |
| Lama2 |
T |
A |
10: 27,298,515 (GRCm39) |
I194F |
probably damaging |
Het |
| Lhx8 |
A |
G |
3: 154,034,063 (GRCm39) |
S33P |
probably benign |
Het |
| Lmo7 |
T |
C |
14: 102,118,297 (GRCm39) |
I174T |
probably damaging |
Het |
| Lrfn2 |
A |
T |
17: 49,376,976 (GRCm39) |
D19V |
possibly damaging |
Het |
| Lrrk1 |
A |
T |
7: 65,928,357 (GRCm39) |
I1257N |
probably damaging |
Het |
| Malrd1 |
T |
A |
2: 15,802,516 (GRCm39) |
H1076Q |
unknown |
Het |
| Map3k14 |
A |
C |
11: 103,128,364 (GRCm39) |
M419R |
probably damaging |
Het |
| Mcm10 |
G |
A |
2: 5,011,372 (GRCm39) |
R200C |
probably benign |
Het |
| Mertk |
A |
G |
2: 128,604,035 (GRCm39) |
N390D |
probably benign |
Het |
| Mitf |
T |
A |
6: 97,990,680 (GRCm39) |
I361N |
probably damaging |
Het |
| Mrgprb1 |
T |
A |
7: 48,097,046 (GRCm39) |
I289F |
possibly damaging |
Het |
| Muc5ac |
A |
T |
7: 141,352,218 (GRCm39) |
D659V |
probably damaging |
Het |
| Nox4 |
G |
A |
7: 87,025,448 (GRCm39) |
R525Q |
probably benign |
Het |
| Nphp3 |
T |
G |
9: 103,909,214 (GRCm39) |
L808R |
probably damaging |
Het |
| Or14c42-ps1 |
G |
A |
7: 86,211,156 (GRCm39) |
C72Y |
unknown |
Het |
| Or1e1 |
T |
C |
11: 73,245,316 (GRCm39) |
S246P |
probably damaging |
Het |
| Or5an1 |
T |
A |
19: 12,260,808 (GRCm39) |
L132Q |
probably damaging |
Het |
| Or5b113 |
T |
A |
19: 13,342,755 (GRCm39) |
S254R |
possibly damaging |
Het |
| Pagr1a |
T |
C |
7: 126,615,954 (GRCm39) |
E47G |
probably benign |
Het |
| Papss2 |
G |
T |
19: 32,618,764 (GRCm39) |
R274L |
probably damaging |
Het |
| Pcdhga10 |
C |
A |
18: 37,880,960 (GRCm39) |
F240L |
probably damaging |
Het |
| Pcsk5 |
T |
G |
19: 17,563,472 (GRCm39) |
E555A |
|
Het |
| Peg10 |
C |
CTCA |
6: 4,756,453 (GRCm39) |
|
probably benign |
Het |
| Pgrmc2 |
T |
A |
3: 41,023,099 (GRCm39) |
D206V |
probably damaging |
Het |
| Pkd1 |
T |
C |
17: 24,790,976 (GRCm39) |
V1057A |
|
Het |
| Plekha5 |
T |
C |
6: 140,480,239 (GRCm39) |
I113T |
probably damaging |
Het |
| Prorp |
T |
A |
12: 55,426,189 (GRCm39) |
L513Q |
probably damaging |
Het |
| Prss32 |
C |
T |
17: 24,078,199 (GRCm39) |
T295I |
possibly damaging |
Het |
| Ptprk |
G |
T |
10: 28,456,413 (GRCm39) |
V1072F |
probably damaging |
Het |
| Rasd2 |
T |
A |
8: 75,945,174 (GRCm39) |
M1K |
probably null |
Het |
| Rhag |
T |
A |
17: 41,139,302 (GRCm39) |
M79K |
probably damaging |
Het |
| Rnf19a |
C |
A |
15: 36,253,310 (GRCm39) |
|
probably null |
Het |
| Rnf213 |
G |
T |
11: 119,299,573 (GRCm39) |
G101C |
|
Het |
| Sap130 |
T |
A |
18: 31,780,116 (GRCm39) |
D45E |
probably benign |
Het |
| Scel |
T |
A |
14: 103,839,626 (GRCm39) |
F510I |
probably benign |
Het |
| Sertad2 |
A |
T |
11: 20,598,425 (GRCm39) |
E207V |
probably benign |
Het |
| Shoc2 |
T |
A |
19: 53,976,310 (GRCm39) |
S67T |
probably benign |
Het |
| Slc22a3 |
T |
C |
17: 12,645,619 (GRCm39) |
I441V |
possibly damaging |
Het |
| Slfn5 |
A |
G |
11: 82,851,503 (GRCm39) |
D600G |
probably benign |
Het |
| Smim7 |
G |
A |
8: 73,324,757 (GRCm39) |
T10M |
probably damaging |
Het |
| Sntb2 |
A |
T |
8: 107,662,831 (GRCm39) |
Q133L |
possibly damaging |
Het |
| Steap3 |
A |
C |
1: 120,162,048 (GRCm39) |
M408R |
probably benign |
Het |
| Supt4a |
T |
C |
11: 87,633,624 (GRCm39) |
I60T |
probably benign |
Het |
| Swt1 |
A |
C |
1: 151,244,239 (GRCm39) |
C899G |
possibly damaging |
Het |
| Taok3 |
A |
G |
5: 117,344,744 (GRCm39) |
E157G |
probably damaging |
Het |
| Taok3 |
C |
T |
5: 117,379,245 (GRCm39) |
L427F |
possibly damaging |
Het |
| Taok3 |
T |
C |
5: 117,379,168 (GRCm39) |
V401A |
probably benign |
Het |
| Tcf25 |
A |
G |
8: 124,108,182 (GRCm39) |
E79G |
probably benign |
Het |
| Tigit |
G |
A |
16: 43,479,876 (GRCm39) |
L140F |
possibly damaging |
Het |
| Tmem143 |
G |
T |
7: 45,546,802 (GRCm39) |
|
probably benign |
Het |
| Tmem151b |
C |
T |
17: 45,856,355 (GRCm39) |
V362M |
possibly damaging |
Het |
| Tmem230 |
A |
G |
2: 132,085,989 (GRCm39) |
F58L |
probably benign |
Het |
| Trim25 |
T |
C |
11: 88,899,988 (GRCm39) |
M245T |
probably benign |
Het |
| Trim36 |
A |
C |
18: 46,302,410 (GRCm39) |
V546G |
probably benign |
Het |
| Triml1 |
T |
C |
8: 43,583,624 (GRCm39) |
N326D |
probably damaging |
Het |
| Trp53bp2 |
T |
C |
1: 182,286,328 (GRCm39) |
V1056A |
probably damaging |
Het |
| Trpa1 |
C |
A |
1: 14,952,435 (GRCm39) |
M865I |
probably damaging |
Het |
| Ttbk1 |
A |
T |
17: 46,790,132 (GRCm39) |
Y104* |
probably null |
Het |
| Tubg1 |
T |
A |
11: 101,014,257 (GRCm39) |
H139Q |
probably damaging |
Het |
| Ufsp2 |
A |
G |
8: 46,447,050 (GRCm39) |
|
probably null |
Het |
| Usp47 |
A |
T |
7: 111,652,431 (GRCm39) |
N36I |
probably benign |
Het |
| Vmn1r32 |
G |
A |
6: 66,530,120 (GRCm39) |
R219* |
probably null |
Het |
| Vmn2r59 |
G |
A |
7: 41,693,125 (GRCm39) |
P492S |
probably benign |
Het |
| Vmn2r59 |
G |
C |
7: 41,693,127 (GRCm39) |
A491G |
|
Het |
| Wdr76 |
T |
C |
2: 121,364,592 (GRCm39) |
Y299H |
probably damaging |
Het |
| Wnt5a |
C |
T |
14: 28,240,309 (GRCm39) |
A153V |
probably benign |
Het |
| Zfp202 |
T |
C |
9: 40,120,237 (GRCm39) |
V226A |
possibly damaging |
Het |
| Zfp219 |
C |
T |
14: 52,244,598 (GRCm39) |
R527H |
probably damaging |
Het |
| Zfp408 |
A |
T |
2: 91,475,528 (GRCm39) |
L542H |
probably damaging |
Het |
| Zfyve9 |
A |
T |
4: 108,539,386 (GRCm39) |
C271* |
probably null |
Het |
|
| Other mutations in Asxl3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00429:Asxl3
|
APN |
18 |
22,658,280 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL00510:Asxl3
|
APN |
18 |
22,656,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00864:Asxl3
|
APN |
18 |
22,655,503 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01074:Asxl3
|
APN |
18 |
22,655,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01305:Asxl3
|
APN |
18 |
22,649,503 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01313:Asxl3
|
APN |
18 |
22,650,516 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL01349:Asxl3
|
APN |
18 |
22,657,294 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL01529:Asxl3
|
APN |
18 |
22,650,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01574:Asxl3
|
APN |
18 |
22,656,621 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01583:Asxl3
|
APN |
18 |
22,649,654 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01619:Asxl3
|
APN |
18 |
22,656,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01720:Asxl3
|
APN |
18 |
22,658,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01816:Asxl3
|
APN |
18 |
22,655,545 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL01828:Asxl3
|
APN |
18 |
22,658,615 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL01903:Asxl3
|
APN |
18 |
22,567,633 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01906:Asxl3
|
APN |
18 |
22,655,338 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01962:Asxl3
|
APN |
18 |
22,655,502 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01991:Asxl3
|
APN |
18 |
22,649,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02064:Asxl3
|
APN |
18 |
22,657,401 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02187:Asxl3
|
APN |
18 |
22,658,035 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02219:Asxl3
|
APN |
18 |
22,586,683 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02309:Asxl3
|
APN |
18 |
22,655,510 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02478:Asxl3
|
APN |
18 |
22,656,070 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02506:Asxl3
|
APN |
18 |
22,585,456 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02660:Asxl3
|
APN |
18 |
22,657,402 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02828:Asxl3
|
APN |
18 |
22,657,718 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02863:Asxl3
|
APN |
18 |
22,656,541 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03001:Asxl3
|
APN |
18 |
22,650,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03143:Asxl3
|
APN |
18 |
22,656,031 (GRCm39) |
missense |
probably benign |
0.43 |
|
ANU22:Asxl3
|
UTSW |
18 |
22,649,503 (GRCm39) |
missense |
probably benign |
0.06 |
|
BB001:Asxl3
|
UTSW |
18 |
22,658,602 (GRCm39) |
missense |
probably damaging |
0.98 |
|
BB011:Asxl3
|
UTSW |
18 |
22,658,602 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0145:Asxl3
|
UTSW |
18 |
22,586,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0201:Asxl3
|
UTSW |
18 |
22,656,211 (GRCm39) |
missense |
probably benign |
|
|
R0207:Asxl3
|
UTSW |
18 |
22,544,553 (GRCm39) |
splice site |
probably benign |
|
|
R0230:Asxl3
|
UTSW |
18 |
22,585,383 (GRCm39) |
splice site |
probably benign |
|
|
R0242:Asxl3
|
UTSW |
18 |
22,649,738 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0242:Asxl3
|
UTSW |
18 |
22,649,738 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0344:Asxl3
|
UTSW |
18 |
22,650,668 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0519:Asxl3
|
UTSW |
18 |
22,656,577 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0520:Asxl3
|
UTSW |
18 |
22,656,043 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0548:Asxl3
|
UTSW |
18 |
22,654,849 (GRCm39) |
splice site |
probably benign |
|
|
R0626:Asxl3
|
UTSW |
18 |
22,655,937 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0711:Asxl3
|
UTSW |
18 |
22,657,508 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0744:Asxl3
|
UTSW |
18 |
22,649,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0833:Asxl3
|
UTSW |
18 |
22,649,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1035:Asxl3
|
UTSW |
18 |
22,658,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1170:Asxl3
|
UTSW |
18 |
22,657,564 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1372:Asxl3
|
UTSW |
18 |
22,543,066 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1440:Asxl3
|
UTSW |
18 |
22,658,281 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1463:Asxl3
|
UTSW |
18 |
22,649,810 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1471:Asxl3
|
UTSW |
18 |
22,649,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1618:Asxl3
|
UTSW |
18 |
22,650,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1720:Asxl3
|
UTSW |
18 |
22,585,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1819:Asxl3
|
UTSW |
18 |
22,655,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1824:Asxl3
|
UTSW |
18 |
22,655,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1851:Asxl3
|
UTSW |
18 |
22,650,796 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1989:Asxl3
|
UTSW |
18 |
22,585,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2041:Asxl3
|
UTSW |
18 |
22,656,508 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2174:Asxl3
|
UTSW |
18 |
22,586,701 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R2175:Asxl3
|
UTSW |
18 |
22,649,652 (GRCm39) |
missense |
probably benign |
|
|
R2443:Asxl3
|
UTSW |
18 |
22,544,596 (GRCm39) |
missense |
probably benign |
0.12 |
|
R2907:Asxl3
|
UTSW |
18 |
22,650,330 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R4246:Asxl3
|
UTSW |
18 |
22,658,557 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4254:Asxl3
|
UTSW |
18 |
22,657,423 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R4441:Asxl3
|
UTSW |
18 |
22,657,290 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4660:Asxl3
|
UTSW |
18 |
22,649,534 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4661:Asxl3
|
UTSW |
18 |
22,649,534 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4674:Asxl3
|
UTSW |
18 |
22,650,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4749:Asxl3
|
UTSW |
18 |
22,649,826 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4817:Asxl3
|
UTSW |
18 |
22,658,511 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4935:Asxl3
|
UTSW |
18 |
22,656,369 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5062:Asxl3
|
UTSW |
18 |
22,655,775 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5064:Asxl3
|
UTSW |
18 |
22,649,076 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5065:Asxl3
|
UTSW |
18 |
22,658,356 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5066:Asxl3
|
UTSW |
18 |
22,658,356 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5067:Asxl3
|
UTSW |
18 |
22,658,356 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5133:Asxl3
|
UTSW |
18 |
22,649,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5174:Asxl3
|
UTSW |
18 |
22,656,172 (GRCm39) |
missense |
probably benign |
0.45 |
|
R5183:Asxl3
|
UTSW |
18 |
22,658,356 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5294:Asxl3
|
UTSW |
18 |
22,649,496 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R5416:Asxl3
|
UTSW |
18 |
22,657,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5587:Asxl3
|
UTSW |
18 |
22,658,304 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5873:Asxl3
|
UTSW |
18 |
22,649,142 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6240:Asxl3
|
UTSW |
18 |
22,598,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6242:Asxl3
|
UTSW |
18 |
22,655,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6316:Asxl3
|
UTSW |
18 |
22,655,839 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6348:Asxl3
|
UTSW |
18 |
22,650,330 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6518:Asxl3
|
UTSW |
18 |
22,649,397 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6605:Asxl3
|
UTSW |
18 |
22,650,134 (GRCm39) |
nonsense |
probably null |
|
|
R6704:Asxl3
|
UTSW |
18 |
22,650,362 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6706:Asxl3
|
UTSW |
18 |
22,586,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6786:Asxl3
|
UTSW |
18 |
22,658,497 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6799:Asxl3
|
UTSW |
18 |
22,598,457 (GRCm39) |
nonsense |
probably null |
|
|
R6811:Asxl3
|
UTSW |
18 |
22,655,968 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6817:Asxl3
|
UTSW |
18 |
22,656,637 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6830:Asxl3
|
UTSW |
18 |
22,658,445 (GRCm39) |
missense |
probably benign |
0.45 |
|
R6957:Asxl3
|
UTSW |
18 |
22,655,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7015:Asxl3
|
UTSW |
18 |
22,656,978 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7058:Asxl3
|
UTSW |
18 |
22,650,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7135:Asxl3
|
UTSW |
18 |
22,650,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7135:Asxl3
|
UTSW |
18 |
22,650,758 (GRCm39) |
nonsense |
probably null |
|
|
R7231:Asxl3
|
UTSW |
18 |
22,650,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7231:Asxl3
|
UTSW |
18 |
22,544,556 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7431:Asxl3
|
UTSW |
18 |
22,650,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7851:Asxl3
|
UTSW |
18 |
22,650,279 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R7871:Asxl3
|
UTSW |
18 |
22,657,281 (GRCm39) |
missense |
not run |
|
|
R7880:Asxl3
|
UTSW |
18 |
22,655,208 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7924:Asxl3
|
UTSW |
18 |
22,658,602 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8061:Asxl3
|
UTSW |
18 |
22,657,300 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R8115:Asxl3
|
UTSW |
18 |
22,650,642 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8174:Asxl3
|
UTSW |
18 |
22,650,800 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8303:Asxl3
|
UTSW |
18 |
22,657,473 (GRCm39) |
missense |
probably benign |
|
|
R8360:Asxl3
|
UTSW |
18 |
22,649,174 (GRCm39) |
missense |
probably benign |
|
|
R8547:Asxl3
|
UTSW |
18 |
22,655,829 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8699:Asxl3
|
UTSW |
18 |
22,567,664 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8774:Asxl3
|
UTSW |
18 |
22,657,101 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8774-TAIL:Asxl3
|
UTSW |
18 |
22,657,101 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8867:Asxl3
|
UTSW |
18 |
22,649,547 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8915:Asxl3
|
UTSW |
18 |
22,657,763 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8954:Asxl3
|
UTSW |
18 |
22,650,807 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9031:Asxl3
|
UTSW |
18 |
22,657,401 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9047:Asxl3
|
UTSW |
18 |
22,585,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9047:Asxl3
|
UTSW |
18 |
22,585,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9135:Asxl3
|
UTSW |
18 |
22,649,670 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9210:Asxl3
|
UTSW |
18 |
22,655,389 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9212:Asxl3
|
UTSW |
18 |
22,655,389 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9285:Asxl3
|
UTSW |
18 |
22,654,989 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9572:Asxl3
|
UTSW |
18 |
22,649,112 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9707:Asxl3
|
UTSW |
18 |
22,656,304 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9768:Asxl3
|
UTSW |
18 |
22,650,101 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9784:Asxl3
|
UTSW |
18 |
22,650,311 (GRCm39) |
missense |
probably benign |
|
|
Z1088:Asxl3
|
UTSW |
18 |
22,649,829 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Asxl3
|
UTSW |
18 |
22,655,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Asxl3
|
UTSW |
18 |
22,656,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Asxl3
|
UTSW |
18 |
22,649,396 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAAATGCCATCCAGCTCTCC -3'
(R):5'- TGGGCATTTGGTAGAACTGC -3'
Sequencing Primer
(F):5'- CTATTTGGCAGGGACTCTAGCAC -3'
(R):5'- AGAACTGCTGTCTATGTGAGGTACC -3'
|
| Posted On |
2022-01-20 |
Incidental Mutation