Incidental Mutation 'R9139:Vmn2r6'
| ID |
694195 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r6
|
| Ensembl Gene |
ENSMUSG00000090581 |
| Gene Name |
vomeronasal 2, receptor 6 |
| Synonyms |
EG620718, EG667069 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.184)
|
| Stock # |
R9139 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
64537561-64565298 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 64556856 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 186
(S186P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135148
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165012]
[ENSMUST00000176481]
|
| AlphaFold |
H3BK29 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165012
AA Change: S97P
PolyPhen 2
Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000131831
Gene: ENSMUSG00000090581
AA Change: S97P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
1 |
416 |
1.4e-72 |
PFAM |
|
Pfam:Peripla_BP_6
|
58 |
244 |
1.2e-10 |
PFAM |
|
Pfam:NCD3G
|
458 |
511 |
1.8e-17 |
PFAM |
|
Pfam:7tm_3
|
542 |
779 |
3.9e-76 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176481
AA Change: S186P
PolyPhen 2
Score 0.124 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000135148
Gene: ENSMUSG00000090581
AA Change: S186P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
88 |
505 |
9.8e-77 |
PFAM |
|
Pfam:Peripla_BP_6
|
142 |
331 |
3.4e-10 |
PFAM |
|
Pfam:NCD3G
|
547 |
600 |
5.4e-17 |
PFAM |
|
Pfam:7tm_3
|
633 |
867 |
3.9e-47 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 65 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aamp |
A |
G |
1: 74,281,546 (GRCm38) |
V288A |
possibly damaging |
Het |
| Ankhd1 |
T |
A |
18: 36,578,757 (GRCm38) |
S135R |
|
Het |
| Axl |
G |
A |
7: 25,761,421 (GRCm38) |
T721I |
probably damaging |
Het |
| Blnk |
G |
A |
19: 40,934,518 (GRCm38) |
A388V |
probably benign |
Het |
| C8b |
T |
C |
4: 104,784,434 (GRCm38) |
V189A |
probably damaging |
Het |
| Ccdc33 |
G |
C |
9: 58,076,559 (GRCm38) |
I452M |
probably benign |
Het |
| Cfap57 |
T |
C |
4: 118,554,851 (GRCm38) |
T1199A |
probably benign |
Het |
| Chga |
G |
A |
12: 102,561,885 (GRCm38) |
V212M |
probably benign |
Het |
| Cspp1 |
T |
A |
1: 10,116,650 (GRCm38) |
M887K |
probably damaging |
Het |
| Cyp3a16 |
G |
C |
5: 145,469,624 (GRCm38) |
A6G |
unknown |
Het |
| Cyp4f17 |
G |
T |
17: 32,524,894 (GRCm38) |
E349* |
probably null |
Het |
| Dnajc13 |
A |
T |
9: 104,207,840 (GRCm38) |
D791E |
probably benign |
Het |
| Dpysl5 |
T |
C |
5: 30,778,053 (GRCm38) |
Y167H |
probably benign |
Het |
| Dqx1 |
G |
T |
6: 83,059,778 (GRCm38) |
Q254H |
possibly damaging |
Het |
| Eef1g |
A |
G |
19: 8,978,019 (GRCm38) |
T411A |
probably benign |
Het |
| Fancl |
C |
A |
11: 26,387,231 (GRCm38) |
A6E |
probably benign |
Het |
| Gabrr3 |
A |
G |
16: 59,407,467 (GRCm38) |
Q29R |
probably benign |
Het |
| Gtf2h2 |
A |
C |
13: 100,481,270 (GRCm38) |
L168R |
probably damaging |
Het |
| Hacl1 |
T |
A |
14: 31,616,381 (GRCm38) |
Q413L |
probably benign |
Het |
| Hdc |
A |
T |
2: 126,597,917 (GRCm38) |
V372E |
probably damaging |
Het |
| Hr |
A |
T |
14: 70,557,639 (GRCm38) |
H208L |
possibly damaging |
Het |
| Htr6 |
T |
C |
4: 139,062,190 (GRCm38) |
R255G |
possibly damaging |
Het |
| Jup |
C |
T |
11: 100,379,565 (GRCm38) |
C372Y |
probably damaging |
Het |
| Kank2 |
A |
G |
9: 21,770,074 (GRCm38) |
V747A |
probably damaging |
Het |
| Kif5c |
A |
G |
2: 49,730,279 (GRCm38) |
T508A |
probably benign |
Het |
| Klhdc8b |
A |
G |
9: 108,449,728 (GRCm38) |
V145A |
probably damaging |
Het |
| Klk1b21 |
T |
A |
7: 44,105,500 (GRCm38) |
V73D |
probably damaging |
Het |
| Ksr1 |
T |
A |
11: 79,020,746 (GRCm38) |
M737L |
probably benign |
Het |
| Macf1 |
T |
C |
4: 123,434,771 (GRCm38) |
Y4723C |
probably damaging |
Het |
| Mcm7 |
T |
C |
5: 138,169,135 (GRCm38) |
Y182C |
probably damaging |
Het |
| Mtf2 |
T |
C |
5: 108,104,532 (GRCm38) |
|
probably null |
Het |
| Nrxn2 |
A |
T |
19: 6,448,269 (GRCm38) |
T255S |
probably benign |
Het |
| Olfr1154 |
A |
T |
2: 87,902,764 (GRCm38) |
M304K |
probably benign |
Het |
| Olfr1418 |
A |
G |
19: 11,855,302 (GRCm38) |
L217P |
probably damaging |
Het |
| Olfr248 |
A |
T |
1: 174,391,083 (GRCm38) |
T5S |
probably damaging |
Het |
| Olfr30 |
T |
A |
11: 58,455,173 (GRCm38) |
T259S |
possibly damaging |
Het |
| Olfr552 |
T |
A |
7: 102,604,978 (GRCm38) |
I208N |
probably damaging |
Het |
| Olfr741 |
T |
C |
14: 50,486,250 (GRCm38) |
L264P |
probably damaging |
Het |
| Pamr1 |
T |
A |
2: 102,634,421 (GRCm38) |
V305E |
probably benign |
Het |
| Peg10 |
GAT |
GATCAT |
6: 4,756,449 (GRCm38) |
|
probably benign |
Het |
| Peg10 |
C |
T |
6: 4,757,128 (GRCm38) |
T568M |
unknown |
Het |
| Polr3a |
A |
G |
14: 24,469,348 (GRCm38) |
F664S |
probably damaging |
Het |
| Prb1 |
T |
A |
6: 132,208,343 (GRCm38) |
N109I |
unknown |
Het |
| Prdm2 |
T |
C |
4: 143,132,182 (GRCm38) |
I1513V |
probably benign |
Het |
| Prkd3 |
A |
C |
17: 78,962,540 (GRCm38) |
V564G |
possibly damaging |
Het |
| Prss16 |
A |
G |
13: 22,008,343 (GRCm38) |
S151P |
probably damaging |
Het |
| Rnf150 |
C |
T |
8: 82,863,959 (GRCm38) |
|
probably benign |
Het |
| Rttn |
A |
G |
18: 89,020,137 (GRCm38) |
T786A |
probably benign |
Het |
| Scin |
A |
G |
12: 40,063,237 (GRCm38) |
V645A |
possibly damaging |
Het |
| Slc25a20 |
T |
A |
9: 108,680,199 (GRCm38) |
M177K |
probably benign |
Het |
| Slc2a6 |
G |
A |
2: 27,024,322 (GRCm38) |
S261L |
possibly damaging |
Het |
| Slc4a7 |
A |
T |
14: 14,796,115 (GRCm38) |
D1118V |
probably damaging |
Het |
| Slc7a2 |
T |
C |
8: 40,905,672 (GRCm38) |
W351R |
probably damaging |
Het |
| Sp8 |
G |
A |
12: 118,848,439 (GRCm38) |
G10S |
probably damaging |
Het |
| St8sia2 |
A |
G |
7: 73,966,765 (GRCm38) |
I175T |
probably damaging |
Het |
| Tas2r122 |
T |
A |
6: 132,711,816 (GRCm38) |
N38I |
probably benign |
Het |
| Trim31 |
C |
T |
17: 36,898,490 (GRCm38) |
T46M |
possibly damaging |
Het |
| Trim31 |
A |
G |
17: 36,909,253 (GRCm38) |
K354E |
probably benign |
Het |
| Trio |
G |
A |
15: 27,749,836 (GRCm38) |
Q2260* |
probably null |
Het |
| Trpm1 |
T |
C |
7: 64,199,195 (GRCm38) |
I63T |
probably benign |
Het |
| Ugt2b37 |
T |
C |
5: 87,251,777 (GRCm38) |
K291E |
probably benign |
Het |
| Usp54 |
T |
C |
14: 20,577,094 (GRCm38) |
T499A |
probably benign |
Het |
| Vmn1r35 |
T |
C |
6: 66,678,949 (GRCm38) |
I246V |
probably benign |
Het |
| Vmn2r76 |
T |
A |
7: 86,229,962 (GRCm38) |
M377L |
probably benign |
Het |
| Zeb2 |
A |
C |
2: 44,988,625 (GRCm38) |
M1243R |
possibly damaging |
Het |
|
| Other mutations in Vmn2r6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01547:Vmn2r6
|
APN |
3 |
64,538,104 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01968:Vmn2r6
|
APN |
3 |
64,556,345 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL02009:Vmn2r6
|
APN |
3 |
64,537,902 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
IGL02039:Vmn2r6
|
APN |
3 |
64,556,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02652:Vmn2r6
|
APN |
3 |
64,556,328 (GRCm38) |
missense |
probably benign |
0.24 |
|
IGL02737:Vmn2r6
|
APN |
3 |
64,556,490 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
IGL02808:Vmn2r6
|
APN |
3 |
64,556,496 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03066:Vmn2r6
|
APN |
3 |
64,565,153 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03331:Vmn2r6
|
APN |
3 |
64,538,007 (GRCm38) |
missense |
probably damaging |
1.00 |
|
BB010:Vmn2r6
|
UTSW |
3 |
64,559,803 (GRCm38) |
missense |
probably benign |
0.02 |
|
BB020:Vmn2r6
|
UTSW |
3 |
64,559,803 (GRCm38) |
missense |
probably benign |
0.02 |
|
R0010:Vmn2r6
|
UTSW |
3 |
64,559,545 (GRCm38) |
nonsense |
probably null |
|
|
R0206:Vmn2r6
|
UTSW |
3 |
64,539,912 (GRCm38) |
missense |
probably benign |
|
|
R0206:Vmn2r6
|
UTSW |
3 |
64,539,912 (GRCm38) |
missense |
probably benign |
|
|
R0208:Vmn2r6
|
UTSW |
3 |
64,539,912 (GRCm38) |
missense |
probably benign |
|
|
R0427:Vmn2r6
|
UTSW |
3 |
64,559,587 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0466:Vmn2r6
|
UTSW |
3 |
64,556,302 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1018:Vmn2r6
|
UTSW |
3 |
64,556,840 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1104:Vmn2r6
|
UTSW |
3 |
64,538,066 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R1186:Vmn2r6
|
UTSW |
3 |
64,565,067 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1245:Vmn2r6
|
UTSW |
3 |
64,556,790 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R1295:Vmn2r6
|
UTSW |
3 |
64,538,273 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1473:Vmn2r6
|
UTSW |
3 |
64,538,158 (GRCm38) |
nonsense |
probably null |
|
|
R1498:Vmn2r6
|
UTSW |
3 |
64,556,469 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1925:Vmn2r6
|
UTSW |
3 |
64,556,277 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R2044:Vmn2r6
|
UTSW |
3 |
64,537,841 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R2069:Vmn2r6
|
UTSW |
3 |
64,556,098 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R2253:Vmn2r6
|
UTSW |
3 |
64,559,718 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2261:Vmn2r6
|
UTSW |
3 |
64,556,669 (GRCm38) |
missense |
probably benign |
0.24 |
|
R2262:Vmn2r6
|
UTSW |
3 |
64,556,669 (GRCm38) |
missense |
probably benign |
0.24 |
|
R2350:Vmn2r6
|
UTSW |
3 |
64,556,352 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2680:Vmn2r6
|
UTSW |
3 |
64,538,286 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R2846:Vmn2r6
|
UTSW |
3 |
64,556,790 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R2860:Vmn2r6
|
UTSW |
3 |
64,547,339 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2861:Vmn2r6
|
UTSW |
3 |
64,547,339 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3766:Vmn2r6
|
UTSW |
3 |
64,556,508 (GRCm38) |
missense |
probably benign |
0.19 |
|
R3870:Vmn2r6
|
UTSW |
3 |
64,556,621 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4018:Vmn2r6
|
UTSW |
3 |
64,556,472 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4024:Vmn2r6
|
UTSW |
3 |
64,538,250 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R4026:Vmn2r6
|
UTSW |
3 |
64,538,250 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R4227:Vmn2r6
|
UTSW |
3 |
64,537,948 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4526:Vmn2r6
|
UTSW |
3 |
64,537,724 (GRCm38) |
missense |
probably benign |
0.32 |
|
R4570:Vmn2r6
|
UTSW |
3 |
64,559,647 (GRCm38) |
missense |
probably benign |
0.31 |
|
R4894:Vmn2r6
|
UTSW |
3 |
64,547,408 (GRCm38) |
missense |
probably benign |
|
|
R4934:Vmn2r6
|
UTSW |
3 |
64,556,345 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5057:Vmn2r6
|
UTSW |
3 |
64,537,786 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5059:Vmn2r6
|
UTSW |
3 |
64,537,623 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R5148:Vmn2r6
|
UTSW |
3 |
64,556,594 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5155:Vmn2r6
|
UTSW |
3 |
64,538,514 (GRCm38) |
missense |
probably benign |
0.44 |
|
R5179:Vmn2r6
|
UTSW |
3 |
64,537,990 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5256:Vmn2r6
|
UTSW |
3 |
64,556,842 (GRCm38) |
missense |
probably benign |
0.33 |
|
R5861:Vmn2r6
|
UTSW |
3 |
64,556,033 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5950:Vmn2r6
|
UTSW |
3 |
64,565,231 (GRCm38) |
missense |
probably benign |
0.05 |
|
R6081:Vmn2r6
|
UTSW |
3 |
64,556,532 (GRCm38) |
missense |
probably benign |
0.25 |
|
R6173:Vmn2r6
|
UTSW |
3 |
64,559,755 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6190:Vmn2r6
|
UTSW |
3 |
64,538,003 (GRCm38) |
missense |
probably benign |
0.04 |
|
R6240:Vmn2r6
|
UTSW |
3 |
64,556,805 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6433:Vmn2r6
|
UTSW |
3 |
64,547,380 (GRCm38) |
nonsense |
probably null |
|
|
R6645:Vmn2r6
|
UTSW |
3 |
64,556,876 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6791:Vmn2r6
|
UTSW |
3 |
64,538,159 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7265:Vmn2r6
|
UTSW |
3 |
64,556,774 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7503:Vmn2r6
|
UTSW |
3 |
64,539,951 (GRCm38) |
nonsense |
probably null |
|
|
R7562:Vmn2r6
|
UTSW |
3 |
64,556,520 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7584:Vmn2r6
|
UTSW |
3 |
64,565,262 (GRCm38) |
missense |
probably benign |
0.07 |
|
R7611:Vmn2r6
|
UTSW |
3 |
64,565,142 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7759:Vmn2r6
|
UTSW |
3 |
64,556,570 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7834:Vmn2r6
|
UTSW |
3 |
64,538,022 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7933:Vmn2r6
|
UTSW |
3 |
64,559,803 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7982:Vmn2r6
|
UTSW |
3 |
64,559,820 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8024:Vmn2r6
|
UTSW |
3 |
64,559,824 (GRCm38) |
missense |
probably benign |
0.40 |
|
R8074:Vmn2r6
|
UTSW |
3 |
64,547,643 (GRCm38) |
intron |
probably benign |
|
|
R8169:Vmn2r6
|
UTSW |
3 |
64,539,889 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8337:Vmn2r6
|
UTSW |
3 |
64,556,105 (GRCm38) |
nonsense |
probably null |
|
|
R8736:Vmn2r6
|
UTSW |
3 |
64,559,800 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8962:Vmn2r6
|
UTSW |
3 |
64,556,155 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9206:Vmn2r6
|
UTSW |
3 |
64,559,611 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9295:Vmn2r6
|
UTSW |
3 |
64,556,063 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9332:Vmn2r6
|
UTSW |
3 |
64,547,250 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9616:Vmn2r6
|
UTSW |
3 |
64,538,303 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9663:Vmn2r6
|
UTSW |
3 |
64,556,128 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R9685:Vmn2r6
|
UTSW |
3 |
64,556,660 (GRCm38) |
missense |
probably benign |
0.19 |
|
X0020:Vmn2r6
|
UTSW |
3 |
64,538,450 (GRCm38) |
missense |
probably benign |
|
|
X0066:Vmn2r6
|
UTSW |
3 |
64,547,378 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r6
|
UTSW |
3 |
64,556,325 (GRCm38) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACACAAAGGTTGGCCCTCTC -3'
(R):5'- TGTCAAAATTGTCCCCATCTACACC -3'
Sequencing Primer
(F):5'- AAAGGTTGGCCCTCTCCATTTC -3'
(R):5'- TTGTCCCCATCTACACCCAGAAAG -3'
|
| Posted On |
2022-01-20 |
Incidental Mutation