Incidental Mutation 'R9139:Vmn2r6'
ID |
694195 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r6
|
Ensembl Gene |
ENSMUSG00000090581 |
Gene Name |
vomeronasal 2, receptor 6 |
Synonyms |
EG667069, EG620718 |
MMRRC Submission |
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.198)
|
Stock # |
R9139 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
3 |
Chromosomal Location |
64444916-64472855 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 64464277 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Proline
at position 186
(S186P)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000135148
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165012]
[ENSMUST00000176481]
|
AlphaFold |
H3BK29 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000165012
AA Change: S97P
PolyPhen 2
Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
|
SMART Domains |
Protein: ENSMUSP00000131831 Gene: ENSMUSG00000090581 AA Change: S97P
Domain | Start | End | E-Value | Type |
Pfam:ANF_receptor
|
1 |
416 |
1.4e-72 |
PFAM |
Pfam:Peripla_BP_6
|
58 |
244 |
1.2e-10 |
PFAM |
Pfam:NCD3G
|
458 |
511 |
1.8e-17 |
PFAM |
Pfam:7tm_3
|
542 |
779 |
3.9e-76 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000176481
AA Change: S186P
PolyPhen 2
Score 0.124 (Sensitivity: 0.93; Specificity: 0.86)
|
SMART Domains |
Protein: ENSMUSP00000135148 Gene: ENSMUSG00000090581 AA Change: S186P
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
88 |
505 |
9.8e-77 |
PFAM |
Pfam:Peripla_BP_6
|
142 |
331 |
3.4e-10 |
PFAM |
Pfam:NCD3G
|
547 |
600 |
5.4e-17 |
PFAM |
Pfam:7tm_3
|
633 |
867 |
3.9e-47 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 65 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aamp |
A |
G |
1: 74,320,705 (GRCm39) |
V288A |
possibly damaging |
Het |
Ankhd1 |
T |
A |
18: 36,711,810 (GRCm39) |
S135R |
|
Het |
Axl |
G |
A |
7: 25,460,846 (GRCm39) |
T721I |
probably damaging |
Het |
Blnk |
G |
A |
19: 40,922,962 (GRCm39) |
A388V |
probably benign |
Het |
C8b |
T |
C |
4: 104,641,631 (GRCm39) |
V189A |
probably damaging |
Het |
Ccdc33 |
G |
C |
9: 57,983,842 (GRCm39) |
I452M |
probably benign |
Het |
Cfap57 |
T |
C |
4: 118,412,048 (GRCm39) |
T1199A |
probably benign |
Het |
Chga |
G |
A |
12: 102,528,144 (GRCm39) |
V212M |
probably benign |
Het |
Cspp1 |
T |
A |
1: 10,186,875 (GRCm39) |
M887K |
probably damaging |
Het |
Cyp3a16 |
G |
C |
5: 145,406,434 (GRCm39) |
A6G |
unknown |
Het |
Cyp4f17 |
G |
T |
17: 32,743,868 (GRCm39) |
E349* |
probably null |
Het |
Dnajc13 |
A |
T |
9: 104,085,039 (GRCm39) |
D791E |
probably benign |
Het |
Dpysl5 |
T |
C |
5: 30,935,397 (GRCm39) |
Y167H |
probably benign |
Het |
Dqx1 |
G |
T |
6: 83,036,759 (GRCm39) |
Q254H |
possibly damaging |
Het |
Eef1g |
A |
G |
19: 8,955,383 (GRCm39) |
T411A |
probably benign |
Het |
Fancl |
C |
A |
11: 26,337,231 (GRCm39) |
A6E |
probably benign |
Het |
Gabrr3 |
A |
G |
16: 59,227,830 (GRCm39) |
Q29R |
probably benign |
Het |
Gtf2h2 |
A |
C |
13: 100,617,778 (GRCm39) |
L168R |
probably damaging |
Het |
Hacl1 |
T |
A |
14: 31,338,338 (GRCm39) |
Q413L |
probably benign |
Het |
Hdc |
A |
T |
2: 126,439,837 (GRCm39) |
V372E |
probably damaging |
Het |
Hr |
A |
T |
14: 70,795,079 (GRCm39) |
H208L |
possibly damaging |
Het |
Htr6 |
T |
C |
4: 138,789,501 (GRCm39) |
R255G |
possibly damaging |
Het |
Jup |
C |
T |
11: 100,270,391 (GRCm39) |
C372Y |
probably damaging |
Het |
Kank2 |
A |
G |
9: 21,681,370 (GRCm39) |
V747A |
probably damaging |
Het |
Kif5c |
A |
G |
2: 49,620,291 (GRCm39) |
T508A |
probably benign |
Het |
Klhdc8b |
A |
G |
9: 108,326,927 (GRCm39) |
V145A |
probably damaging |
Het |
Klk1b21 |
T |
A |
7: 43,754,924 (GRCm39) |
V73D |
probably damaging |
Het |
Ksr1 |
T |
A |
11: 78,911,572 (GRCm39) |
M737L |
probably benign |
Het |
Macf1 |
T |
C |
4: 123,328,564 (GRCm39) |
Y4723C |
probably damaging |
Het |
Mcm7 |
T |
C |
5: 138,167,397 (GRCm39) |
Y182C |
probably damaging |
Het |
Mtf2 |
T |
C |
5: 108,252,398 (GRCm39) |
|
probably null |
Het |
Nrxn2 |
A |
T |
19: 6,498,299 (GRCm39) |
T255S |
probably benign |
Het |
Or10v9 |
A |
G |
19: 11,832,666 (GRCm39) |
L217P |
probably damaging |
Het |
Or10x4 |
A |
T |
1: 174,218,649 (GRCm39) |
T5S |
probably damaging |
Het |
Or11g25 |
T |
C |
14: 50,723,707 (GRCm39) |
L264P |
probably damaging |
Het |
Or2z2 |
T |
A |
11: 58,345,999 (GRCm39) |
T259S |
possibly damaging |
Het |
Or52k2 |
T |
A |
7: 102,254,185 (GRCm39) |
I208N |
probably damaging |
Het |
Or9m1 |
A |
T |
2: 87,733,108 (GRCm39) |
M304K |
probably benign |
Het |
Pamr1 |
T |
A |
2: 102,464,766 (GRCm39) |
V305E |
probably benign |
Het |
Peg10 |
GAT |
GATCAT |
6: 4,756,449 (GRCm39) |
|
probably benign |
Het |
Peg10 |
C |
T |
6: 4,757,128 (GRCm39) |
T568M |
unknown |
Het |
Polr3a |
A |
G |
14: 24,519,416 (GRCm39) |
F664S |
probably damaging |
Het |
Prb1a |
T |
A |
6: 132,185,306 (GRCm39) |
N109I |
unknown |
Het |
Prdm2 |
T |
C |
4: 142,858,752 (GRCm39) |
I1513V |
probably benign |
Het |
Prkd3 |
A |
C |
17: 79,269,969 (GRCm39) |
V564G |
possibly damaging |
Het |
Prss16 |
A |
G |
13: 22,192,513 (GRCm39) |
S151P |
probably damaging |
Het |
Rnf150 |
C |
T |
8: 83,590,588 (GRCm39) |
|
probably benign |
Het |
Rttn |
A |
G |
18: 89,038,261 (GRCm39) |
T786A |
probably benign |
Het |
Scin |
A |
G |
12: 40,113,236 (GRCm39) |
V645A |
possibly damaging |
Het |
Slc25a20 |
T |
A |
9: 108,557,398 (GRCm39) |
M177K |
probably benign |
Het |
Slc2a6 |
G |
A |
2: 26,914,334 (GRCm39) |
S261L |
possibly damaging |
Het |
Slc4a7 |
A |
T |
14: 14,796,115 (GRCm38) |
D1118V |
probably damaging |
Het |
Slc7a2 |
T |
C |
8: 41,358,709 (GRCm39) |
W351R |
probably damaging |
Het |
Sp8 |
G |
A |
12: 118,812,174 (GRCm39) |
G10S |
probably damaging |
Het |
St8sia2 |
A |
G |
7: 73,616,513 (GRCm39) |
I175T |
probably damaging |
Het |
Tas2r122 |
T |
A |
6: 132,688,779 (GRCm39) |
N38I |
probably benign |
Het |
Trim31 |
C |
T |
17: 37,209,382 (GRCm39) |
T46M |
possibly damaging |
Het |
Trim31 |
A |
G |
17: 37,220,145 (GRCm39) |
K354E |
probably benign |
Het |
Trio |
G |
A |
15: 27,749,922 (GRCm39) |
Q2260* |
probably null |
Het |
Trpm1 |
T |
C |
7: 63,848,943 (GRCm39) |
I63T |
probably benign |
Het |
Ugt2b37 |
T |
C |
5: 87,399,636 (GRCm39) |
K291E |
probably benign |
Het |
Usp54 |
T |
C |
14: 20,627,162 (GRCm39) |
T499A |
probably benign |
Het |
Vmn1r35 |
T |
C |
6: 66,655,933 (GRCm39) |
I246V |
probably benign |
Het |
Vmn2r76 |
T |
A |
7: 85,879,170 (GRCm39) |
M377L |
probably benign |
Het |
Zeb2 |
A |
C |
2: 44,878,637 (GRCm39) |
M1243R |
possibly damaging |
Het |
|
Other mutations in Vmn2r6 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01547:Vmn2r6
|
APN |
3 |
64,445,525 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01968:Vmn2r6
|
APN |
3 |
64,463,766 (GRCm39) |
missense |
possibly damaging |
0.94 |
IGL02009:Vmn2r6
|
APN |
3 |
64,445,323 (GRCm39) |
missense |
possibly damaging |
0.61 |
IGL02039:Vmn2r6
|
APN |
3 |
64,463,610 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02652:Vmn2r6
|
APN |
3 |
64,463,749 (GRCm39) |
missense |
probably benign |
0.24 |
IGL02737:Vmn2r6
|
APN |
3 |
64,463,911 (GRCm39) |
missense |
possibly damaging |
0.55 |
IGL02808:Vmn2r6
|
APN |
3 |
64,463,917 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03066:Vmn2r6
|
APN |
3 |
64,472,574 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL03331:Vmn2r6
|
APN |
3 |
64,445,428 (GRCm39) |
missense |
probably damaging |
1.00 |
BB010:Vmn2r6
|
UTSW |
3 |
64,467,224 (GRCm39) |
missense |
probably benign |
0.02 |
BB020:Vmn2r6
|
UTSW |
3 |
64,467,224 (GRCm39) |
missense |
probably benign |
0.02 |
R0010:Vmn2r6
|
UTSW |
3 |
64,466,966 (GRCm39) |
nonsense |
probably null |
|
R0206:Vmn2r6
|
UTSW |
3 |
64,447,333 (GRCm39) |
missense |
probably benign |
|
R0206:Vmn2r6
|
UTSW |
3 |
64,447,333 (GRCm39) |
missense |
probably benign |
|
R0208:Vmn2r6
|
UTSW |
3 |
64,447,333 (GRCm39) |
missense |
probably benign |
|
R0427:Vmn2r6
|
UTSW |
3 |
64,467,008 (GRCm39) |
missense |
probably damaging |
1.00 |
R0466:Vmn2r6
|
UTSW |
3 |
64,463,723 (GRCm39) |
missense |
probably damaging |
1.00 |
R1018:Vmn2r6
|
UTSW |
3 |
64,464,261 (GRCm39) |
missense |
probably benign |
0.00 |
R1104:Vmn2r6
|
UTSW |
3 |
64,445,487 (GRCm39) |
missense |
possibly damaging |
0.93 |
R1186:Vmn2r6
|
UTSW |
3 |
64,472,488 (GRCm39) |
missense |
probably benign |
0.01 |
R1245:Vmn2r6
|
UTSW |
3 |
64,464,211 (GRCm39) |
missense |
possibly damaging |
0.53 |
R1295:Vmn2r6
|
UTSW |
3 |
64,445,694 (GRCm39) |
missense |
probably damaging |
1.00 |
R1473:Vmn2r6
|
UTSW |
3 |
64,445,579 (GRCm39) |
nonsense |
probably null |
|
R1498:Vmn2r6
|
UTSW |
3 |
64,463,890 (GRCm39) |
missense |
probably damaging |
1.00 |
R1925:Vmn2r6
|
UTSW |
3 |
64,463,698 (GRCm39) |
missense |
possibly damaging |
0.87 |
R2044:Vmn2r6
|
UTSW |
3 |
64,445,262 (GRCm39) |
missense |
probably damaging |
0.96 |
R2069:Vmn2r6
|
UTSW |
3 |
64,463,519 (GRCm39) |
missense |
possibly damaging |
0.89 |
R2253:Vmn2r6
|
UTSW |
3 |
64,467,139 (GRCm39) |
missense |
probably damaging |
1.00 |
R2261:Vmn2r6
|
UTSW |
3 |
64,464,090 (GRCm39) |
missense |
probably benign |
0.24 |
R2262:Vmn2r6
|
UTSW |
3 |
64,464,090 (GRCm39) |
missense |
probably benign |
0.24 |
R2350:Vmn2r6
|
UTSW |
3 |
64,463,773 (GRCm39) |
missense |
probably benign |
0.01 |
R2680:Vmn2r6
|
UTSW |
3 |
64,445,707 (GRCm39) |
missense |
possibly damaging |
0.91 |
R2846:Vmn2r6
|
UTSW |
3 |
64,464,211 (GRCm39) |
missense |
possibly damaging |
0.53 |
R2860:Vmn2r6
|
UTSW |
3 |
64,454,760 (GRCm39) |
missense |
probably benign |
0.00 |
R2861:Vmn2r6
|
UTSW |
3 |
64,454,760 (GRCm39) |
missense |
probably benign |
0.00 |
R3766:Vmn2r6
|
UTSW |
3 |
64,463,929 (GRCm39) |
missense |
probably benign |
0.19 |
R3870:Vmn2r6
|
UTSW |
3 |
64,464,042 (GRCm39) |
missense |
probably damaging |
0.96 |
R4018:Vmn2r6
|
UTSW |
3 |
64,463,893 (GRCm39) |
missense |
probably benign |
0.05 |
R4024:Vmn2r6
|
UTSW |
3 |
64,445,671 (GRCm39) |
missense |
possibly damaging |
0.73 |
R4026:Vmn2r6
|
UTSW |
3 |
64,445,671 (GRCm39) |
missense |
possibly damaging |
0.73 |
R4227:Vmn2r6
|
UTSW |
3 |
64,445,369 (GRCm39) |
missense |
probably damaging |
0.99 |
R4526:Vmn2r6
|
UTSW |
3 |
64,445,145 (GRCm39) |
missense |
probably benign |
0.32 |
R4570:Vmn2r6
|
UTSW |
3 |
64,467,068 (GRCm39) |
missense |
probably benign |
0.31 |
R4894:Vmn2r6
|
UTSW |
3 |
64,454,829 (GRCm39) |
missense |
probably benign |
|
R4934:Vmn2r6
|
UTSW |
3 |
64,463,766 (GRCm39) |
missense |
probably damaging |
0.99 |
R5057:Vmn2r6
|
UTSW |
3 |
64,445,207 (GRCm39) |
missense |
probably damaging |
1.00 |
R5059:Vmn2r6
|
UTSW |
3 |
64,445,044 (GRCm39) |
missense |
possibly damaging |
0.89 |
R5148:Vmn2r6
|
UTSW |
3 |
64,464,015 (GRCm39) |
missense |
probably damaging |
0.99 |
R5155:Vmn2r6
|
UTSW |
3 |
64,445,935 (GRCm39) |
missense |
probably benign |
0.44 |
R5179:Vmn2r6
|
UTSW |
3 |
64,445,411 (GRCm39) |
missense |
probably benign |
0.00 |
R5256:Vmn2r6
|
UTSW |
3 |
64,464,263 (GRCm39) |
missense |
probably benign |
0.33 |
R5861:Vmn2r6
|
UTSW |
3 |
64,463,454 (GRCm39) |
missense |
probably benign |
0.00 |
R5950:Vmn2r6
|
UTSW |
3 |
64,472,652 (GRCm39) |
missense |
probably benign |
0.05 |
R6081:Vmn2r6
|
UTSW |
3 |
64,463,953 (GRCm39) |
missense |
probably benign |
0.25 |
R6173:Vmn2r6
|
UTSW |
3 |
64,467,176 (GRCm39) |
missense |
probably damaging |
1.00 |
R6190:Vmn2r6
|
UTSW |
3 |
64,445,424 (GRCm39) |
missense |
probably benign |
0.04 |
R6240:Vmn2r6
|
UTSW |
3 |
64,464,226 (GRCm39) |
missense |
probably damaging |
1.00 |
R6433:Vmn2r6
|
UTSW |
3 |
64,454,801 (GRCm39) |
nonsense |
probably null |
|
R6645:Vmn2r6
|
UTSW |
3 |
64,464,297 (GRCm39) |
missense |
probably damaging |
1.00 |
R6791:Vmn2r6
|
UTSW |
3 |
64,445,580 (GRCm39) |
missense |
probably damaging |
1.00 |
R7265:Vmn2r6
|
UTSW |
3 |
64,464,195 (GRCm39) |
missense |
probably benign |
0.00 |
R7503:Vmn2r6
|
UTSW |
3 |
64,447,372 (GRCm39) |
nonsense |
probably null |
|
R7562:Vmn2r6
|
UTSW |
3 |
64,463,941 (GRCm39) |
missense |
probably benign |
0.00 |
R7584:Vmn2r6
|
UTSW |
3 |
64,472,683 (GRCm39) |
missense |
probably benign |
0.07 |
R7611:Vmn2r6
|
UTSW |
3 |
64,472,563 (GRCm39) |
missense |
probably damaging |
0.98 |
R7759:Vmn2r6
|
UTSW |
3 |
64,463,991 (GRCm39) |
missense |
probably damaging |
1.00 |
R7834:Vmn2r6
|
UTSW |
3 |
64,445,443 (GRCm39) |
missense |
probably damaging |
1.00 |
R7933:Vmn2r6
|
UTSW |
3 |
64,467,224 (GRCm39) |
missense |
probably benign |
0.02 |
R7982:Vmn2r6
|
UTSW |
3 |
64,467,241 (GRCm39) |
missense |
probably damaging |
1.00 |
R8024:Vmn2r6
|
UTSW |
3 |
64,467,245 (GRCm39) |
missense |
probably benign |
0.40 |
R8074:Vmn2r6
|
UTSW |
3 |
64,455,064 (GRCm39) |
intron |
probably benign |
|
R8169:Vmn2r6
|
UTSW |
3 |
64,447,310 (GRCm39) |
missense |
probably benign |
0.01 |
R8337:Vmn2r6
|
UTSW |
3 |
64,463,526 (GRCm39) |
nonsense |
probably null |
|
R8736:Vmn2r6
|
UTSW |
3 |
64,467,221 (GRCm39) |
missense |
probably damaging |
1.00 |
R8962:Vmn2r6
|
UTSW |
3 |
64,463,576 (GRCm39) |
missense |
probably damaging |
1.00 |
R9206:Vmn2r6
|
UTSW |
3 |
64,467,032 (GRCm39) |
missense |
probably damaging |
0.97 |
R9295:Vmn2r6
|
UTSW |
3 |
64,463,484 (GRCm39) |
missense |
probably benign |
0.00 |
R9332:Vmn2r6
|
UTSW |
3 |
64,454,671 (GRCm39) |
missense |
probably benign |
0.01 |
R9616:Vmn2r6
|
UTSW |
3 |
64,445,724 (GRCm39) |
missense |
probably damaging |
1.00 |
R9663:Vmn2r6
|
UTSW |
3 |
64,463,549 (GRCm39) |
missense |
possibly damaging |
0.90 |
R9685:Vmn2r6
|
UTSW |
3 |
64,464,081 (GRCm39) |
missense |
probably benign |
0.19 |
X0020:Vmn2r6
|
UTSW |
3 |
64,445,871 (GRCm39) |
missense |
probably benign |
|
X0066:Vmn2r6
|
UTSW |
3 |
64,454,799 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Vmn2r6
|
UTSW |
3 |
64,463,746 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Predicted Primers |
PCR Primer
(F):5'- ACACAAAGGTTGGCCCTCTC -3'
(R):5'- TGTCAAAATTGTCCCCATCTACACC -3'
Sequencing Primer
(F):5'- AAAGGTTGGCCCTCTCCATTTC -3'
(R):5'- TTGTCCCCATCTACACCCAGAAAG -3'
|
Posted On |
2022-01-20 |