Incidental Mutation 'V7580:Lrrc37a'
ID 69421
Institutional Source Beutler Lab
Gene Symbol Lrrc37a
Ensembl Gene ENSMUSG00000078632
Gene Name leucine rich repeat containing 37A
Synonyms LOC237954
Accession Numbers
Essential gene? Probably non essential (E-score: 0.124) question?
Stock # V7580 () of strain stinger
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 103451955-103504597 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to G at 103455512 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Threonine at position 3176 (N3176T)
Ref Sequence ENSEMBL: ENSMUSP00000121903 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000153273]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000153273
AA Change: N3176T

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000121903
Gene: ENSMUSG00000078632
AA Change: N3176T

DomainStartEndE-ValueType
Pfam:LRRC37 199 269 2.6e-15 PFAM
low complexity region 313 329 N/A INTRINSIC
Pfam:LRRC37 363 432 4e-18 PFAM
low complexity region 457 467 N/A INTRINSIC
low complexity region 480 492 N/A INTRINSIC
Pfam:LRRC37 550 619 2.1e-21 PFAM
Pfam:LRRC37 637 704 2.9e-12 PFAM
Pfam:LRRC37 780 851 2.5e-12 PFAM
Pfam:LRRC37 1078 1148 2.7e-18 PFAM
Pfam:LRRC37 1149 1190 2.1e-7 PFAM
Pfam:LRRC37 1187 1258 2.5e-25 PFAM
Pfam:LRRC37 1255 1300 2.6e-7 PFAM
Pfam:LRRC37 1299 1370 2.4e-27 PFAM
Pfam:LRRC37 1369 1420 2.9e-8 PFAM
Pfam:LRRC37 1419 1488 1.3e-24 PFAM
Pfam:LRRC37 1509 1578 9.2e-21 PFAM
Pfam:LRRC37 1575 1620 1.7e-6 PFAM
Pfam:LRRC37 1619 1686 1.7e-20 PFAM
Pfam:LRRC37 1690 1736 7e-10 PFAM
Pfam:LRRC37 1733 1799 7.5e-17 PFAM
Pfam:LRRC37 1789 1854 5.1e-12 PFAM
Pfam:LRRC37 1850 1921 4.2e-21 PFAM
Pfam:LRRC37 1915 1969 1.1e-9 PFAM
low complexity region 2143 2167 N/A INTRINSIC
low complexity region 2185 2209 N/A INTRINSIC
low complexity region 2228 2249 N/A INTRINSIC
low complexity region 2262 2274 N/A INTRINSIC
low complexity region 2284 2297 N/A INTRINSIC
LRR 2419 2438 3.09e1 SMART
LRR 2439 2462 9.96e-1 SMART
LRR 2463 2486 8.24e0 SMART
LRR 2490 2514 3.18e1 SMART
low complexity region 2535 2547 N/A INTRINSIC
coiled coil region 2712 2735 N/A INTRINSIC
low complexity region 2861 2871 N/A INTRINSIC
low complexity region 2937 2950 N/A INTRINSIC
Pfam:LRRC37AB_C 3063 3209 1.1e-77 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 99.0%
  • 10x: 97.8%
  • 20x: 96.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 T A 12: 118,886,179 (GRCm38) M950L probably benign Het
Atp6v1h A G 1: 5,124,443 (GRCm38) T282A possibly damaging Het
Casp8ap2 C T 4: 32,639,944 (GRCm38) H333Y probably benign Het
Cd36 ACTGTCTGT ACTGT 5: 17,820,528 (GRCm38) probably null Het
Cfi T A 3: 129,854,992 (GRCm38) I175K possibly damaging Het
D630003M21Rik T C 2: 158,201,011 (GRCm38) T870A probably benign Het
Dnah12 T A 14: 26,773,093 (GRCm38) N1369K possibly damaging Het
Dnajc22 T A 15: 99,101,482 (GRCm38) Y183N probably damaging Het
Erv3 T C 2: 131,855,926 (GRCm38) H171R possibly damaging Het
Fam221b T C 4: 43,665,865 (GRCm38) T249A probably benign Het
Gm10770 T A 2: 150,179,484 (GRCm38) K38* probably null Het
Gm4787 G A 12: 81,377,567 (GRCm38) Q606* probably null Het
Izumo4 A T 10: 80,703,891 (GRCm38) T155S probably benign Het
Kcnb2 A G 1: 15,710,091 (GRCm38) I396V probably benign Het
Klc1 A T 12: 111,774,572 (GRCm38) I161F probably benign Het
Lpar5 C A 6: 125,081,727 (GRCm38) A137E possibly damaging Het
Lrp4 C T 2: 91,488,518 (GRCm38) S900L possibly damaging Het
Med20 G A 17: 47,618,832 (GRCm38) V65M probably damaging Het
Mylk G T 16: 34,995,204 (GRCm38) probably null Het
Numbl T C 7: 27,279,602 (GRCm38) S379P probably benign Het
Olfr1406 G T 1: 173,183,964 (GRCm38) L157I probably benign Het
Olfr1440 G A 19: 12,394,550 (GRCm38) V96I probably benign Het
Otop3 T A 11: 115,344,838 (GRCm38) L432Q probably damaging Het
Papln C T 12: 83,778,834 (GRCm38) R608C possibly damaging Het
Pelp1 T A 11: 70,398,150 (GRCm38) T257S probably damaging Het
Pigx T C 16: 32,087,422 (GRCm38) D129G probably damaging Het
Pik3cd A C 4: 149,657,319 (GRCm38) L390R probably damaging Het
Plekhb1 T C 7: 100,654,618 (GRCm38) T112A probably benign Het
Ppwd1 A G 13: 104,220,237 (GRCm38) Y257H probably damaging Het
Recql4 T C 15: 76,706,169 (GRCm38) D705G possibly damaging Het
Ror1 A G 4: 100,440,933 (GRCm38) Q501R probably damaging Het
Slc30a4 T A 2: 122,689,538 (GRCm38) M136L probably benign Het
Spaca1 T C 4: 34,039,311 (GRCm38) E192G probably damaging Het
Spata31 C A 13: 64,921,648 (GRCm38) P537T probably benign Het
Sptbn2 C T 19: 4,750,632 (GRCm38) R2292C probably damaging Het
Tnrc6c G A 11: 117,723,326 (GRCm38) R770H probably damaging Het
Trps1 T C 15: 50,831,577 (GRCm38) K150E probably damaging Het
Tspyl3 A G 2: 153,225,060 (GRCm38) V86A probably benign Het
Zfp292 C T 4: 34,806,783 (GRCm38) C2087Y possibly damaging Het
Zmynd8 G A 2: 165,812,394 (GRCm38) R724* probably null Het
Other mutations in Lrrc37a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00518:Lrrc37a APN 11 103,500,351 (GRCm38) missense probably benign 0.09
IGL01339:Lrrc37a APN 11 103,497,937 (GRCm38) missense unknown
IGL01352:Lrrc37a APN 11 103,499,355 (GRCm38) missense probably benign 0.39
IGL01382:Lrrc37a APN 11 103,498,755 (GRCm38) missense probably damaging 0.99
IGL01395:Lrrc37a APN 11 103,503,861 (GRCm38) missense probably benign 0.24
IGL01645:Lrrc37a APN 11 103,504,264 (GRCm38) missense probably benign 0.01
IGL01925:Lrrc37a APN 11 103,498,419 (GRCm38) missense probably benign 0.01
IGL02006:Lrrc37a APN 11 103,456,491 (GRCm38) missense probably damaging 1.00
IGL02127:Lrrc37a APN 11 103,504,539 (GRCm38) missense probably benign 0.01
IGL02184:Lrrc37a APN 11 103,497,609 (GRCm38) missense unknown
IGL02218:Lrrc37a APN 11 103,500,381 (GRCm38) missense probably benign 0.03
IGL02436:Lrrc37a APN 11 103,498,177 (GRCm38) missense unknown
IGL02487:Lrrc37a APN 11 103,496,037 (GRCm38) missense unknown
IGL02597:Lrrc37a APN 11 103,504,287 (GRCm38) missense probably benign 0.01
IGL02634:Lrrc37a APN 11 103,499,112 (GRCm38) missense probably benign 0.09
IGL02818:Lrrc37a APN 11 103,501,306 (GRCm38) missense possibly damaging 0.47
IGL02829:Lrrc37a APN 11 103,491,174 (GRCm38) missense unknown
IGL02987:Lrrc37a APN 11 103,500,413 (GRCm38) missense probably benign 0.03
IGL03081:Lrrc37a APN 11 103,456,595 (GRCm38) missense unknown
IGL03210:Lrrc37a APN 11 103,499,505 (GRCm38) missense probably benign 0.29
IGL03239:Lrrc37a APN 11 103,499,407 (GRCm38) missense probably benign 0.03
IGL03285:Lrrc37a APN 11 103,497,673 (GRCm38) missense unknown
IGL03296:Lrrc37a APN 11 103,497,673 (GRCm38) missense unknown
IGL03299:Lrrc37a APN 11 103,497,673 (GRCm38) missense unknown
IGL03370:Lrrc37a APN 11 103,497,673 (GRCm38) missense unknown
IGL03390:Lrrc37a APN 11 103,496,031 (GRCm38) missense unknown
Lark UTSW 11 103,464,354 (GRCm38) critical splice donor site probably null
Longspur UTSW 11 103,502,314 (GRCm38) missense probably benign 0.42
F5770:Lrrc37a UTSW 11 103,455,512 (GRCm38) missense possibly damaging 0.95
P0035:Lrrc37a UTSW 11 103,503,132 (GRCm38) missense possibly damaging 0.84
PIT4458001:Lrrc37a UTSW 11 103,504,512 (GRCm38) missense probably benign 0.04
R0112:Lrrc37a UTSW 11 103,500,913 (GRCm38) missense probably benign 0.19
R0194:Lrrc37a UTSW 11 103,499,790 (GRCm38) missense possibly damaging 0.82
R0360:Lrrc37a UTSW 11 103,500,640 (GRCm38) missense possibly damaging 0.89
R0364:Lrrc37a UTSW 11 103,500,640 (GRCm38) missense possibly damaging 0.89
R0395:Lrrc37a UTSW 11 103,464,395 (GRCm38) missense unknown
R0418:Lrrc37a UTSW 11 103,503,438 (GRCm38) missense probably benign 0.03
R0505:Lrrc37a UTSW 11 103,503,025 (GRCm38) missense probably benign 0.10
R0583:Lrrc37a UTSW 11 103,498,437 (GRCm38) missense probably benign 0.01
R1078:Lrrc37a UTSW 11 103,497,631 (GRCm38) missense unknown
R1581:Lrrc37a UTSW 11 103,457,017 (GRCm38) nonsense probably null
R1888:Lrrc37a UTSW 11 103,498,761 (GRCm38) missense probably benign 0.18
R1888:Lrrc37a UTSW 11 103,498,761 (GRCm38) missense probably benign 0.18
R1907:Lrrc37a UTSW 11 103,457,156 (GRCm38) missense unknown
R1982:Lrrc37a UTSW 11 103,498,966 (GRCm38) missense probably benign 0.20
R1991:Lrrc37a UTSW 11 103,500,261 (GRCm38) missense probably benign 0.29
R2017:Lrrc37a UTSW 11 103,501,125 (GRCm38) missense probably benign 0.03
R2103:Lrrc37a UTSW 11 103,500,261 (GRCm38) missense probably benign 0.29
R2110:Lrrc37a UTSW 11 103,497,822 (GRCm38) missense unknown
R2190:Lrrc37a UTSW 11 103,500,043 (GRCm38) missense possibly damaging 0.82
R2252:Lrrc37a UTSW 11 103,501,467 (GRCm38) missense probably benign 0.01
R2253:Lrrc37a UTSW 11 103,501,467 (GRCm38) missense probably benign 0.01
R2894:Lrrc37a UTSW 11 103,497,864 (GRCm38) missense unknown
R2899:Lrrc37a UTSW 11 103,497,864 (GRCm38) missense unknown
R3439:Lrrc37a UTSW 11 103,497,864 (GRCm38) missense unknown
R3899:Lrrc37a UTSW 11 103,497,546 (GRCm38) missense unknown
R3916:Lrrc37a UTSW 11 103,455,518 (GRCm38) missense possibly damaging 0.83
R3921:Lrrc37a UTSW 11 103,501,470 (GRCm38) missense probably benign 0.10
R3977:Lrrc37a UTSW 11 103,457,604 (GRCm38) missense unknown
R4043:Lrrc37a UTSW 11 103,498,653 (GRCm38) missense possibly damaging 0.95
R4077:Lrrc37a UTSW 11 103,497,982 (GRCm38) missense unknown
R4237:Lrrc37a UTSW 11 103,502,289 (GRCm38) missense probably damaging 0.97
R4461:Lrrc37a UTSW 11 103,464,354 (GRCm38) critical splice donor site probably null
R4498:Lrrc37a UTSW 11 103,501,798 (GRCm38) missense probably benign 0.20
R4593:Lrrc37a UTSW 11 103,498,969 (GRCm38) missense possibly damaging 0.64
R4670:Lrrc37a UTSW 11 103,504,537 (GRCm38) missense probably benign 0.10
R4698:Lrrc37a UTSW 11 103,504,104 (GRCm38) missense possibly damaging 0.83
R4750:Lrrc37a UTSW 11 103,455,480 (GRCm38) missense probably benign 0.24
R4805:Lrrc37a UTSW 11 103,504,309 (GRCm38) missense probably benign 0.01
R4940:Lrrc37a UTSW 11 103,497,612 (GRCm38) missense unknown
R4983:Lrrc37a UTSW 11 103,497,618 (GRCm38) missense unknown
R4989:Lrrc37a UTSW 11 103,456,739 (GRCm38) missense unknown
R5046:Lrrc37a UTSW 11 103,498,240 (GRCm38) missense unknown
R5217:Lrrc37a UTSW 11 103,456,954 (GRCm38) missense unknown
R5300:Lrrc37a UTSW 11 103,456,958 (GRCm38) missense unknown
R5509:Lrrc37a UTSW 11 103,500,535 (GRCm38) missense probably benign 0.23
R5550:Lrrc37a UTSW 11 103,498,177 (GRCm38) missense unknown
R5655:Lrrc37a UTSW 11 103,498,555 (GRCm38) missense probably benign 0.28
R5668:Lrrc37a UTSW 11 103,500,175 (GRCm38) missense probably benign 0.03
R5750:Lrrc37a UTSW 11 103,458,097 (GRCm38) missense unknown
R5815:Lrrc37a UTSW 11 103,503,786 (GRCm38) missense probably benign 0.01
R5976:Lrrc37a UTSW 11 103,499,071 (GRCm38) missense possibly damaging 0.73
R5990:Lrrc37a UTSW 11 103,500,958 (GRCm38) missense probably benign 0.19
R6004:Lrrc37a UTSW 11 103,502,536 (GRCm38) missense possibly damaging 0.56
R6019:Lrrc37a UTSW 11 103,456,596 (GRCm38) missense unknown
R6056:Lrrc37a UTSW 11 103,497,658 (GRCm38) missense unknown
R6125:Lrrc37a UTSW 11 103,501,560 (GRCm38) missense probably benign 0.19
R6190:Lrrc37a UTSW 11 103,501,216 (GRCm38) missense possibly damaging 0.67
R6295:Lrrc37a UTSW 11 103,497,633 (GRCm38) missense unknown
R6320:Lrrc37a UTSW 11 103,504,051 (GRCm38) missense probably benign 0.10
R6354:Lrrc37a UTSW 11 103,464,387 (GRCm38) missense unknown
R6375:Lrrc37a UTSW 11 103,501,089 (GRCm38) missense probably benign 0.19
R6406:Lrrc37a UTSW 11 103,497,535 (GRCm38) missense unknown
R6468:Lrrc37a UTSW 11 103,460,840 (GRCm38) missense unknown
R6490:Lrrc37a UTSW 11 103,456,660 (GRCm38) missense unknown
R6502:Lrrc37a UTSW 11 103,492,179 (GRCm38) missense unknown
R6509:Lrrc37a UTSW 11 103,504,414 (GRCm38) missense probably benign 0.04
R6749:Lrrc37a UTSW 11 103,502,097 (GRCm38) missense probably benign 0.29
R6768:Lrrc37a UTSW 11 103,500,123 (GRCm38) missense probably benign 0.36
R6912:Lrrc37a UTSW 11 103,457,543 (GRCm38) missense unknown
R7081:Lrrc37a UTSW 11 103,457,955 (GRCm38) missense unknown
R7083:Lrrc37a UTSW 11 103,503,340 (GRCm38) missense probably benign 0.03
R7154:Lrrc37a UTSW 11 103,502,856 (GRCm38) missense probably benign 0.03
R7195:Lrrc37a UTSW 11 103,457,775 (GRCm38) missense unknown
R7265:Lrrc37a UTSW 11 103,498,941 (GRCm38) missense probably benign 0.09
R7276:Lrrc37a UTSW 11 103,456,746 (GRCm38) missense unknown
R7362:Lrrc37a UTSW 11 103,457,509 (GRCm38) missense unknown
R7450:Lrrc37a UTSW 11 103,498,326 (GRCm38) missense probably benign 0.01
R7458:Lrrc37a UTSW 11 103,497,432 (GRCm38) missense unknown
R7487:Lrrc37a UTSW 11 103,498,219 (GRCm38) missense unknown
R7535:Lrrc37a UTSW 11 103,501,857 (GRCm38) missense possibly damaging 0.68
R7593:Lrrc37a UTSW 11 103,500,952 (GRCm38) missense probably benign 0.03
R7677:Lrrc37a UTSW 11 103,499,638 (GRCm38) missense probably benign 0.26
R7686:Lrrc37a UTSW 11 103,498,236 (GRCm38) missense unknown
R7694:Lrrc37a UTSW 11 103,504,378 (GRCm38) missense probably benign 0.12
R7696:Lrrc37a UTSW 11 103,498,437 (GRCm38) missense probably benign 0.01
R7717:Lrrc37a UTSW 11 103,504,300 (GRCm38) missense probably benign 0.01
R7736:Lrrc37a UTSW 11 103,497,459 (GRCm38) missense unknown
R7841:Lrrc37a UTSW 11 103,501,105 (GRCm38) missense probably benign 0.03
R7885:Lrrc37a UTSW 11 103,503,042 (GRCm38) missense probably benign 0.01
R7888:Lrrc37a UTSW 11 103,501,481 (GRCm38) missense probably benign 0.19
R7993:Lrrc37a UTSW 11 103,457,961 (GRCm38) missense unknown
R8051:Lrrc37a UTSW 11 103,503,126 (GRCm38) missense possibly damaging 0.48
R8082:Lrrc37a UTSW 11 103,457,422 (GRCm38) missense unknown
R8097:Lrrc37a UTSW 11 103,504,099 (GRCm38) missense probably benign 0.04
R8108:Lrrc37a UTSW 11 103,503,057 (GRCm38) missense probably benign 0.24
R8269:Lrrc37a UTSW 11 103,497,898 (GRCm38) missense unknown
R8311:Lrrc37a UTSW 11 103,503,421 (GRCm38) missense probably benign 0.05
R8403:Lrrc37a UTSW 11 103,501,585 (GRCm38) missense probably benign 0.10
R8408:Lrrc37a UTSW 11 103,460,809 (GRCm38) missense unknown
R8529:Lrrc37a UTSW 11 103,457,547 (GRCm38) missense unknown
R8711:Lrrc37a UTSW 11 103,497,524 (GRCm38) nonsense probably null
R8757:Lrrc37a UTSW 11 103,457,940 (GRCm38) missense unknown
R8759:Lrrc37a UTSW 11 103,457,940 (GRCm38) missense unknown
R8769:Lrrc37a UTSW 11 103,498,710 (GRCm38) missense probably benign 0.10
R8785:Lrrc37a UTSW 11 103,456,416 (GRCm38) missense probably damaging 1.00
R8837:Lrrc37a UTSW 11 103,503,969 (GRCm38) missense probably benign 0.43
R8850:Lrrc37a UTSW 11 103,502,655 (GRCm38) missense
R8871:Lrrc37a UTSW 11 103,456,549 (GRCm38) missense unknown
R8894:Lrrc37a UTSW 11 103,456,623 (GRCm38) missense unknown
R8971:Lrrc37a UTSW 11 103,500,664 (GRCm38) missense probably benign 0.19
R8979:Lrrc37a UTSW 11 103,503,007 (GRCm38) missense possibly damaging 0.48
R9012:Lrrc37a UTSW 11 103,499,152 (GRCm38) missense probably benign 0.05
R9047:Lrrc37a UTSW 11 103,500,549 (GRCm38) missense probably damaging 0.97
R9167:Lrrc37a UTSW 11 103,456,832 (GRCm38) missense unknown
R9171:Lrrc37a UTSW 11 103,502,314 (GRCm38) missense probably benign 0.42
R9194:Lrrc37a UTSW 11 103,500,850 (GRCm38) missense probably benign 0.03
R9258:Lrrc37a UTSW 11 103,502,196 (GRCm38) missense probably benign 0.20
R9282:Lrrc37a UTSW 11 103,500,807 (GRCm38) missense probably benign 0.03
R9294:Lrrc37a UTSW 11 103,504,533 (GRCm38) missense probably benign 0.10
R9349:Lrrc37a UTSW 11 103,497,628 (GRCm38) missense unknown
R9560:Lrrc37a UTSW 11 103,456,594 (GRCm38) missense unknown
R9595:Lrrc37a UTSW 11 103,501,726 (GRCm38) missense probably benign 0.01
R9628:Lrrc37a UTSW 11 103,503,504 (GRCm38) missense probably benign 0.03
X0018:Lrrc37a UTSW 11 103,499,544 (GRCm38) missense possibly damaging 0.78
Z1176:Lrrc37a UTSW 11 103,501,094 (GRCm38) missense probably benign 0.09
Z1176:Lrrc37a UTSW 11 103,499,034 (GRCm38) missense possibly damaging 0.68
Z1176:Lrrc37a UTSW 11 103,456,486 (GRCm38) missense probably damaging 1.00
Z1177:Lrrc37a UTSW 11 103,500,520 (GRCm38) missense probably benign 0.43
Z1177:Lrrc37a UTSW 11 103,499,967 (GRCm38) missense possibly damaging 0.46
Z1177:Lrrc37a UTSW 11 103,503,027 (GRCm38) missense probably benign 0.20
Z1177:Lrrc37a UTSW 11 103,500,598 (GRCm38) missense probably benign 0.20
Predicted Primers PCR Primer
(F):5'- ATCGAGGAGACATGCTTCCCAGAC -3'
(R):5'- CAAATTCATGGCGGCCTTCTTCAC -3'

Sequencing Primer
(F):5'- ACACGGGGACATCACTTG -3'
(R):5'- GGCCTTCTTCACTTCCCATAG -3'
Posted On 2013-09-04