Mutagenetix > Incidental Mutation

Incidental Mutation 'R9139:Or11g25'

694238

Institutional Source

Beutler Lab

Gene Symbol

Or11g25

Ensembl Gene

ENSMUSG00000095765

Gene Name

olfactory receptor family 11 subfamily G member 25

Synonyms

MOR106-15, MOR106-10, Olfr741, GA_x6K02T2PMLR-6197851-6198786

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

R9139 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

50710514-50723852 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 50723707 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 264 (L264P)

Ref Sequence

ENSEMBL: ENSMUSP00000145848 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071932] [ENSMUST00000205518] [ENSMUST00000213903]

AlphaFold

L7N1Y5

Predicted Effect

probably damaging
Transcript: ENSMUST00000071932
AA Change: L264P

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000071824
Gene: ENSMUSG00000095765
AA Change: L264P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	1.2e-55	PFAM
Pfam:7tm_1	45	294	2.4e-20	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000205518
AA Change: L264P

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)

Predicted Effect

probably damaging
Transcript: ENSMUST00000213903
AA Change: L264P

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aamp	A	G	1: 74,320,705 (GRCm39)	V288A	possibly damaging	Het
Ankhd1	T	A	18: 36,711,810 (GRCm39)	S135R		Het
Axl	G	A	7: 25,460,846 (GRCm39)	T721I	probably damaging	Het
Blnk	G	A	19: 40,922,962 (GRCm39)	A388V	probably benign	Het
C8b	T	C	4: 104,641,631 (GRCm39)	V189A	probably damaging	Het
Ccdc33	G	C	9: 57,983,842 (GRCm39)	I452M	probably benign	Het
Cfap57	T	C	4: 118,412,048 (GRCm39)	T1199A	probably benign	Het
Chga	G	A	12: 102,528,144 (GRCm39)	V212M	probably benign	Het
Cspp1	T	A	1: 10,186,875 (GRCm39)	M887K	probably damaging	Het
Cyp3a16	G	C	5: 145,406,434 (GRCm39)	A6G	unknown	Het
Cyp4f17	G	T	17: 32,743,868 (GRCm39)	E349*	probably null	Het
Dnajc13	A	T	9: 104,085,039 (GRCm39)	D791E	probably benign	Het
Dpysl5	T	C	5: 30,935,397 (GRCm39)	Y167H	probably benign	Het
Dqx1	G	T	6: 83,036,759 (GRCm39)	Q254H	possibly damaging	Het
Eef1g	A	G	19: 8,955,383 (GRCm39)	T411A	probably benign	Het
Fancl	C	A	11: 26,337,231 (GRCm39)	A6E	probably benign	Het
Gabrr3	A	G	16: 59,227,830 (GRCm39)	Q29R	probably benign	Het
Gtf2h2	A	C	13: 100,617,778 (GRCm39)	L168R	probably damaging	Het
Hacl1	T	A	14: 31,338,338 (GRCm39)	Q413L	probably benign	Het
Hdc	A	T	2: 126,439,837 (GRCm39)	V372E	probably damaging	Het
Hr	A	T	14: 70,795,079 (GRCm39)	H208L	possibly damaging	Het
Htr6	T	C	4: 138,789,501 (GRCm39)	R255G	possibly damaging	Het
Jup	C	T	11: 100,270,391 (GRCm39)	C372Y	probably damaging	Het
Kank2	A	G	9: 21,681,370 (GRCm39)	V747A	probably damaging	Het
Kif5c	A	G	2: 49,620,291 (GRCm39)	T508A	probably benign	Het
Klhdc8b	A	G	9: 108,326,927 (GRCm39)	V145A	probably damaging	Het
Klk1b21	T	A	7: 43,754,924 (GRCm39)	V73D	probably damaging	Het
Ksr1	T	A	11: 78,911,572 (GRCm39)	M737L	probably benign	Het
Macf1	T	C	4: 123,328,564 (GRCm39)	Y4723C	probably damaging	Het
Mcm7	T	C	5: 138,167,397 (GRCm39)	Y182C	probably damaging	Het
Mtf2	T	C	5: 108,252,398 (GRCm39)		probably null	Het
Nrxn2	A	T	19: 6,498,299 (GRCm39)	T255S	probably benign	Het
Or10v9	A	G	19: 11,832,666 (GRCm39)	L217P	probably damaging	Het
Or10x4	A	T	1: 174,218,649 (GRCm39)	T5S	probably damaging	Het
Or2z2	T	A	11: 58,345,999 (GRCm39)	T259S	possibly damaging	Het
Or52k2	T	A	7: 102,254,185 (GRCm39)	I208N	probably damaging	Het
Or9m1	A	T	2: 87,733,108 (GRCm39)	M304K	probably benign	Het
Pamr1	T	A	2: 102,464,766 (GRCm39)	V305E	probably benign	Het
Peg10	GAT	GATCAT	6: 4,756,449 (GRCm39)		probably benign	Het
Peg10	C	T	6: 4,757,128 (GRCm39)	T568M	unknown	Het
Polr3a	A	G	14: 24,519,416 (GRCm39)	F664S	probably damaging	Het
Prb1a	T	A	6: 132,185,306 (GRCm39)	N109I	unknown	Het
Prdm2	T	C	4: 142,858,752 (GRCm39)	I1513V	probably benign	Het
Prkd3	A	C	17: 79,269,969 (GRCm39)	V564G	possibly damaging	Het
Prss16	A	G	13: 22,192,513 (GRCm39)	S151P	probably damaging	Het
Rnf150	C	T	8: 83,590,588 (GRCm39)		probably benign	Het
Rttn	A	G	18: 89,038,261 (GRCm39)	T786A	probably benign	Het
Scin	A	G	12: 40,113,236 (GRCm39)	V645A	possibly damaging	Het
Slc25a20	T	A	9: 108,557,398 (GRCm39)	M177K	probably benign	Het
Slc2a6	G	A	2: 26,914,334 (GRCm39)	S261L	possibly damaging	Het
Slc4a7	A	T	14: 14,796,115 (GRCm38)	D1118V	probably damaging	Het
Slc7a2	T	C	8: 41,358,709 (GRCm39)	W351R	probably damaging	Het
Sp8	G	A	12: 118,812,174 (GRCm39)	G10S	probably damaging	Het
St8sia2	A	G	7: 73,616,513 (GRCm39)	I175T	probably damaging	Het
Tas2r122	T	A	6: 132,688,779 (GRCm39)	N38I	probably benign	Het
Trim31	C	T	17: 37,209,382 (GRCm39)	T46M	possibly damaging	Het
Trim31	A	G	17: 37,220,145 (GRCm39)	K354E	probably benign	Het
Trio	G	A	15: 27,749,922 (GRCm39)	Q2260*	probably null	Het
Trpm1	T	C	7: 63,848,943 (GRCm39)	I63T	probably benign	Het
Ugt2b37	T	C	5: 87,399,636 (GRCm39)	K291E	probably benign	Het
Usp54	T	C	14: 20,627,162 (GRCm39)	T499A	probably benign	Het
Vmn1r35	T	C	6: 66,655,933 (GRCm39)	I246V	probably benign	Het
Vmn2r6	A	G	3: 64,464,277 (GRCm39)	S186P	probably benign	Het
Vmn2r76	T	A	7: 85,879,170 (GRCm39)	M377L	probably benign	Het
Zeb2	A	C	2: 44,878,637 (GRCm39)	M1243R	possibly damaging	Het

Other mutations in Or11g25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01773:Or11g25	APN	14	50,723,230 (GRCm39)	missense	probably damaging	0.98
IGL01796:Or11g25	APN	14	50,722,998 (GRCm39)	missense	probably benign	0.28
IGL01916:Or11g25	APN	14	50,722,950 (GRCm39)	missense	probably benign	0.01
IGL02686:Or11g25	APN	14	50,723,426 (GRCm39)	missense	probably benign	0.01
IGL02874:Or11g25	APN	14	50,723,686 (GRCm39)	missense	possibly damaging	0.57
IGL02898:Or11g25	APN	14	50,723,643 (GRCm39)	missense	probably damaging	1.00
PIT4515001:Or11g25	UTSW	14	50,723,536 (GRCm39)	missense	probably benign	0.03
R0085:Or11g25	UTSW	14	50,723,791 (GRCm39)	missense	probably benign	0.16
R1777:Or11g25	UTSW	14	50,723,757 (GRCm39)	missense	probably benign	0.08
R1850:Or11g25	UTSW	14	50,723,055 (GRCm39)	missense	probably benign
R2270:Or11g25	UTSW	14	50,723,494 (GRCm39)	missense	probably damaging	1.00
R2338:Or11g25	UTSW	14	50,723,097 (GRCm39)	missense	possibly damaging	0.47
R2971:Or11g25	UTSW	14	50,723,065 (GRCm39)	missense	probably damaging	0.99
R4594:Or11g25	UTSW	14	50,723,619 (GRCm39)	missense	probably benign	0.00
R5383:Or11g25	UTSW	14	50,723,509 (GRCm39)	nonsense	probably null
R5708:Or11g25	UTSW	14	50,723,452 (GRCm39)	missense	probably damaging	1.00
R6038:Or11g25	UTSW	14	50,723,677 (GRCm39)	missense	probably damaging	1.00
R6038:Or11g25	UTSW	14	50,723,677 (GRCm39)	missense	probably damaging	1.00
R7116:Or11g25	UTSW	14	50,723,025 (GRCm39)	missense	probably benign	0.00
R7702:Or11g25	UTSW	14	50,723,751 (GRCm39)	missense	possibly damaging	0.79
R8169:Or11g25	UTSW	14	50,723,692 (GRCm39)	missense	probably benign	0.13
R9040:Or11g25	UTSW	14	50,722,995 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GGTCCATTATAATGTCTATGCTCCTG -3'
(R):5'- AGGGAGTACAGTATTTGACTTCCC -3'

Sequencing Primer
(F):5'- ATAATGTCTATGCTCCTGGTTATTCC -3'
(R):5'- GAGTACAGTATTTGACTTCCCATAAC -3'

Posted On

2022-01-20