Incidental Mutation 'R9140:Sema6a'
| ID |
694319 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sema6a
|
| Ensembl Gene |
ENSMUSG00000019647 |
| Gene Name |
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A |
| Synonyms |
VIa, Semaq, Sema6A-1, sema, A730020P05Rik |
| MMRRC Submission |
068972-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9140 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
18 |
| Chromosomal Location |
47378321-47504267 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 47415009 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 427
(N427S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000019791
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000019791]
[ENSMUST00000076043]
[ENSMUST00000115449]
[ENSMUST00000135790]
[ENSMUST00000156422]
|
| AlphaFold |
O35464 |
| PDB Structure |
Mouse Semaphorin 6A extracellular domain [X-RAY DIFFRACTION]
Plexin A2 / Semaphorin 6A complex [X-RAY DIFFRACTION]
Mouse Semaphorin 6A, extracellular domains 1-2 [X-RAY DIFFRACTION]
Plexin A2 in complex with Semaphorin 6A [X-RAY DIFFRACTION]
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000019791
AA Change: N427S
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000019791
Gene: ENSMUSG00000019647
AA Change: N427S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
648 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
932 |
951 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000076043
AA Change: N427S
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000075420
Gene: ENSMUSG00000019647
AA Change: N427S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
593 |
615 |
N/A |
INTRINSIC |
|
low complexity region
|
877 |
896 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115449
AA Change: N427S
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000111109
Gene: ENSMUSG00000019647
AA Change: N427S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
461 |
1.24e-168 |
SMART |
|
PSI
|
488 |
543 |
9.57e-1 |
SMART |
|
transmembrane domain
|
622 |
644 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
925 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000123228
|
| SMART Domains |
Protein: ENSMUSP00000120249
Gene: ENSMUSG00000019647
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:PSI
|
2 |
45 |
4e-26 |
BLAST |
|
PDB:3OKY|B
|
2 |
47 |
2e-26 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135790
AA Change: N427S
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000120011
Gene: ENSMUSG00000019647
AA Change: N427S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
665 |
687 |
N/A |
INTRINSIC |
|
low complexity region
|
949 |
968 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156422
AA Change: N427S
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000121442
Gene: ENSMUSG00000019647
AA Change: N427S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
648 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
932 |
951 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0846 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (69/69) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit defects in lamina-specific neurite stratification of specific retinal neuron subtypes and disruption of the dendritic plexus organization of On but not Off starburst amacrine cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actl9 |
A |
T |
17: 33,652,170 (GRCm39) |
I77F |
possibly damaging |
Het |
| Adgb |
G |
A |
10: 10,216,263 (GRCm39) |
R1509* |
probably null |
Het |
| Ago1 |
C |
A |
4: 126,336,977 (GRCm39) |
V547L |
probably benign |
Het |
| Arhgap21 |
T |
A |
2: 20,886,025 (GRCm39) |
Y394F |
probably damaging |
Het |
| C1qa |
A |
C |
4: 136,623,553 (GRCm39) |
I217S |
probably damaging |
Het |
| Cacna1b |
T |
A |
2: 24,525,224 (GRCm39) |
I1651F |
probably damaging |
Het |
| Car8 |
T |
C |
4: 8,183,270 (GRCm39) |
T242A |
probably benign |
Het |
| Ccdc121rt3 |
A |
T |
5: 112,502,723 (GRCm39) |
L327Q |
probably damaging |
Het |
| Ccn4 |
G |
A |
15: 66,791,157 (GRCm39) |
V320M |
probably damaging |
Het |
| Chrnb4 |
G |
A |
9: 54,941,955 (GRCm39) |
H440Y |
|
Het |
| Cic |
T |
C |
7: 24,985,165 (GRCm39) |
V1137A |
probably damaging |
Het |
| Ctdp1 |
C |
T |
18: 80,484,043 (GRCm39) |
|
probably null |
Het |
| Cyp3a16 |
G |
C |
5: 145,406,434 (GRCm39) |
A6G |
unknown |
Het |
| Ddhd1 |
A |
C |
14: 45,894,918 (GRCm39) |
L184R |
probably benign |
Het |
| Dnttip1 |
A |
G |
2: 164,596,082 (GRCm39) |
D109G |
possibly damaging |
Het |
| Dsc3 |
T |
A |
18: 20,122,616 (GRCm39) |
M103L |
probably benign |
Het |
| Dusp9 |
TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG |
TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG |
X: 72,684,217 (GRCm39) |
|
probably benign |
Het |
| Elapor2 |
T |
C |
5: 9,449,226 (GRCm39) |
V118A |
probably benign |
Het |
| Eya2 |
T |
C |
2: 165,608,977 (GRCm39) |
L439S |
probably damaging |
Het |
| Eya3 |
A |
G |
4: 132,428,411 (GRCm39) |
N311S |
possibly damaging |
Het |
| Fam151a |
C |
T |
4: 106,605,344 (GRCm39) |
R569* |
probably null |
Het |
| Fer1l5 |
A |
G |
1: 36,460,047 (GRCm39) |
|
probably benign |
Het |
| Fnbp4 |
A |
G |
2: 90,576,077 (GRCm39) |
T93A |
unknown |
Het |
| Fosl2 |
T |
C |
5: 32,310,042 (GRCm39) |
S164P |
probably damaging |
Het |
| Galc |
T |
C |
12: 98,173,673 (GRCm39) |
T630A |
probably null |
Het |
| Gm5916 |
G |
T |
9: 36,031,982 (GRCm39) |
Q101K |
unknown |
Het |
| Gm7138 |
A |
T |
10: 77,612,682 (GRCm39) |
|
probably benign |
Het |
| Habp2 |
A |
G |
19: 56,307,934 (GRCm39) |
K474R |
probably benign |
Het |
| Ibtk |
A |
G |
9: 85,617,114 (GRCm39) |
F153L |
probably damaging |
Het |
| Idh2 |
TCCCAGG |
T |
7: 79,748,079 (GRCm39) |
|
probably benign |
Het |
| Jup |
C |
T |
11: 100,270,391 (GRCm39) |
C372Y |
probably damaging |
Het |
| Kirrel3 |
C |
T |
9: 34,924,596 (GRCm39) |
A268V |
probably benign |
Het |
| Kprp |
G |
T |
3: 92,732,458 (GRCm39) |
Y197* |
probably null |
Het |
| Kri1 |
C |
T |
9: 21,187,434 (GRCm39) |
R471H |
|
Het |
| Krt17 |
C |
A |
11: 100,148,476 (GRCm39) |
A322S |
possibly damaging |
Het |
| Leng9 |
A |
T |
7: 4,152,657 (GRCm39) |
D6E |
probably benign |
Het |
| Macf1 |
A |
T |
4: 123,367,855 (GRCm39) |
I2302K |
possibly damaging |
Het |
| Manba |
G |
A |
3: 135,191,490 (GRCm39) |
V17M |
probably benign |
Het |
| Mical2 |
A |
G |
7: 112,006,826 (GRCm39) |
K582E |
probably damaging |
Het |
| Mknk2 |
A |
G |
10: 80,507,427 (GRCm39) |
V102A |
probably benign |
Het |
| Myh1 |
G |
A |
11: 67,100,089 (GRCm39) |
G636D |
probably benign |
Het |
| Or51q1c |
A |
G |
7: 103,653,322 (GRCm39) |
N280S |
probably damaging |
Het |
| P2rx7 |
G |
A |
5: 122,790,789 (GRCm39) |
|
probably null |
Het |
| Pcmt1 |
A |
G |
10: 7,514,678 (GRCm39) |
*177R |
probably null |
Het |
| Pla2r1 |
T |
C |
2: 60,271,455 (GRCm39) |
K959R |
probably benign |
Het |
| Plat |
A |
G |
8: 23,270,562 (GRCm39) |
D493G |
probably damaging |
Het |
| Prr30 |
A |
G |
14: 101,436,430 (GRCm39) |
L44P |
probably benign |
Het |
| Ptx4 |
T |
C |
17: 25,344,180 (GRCm39) |
C477R |
probably damaging |
Het |
| Pus10 |
A |
G |
11: 23,622,625 (GRCm39) |
S82G |
probably benign |
Het |
| Pygo1 |
A |
G |
9: 72,852,988 (GRCm39) |
T392A |
probably benign |
Het |
| Rad54b |
C |
A |
4: 11,610,386 (GRCm39) |
L668I |
probably damaging |
Het |
| Rdh19 |
A |
C |
10: 127,692,830 (GRCm39) |
M166L |
|
Het |
| Retnlg |
C |
A |
16: 48,693,288 (GRCm39) |
Q22K |
possibly damaging |
Het |
| Rfc3 |
G |
T |
5: 151,568,141 (GRCm39) |
T249K |
probably benign |
Het |
| Rgs16 |
T |
A |
1: 153,619,381 (GRCm39) |
V129E |
probably damaging |
Het |
| Rptn |
T |
A |
3: 93,303,445 (GRCm39) |
Y259* |
probably null |
Het |
| Slc7a13 |
T |
C |
4: 19,819,487 (GRCm39) |
I229T |
possibly damaging |
Het |
| Slitrk3 |
A |
T |
3: 72,957,792 (GRCm39) |
Y327N |
probably benign |
Het |
| Smtnl2 |
A |
G |
11: 72,290,793 (GRCm39) |
L384P |
probably damaging |
Het |
| Stil |
G |
T |
4: 114,864,449 (GRCm39) |
V117F |
probably damaging |
Het |
| Tada1 |
T |
C |
1: 166,216,177 (GRCm39) |
V126A |
probably benign |
Het |
| Tasor2 |
G |
A |
13: 3,638,441 (GRCm39) |
T430I |
probably benign |
Het |
| Tmem30c |
T |
C |
16: 57,090,482 (GRCm39) |
I242V |
probably damaging |
Het |
| Tnnt2 |
T |
A |
1: 135,768,635 (GRCm39) |
V8E |
|
Het |
| Ttn |
A |
G |
2: 76,774,240 (GRCm39) |
V2268A |
unknown |
Het |
| Uspl1 |
G |
T |
5: 149,150,290 (GRCm39) |
A497S |
possibly damaging |
Het |
| Vmn2r1 |
A |
T |
3: 63,997,465 (GRCm39) |
N374Y |
probably benign |
Het |
| Vmn2r27 |
A |
G |
6: 124,169,207 (GRCm39) |
F641S |
probably damaging |
Het |
| Vmn2r52 |
T |
A |
7: 9,892,643 (GRCm39) |
Y832F |
probably damaging |
Het |
| Zfp748 |
C |
T |
13: 67,689,073 (GRCm39) |
C729Y |
probably damaging |
Het |
|
| Other mutations in Sema6a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00336:Sema6a
|
APN |
18 |
47,423,042 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01351:Sema6a
|
APN |
18 |
47,414,369 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL01594:Sema6a
|
APN |
18 |
47,381,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01953:Sema6a
|
APN |
18 |
47,423,187 (GRCm39) |
nonsense |
probably null |
|
|
IGL02077:Sema6a
|
APN |
18 |
47,416,465 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02632:Sema6a
|
APN |
18 |
47,423,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02957:Sema6a
|
APN |
18 |
47,382,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03013:Sema6a
|
APN |
18 |
47,381,461 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03279:Sema6a
|
APN |
18 |
47,433,157 (GRCm39) |
nonsense |
probably null |
|
|
saphire
|
UTSW |
18 |
47,439,496 (GRCm39) |
nonsense |
probably null |
|
|
IGL02988:Sema6a
|
UTSW |
18 |
47,431,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0114:Sema6a
|
UTSW |
18 |
47,423,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0311:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0312:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0347:Sema6a
|
UTSW |
18 |
47,424,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0350:Sema6a
|
UTSW |
18 |
47,403,785 (GRCm39) |
missense |
probably benign |
|
|
R0366:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0368:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0391:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0403:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0466:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0515:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0517:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0542:Sema6a
|
UTSW |
18 |
47,381,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0557:Sema6a
|
UTSW |
18 |
47,382,567 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0569:Sema6a
|
UTSW |
18 |
47,403,872 (GRCm39) |
splice site |
probably null |
|
|
R0650:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0689:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0694:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0726:Sema6a
|
UTSW |
18 |
47,425,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0741:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0821:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0824:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0924:Sema6a
|
UTSW |
18 |
47,381,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1108:Sema6a
|
UTSW |
18 |
47,439,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1255:Sema6a
|
UTSW |
18 |
47,382,366 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1422:Sema6a
|
UTSW |
18 |
47,439,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1531:Sema6a
|
UTSW |
18 |
47,382,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1707:Sema6a
|
UTSW |
18 |
47,416,512 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1746:Sema6a
|
UTSW |
18 |
47,439,416 (GRCm39) |
splice site |
probably benign |
|
|
R1807:Sema6a
|
UTSW |
18 |
47,409,491 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1974:Sema6a
|
UTSW |
18 |
47,403,696 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1987:Sema6a
|
UTSW |
18 |
47,433,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2044:Sema6a
|
UTSW |
18 |
47,439,496 (GRCm39) |
nonsense |
probably null |
|
|
R3719:Sema6a
|
UTSW |
18 |
47,382,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4491:Sema6a
|
UTSW |
18 |
47,439,524 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R4552:Sema6a
|
UTSW |
18 |
47,424,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4707:Sema6a
|
UTSW |
18 |
47,381,779 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4710:Sema6a
|
UTSW |
18 |
47,403,750 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4713:Sema6a
|
UTSW |
18 |
47,382,363 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4963:Sema6a
|
UTSW |
18 |
47,431,318 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5088:Sema6a
|
UTSW |
18 |
47,382,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5133:Sema6a
|
UTSW |
18 |
47,433,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5135:Sema6a
|
UTSW |
18 |
47,424,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5141:Sema6a
|
UTSW |
18 |
47,381,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5277:Sema6a
|
UTSW |
18 |
47,409,611 (GRCm39) |
intron |
probably benign |
|
|
R5551:Sema6a
|
UTSW |
18 |
47,381,595 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5618:Sema6a
|
UTSW |
18 |
47,415,015 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5717:Sema6a
|
UTSW |
18 |
47,382,330 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5729:Sema6a
|
UTSW |
18 |
47,414,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5779:Sema6a
|
UTSW |
18 |
47,381,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5917:Sema6a
|
UTSW |
18 |
47,414,405 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6054:Sema6a
|
UTSW |
18 |
47,416,470 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6142:Sema6a
|
UTSW |
18 |
47,414,266 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6209:Sema6a
|
UTSW |
18 |
47,431,369 (GRCm39) |
splice site |
probably null |
|
|
R6307:Sema6a
|
UTSW |
18 |
47,382,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6734:Sema6a
|
UTSW |
18 |
47,412,236 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7014:Sema6a
|
UTSW |
18 |
47,431,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7033:Sema6a
|
UTSW |
18 |
47,381,637 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7574:Sema6a
|
UTSW |
18 |
47,424,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8054:Sema6a
|
UTSW |
18 |
47,424,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8250:Sema6a
|
UTSW |
18 |
47,423,182 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8408:Sema6a
|
UTSW |
18 |
47,381,958 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8411:Sema6a
|
UTSW |
18 |
47,382,022 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8900:Sema6a
|
UTSW |
18 |
47,424,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9158:Sema6a
|
UTSW |
18 |
47,431,330 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9488:Sema6a
|
UTSW |
18 |
47,437,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9565:Sema6a
|
UTSW |
18 |
47,382,594 (GRCm39) |
missense |
probably null |
1.00 |
|
R9652:Sema6a
|
UTSW |
18 |
47,382,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9732:Sema6a
|
UTSW |
18 |
47,381,925 (GRCm39) |
missense |
probably damaging |
0.96 |
|
X0065:Sema6a
|
UTSW |
18 |
47,416,386 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGTCTGCCAAGATTTTCCATG -3'
(R):5'- TAAGGGACCAGACCAGCTTG -3'
Sequencing Primer
(F):5'- GTCTGCCAAGATTTTCCATGAATGG -3'
(R):5'- CCAGCTTGAGAACATTACTTACATGC -3'
|
| Posted On |
2022-01-20 |
Incidental Mutation