Incidental Mutation 'R9144:Fpr1'
ID 694524
Institutional Source Beutler Lab
Gene Symbol Fpr1
Ensembl Gene ENSMUSG00000045551
Gene Name formyl peptide receptor 1
Synonyms fMLF-R, FPR
MMRRC Submission 068935-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9144 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 18096733-18104201 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 18097626 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 121 (V121D)
Ref Sequence ENSEMBL: ENSMUSP00000052894 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061516]
AlphaFold P33766
Predicted Effect probably damaging
Transcript: ENSMUST00000061516
AA Change: V121D

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000052894
Gene: ENSMUSG00000045551
AA Change: V121D

DomainStartEndE-ValueType
Pfam:7tm_1 51 312 8.2e-40 PFAM
Meta Mutation Damage Score 0.8573 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
PHENOTYPE: Targeted null mice are viable and developmentally normal but show increased susceptibility to L. monocytogenes challenge, as shown by increased mortality and bacterial burden in liver/spleen early post-infection. Mutant neutrophils fail to respond to fMLF either in calcium flux or chemotaxis assays. [provided by MGI curators]
Allele List at MGI

All alleles(1) : Targeted, knock-out(1)

Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg4 C T 9: 44,192,708 (GRCm39) V176M possibly damaging Het
Acp5 T C 9: 22,041,242 (GRCm39) T62A probably benign Het
Alad A T 4: 62,430,257 (GRCm39) D88E probably damaging Het
Arap1 T C 7: 101,047,602 (GRCm39) I803T probably damaging Het
Bckdhb C A 9: 83,894,662 (GRCm39) T312K probably damaging Het
Cfap206 A G 4: 34,722,667 (GRCm39) V138A possibly damaging Het
Cntnap5b A G 1: 99,978,512 (GRCm39) Y176C probably damaging Het
Creld1 A T 6: 113,461,468 (GRCm39) T63S probably damaging Het
Dsc1 G A 18: 20,218,639 (GRCm39) T878I possibly damaging Het
Ehbp1 C T 11: 22,018,463 (GRCm39) R873H probably damaging Het
Eml2 T C 7: 18,935,564 (GRCm39) V466A possibly damaging Het
Ercc5 T A 1: 44,213,511 (GRCm39) Y836N probably damaging Het
Fgf20 T C 8: 40,732,958 (GRCm39) D160G Het
Fgfr4 A T 13: 55,315,837 (GRCm39) probably null Het
Gabbr1 A G 17: 37,362,049 (GRCm39) K218E probably benign Het
Galnt12 T C 4: 47,113,822 (GRCm39) L372P Het
Gldc A G 19: 30,114,593 (GRCm39) F439S Het
Gm6465 A G 5: 11,896,726 (GRCm39) T32A possibly damaging Het
Has2 T C 15: 56,545,588 (GRCm39) R5G probably benign Het
Hexb T C 13: 97,317,599 (GRCm39) Y366C probably damaging Het
Ier2 C T 8: 85,389,266 (GRCm39) V39I probably benign Het
Ifi214 A G 1: 173,355,434 (GRCm39) S125P possibly damaging Het
Kcnk15 A G 2: 163,700,451 (GRCm39) D230G probably benign Het
Kdm3b A T 18: 34,927,558 (GRCm39) Y140F probably benign Het
Klk1b11 T C 7: 43,427,055 (GRCm39) V140A probably damaging Het
Klra5 C T 6: 129,886,911 (GRCm39) C39Y probably benign Het
Ltbp2 T C 12: 84,856,426 (GRCm39) I699M probably damaging Het
Mak C A 13: 41,201,594 (GRCm39) E256* probably null Het
Mark3 C A 12: 111,606,376 (GRCm39) N496K probably benign Het
Mex3c A G 18: 73,723,397 (GRCm39) T497A probably benign Het
Myt1 A G 2: 181,467,805 (GRCm39) I1160V possibly damaging Het
Notch1 T C 2: 26,349,587 (GRCm39) T2518A probably benign Het
Nsg1 A G 5: 38,302,088 (GRCm39) Y108H probably benign Het
Nxt2 C T X: 141,020,747 (GRCm39) A118V possibly damaging Het
Obscn A G 11: 58,960,103 (GRCm39) S3255P possibly damaging Het
Or5w18 A G 2: 87,633,482 (GRCm39) T246A probably benign Het
Plxna4 A G 6: 32,162,496 (GRCm39) V1339A possibly damaging Het
Ppp2r5e C T 12: 75,506,468 (GRCm39) R433H possibly damaging Het
Pwwp2a T A 11: 43,596,721 (GRCm39) C629S probably benign Het
Rasl10a T A 11: 5,008,473 (GRCm39) S56R probably benign Het
Rhob A G 12: 8,549,124 (GRCm39) V170A probably damaging Het
Rlf A T 4: 121,003,900 (GRCm39) N1803K probably benign Het
Rmdn3 G T 2: 118,969,847 (GRCm39) Q405K probably benign Het
Rpap3 G A 15: 97,589,184 (GRCm39) T250M possibly damaging Het
Rraga T C 4: 86,494,796 (GRCm39) I214T probably damaging Het
Rundc3a A T 11: 102,290,862 (GRCm39) Q315L probably benign Het
Sh3bgr T A 16: 96,001,931 (GRCm39) S10T probably benign Het
Skint6 A T 4: 112,985,102 (GRCm39) S421R possibly damaging Het
Spag16 G C 1: 70,420,459 (GRCm39) L482F probably damaging Het
Sppl2a A G 2: 126,769,743 (GRCm39) S38P probably benign Het
Tex14 T A 11: 87,413,423 (GRCm39) probably null Het
Tmem181a G A 17: 6,346,048 (GRCm39) V181M possibly damaging Het
Traf3 T A 12: 111,228,294 (GRCm39) S502T probably benign Het
Trav9n-4 T G 14: 53,532,236 (GRCm39) V30G probably damaging Het
Trpm2 C A 10: 77,765,122 (GRCm39) V960L probably benign Het
Unc13b T A 4: 43,173,649 (GRCm39) D1492E unknown Het
Usp44 A G 10: 93,681,645 (GRCm39) T32A probably benign Het
Vmn1r38 A G 6: 66,753,612 (GRCm39) M168T probably benign Het
Vmn1r9 A G 6: 57,048,788 (GRCm39) I288V probably benign Het
Zfhx3 A G 8: 109,676,794 (GRCm39) T2615A possibly damaging Het
Other mutations in Fpr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00500:Fpr1 APN 17 18,097,263 (GRCm39) missense probably benign 0.00
IGL01473:Fpr1 APN 17 18,097,954 (GRCm39) missense possibly damaging 0.95
IGL01704:Fpr1 APN 17 18,097,234 (GRCm39) missense possibly damaging 0.64
IGL01900:Fpr1 APN 17 18,097,783 (GRCm39) missense probably damaging 0.96
IGL02548:Fpr1 APN 17 18,096,915 (GRCm39) missense probably benign 0.01
G5030:Fpr1 UTSW 17 18,097,068 (GRCm39) missense probably damaging 1.00
PIT4445001:Fpr1 UTSW 17 18,097,155 (GRCm39) missense probably benign
R0284:Fpr1 UTSW 17 18,097,618 (GRCm39) missense probably damaging 0.99
R1440:Fpr1 UTSW 17 18,097,525 (GRCm39) missense probably benign 0.01
R1631:Fpr1 UTSW 17 18,097,263 (GRCm39) missense probably benign 0.00
R1823:Fpr1 UTSW 17 18,097,315 (GRCm39) missense probably benign 0.00
R1994:Fpr1 UTSW 17 18,097,879 (GRCm39) missense probably benign 0.01
R2168:Fpr1 UTSW 17 18,097,471 (GRCm39) missense possibly damaging 0.52
R2364:Fpr1 UTSW 17 18,097,872 (GRCm39) nonsense probably null
R3110:Fpr1 UTSW 17 18,096,897 (GRCm39) missense probably benign 0.01
R3111:Fpr1 UTSW 17 18,096,897 (GRCm39) missense probably benign 0.01
R3112:Fpr1 UTSW 17 18,096,897 (GRCm39) missense probably benign 0.01
R3440:Fpr1 UTSW 17 18,097,420 (GRCm39) missense probably benign
R3949:Fpr1 UTSW 17 18,097,191 (GRCm39) missense probably benign
R5745:Fpr1 UTSW 17 18,097,344 (GRCm39) missense probably benign 0.05
R5750:Fpr1 UTSW 17 18,097,525 (GRCm39) missense probably benign 0.01
R6130:Fpr1 UTSW 17 18,097,897 (GRCm39) missense probably benign 0.13
R6187:Fpr1 UTSW 17 18,097,190 (GRCm39) nonsense probably null
R7017:Fpr1 UTSW 17 18,097,654 (GRCm39) missense probably benign 0.00
R7358:Fpr1 UTSW 17 18,097,242 (GRCm39) missense probably damaging 0.99
R7840:Fpr1 UTSW 17 18,097,634 (GRCm39) missense probably benign 0.15
R8762:Fpr1 UTSW 17 18,097,851 (GRCm39) missense probably damaging 1.00
R9033:Fpr1 UTSW 17 18,097,691 (GRCm39) nonsense probably null
R9080:Fpr1 UTSW 17 18,097,212 (GRCm39) missense probably benign 0.02
R9260:Fpr1 UTSW 17 18,098,006 (GRCm39) splice site probably benign
R9655:Fpr1 UTSW 17 18,097,618 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TATTAGGGACTGTGGTCAAACG -3'
(R):5'- CGTCACATTTGTCCTTGGGG -3'

Sequencing Primer
(F):5'- CTGTGGTCAAACGAATGATAACTGGC -3'
(R):5'- TTTCCGCATGAAACACACTGTC -3'
Posted On 2022-01-20