Mutagenetix > Incidental Mutation

Incidental Mutation 'R9145:Nlrp1b'

694586

Institutional Source

Beutler Lab

Gene Symbol

Nlrp1b

Ensembl Gene

ENSMUSG00000070390

Gene Name

NLR family, pyrin domain containing 1B

Synonyms

Nalp1b

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

R9145 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

71153102-71230733 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 71218367 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 103 (Y103H)

Ref Sequence

ENSEMBL: ENSMUSP00000104156 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094046] [ENSMUST00000108516] [ENSMUST00000136493]

AlphaFold

A1Z198

Predicted Effect

probably benign
Transcript: ENSMUST00000094046
AA Change: Y103H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000091588
Gene: ENSMUSG00000070390
AA Change: Y103H

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	6.7e-43	PFAM
LRR	627	654	2.24e0	SMART
LRR	656	683	8.82e0	SMART
LRR	684	711	3.49e-5	SMART
Pfam:FIIND	812	1064	8.2e-104	PFAM
Pfam:CARD	1083	1166	3.1e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000108516
AA Change: Y103H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000104156
Gene: ENSMUSG00000070390
AA Change: Y103H

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	2.2e-42	PFAM
LRR	627	654	2.24e0	SMART
LRR	656	683	8.82e0	SMART
LRR	684	711	3.49e-5	SMART
Pfam:FIIND	811	1065	3.9e-136	PFAM
Pfam:CARD	1083	1166	1.1e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000136493
AA Change: Y103H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000121155
Gene: ENSMUSG00000070390
AA Change: Y103H

Domain	Start	End	E-Value	Type
Pfam:NACHT	131	300	8.9e-43	PFAM
PDB:4IM6\|A	610	662	6e-10	PDB
Blast:LRR	627	654	3e-11	BLAST

Meta Mutation Damage Score

0.0846

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.1%

Validation Efficiency

100% (79/79)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit protection from anthrax lethal toxin-induced lung injury and pyroptosis of macrophages. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 78 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	T	A	6: 128,559,069	H720L	probably benign	Het
Abca15	T	C	7: 120,388,165	Y1225H	probably benign	Het
Adck1	C	A	12: 88,368,423	N26K	probably benign	Het
Adcy3	A	G	12: 4,195,208	D382G	probably damaging	Het
Ahi1	T	A	10: 21,000,589	C800S	probably benign	Het
Ahnak	G	T	19: 9,014,923	V4524L	probably benign	Het
Apol11a	C	T	15: 77,513,578	A43V	probably benign	Het
Arid1a	T	C	4: 133,693,903	M479V	unknown	Het
Atp13a2	T	A	4: 140,996,745	C324S	probably damaging	Het
C2cd2	T	G	16: 97,876,286	T413P	probably damaging	Het
Cct5	A	C	15: 31,590,961	D531E		Het
Chst1	A	T	2: 92,614,178	I332F	probably damaging	Het
Col12a1	A	T	9: 79,620,062	V2662D	probably benign	Het
Cts3	A	G	13: 61,564,986	Y307H	probably benign	Het
D630023F18Rik	G	A	1: 65,121,212		probably benign	Het
Dhx9	A	G	1: 153,461,080	I807T	probably damaging	Het
Doxl2	C	A	6: 48,975,956	R272S	probably benign	Het
Exoc3l4	T	C	12: 111,422,152	L25P	probably benign	Het
Ggcx	T	A	6: 72,425,922	C288S	probably benign	Het
Gjb3	A	G	4: 127,326,347	Y131H	probably damaging	Het
Hdhd3	A	G	4: 62,499,337	S201P	probably benign	Het
Helz2	A	T	2: 181,240,055	V315E	probably damaging	Het
Hsp90aa1	A	G	12: 110,696,250		probably null	Het
Il12a	C	T	3: 68,691,542	R19W	unknown	Het
Isoc1	C	T	18: 58,673,275	A219V	possibly damaging	Het
Jup	T	A	11: 100,378,298	T430S	probably benign	Het
Klra5	C	T	6: 129,909,948	C39Y	probably benign	Het
Map4	A	T	9: 110,026,200	Q131L	probably damaging	Het
Mau2	T	A	8: 70,027,515	K314M	probably damaging	Het
Mga	A	G	2: 119,964,012	M2726V	probably benign	Het
Mgme1	G	A	2: 144,272,485		probably null	Het
Msrb2	A	G	2: 19,394,255	E143G	probably benign	Het
Muc5b	G	T	7: 141,857,613	C1432F	unknown	Het
Naglu	T	C	11: 101,071,114	Y138H	probably damaging	Het
Nicn1	C	T	9: 108,294,509	R163C	possibly damaging	Het
Nodal	A	G	10: 61,423,680	N299D	probably damaging	Het
Notch1	T	C	2: 26,459,575	T2518A	probably benign	Het
Nr2e1	A	C	10: 42,572,952	S97A	probably benign	Het
Nuak1	A	T	10: 84,374,723	S500R	probably benign	Het
Nxt2	C	T	X: 142,237,751	A118V	possibly damaging	Het
Nyap1	T	C	5: 137,737,913	E104G	probably benign	Het
Olfr401	C	T	11: 74,121,700	T137I	probably benign	Het
Olfr670	T	A	7: 104,959,997	H245L	probably damaging	Het
Palld	T	C	8: 61,877,073	T257A	probably benign	Het
Pcnx4	C	T	12: 72,556,269	P435L	probably damaging	Het
Piezo1	T	C	8: 122,482,014	T2538A	unknown	Het
Plagl1	T	C	10: 13,128,128	L380P	unknown	Het
Polrmt	G	T	10: 79,740,581	Q514K	probably benign	Het
Psg17	T	G	7: 18,819,926	D133A	probably benign	Het
Rab3b	G	A	4: 108,940,706	D185N	probably benign	Het
Ranbp2	T	A	10: 58,455,914	S248T	probably benign	Het
Rdh10	C	A	1: 16,129,206	A212D	probably damaging	Het
Rinl	A	G	7: 28,795,664	H154R		Het
Selenbp1	T	C	3: 94,944,103	M389T	probably benign	Het
Serpina1c	T	A	12: 103,896,141	H305L	possibly damaging	Het
Sh3rf2	T	A	18: 42,149,681	S467T		Het
Sipa1l1	A	G	12: 82,396,561	D875G	probably benign	Het
Slc10a6	A	T	5: 103,628,934	V100D	probably damaging	Het
Slc13a4	T	C	6: 35,270,355	I577V	possibly damaging	Het
Slc20a2	T	C	8: 22,540,431	F168L	probably benign	Het
Slc25a1	A	T	16: 17,927,244		probably null	Het
Slc5a12	A	G	2: 110,640,897	S495G	probably benign	Het
Smpdl3a	A	G	10: 57,800,932	D42G	possibly damaging	Het
Spag16	G	C	1: 70,381,300	L482F	probably damaging	Het
Susd5	G	A	9: 114,096,221	G391R	probably damaging	Het
Sync	G	T	4: 129,293,825	A217S		Het
Tha1	T	A	11: 117,868,686	N326Y	probably damaging	Het
Tjp1	A	T	7: 65,302,816	F1590Y	probably benign	Het
Tle4	T	C	19: 14,468,219	N221S	probably benign	Het
Tln1	T	C	4: 43,536,024	T2054A	probably damaging	Het
Ttc30a1	A	T	2: 75,980,079	Y553*	probably null	Het
Ttll4	A	G	1: 74,679,790	K267E	probably benign	Het
Usp32	C	T	11: 85,022,292	G930D	probably damaging	Het
Vmn2r75	T	C	7: 86,164,239	N452D	probably damaging	Het
Vmn2r81	T	C	10: 79,268,194	L217P	possibly damaging	Het
Wnt2	T	A	6: 18,030,398		probably benign	Het
Zfp459	C	T	13: 67,408,616	S116N	probably benign	Het
Zfp981	C	A	4: 146,537,953	T445N	possibly damaging	Het

Other mutations in Nlrp1b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00161:Nlrp1b	APN	11	71181181	intron	probably benign
IGL00571:Nlrp1b	APN	11	71163973	missense	probably null	0.48
IGL01358:Nlrp1b	APN	11	71181856	missense	possibly damaging	0.91
IGL01937:Nlrp1b	APN	11	71181407	missense	probably damaging	0.98
IGL01945:Nlrp1b	APN	11	71181407	missense	probably damaging	0.98
IGL02375:Nlrp1b	APN	11	71161680	missense	probably damaging	1.00
IGL02552:Nlrp1b	APN	11	71182052	missense	possibly damaging	0.57
IGL02552:Nlrp1b	APN	11	71172231	missense	possibly damaging	0.96
IGL02588:Nlrp1b	APN	11	71182279	nonsense	probably null
IGL02833:Nlrp1b	APN	11	71161172	missense	probably benign
IGL02955:Nlrp1b	APN	11	71169811	missense	possibly damaging	0.73
IGL03002:Nlrp1b	APN	11	71168859	missense	probably benign	0.00
IGL03033:Nlrp1b	APN	11	71161839	missense	probably benign	0.22
IGL03122:Nlrp1b	APN	11	71181833	missense	probably benign	0.00
IGL03131:Nlrp1b	APN	11	71161915	missense	possibly damaging	0.82
androcles	UTSW	11	71172075	nonsense	probably null
Fangled	UTSW	11	71172171	missense	possibly damaging	0.94
glitz	UTSW	11	71181550	missense	possibly damaging	0.89
honeydew	UTSW	11	71217884	missense	possibly damaging	0.93
Mush	UTSW	11	71156079	missense	probably damaging	1.00
Thorn	UTSW	11	71156300	splice site	probably benign
R0001:Nlrp1b	UTSW	11	71161759	missense	probably damaging	1.00
R0022:Nlrp1b	UTSW	11	71161929	missense	possibly damaging	0.61
R0022:Nlrp1b	UTSW	11	71161929	missense	possibly damaging	0.61
R0038:Nlrp1b	UTSW	11	71172171	missense	possibly damaging	0.94
R0038:Nlrp1b	UTSW	11	71172171	missense	possibly damaging	0.94
R0164:Nlrp1b	UTSW	11	71164099	missense	probably damaging	1.00
R0164:Nlrp1b	UTSW	11	71164099	missense	probably damaging	1.00
R0271:Nlrp1b	UTSW	11	71161765	missense	possibly damaging	0.51
R0464:Nlrp1b	UTSW	11	71218244	missense	probably damaging	1.00
R0504:Nlrp1b	UTSW	11	71182415	missense	probably damaging	0.99
R0605:Nlrp1b	UTSW	11	71156179	missense	possibly damaging	0.88
R0863:Nlrp1b	UTSW	11	71181347	missense	probably benign	0.00
R1075:Nlrp1b	UTSW	11	71181686	missense	probably benign	0.35
R1221:Nlrp1b	UTSW	11	71181464	missense	probably benign	0.07
R1501:Nlrp1b	UTSW	11	71156059	missense	probably damaging	1.00
R1654:Nlrp1b	UTSW	11	71181298	missense	probably damaging	0.99
R1671:Nlrp1b	UTSW	11	71201259	missense	probably benign	0.45
R1676:Nlrp1b	UTSW	11	71182811	missense	probably benign	0.13
R1694:Nlrp1b	UTSW	11	71216855	critical splice donor site	probably null
R1709:Nlrp1b	UTSW	11	71201273	missense	probably benign	0.11
R1770:Nlrp1b	UTSW	11	71160153	missense	probably benign	0.22
R1775:Nlrp1b	UTSW	11	71161821	missense	probably damaging	1.00
R1851:Nlrp1b	UTSW	11	71182616	missense	possibly damaging	0.96
R1932:Nlrp1b	UTSW	11	71182138	missense	probably damaging	0.96
R2063:Nlrp1b	UTSW	11	71161086	missense	probably benign	0.09
R2189:Nlrp1b	UTSW	11	71169795	missense	probably damaging	1.00
R2223:Nlrp1b	UTSW	11	71155989	splice site	probably benign
R2284:Nlrp1b	UTSW	11	71156284	missense	probably benign	0.00
R2434:Nlrp1b	UTSW	11	71156726	splice site	probably null
R3079:Nlrp1b	UTSW	11	71217968	missense	probably benign	0.27
R3775:Nlrp1b	UTSW	11	71156300	splice site	probably benign
R3980:Nlrp1b	UTSW	11	71181611	missense	possibly damaging	0.56
R4016:Nlrp1b	UTSW	11	71173085	missense	probably damaging	1.00
R4085:Nlrp1b	UTSW	11	71161762	missense	probably damaging	0.98
R4542:Nlrp1b	UTSW	11	71228325	missense	probably damaging	1.00
R4623:Nlrp1b	UTSW	11	71161843	missense	probably benign	0.00
R4726:Nlrp1b	UTSW	11	71181406	missense	probably benign	0.10
R4764:Nlrp1b	UTSW	11	71182663	missense	probably damaging	1.00
R4885:Nlrp1b	UTSW	11	71217884	missense	possibly damaging	0.93
R4910:Nlrp1b	UTSW	11	71217277	missense	probably benign	0.09
R4997:Nlrp1b	UTSW	11	71218334	missense	probably damaging	1.00
R5046:Nlrp1b	UTSW	11	71160072	missense	possibly damaging	0.95
R5126:Nlrp1b	UTSW	11	71181533	missense	possibly damaging	0.67
R5369:Nlrp1b	UTSW	11	71181799	missense	probably benign
R5388:Nlrp1b	UTSW	11	71172141	missense	probably damaging	1.00
R5445:Nlrp1b	UTSW	11	71217875	missense	probably benign	0.21
R5546:Nlrp1b	UTSW	11	71217276	missense	probably benign	0.04
R5567:Nlrp1b	UTSW	11	71181403	missense	probably benign
R5826:Nlrp1b	UTSW	11	71181196	missense	probably benign	0.17
R5955:Nlrp1b	UTSW	11	71217865	missense	probably damaging	1.00
R5995:Nlrp1b	UTSW	11	71181746	missense	probably damaging	1.00
R6059:Nlrp1b	UTSW	11	71217010	missense	possibly damaging	0.53
R6170:Nlrp1b	UTSW	11	71156079	missense	probably damaging	1.00
R6191:Nlrp1b	UTSW	11	71218457	nonsense	probably null
R6250:Nlrp1b	UTSW	11	71181799	missense	probably benign	0.11
R6312:Nlrp1b	UTSW	11	71228397	missense	probably benign	0.38
R6352:Nlrp1b	UTSW	11	71181701	missense	probably damaging	0.99
R6807:Nlrp1b	UTSW	11	71217704	missense	probably damaging	1.00
R6854:Nlrp1b	UTSW	11	71228433	missense	possibly damaging	0.93
R6908:Nlrp1b	UTSW	11	71217296	missense	probably benign
R6938:Nlrp1b	UTSW	11	71218216	missense	probably damaging	1.00
R7098:Nlrp1b	UTSW	11	71218274	missense	possibly damaging	0.89
R7142:Nlrp1b	UTSW	11	71172075	nonsense	probably null
R7149:Nlrp1b	UTSW	11	71181656	nonsense	probably null
R7349:Nlrp1b	UTSW	11	71182117	missense	probably benign	0.36
R7354:Nlrp1b	UTSW	11	71181550	missense	possibly damaging	0.89
R7750:Nlrp1b	UTSW	11	71168839	missense	probably benign	0.11
R7913:Nlrp1b	UTSW	11	71217711	missense	possibly damaging	0.93
R8031:Nlrp1b	UTSW	11	71216921	missense	probably benign	0.15
R8087:Nlrp1b	UTSW	11	71172071	missense	probably benign	0.04
R8164:Nlrp1b	UTSW	11	71228417	missense	possibly damaging	0.78
R8378:Nlrp1b	UTSW	11	71161719	missense	possibly damaging	0.95
R8405:Nlrp1b	UTSW	11	71182530	missense	possibly damaging	0.66
R8441:Nlrp1b	UTSW	11	71182378	missense	probably damaging	1.00
R8792:Nlrp1b	UTSW	11	71160093	missense	probably benign	0.02
R8898:Nlrp1b	UTSW	11	71182462	missense	probably damaging	1.00
R8953:Nlrp1b	UTSW	11	71161806	missense	probably damaging	0.96
R8963:Nlrp1b	UTSW	11	71217832	missense	probably damaging	1.00
R9184:Nlrp1b	UTSW	11	71181241	missense	probably damaging	1.00
R9286:Nlrp1b	UTSW	11	71169747	missense	probably benign
R9322:Nlrp1b	UTSW	11	71217292	missense	probably benign	0.12
R9453:Nlrp1b	UTSW	11	71182087	missense	probably damaging	0.98
R9533:Nlrp1b	UTSW	11	71218269	missense	probably benign	0.12
R9659:Nlrp1b	UTSW	11	71182306	missense	possibly damaging	0.77
Z1176:Nlrp1b	UTSW	11	71182270	missense	probably damaging	1.00
Z1177:Nlrp1b	UTSW	11	71181299	nonsense	probably null
Z1177:Nlrp1b	UTSW	11	71217224	missense	probably benign	0.03
Z1186:Nlrp1b	UTSW	11	71181708	missense	probably benign	0.02
Z1186:Nlrp1b	UTSW	11	71181713	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71181799	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71182309	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71182322	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71182440	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71182454	missense	probably benign	0.00
Z1186:Nlrp1b	UTSW	11	71182544	missense	probably benign	0.00
Z1186:Nlrp1b	UTSW	11	71182552	missense	probably benign
Z1186:Nlrp1b	UTSW	11	71182570	missense	probably benign	0.02
Z1186:Nlrp1b	UTSW	11	71182677	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71181708	missense	probably benign	0.02
Z1187:Nlrp1b	UTSW	11	71181713	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71181799	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71182322	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71182440	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71182454	missense	probably benign	0.00
Z1187:Nlrp1b	UTSW	11	71182544	missense	probably benign	0.00
Z1187:Nlrp1b	UTSW	11	71182552	missense	probably benign
Z1187:Nlrp1b	UTSW	11	71182570	missense	probably benign	0.02
Z1187:Nlrp1b	UTSW	11	71182677	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71181708	missense	probably benign	0.02
Z1188:Nlrp1b	UTSW	11	71181713	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71181799	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71182309	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71182322	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71182440	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71182454	missense	probably benign	0.00
Z1188:Nlrp1b	UTSW	11	71182544	missense	probably benign	0.00
Z1188:Nlrp1b	UTSW	11	71182552	missense	probably benign
Z1188:Nlrp1b	UTSW	11	71182570	missense	probably benign	0.02
Z1188:Nlrp1b	UTSW	11	71182677	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71181708	missense	probably benign	0.02
Z1189:Nlrp1b	UTSW	11	71181713	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71181799	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71182309	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71182322	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71182440	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71182454	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71182544	missense	probably benign	0.00
Z1189:Nlrp1b	UTSW	11	71182552	missense	probably benign
Z1189:Nlrp1b	UTSW	11	71182570	missense	probably benign	0.02
Z1189:Nlrp1b	UTSW	11	71182677	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71181708	missense	probably benign	0.02
Z1190:Nlrp1b	UTSW	11	71181713	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71181799	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71182309	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71182322	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71182440	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71182454	missense	probably benign	0.00
Z1190:Nlrp1b	UTSW	11	71182544	missense	probably benign	0.00
Z1190:Nlrp1b	UTSW	11	71182552	missense	probably benign
Z1190:Nlrp1b	UTSW	11	71182570	missense	probably benign	0.02
Z1190:Nlrp1b	UTSW	11	71182677	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71181708	missense	probably benign	0.02
Z1191:Nlrp1b	UTSW	11	71181713	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71181799	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71182309	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71182322	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71182440	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71182454	missense	probably benign	0.00
Z1191:Nlrp1b	UTSW	11	71182544	missense	probably benign	0.00
Z1191:Nlrp1b	UTSW	11	71182552	missense	probably benign
Z1191:Nlrp1b	UTSW	11	71182570	missense	probably benign	0.02
Z1191:Nlrp1b	UTSW	11	71182677	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71181708	missense	probably benign	0.02
Z1192:Nlrp1b	UTSW	11	71181799	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71182322	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71182440	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71182454	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71182544	missense	probably benign	0.00
Z1192:Nlrp1b	UTSW	11	71182552	missense	probably benign
Z1192:Nlrp1b	UTSW	11	71182570	missense	probably benign	0.02
Z1192:Nlrp1b	UTSW	11	71182677	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- TGTAGAGCTGGCCTTCCTTC -3'
(R):5'- CAGGTGGCTAACTCAATCCAGATG -3'

Sequencing Primer
(F):5'- CCAGGCTCTCTTCACCTGC -3'
(R):5'- GGCTAACTCAATCCAGATGTTGAAG -3'

Posted On

2022-01-20