Incidental Mutation 'R9146:Or6c7'
ID 694653
Institutional Source Beutler Lab
Gene Symbol Or6c7
Ensembl Gene ENSMUSG00000111273
Gene Name olfactory receptor family 6 subfamily C member 7
Synonyms MOR111-13, Olfr789-ps1, MOR111-9P, Olfr789, GA_x6K02T2PULF-11165842-11166815
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R9146 (G1)
Quality Score 82.0076
Status Validated
Chromosome 10
Chromosomal Location 129322881-129323819 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 129323392 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 171 (V171A)
Ref Sequence ENSEMBL: ENSMUSP00000150482 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000213236] [ENSMUST00000213992]
AlphaFold A0A1L1SV77
Predicted Effect possibly damaging
Transcript: ENSMUST00000213236
AA Change: V171A

PolyPhen 2 Score 0.607 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000213992
AA Change: V171A

PolyPhen 2 Score 0.607 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ache G A 5: 137,289,077 (GRCm39) G261D probably damaging Het
Adgrv1 T A 13: 81,561,291 (GRCm39) T5408S probably benign Het
Aff3 T C 1: 38,359,200 (GRCm39) N362D probably benign Het
Aff4 A G 11: 53,298,963 (GRCm39) N956S probably benign Het
Alg10b A G 15: 90,112,401 (GRCm39) E415G probably damaging Het
Ate1 T C 7: 130,069,022 (GRCm39) Y415C probably damaging Het
Cage1 T C 13: 38,207,005 (GRCm39) D280G probably benign Het
Catsperg1 G C 7: 28,909,912 (GRCm39) P72R probably benign Het
Cep290 A G 10: 100,377,665 (GRCm39) E1565G probably benign Het
Csmd1 T A 8: 16,048,832 (GRCm39) Y2290F probably benign Het
Cyp2c39 A T 19: 39,527,344 (GRCm39) H230L Het
Efhb A G 17: 53,769,644 (GRCm39) S222P probably benign Het
Emilin2 G A 17: 71,581,331 (GRCm39) T465M probably damaging Het
Ep400 A T 5: 110,849,635 (GRCm39) Y1431* probably null Het
Gm10912 T C 2: 103,897,053 (GRCm39) V64A possibly damaging Het
Gpat2 T C 2: 127,273,206 (GRCm39) S197P possibly damaging Het
Hc T C 2: 34,924,571 (GRCm39) Y452C probably damaging Het
Hectd4 T C 5: 121,487,097 (GRCm39) I3364T probably benign Het
Hjurp TCTGGGAGGGCTTGCTCCGGGGGCAGTGTGTCCTGTTCTTGTGCAGCCCCTGCT TCT 1: 88,194,000 (GRCm39) probably benign Het
Hmcn1 G A 1: 150,474,141 (GRCm39) T4767M probably benign Het
Hspa4l A G 3: 40,736,101 (GRCm39) D595G probably benign Het
Kdm1a G T 4: 136,329,739 (GRCm39) T53K unknown Het
Kirrel1 T C 3: 87,003,015 (GRCm39) D126G probably damaging Het
Kit T A 5: 75,810,305 (GRCm39) D822E probably damaging Het
Kiz C T 2: 146,705,740 (GRCm39) T100M probably benign Het
Kmt2a T A 9: 44,725,938 (GRCm39) K3663* probably null Het
Krt8 T A 15: 101,907,370 (GRCm39) I238F probably damaging Het
Ky C T 9: 102,419,405 (GRCm39) P471S Het
Lca5l T C 16: 95,960,998 (GRCm39) E493G probably damaging Het
Lrrc2 C T 9: 110,808,582 (GRCm39) T273I probably damaging Het
Mcoln2 T C 3: 145,869,303 (GRCm39) S31P probably benign Het
Mmp1a A G 9: 7,464,997 (GRCm39) D77G probably damaging Het
Mrgprb8 T A 7: 48,039,200 (GRCm39) C290* probably null Het
Nfe2l3 G T 6: 51,410,172 (GRCm39) A96S probably damaging Het
Notch2 A G 3: 98,011,854 (GRCm39) D624G probably damaging Het
Nup98 C A 7: 101,788,037 (GRCm39) R1011L probably benign Het
Nxt2 C T X: 141,020,747 (GRCm39) A118V possibly damaging Het
Or52n2 T A 7: 104,542,452 (GRCm39) I128F probably damaging Het
Pcdh10 G A 3: 45,334,351 (GRCm39) A222T probably benign Het
Piezo1 G A 8: 123,227,002 (GRCm39) H420Y Het
Pik3r1 C A 13: 101,825,136 (GRCm39) probably benign Het
Plcb1 T A 2: 135,182,615 (GRCm39) Y642N probably damaging Het
Ralgapa2 T A 2: 146,184,252 (GRCm39) H1538L probably benign Het
Raph1 A G 1: 60,558,137 (GRCm39) probably null Het
Rnf213 T C 11: 119,334,499 (GRCm39) F3237S Het
Sctr A G 1: 119,982,010 (GRCm39) D286G probably damaging Het
Smyd3 A G 1: 178,920,529 (GRCm39) S202P probably damaging Het
Ssh2 G A 11: 77,328,502 (GRCm39) G356E probably damaging Het
Stat3 A T 11: 100,784,492 (GRCm39) S629R probably benign Het
Stc2 A G 11: 31,317,847 (GRCm39) V58A probably damaging Het
Tcerg1l T A 7: 137,831,588 (GRCm39) D463V probably damaging Het
Tctn1 A G 5: 122,389,745 (GRCm39) V259A possibly damaging Het
Tmem248 A G 5: 130,260,851 (GRCm39) T139A probably benign Het
Trip12 G T 1: 84,771,881 (GRCm39) A89E possibly damaging Het
Vmn2r54 C T 7: 12,366,647 (GRCm39) V96I probably benign Het
Vmn2r79 C T 7: 86,650,681 (GRCm39) Q156* probably null Het
Zfp831 C A 2: 174,487,461 (GRCm39) T712N possibly damaging Het
Zfy1 A T Y: 726,033 (GRCm39) H577Q possibly damaging Het
Zscan4-ps2 T G 7: 11,251,679 (GRCm39) S238R possibly damaging Het
Other mutations in Or6c7
AlleleSourceChrCoordTypePredicted EffectPPH Score
R6154:Or6c7 UTSW 10 129,323,545 (GRCm39) missense probably damaging 1.00
R6286:Or6c7 UTSW 10 129,323,497 (GRCm39) missense probably damaging 1.00
R6961:Or6c7 UTSW 10 129,323,331 (GRCm39) missense probably damaging 0.99
R7007:Or6c7 UTSW 10 129,323,277 (GRCm39) missense probably damaging 0.96
R9097:Or6c7 UTSW 10 129,323,647 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- ACGGCTATGTCTTATGATCGC -3'
(R):5'- TGGCAGAAGGGTTAGCATAC -3'

Sequencing Primer
(F):5'- GCTATGTGGCCATCTGCAAAC -3'
(R):5'- GGAGCATGTAGAGAAAGCCTTTTTCC -3'
Posted On 2022-01-20