Incidental Mutation 'R9147:Or1j19'
ID 694678
Institutional Source Beutler Lab
Gene Symbol Or1j19
Ensembl Gene ENSMUSG00000049315
Gene Name olfactory receptor family 1 subfamily J member 19
Synonyms GA_x6K02T2NLDC-33481050-33481991, Olfr348, MOR136-8
MMRRC Submission 068936-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R9147 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 36676539-36677480 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 36676938 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 134 (T134A)
Ref Sequence ENSEMBL: ENSMUSP00000151006 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056865] [ENSMUST00000213498] [ENSMUST00000214909] [ENSMUST00000215199] [ENSMUST00000216753] [ENSMUST00000217041]
AlphaFold Q8VGK3
Predicted Effect probably benign
Transcript: ENSMUST00000056865
AA Change: T134A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000054037
Gene: ENSMUSG00000049315
AA Change: T134A

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 1.3e-56 PFAM
Pfam:7TM_GPCR_Srsx 36 306 3e-6 PFAM
Pfam:7tm_1 42 291 2.7e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213498
AA Change: T134A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Predicted Effect probably benign
Transcript: ENSMUST00000214909
AA Change: T134A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Predicted Effect probably benign
Transcript: ENSMUST00000215199
AA Change: T134A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Predicted Effect probably benign
Transcript: ENSMUST00000216753
Predicted Effect probably benign
Transcript: ENSMUST00000217041
Meta Mutation Damage Score 0.1287 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 97% (93/96)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 96 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110032F04Rik T A 3: 68,777,345 (GRCm39) I102N probably damaging Het
2610008E11Rik A T 10: 78,903,406 (GRCm39) C303* probably null Het
A430033K04Rik T A 5: 138,644,547 (GRCm39) V144D possibly damaging Het
Adamts13 T A 2: 26,883,024 (GRCm39) M858K probably benign Het
Ankrd29 T C 18: 12,408,760 (GRCm39) probably benign Het
Apc T A 18: 34,450,710 (GRCm39) S2535R probably damaging Het
C1s1 T C 6: 124,517,758 (GRCm39) D74G probably damaging Het
Cacnb2 G A 2: 14,972,773 (GRCm39) G227S possibly damaging Het
Cbs T C 17: 31,844,889 (GRCm39) D137G probably damaging Het
Ccdc136 A G 6: 29,418,070 (GRCm39) E846G probably damaging Het
Cd6 A T 19: 10,776,855 (GRCm39) S57T probably benign Het
Col11a2 T A 17: 34,273,119 (GRCm39) probably benign Het
Ctsj T C 13: 61,149,249 (GRCm39) Y264C probably damaging Het
Dennd3 T A 15: 73,429,463 (GRCm39) N915K probably damaging Het
Dst T C 1: 34,228,149 (GRCm39) L1914P probably damaging Het
E2f2 A T 4: 135,908,595 (GRCm39) probably null Het
Edc4 T C 8: 106,612,478 (GRCm39) L172P probably damaging Het
Epb41l5 A T 1: 119,570,319 (GRCm39) L23H probably damaging Het
Fbxo2 A G 4: 148,250,166 (GRCm39) E232G probably damaging Het
Fmn1 A C 2: 113,271,973 (GRCm39) N114H unknown Het
Foxj1 T G 11: 116,225,236 (GRCm39) I44L probably damaging Het
Foxp1 TTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGTTGCTGCTGCTGTTGCTGCTGTTGCTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGCTGCTGCTG TTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGTTGCTGCTGCTGTTGCTGCTGTTGCTGCTGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGTTGCTGCTGCTG 6: 99,052,866 (GRCm39) probably benign Het
Foxp2 A T 6: 15,286,711 (GRCm39) Q67L possibly damaging Het
Fuz C T 7: 44,549,710 (GRCm39) P396L probably damaging Het
Galntl5 A T 5: 25,415,353 (GRCm39) I295L possibly damaging Het
Gjd4 T A 18: 9,280,095 (GRCm39) T328S probably benign Het
Gramd1a A T 7: 30,837,606 (GRCm39) probably benign Het
Gzmb T C 14: 56,496,964 (GRCm39) Y219C possibly damaging Het
Hs3st5 A T 10: 36,708,917 (GRCm39) I151F probably damaging Het
Hspa12a T G 19: 58,793,890 (GRCm39) T324P probably damaging Het
Ighv4-1 A T 12: 113,912,000 (GRCm39) D84E possibly damaging Het
Il31ra C T 13: 112,670,276 (GRCm39) E371K probably benign Het
Imp4 G T 1: 34,482,473 (GRCm39) V71L probably benign Het
Itgax A G 7: 127,747,913 (GRCm39) T1068A possibly damaging Het
Klhl24 C T 16: 19,936,690 (GRCm39) R433C probably damaging Het
Larp4b C A 13: 9,186,819 (GRCm39) P49Q possibly damaging Het
Macc1 T C 12: 119,414,091 (GRCm39) S756P possibly damaging Het
Mael A G 1: 166,029,259 (GRCm39) V388A probably benign Het
Megf6 A G 4: 154,339,130 (GRCm39) T556A probably benign Het
Mettl6 T C 14: 31,204,855 (GRCm39) D189G probably damaging Het
Moxd2 C A 6: 40,860,978 (GRCm39) C271F probably damaging Het
Ncor1 A T 11: 62,224,672 (GRCm39) Y863N probably damaging Het
Ndst4 C T 3: 125,231,722 (GRCm39) A97V probably damaging Het
Nherf4 A G 9: 44,160,676 (GRCm39) C240R probably damaging Het
Nos1 G C 5: 118,017,402 (GRCm39) R255P probably benign Het
Nup160 A G 2: 90,533,489 (GRCm39) D646G probably damaging Het
Nxt2 C T X: 141,020,747 (GRCm39) A118V possibly damaging Het
Or1p1 A C 11: 74,180,169 (GRCm39) Q232H probably damaging Het
Or5c1 T C 2: 37,222,017 (GRCm39) L86P possibly damaging Het
Or7h8 T A 9: 20,124,358 (GRCm39) F238I probably damaging Het
Or8k24 A G 2: 86,216,324 (GRCm39) V146A probably benign Het
Pabpc6 C T 17: 9,886,937 (GRCm39) S538N probably benign Het
Pcdhga1 C A 18: 37,796,433 (GRCm39) A479D possibly damaging Het
Pdgfd A T 9: 6,333,328 (GRCm39) D172V probably benign Het
Pfpl A T 19: 12,405,804 (GRCm39) E18D possibly damaging Het
Pih1d2 T A 9: 50,532,321 (GRCm39) D126E possibly damaging Het
Ppp1r13b T C 12: 111,800,268 (GRCm39) H626R probably benign Het
Ppp6r3 A T 19: 3,543,974 (GRCm39) V347D probably damaging Het
Ptpra T A 2: 30,328,255 (GRCm39) M192K probably damaging Het
Ptpra G T 2: 30,328,256 (GRCm39) M192I probably benign Het
Ptprj G A 2: 90,288,562 (GRCm39) S801L probably benign Het
Rasd2 C T 8: 75,948,847 (GRCm39) R258* probably null Het
Rfx3 A T 19: 27,878,207 (GRCm39) V30E possibly damaging Het
Rgs2 A G 1: 143,877,925 (GRCm39) S124P probably damaging Het
Ros1 A G 10: 51,927,039 (GRCm39) F2215L probably benign Het
Rph3a T C 5: 121,086,880 (GRCm39) N440S possibly damaging Het
Sacs T C 14: 61,450,137 (GRCm39) V4061A possibly damaging Het
Scgb1b3 G A 7: 31,075,051 (GRCm39) V7M unknown Het
Scn7a T C 2: 66,514,507 (GRCm39) D1089G possibly damaging Het
Sdk2 C T 11: 113,714,226 (GRCm39) R1582Q probably benign Het
Sdr16c5 T C 4: 3,996,200 (GRCm39) M298V probably benign Het
Sebox A G 11: 78,395,222 (GRCm39) D188G possibly damaging Het
Serpinf2 A T 11: 75,323,418 (GRCm39) F429L probably damaging Het
Six4 A C 12: 73,155,681 (GRCm39) S429A probably benign Het
Slc2a10 A T 2: 165,357,543 (GRCm39) H401L possibly damaging Het
Ssbp2 T C 13: 91,842,141 (GRCm39) S321P probably damaging Het
Syne2 A G 12: 75,937,158 (GRCm39) E252G probably damaging Het
Synj2 T C 17: 6,084,172 (GRCm39) I1178T probably damaging Het
Tafa5 T C 15: 87,428,775 (GRCm39) I28T probably benign Het
Tbc1d10a G T 11: 4,136,835 (GRCm39) R16L unknown Het
Tmem132b C A 5: 125,864,167 (GRCm39) Q758K probably damaging Het
Tnrc6a T G 7: 122,785,667 (GRCm39) probably benign Het
Tril A G 6: 53,795,137 (GRCm39) L695P probably damaging Het
Tspan3 A T 9: 56,043,960 (GRCm39) Y243* probably null Het
Ufl1 A T 4: 25,278,712 (GRCm39) probably benign Het
Utp4 A T 8: 107,621,310 (GRCm39) N29I possibly damaging Het
Vmn1r176 C T 7: 23,534,785 (GRCm39) G123S probably benign Het
Vmn1r225 T A 17: 20,722,577 (GRCm39) M6K possibly damaging Het
Vmn1r229 T C 17: 21,034,758 (GRCm39) M1T probably null Het
Vmn2r80 A T 10: 79,030,687 (GRCm39) I838F probably damaging Het
Vmn2r98 T A 17: 19,286,383 (GRCm39) W294R probably benign Het
Wnk1 A G 6: 119,925,631 (GRCm39) S1527P unknown Het
Zdhhc17 A T 10: 110,785,503 (GRCm39) S436R possibly damaging Het
Zfp12 T C 5: 143,230,389 (GRCm39) S271P probably damaging Het
Zfp330 T C 8: 83,491,063 (GRCm39) Y249C Het
Zfp444 A G 7: 6,192,678 (GRCm39) H232R probably damaging Het
Other mutations in Or1j19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01388:Or1j19 APN 2 36,677,367 (GRCm39) missense probably benign 0.03
IGL01943:Or1j19 APN 2 36,677,095 (GRCm39) missense probably benign 0.13
IGL02030:Or1j19 APN 2 36,677,410 (GRCm39) missense probably damaging 1.00
IGL02338:Or1j19 APN 2 36,676,557 (GRCm39) nonsense probably null
IGL02349:Or1j19 APN 2 36,677,058 (GRCm39) missense possibly damaging 0.95
IGL02695:Or1j19 APN 2 36,677,332 (GRCm39) missense possibly damaging 0.72
IGL03004:Or1j19 APN 2 36,677,194 (GRCm39) missense probably damaging 1.00
IGL03007:Or1j19 APN 2 36,676,812 (GRCm39) missense probably damaging 0.99
IGL03024:Or1j19 APN 2 36,676,858 (GRCm39) missense possibly damaging 0.55
R0360:Or1j19 UTSW 2 36,677,452 (GRCm39) missense probably benign 0.03
R0388:Or1j19 UTSW 2 36,676,874 (GRCm39) missense probably benign 0.43
R0614:Or1j19 UTSW 2 36,676,705 (GRCm39) missense probably damaging 1.00
R1498:Or1j19 UTSW 2 36,677,358 (GRCm39) missense probably damaging 1.00
R1562:Or1j19 UTSW 2 36,676,696 (GRCm39) missense probably damaging 1.00
R2882:Or1j19 UTSW 2 36,677,202 (GRCm39) missense probably damaging 1.00
R3731:Or1j19 UTSW 2 36,676,578 (GRCm39) missense possibly damaging 0.53
R4513:Or1j19 UTSW 2 36,676,782 (GRCm39) missense probably benign 0.05
R4899:Or1j19 UTSW 2 36,676,810 (GRCm39) missense probably benign 0.04
R5005:Or1j19 UTSW 2 36,677,370 (GRCm39) missense probably benign
R5035:Or1j19 UTSW 2 36,676,903 (GRCm39) missense probably damaging 1.00
R5490:Or1j19 UTSW 2 36,677,193 (GRCm39) missense probably damaging 1.00
R6361:Or1j19 UTSW 2 36,676,792 (GRCm39) missense probably damaging 1.00
R7762:Or1j19 UTSW 2 36,677,022 (GRCm39) missense probably benign 0.03
R8109:Or1j19 UTSW 2 36,676,618 (GRCm39) missense probably benign 0.00
R8223:Or1j19 UTSW 2 36,677,409 (GRCm39) missense
R8826:Or1j19 UTSW 2 36,676,855 (GRCm39) nonsense probably null
R8906:Or1j19 UTSW 2 36,676,621 (GRCm39) missense probably benign 0.01
R9138:Or1j19 UTSW 2 36,676,702 (GRCm39) missense probably benign 0.00
R9148:Or1j19 UTSW 2 36,676,938 (GRCm39) missense probably benign 0.01
R9267:Or1j19 UTSW 2 36,676,530 (GRCm39) unclassified probably benign
R9306:Or1j19 UTSW 2 36,677,407 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CACTTGGCCTTCACAGACATC -3'
(R):5'- CAAGCTCATTGATGGAGGTATCTG -3'

Sequencing Primer
(F):5'- TTTCTCATCAGTCACAGCTCCAAAG -3'
(R):5'- CTCATTGATGGAGGTATCTGAGCTAG -3'
Posted On 2022-01-20