Incidental Mutation 'R9148:Ptprj'
| ID |
694773 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ptprj
|
| Ensembl Gene |
ENSMUSG00000025314 |
| Gene Name |
protein tyrosine phosphatase receptor type J |
| Synonyms |
Byp, RPTPJ, Scc1, CD148, DEP-1, Scc-1 |
| MMRRC Submission |
068937-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.251)
|
| Stock # |
R9148 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
90260098-90410939 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 90288562 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Leucine
at position 801
(S801L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129592
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000111493]
[ENSMUST00000111495]
[ENSMUST00000168621]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111493
AA Change: S615L
PolyPhen 2
Score 0.058 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000107119
Gene: ENSMUSG00000025314
AA Change: S615L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
46 |
N/A |
INTRINSIC |
|
FN3
|
47 |
182 |
3.76e-6 |
SMART |
|
FN3
|
194 |
271 |
4.56e-5 |
SMART |
|
FN3
|
282 |
357 |
5.32e-6 |
SMART |
|
FN3
|
368 |
446 |
2.19e-7 |
SMART |
|
FN3
|
455 |
531 |
5e-2 |
SMART |
|
FN3
|
546 |
628 |
2.77e1 |
SMART |
|
low complexity region
|
637 |
650 |
N/A |
INTRINSIC |
|
Blast:PTPc
|
714 |
797 |
8e-26 |
BLAST |
|
PTPc
|
867 |
1127 |
3.37e-133 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111495
AA Change: S708L
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000107121
Gene: ENSMUSG00000025314
AA Change: S708L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
25 |
N/A |
INTRINSIC |
|
FN3
|
59 |
131 |
2.85e-6 |
SMART |
|
FN3
|
140 |
275 |
3.76e-6 |
SMART |
|
FN3
|
287 |
364 |
4.56e-5 |
SMART |
|
FN3
|
375 |
450 |
5.32e-6 |
SMART |
|
FN3
|
461 |
539 |
2.19e-7 |
SMART |
|
FN3
|
548 |
624 |
5e-2 |
SMART |
|
FN3
|
639 |
721 |
2.77e1 |
SMART |
|
low complexity region
|
730 |
743 |
N/A |
INTRINSIC |
|
Blast:PTPc
|
807 |
890 |
1e-25 |
BLAST |
|
PTPc
|
960 |
1220 |
3.37e-133 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168621
AA Change: S801L
PolyPhen 2
Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000129592
Gene: ENSMUSG00000025314
AA Change: S801L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
16 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
94 |
N/A |
INTRINSIC |
|
low complexity region
|
133 |
140 |
N/A |
INTRINSIC |
|
FN3
|
152 |
224 |
2.85e-6 |
SMART |
|
FN3
|
233 |
368 |
3.76e-6 |
SMART |
|
FN3
|
380 |
457 |
4.56e-5 |
SMART |
|
FN3
|
468 |
543 |
5.32e-6 |
SMART |
|
FN3
|
554 |
632 |
2.19e-7 |
SMART |
|
FN3
|
641 |
717 |
5e-2 |
SMART |
|
FN3
|
732 |
814 |
2.77e1 |
SMART |
|
low complexity region
|
823 |
836 |
N/A |
INTRINSIC |
|
Blast:PTPc
|
900 |
983 |
1e-25 |
BLAST |
|
PTPc
|
1053 |
1313 |
3.37e-133 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
96% (94/98) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele die in utero displaying severe growth retardation and cardiovascular defects. Homozygotes for a second null allele are viable, fertile and healthy with no spontaneous tumor formation. Homozygotes for a third null allele show sterility and a block B cell development. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110032F04Rik |
T |
A |
3: 68,777,345 (GRCm39) |
I102N |
probably damaging |
Het |
| 2610008E11Rik |
A |
T |
10: 78,903,406 (GRCm39) |
C303* |
probably null |
Het |
| A430033K04Rik |
T |
A |
5: 138,644,547 (GRCm39) |
V144D |
possibly damaging |
Het |
| Adamts13 |
T |
A |
2: 26,883,024 (GRCm39) |
M858K |
probably benign |
Het |
| Ankrd29 |
T |
C |
18: 12,408,760 (GRCm39) |
|
probably benign |
Het |
| Arg1 |
A |
C |
10: 24,796,655 (GRCm39) |
D57E |
probably benign |
Het |
| Bend4 |
G |
A |
5: 67,557,415 (GRCm39) |
T467M |
probably damaging |
Het |
| C1s1 |
T |
C |
6: 124,517,758 (GRCm39) |
D74G |
probably damaging |
Het |
| Cacnb2 |
G |
A |
2: 14,972,773 (GRCm39) |
G227S |
possibly damaging |
Het |
| Cbs |
T |
C |
17: 31,844,889 (GRCm39) |
D137G |
probably damaging |
Het |
| Ccdc136 |
A |
G |
6: 29,418,070 (GRCm39) |
E846G |
probably damaging |
Het |
| Cd6 |
A |
T |
19: 10,776,855 (GRCm39) |
S57T |
probably benign |
Het |
| Cep20 |
G |
A |
16: 14,135,222 (GRCm39) |
|
probably benign |
Het |
| Col11a2 |
T |
A |
17: 34,273,119 (GRCm39) |
|
probably benign |
Het |
| Col7a1 |
T |
C |
9: 108,789,274 (GRCm39) |
S829P |
unknown |
Het |
| Ctsj |
T |
C |
13: 61,149,249 (GRCm39) |
Y264C |
probably damaging |
Het |
| Dennd3 |
T |
A |
15: 73,429,463 (GRCm39) |
N915K |
probably damaging |
Het |
| E2f2 |
A |
T |
4: 135,908,595 (GRCm39) |
|
probably null |
Het |
| Eme1 |
T |
C |
11: 94,538,855 (GRCm39) |
T342A |
possibly damaging |
Het |
| Epc1 |
A |
T |
18: 6,453,266 (GRCm39) |
|
probably benign |
Het |
| Fat1 |
T |
C |
8: 45,405,682 (GRCm39) |
V811A |
possibly damaging |
Het |
| Fbxo2 |
A |
G |
4: 148,250,166 (GRCm39) |
E232G |
probably damaging |
Het |
| Flnb |
G |
T |
14: 7,817,996 (GRCm38) |
|
probably benign |
Het |
| Fmn1 |
A |
C |
2: 113,271,973 (GRCm39) |
N114H |
unknown |
Het |
| Foxp2 |
A |
T |
6: 15,286,711 (GRCm39) |
Q67L |
possibly damaging |
Het |
| Galntl5 |
A |
T |
5: 25,415,353 (GRCm39) |
I295L |
possibly damaging |
Het |
| Gjd4 |
T |
A |
18: 9,280,095 (GRCm39) |
T328S |
probably benign |
Het |
| Hint2 |
A |
G |
4: 43,654,952 (GRCm39) |
I59T |
probably damaging |
Het |
| Hpn |
C |
T |
7: 30,802,043 (GRCm39) |
R252Q |
probably benign |
Het |
| Hspa12a |
T |
G |
19: 58,793,890 (GRCm39) |
T324P |
probably damaging |
Het |
| Ighv4-1 |
A |
T |
12: 113,912,000 (GRCm39) |
D84E |
possibly damaging |
Het |
| Il1r2 |
T |
A |
1: 40,151,258 (GRCm39) |
I171N |
probably damaging |
Het |
| Il31ra |
C |
T |
13: 112,670,276 (GRCm39) |
E371K |
probably benign |
Het |
| Klhl24 |
C |
T |
16: 19,936,690 (GRCm39) |
R433C |
probably damaging |
Het |
| Klra5 |
C |
T |
6: 129,886,911 (GRCm39) |
C39Y |
probably benign |
Het |
| Lypd8l |
T |
A |
11: 58,499,338 (GRCm39) |
D160V |
probably benign |
Het |
| Macc1 |
T |
C |
12: 119,414,091 (GRCm39) |
S756P |
possibly damaging |
Het |
| Mael |
A |
G |
1: 166,029,259 (GRCm39) |
V388A |
probably benign |
Het |
| Mast3 |
A |
G |
8: 71,233,091 (GRCm39) |
S1074P |
probably damaging |
Het |
| Med13 |
A |
G |
11: 86,192,297 (GRCm39) |
C823R |
probably benign |
Het |
| Megf6 |
A |
G |
4: 154,339,130 (GRCm39) |
T556A |
probably benign |
Het |
| Mlip |
A |
G |
9: 77,045,694 (GRCm39) |
F14L |
possibly damaging |
Het |
| Moxd2 |
C |
A |
6: 40,860,978 (GRCm39) |
C271F |
probably damaging |
Het |
| Myo1e |
A |
T |
9: 70,283,830 (GRCm39) |
D842V |
probably damaging |
Het |
| Ndst4 |
C |
T |
3: 125,231,722 (GRCm39) |
A97V |
probably damaging |
Het |
| Nherf4 |
A |
G |
9: 44,160,676 (GRCm39) |
C240R |
probably damaging |
Het |
| Nicn1 |
C |
T |
9: 108,171,708 (GRCm39) |
R163C |
possibly damaging |
Het |
| Nos1 |
G |
C |
5: 118,017,402 (GRCm39) |
R255P |
probably benign |
Het |
| Nptx2 |
A |
G |
5: 144,492,980 (GRCm39) |
T356A |
probably benign |
Het |
| Nup160 |
A |
G |
2: 90,533,489 (GRCm39) |
D646G |
probably damaging |
Het |
| Nup98 |
C |
A |
7: 101,788,037 (GRCm39) |
R1011L |
probably benign |
Het |
| Nxt2 |
C |
T |
X: 141,020,747 (GRCm39) |
A118V |
possibly damaging |
Het |
| Or1j19 |
A |
G |
2: 36,676,938 (GRCm39) |
T134A |
probably benign |
Het |
| Or1p1 |
A |
C |
11: 74,180,169 (GRCm39) |
Q232H |
probably damaging |
Het |
| Or5c1 |
T |
C |
2: 37,222,017 (GRCm39) |
L86P |
possibly damaging |
Het |
| Or7h8 |
T |
A |
9: 20,124,358 (GRCm39) |
F238I |
probably damaging |
Het |
| Or8k24 |
A |
G |
2: 86,216,324 (GRCm39) |
V146A |
probably benign |
Het |
| Osbp2 |
A |
G |
11: 3,665,143 (GRCm39) |
L67P |
probably damaging |
Het |
| Pabpc6 |
C |
T |
17: 9,886,937 (GRCm39) |
S538N |
probably benign |
Het |
| Pcdhga1 |
C |
A |
18: 37,796,433 (GRCm39) |
A479D |
possibly damaging |
Het |
| Pdgfd |
A |
T |
9: 6,333,328 (GRCm39) |
D172V |
probably benign |
Het |
| Pfpl |
A |
T |
19: 12,405,804 (GRCm39) |
E18D |
possibly damaging |
Het |
| Plat |
A |
G |
8: 23,268,466 (GRCm39) |
T373A |
probably damaging |
Het |
| Plekhg1 |
G |
A |
10: 3,907,527 (GRCm39) |
D870N |
|
Het |
| Ppp1r13b |
T |
C |
12: 111,800,268 (GRCm39) |
H626R |
probably benign |
Het |
| Ppp6r3 |
A |
T |
19: 3,543,974 (GRCm39) |
V347D |
probably damaging |
Het |
| Prr12 |
G |
T |
7: 44,697,242 (GRCm39) |
P891H |
unknown |
Het |
| Psg22 |
T |
A |
7: 18,460,682 (GRCm39) |
I437K |
probably benign |
Het |
| Ptpra |
T |
A |
2: 30,328,255 (GRCm39) |
M192K |
probably damaging |
Het |
| Ptpra |
G |
T |
2: 30,328,256 (GRCm39) |
M192I |
probably benign |
Het |
| Relb |
T |
C |
7: 19,350,276 (GRCm39) |
Y228C |
probably damaging |
Het |
| Rfx3 |
A |
T |
19: 27,878,207 (GRCm39) |
V30E |
possibly damaging |
Het |
| Rgs2 |
A |
G |
1: 143,877,925 (GRCm39) |
S124P |
probably damaging |
Het |
| Rph3a |
T |
C |
5: 121,086,880 (GRCm39) |
N440S |
possibly damaging |
Het |
| Ryr2 |
T |
C |
13: 11,900,424 (GRCm39) |
T104A |
probably benign |
Het |
| Scn7a |
T |
C |
2: 66,514,507 (GRCm39) |
D1089G |
possibly damaging |
Het |
| Sebox |
A |
G |
11: 78,395,222 (GRCm39) |
D188G |
possibly damaging |
Het |
| Serpinf2 |
A |
T |
11: 75,323,418 (GRCm39) |
F429L |
probably damaging |
Het |
| Six4 |
A |
C |
12: 73,155,681 (GRCm39) |
S429A |
probably benign |
Het |
| Slc2a10 |
A |
T |
2: 165,357,543 (GRCm39) |
H401L |
possibly damaging |
Het |
| Spag16 |
G |
C |
1: 70,420,459 (GRCm39) |
L482F |
probably damaging |
Het |
| Ssbp2 |
T |
C |
13: 91,842,141 (GRCm39) |
S321P |
probably damaging |
Het |
| Syne2 |
A |
G |
12: 75,937,158 (GRCm39) |
E252G |
probably damaging |
Het |
| Synj2 |
T |
C |
17: 6,084,172 (GRCm39) |
I1178T |
probably damaging |
Het |
| Tafa5 |
T |
C |
15: 87,428,775 (GRCm39) |
I28T |
probably benign |
Het |
| Tmem132b |
C |
A |
5: 125,864,167 (GRCm39) |
Q758K |
probably damaging |
Het |
| Tril |
A |
G |
6: 53,795,137 (GRCm39) |
L695P |
probably damaging |
Het |
| Ubap1l |
T |
C |
9: 65,276,603 (GRCm39) |
L35P |
probably damaging |
Het |
| Vmn1r225 |
T |
A |
17: 20,722,577 (GRCm39) |
M6K |
possibly damaging |
Het |
| Vmn1r229 |
T |
C |
17: 21,034,758 (GRCm39) |
M1T |
probably null |
Het |
| Vmn2r80 |
A |
T |
10: 79,030,687 (GRCm39) |
I838F |
probably damaging |
Het |
| Vmn2r98 |
T |
A |
17: 19,286,383 (GRCm39) |
W294R |
probably benign |
Het |
| Wnk1 |
A |
G |
6: 119,925,631 (GRCm39) |
S1527P |
unknown |
Het |
| Wnt11 |
G |
A |
7: 98,488,241 (GRCm39) |
|
probably benign |
Het |
| Zdhhc17 |
A |
T |
10: 110,785,503 (GRCm39) |
S436R |
possibly damaging |
Het |
| Zfp12 |
T |
C |
5: 143,230,389 (GRCm39) |
S271P |
probably damaging |
Het |
|
| Other mutations in Ptprj |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01528:Ptprj
|
APN |
2 |
90,282,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01594:Ptprj
|
APN |
2 |
90,271,139 (GRCm39) |
splice site |
probably benign |
|
|
IGL01767:Ptprj
|
APN |
2 |
90,299,918 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL01917:Ptprj
|
APN |
2 |
90,300,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01981:Ptprj
|
APN |
2 |
90,270,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02830:Ptprj
|
APN |
2 |
90,283,488 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL02955:Ptprj
|
APN |
2 |
90,298,808 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL03102:Ptprj
|
APN |
2 |
90,309,312 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03150:Ptprj
|
APN |
2 |
90,290,955 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03210:Ptprj
|
APN |
2 |
90,300,070 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02799:Ptprj
|
UTSW |
2 |
90,299,942 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0083:Ptprj
|
UTSW |
2 |
90,300,121 (GRCm39) |
splice site |
probably null |
|
|
R0108:Ptprj
|
UTSW |
2 |
90,300,121 (GRCm39) |
splice site |
probably null |
|
|
R0579:Ptprj
|
UTSW |
2 |
90,266,913 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1130:Ptprj
|
UTSW |
2 |
90,283,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1160:Ptprj
|
UTSW |
2 |
90,274,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1238:Ptprj
|
UTSW |
2 |
90,274,758 (GRCm39) |
splice site |
probably null |
|
|
R1507:Ptprj
|
UTSW |
2 |
90,301,631 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1552:Ptprj
|
UTSW |
2 |
90,301,497 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1607:Ptprj
|
UTSW |
2 |
90,293,664 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1693:Ptprj
|
UTSW |
2 |
90,280,141 (GRCm39) |
nonsense |
probably null |
|
|
R2016:Ptprj
|
UTSW |
2 |
90,294,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Ptprj
|
UTSW |
2 |
90,294,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2044:Ptprj
|
UTSW |
2 |
90,293,439 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2322:Ptprj
|
UTSW |
2 |
90,301,473 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2516:Ptprj
|
UTSW |
2 |
90,305,340 (GRCm39) |
splice site |
probably benign |
|
|
R3106:Ptprj
|
UTSW |
2 |
90,270,975 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3964:Ptprj
|
UTSW |
2 |
90,298,785 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4201:Ptprj
|
UTSW |
2 |
90,293,439 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4533:Ptprj
|
UTSW |
2 |
90,270,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4680:Ptprj
|
UTSW |
2 |
90,290,840 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4738:Ptprj
|
UTSW |
2 |
90,270,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4983:Ptprj
|
UTSW |
2 |
90,290,876 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5137:Ptprj
|
UTSW |
2 |
90,299,992 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R5349:Ptprj
|
UTSW |
2 |
90,301,605 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5369:Ptprj
|
UTSW |
2 |
90,299,985 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5718:Ptprj
|
UTSW |
2 |
90,288,613 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5914:Ptprj
|
UTSW |
2 |
90,283,684 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6022:Ptprj
|
UTSW |
2 |
90,301,667 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6341:Ptprj
|
UTSW |
2 |
90,288,693 (GRCm39) |
missense |
probably benign |
|
|
R6421:Ptprj
|
UTSW |
2 |
90,301,484 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6724:Ptprj
|
UTSW |
2 |
90,281,195 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6831:Ptprj
|
UTSW |
2 |
90,290,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6939:Ptprj
|
UTSW |
2 |
90,289,858 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6972:Ptprj
|
UTSW |
2 |
90,410,747 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7134:Ptprj
|
UTSW |
2 |
90,294,822 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7149:Ptprj
|
UTSW |
2 |
90,274,790 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7243:Ptprj
|
UTSW |
2 |
90,276,765 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7335:Ptprj
|
UTSW |
2 |
90,271,126 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7439:Ptprj
|
UTSW |
2 |
90,280,163 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7441:Ptprj
|
UTSW |
2 |
90,280,163 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7498:Ptprj
|
UTSW |
2 |
90,266,909 (GRCm39) |
nonsense |
probably null |
|
|
R7571:Ptprj
|
UTSW |
2 |
90,285,530 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7657:Ptprj
|
UTSW |
2 |
90,282,501 (GRCm39) |
splice site |
probably null |
|
|
R7672:Ptprj
|
UTSW |
2 |
90,290,940 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7849:Ptprj
|
UTSW |
2 |
90,274,804 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7939:Ptprj
|
UTSW |
2 |
90,295,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7958:Ptprj
|
UTSW |
2 |
90,299,971 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8338:Ptprj
|
UTSW |
2 |
90,301,481 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R8354:Ptprj
|
UTSW |
2 |
90,300,061 (GRCm39) |
missense |
probably benign |
0.43 |
|
R8556:Ptprj
|
UTSW |
2 |
90,271,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8695:Ptprj
|
UTSW |
2 |
90,301,481 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R8784:Ptprj
|
UTSW |
2 |
90,290,856 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R8984:Ptprj
|
UTSW |
2 |
90,270,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9054:Ptprj
|
UTSW |
2 |
90,290,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9056:Ptprj
|
UTSW |
2 |
90,288,613 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9147:Ptprj
|
UTSW |
2 |
90,288,562 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9168:Ptprj
|
UTSW |
2 |
90,294,916 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R9314:Ptprj
|
UTSW |
2 |
90,301,631 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9337:Ptprj
|
UTSW |
2 |
90,270,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9546:Ptprj
|
UTSW |
2 |
90,274,805 (GRCm39) |
missense |
probably benign |
0.08 |
|
RF013:Ptprj
|
UTSW |
2 |
90,301,514 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Ptprj
|
UTSW |
2 |
90,290,913 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCTGCGGAATGAGGTAAGC -3'
(R):5'- AGTGACCTCCTTCCACTGTG -3'
Sequencing Primer
(F):5'- TGAGGTAAGCTGCTGATAAAAATAC -3'
(R):5'- CACTGTGAAGTGGTCCCTAAG -3'
|
| Posted On |
2022-01-20 |
Incidental Mutation