Incidental Mutation 'R9150:Or5m3'
ID 694948
Institutional Source Beutler Lab
Gene Symbol Or5m3
Ensembl Gene ENSMUSG00000042796
Gene Name olfactory receptor family 5 subfamily M member 3
Synonyms Olfr1032, MOR199-1, GA_x6K02T2Q125-47485813-47486745
MMRRC Submission 068938-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R9150 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 85838122-85839054 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 85838626 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 169 (K169*)
Ref Sequence ENSEMBL: ENSMUSP00000107216 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062166] [ENSMUST00000079298] [ENSMUST00000111589]
AlphaFold A2ATE5
Predicted Effect probably null
Transcript: ENSMUST00000062166
AA Change: K169*
SMART Domains Protein: ENSMUSP00000054494
Gene: ENSMUSG00000042796
AA Change: K169*

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 5.6e-50 PFAM
Pfam:7tm_1 39 288 1.1e-22 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000079298
AA Change: K169*
SMART Domains Protein: ENSMUSP00000078279
Gene: ENSMUSG00000042796
AA Change: K169*

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.3e-50 PFAM
Pfam:7tm_1 39 288 9.9e-23 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000111589
AA Change: K169*
SMART Domains Protein: ENSMUSP00000107216
Gene: ENSMUSG00000042796
AA Change: K169*

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.4e-50 PFAM
Pfam:7tm_1 39 288 3.5e-21 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 98% (56/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl6b CTCCGGTGAGTGCCTCATCC CTCC 5: 137,553,354 (GRCm39) probably null Het
Ampd1 A T 3: 102,988,359 (GRCm39) I101F possibly damaging Het
Arhgap11a A G 2: 113,673,614 (GRCm39) V92A possibly damaging Het
Arih1 C A 9: 59,344,069 (GRCm39) L189F possibly damaging Het
B4galt3 A G 1: 171,103,899 (GRCm39) R379G probably benign Het
Capn12 A G 7: 28,590,378 (GRCm39) N642D probably benign Het
Cdc42ep3 T C 17: 79,642,299 (GRCm39) H207R probably benign Het
Dcps A T 9: 35,035,938 (GRCm39) L316H probably damaging Het
Dmgdh A G 13: 93,825,103 (GRCm39) Y142C probably damaging Het
Elmo2 A G 2: 165,140,607 (GRCm39) V300A probably damaging Het
Eml6 A T 11: 29,755,791 (GRCm39) V821E probably benign Het
Fam181a A T 12: 103,282,139 (GRCm39) N15Y probably damaging Het
Gm26657 G T 4: 56,740,835 (GRCm39) E7* probably null Het
Gm8267 A T 14: 44,955,362 (GRCm39) S220T probably benign Het
Gpld1 A T 13: 25,146,305 (GRCm39) Y183F probably damaging Het
Gpr158 G A 2: 21,831,251 (GRCm39) G784R probably benign Het
Grm2 A G 9: 106,524,657 (GRCm39) L215P Het
Gtpbp1 A G 15: 79,592,165 (GRCm39) D252G probably damaging Het
Heatr5b A G 17: 79,103,448 (GRCm39) V1135A probably benign Het
Irag1 T C 7: 110,498,205 (GRCm39) T397A probably benign Het
Lrrc8e A C 8: 4,286,030 (GRCm39) K752Q probably benign Het
Ltbp2 G A 12: 84,837,864 (GRCm39) P1192L probably benign Het
Mapre2 A G 18: 23,991,208 (GRCm39) T201A probably benign Het
Mcm9 A T 10: 53,502,110 (GRCm39) N85K Het
Mdga1 T C 17: 30,057,420 (GRCm39) T92A probably damaging Het
Nemf A C 12: 69,387,820 (GRCm39) D421E probably benign Het
Oga A T 19: 45,771,421 (GRCm39) V50E probably benign Het
Or13g1 G C 7: 85,955,942 (GRCm39) F126L probably damaging Het
Or5k14 G T 16: 58,693,005 (GRCm39) C169* probably null Het
Or8k53 A T 2: 86,177,336 (GRCm39) M258K probably damaging Het
Pcdhga5 A C 18: 37,827,933 (GRCm39) N127T probably damaging Het
Phyhipl A T 10: 70,404,887 (GRCm39) V107E probably damaging Het
Pkd1l1 G A 11: 8,786,256 (GRCm39) R2383C Het
Ppp1r16a G A 15: 76,575,054 (GRCm39) probably benign Het
Pramel20 A G 4: 143,298,531 (GRCm39) Y158C probably benign Het
Rnf41 T C 10: 128,272,399 (GRCm39) V142A Het
Sgcd C T 11: 46,870,170 (GRCm39) V264I probably damaging Het
Six2 A G 17: 85,992,763 (GRCm39) S247P probably benign Het
Slc17a7 T G 7: 44,820,167 (GRCm39) Y241D probably damaging Het
Slc30a5 T A 13: 100,939,915 (GRCm39) K724* probably null Het
Slitrk1 T A 14: 109,149,101 (GRCm39) I537F possibly damaging Het
Sp140l2 T A 1: 85,091,359 (GRCm39) Q33L probably damaging Het
Spen C T 4: 141,244,468 (GRCm39) R189Q unknown Het
Srd5a3 T A 5: 76,297,615 (GRCm39) L139Q probably damaging Het
Tgfbrap1 A T 1: 43,114,985 (GRCm39) Y38* probably null Het
Tln2 A T 9: 67,128,778 (GRCm39) M1437K probably damaging Het
Tmem87b T C 2: 128,687,401 (GRCm39) I467T probably damaging Het
Tnfrsf21 T A 17: 43,398,691 (GRCm39) I599N probably damaging Het
Trmt112 T A 19: 6,887,620 (GRCm39) L23Q probably damaging Het
Tsc22d1 T A 14: 76,654,056 (GRCm39) N178K probably damaging Het
Ttc23 A G 7: 67,375,850 (GRCm39) Y476C probably damaging Het
Twf1 A T 15: 94,484,274 (GRCm39) W83R probably damaging Het
Vmn2r14 T A 5: 109,367,783 (GRCm39) H403L probably damaging Het
Wiz A T 17: 32,586,809 (GRCm39) I167N probably benign Het
Zdhhc22 G A 12: 87,035,192 (GRCm39) P87S probably benign Het
Zfp618 C T 4: 63,039,603 (GRCm39) Q401* probably null Het
Zfp715 T A 7: 42,948,713 (GRCm39) I416F possibly damaging Het
Other mutations in Or5m3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01069:Or5m3 APN 2 85,838,891 (GRCm39) missense probably damaging 1.00
IGL03110:Or5m3 APN 2 85,838,942 (GRCm39) missense probably damaging 0.99
IGL03167:Or5m3 APN 2 85,838,511 (GRCm39) nonsense probably null
R0206:Or5m3 UTSW 2 85,838,636 (GRCm39) missense probably damaging 1.00
R0206:Or5m3 UTSW 2 85,838,636 (GRCm39) missense probably damaging 1.00
R0919:Or5m3 UTSW 2 85,838,984 (GRCm39) missense possibly damaging 0.52
R2018:Or5m3 UTSW 2 85,838,567 (GRCm39) missense probably damaging 1.00
R2019:Or5m3 UTSW 2 85,838,567 (GRCm39) missense probably damaging 1.00
R2938:Or5m3 UTSW 2 85,838,357 (GRCm39) missense probably damaging 0.97
R3843:Or5m3 UTSW 2 85,838,548 (GRCm39) missense probably benign 0.09
R4295:Or5m3 UTSW 2 85,838,614 (GRCm39) missense probably benign 0.01
R5813:Or5m3 UTSW 2 85,838,636 (GRCm39) missense probably damaging 1.00
R6283:Or5m3 UTSW 2 85,838,443 (GRCm39) missense possibly damaging 0.73
R7031:Or5m3 UTSW 2 85,838,939 (GRCm39) missense probably benign 0.26
R7427:Or5m3 UTSW 2 85,838,563 (GRCm39) missense probably benign 0.00
R7428:Or5m3 UTSW 2 85,838,563 (GRCm39) missense probably benign 0.00
R7856:Or5m3 UTSW 2 85,838,640 (GRCm39) missense probably damaging 0.99
R8048:Or5m3 UTSW 2 85,838,524 (GRCm39) missense probably damaging 0.96
R8504:Or5m3 UTSW 2 85,838,149 (GRCm39) missense probably damaging 0.99
R9129:Or5m3 UTSW 2 85,838,356 (GRCm39) missense
R9180:Or5m3 UTSW 2 85,838,325 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCTGCTTAGTACAGTGCTTC -3'
(R):5'- AGCGCATTCTGAGAATGGC -3'

Sequencing Primer
(F):5'- GCCCTTGTTCATGTGGAAATC -3'
(R):5'- CGCATTCTGAGAATGGCAATGAG -3'
Posted On 2022-01-20