Incidental Mutation 'R9153:Rgs10'
ID 695154
Institutional Source Beutler Lab
Gene Symbol Rgs10
Ensembl Gene ENSMUSG00000030844
Gene Name regulator of G-protein signalling 10
Synonyms 2310010N19Rik
MMRRC Submission 068940-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.271) question?
Stock # R9153 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 127975345-128020482 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 127975733 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 145 (R145C)
Ref Sequence ENSEMBL: ENSMUSP00000033133 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033133]
AlphaFold Q9CQE5
Predicted Effect probably damaging
Transcript: ENSMUST00000033133
AA Change: R145C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000033133
Gene: ENSMUSG00000030844
AA Change: R145C

DomainStartEndE-ValueType
low complexity region 16 31 N/A INTRINSIC
RGS 41 156 7.05e-46 SMART
Meta Mutation Damage Score 0.9557 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 99% (73/74)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: A gene trap mutation of this gene results in impaired glucose tolerance and increased fasting glucose levels whereas a targeted knockout shows defects in osteoclast differentiation and in the skeleton. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 A T 11: 110,107,481 (GRCm39) S711R possibly damaging Het
Adnp C A 2: 168,026,580 (GRCm39) Q238H possibly damaging Het
Akap13 A G 7: 75,259,229 (GRCm39) T618A probably benign Het
Ankfn1 G A 11: 89,302,845 (GRCm39) R58W probably damaging Het
Atp8b5 A G 4: 43,308,493 (GRCm39) probably benign Het
Borcs5 G T 6: 134,618,108 (GRCm39) probably benign Het
C1s1 T C 6: 124,517,906 (GRCm39) M25V possibly damaging Het
Canx A T 11: 50,188,162 (GRCm39) D527E probably benign Het
Ccdc154 G A 17: 25,382,152 (GRCm39) D24N probably damaging Het
Ccnt1 G A 15: 98,441,159 (GRCm39) T703I probably benign Het
Cd46 T C 1: 194,774,479 (GRCm39) S19G possibly damaging Het
Cdc25b G A 2: 131,034,564 (GRCm39) E264K possibly damaging Het
Cdhr17 A T 5: 17,040,916 (GRCm39) probably null Het
Cog5 A C 12: 31,710,810 (GRCm39) K63N possibly damaging Het
Col28a1 G A 6: 8,022,765 (GRCm39) T726I probably benign Het
Dhx40 A G 11: 86,690,365 (GRCm39) S219P probably damaging Het
Dnah12 T A 14: 26,536,569 (GRCm39) W2162R probably damaging Het
Eef1a2 A G 2: 180,789,774 (GRCm39) *464R probably null Het
Eif1a T A 18: 46,741,036 (GRCm39) D90E probably damaging Het
Fasn C T 11: 120,706,496 (GRCm39) R996Q possibly damaging Het
Foxred2 A G 15: 77,839,787 (GRCm39) probably null Het
Frat2 A G 19: 41,835,806 (GRCm39) L182P probably damaging Het
Fxyd2 G T 9: 45,319,609 (GRCm39) V24F probably damaging Het
Gabrd C T 4: 155,470,496 (GRCm39) V319I probably damaging Het
H13 T G 2: 152,533,788 (GRCm39) V267G possibly damaging Het
Hnf4g T C 3: 3,573,378 (GRCm39) probably benign Het
Iglon5 T A 7: 43,125,421 (GRCm39) T272S possibly damaging Het
Iqgap2 T A 13: 95,844,547 (GRCm39) M454L probably benign Het
Irf8 T C 8: 121,480,400 (GRCm39) C304R probably benign Het
Itga2 A G 13: 115,001,941 (GRCm39) F614L probably benign Het
Itgb4 A C 11: 115,874,879 (GRCm39) H412P probably benign Het
Jarid2 T C 13: 45,064,678 (GRCm39) F921S probably damaging Het
Kctd13 A G 7: 126,541,327 (GRCm39) D189G probably damaging Het
Meis2 G T 2: 115,697,756 (GRCm39) P381T probably benign Het
Mertk G T 2: 128,624,487 (GRCm39) A633S probably damaging Het
Morn5 A G 2: 35,942,993 (GRCm39) Y31C probably damaging Het
Mug2 A T 6: 122,017,627 (GRCm39) T455S possibly damaging Het
Myo3a A G 2: 22,404,744 (GRCm39) N700S probably benign Het
Nisch T C 14: 30,896,782 (GRCm39) T807A unknown Het
Nkx1-1 A T 5: 33,588,703 (GRCm39) V195E unknown Het
Numa1 A G 7: 101,649,118 (GRCm39) T950A probably benign Het
Nup160 A G 2: 90,514,429 (GRCm39) T126A possibly damaging Het
Oca2 C T 7: 55,943,586 (GRCm39) T253I probably benign Het
Odad2 T C 18: 7,286,733 (GRCm39) K166R possibly damaging Het
Or6c209 T A 10: 129,483,306 (GRCm39) I103N possibly damaging Het
P4ha1 A G 10: 59,203,112 (GRCm39) K435R probably damaging Het
Pcdhgb4 T A 18: 37,854,131 (GRCm39) N175K possibly damaging Het
Per3 A G 4: 151,111,796 (GRCm39) L396P probably benign Het
Phactr3 A T 2: 177,925,739 (GRCm39) E338V possibly damaging Het
Plec G T 15: 76,064,725 (GRCm39) R1782S unknown Het
Prpf39 A T 12: 65,106,671 (GRCm39) Q593L probably damaging Het
Ptprq T C 10: 107,416,126 (GRCm39) Y1724C probably damaging Het
Pygo1 T A 9: 72,852,143 (GRCm39) V110D possibly damaging Het
Rasgrf1 T A 9: 89,826,790 (GRCm39) L133Q probably damaging Het
Secisbp2 A G 13: 51,833,855 (GRCm39) Y665C possibly damaging Het
Sel1l3 T A 5: 53,293,188 (GRCm39) T843S probably benign Het
Senp7 G A 16: 56,006,486 (GRCm39) V964I probably benign Het
Setd4 T A 16: 93,384,722 (GRCm39) D322V possibly damaging Het
Sftpc T A 14: 70,759,650 (GRCm39) T90S probably benign Het
Shq1 A T 6: 100,588,738 (GRCm39) D382E probably damaging Het
Sim1 A G 10: 50,772,029 (GRCm39) R13G probably damaging Het
Slc12a1 T G 2: 125,002,989 (GRCm39) probably benign Het
Slc27a6 T C 18: 58,731,805 (GRCm39) F385S probably benign Het
Stk38l A G 6: 146,660,048 (GRCm39) T27A probably benign Het
Tasp1 A G 2: 139,899,327 (GRCm39) S9P probably damaging Het
Tcstv1a T A 13: 120,355,290 (GRCm39) D114V probably damaging Het
Tmigd1 A T 11: 76,795,468 (GRCm39) R25S probably benign Het
Tnrc6a T A 7: 122,773,519 (GRCm39) Y1154N probably damaging Het
Tox2 T C 2: 163,045,091 (GRCm39) V3A Het
Ubr1 A T 2: 120,756,469 (GRCm39) D719E probably benign Het
Ubr3 A G 2: 69,795,822 (GRCm39) K923R Het
Vmn2r12 C T 5: 109,234,203 (GRCm39) V670M probably damaging Het
Zfp983 T C 17: 21,876,522 (GRCm39) S9P probably benign Het
Zfp986 A T 4: 145,626,030 (GRCm39) H230L probably damaging Het
Zscan4f G A 7: 11,135,241 (GRCm39) E216K probably benign Het
Other mutations in Rgs10
AlleleSourceChrCoordTypePredicted EffectPPH Score
comptroller UTSW 7 127,975,733 (GRCm39) missense probably damaging 1.00
R1682:Rgs10 UTSW 7 127,975,694 (GRCm39) missense probably benign
R1714:Rgs10 UTSW 7 128,004,946 (GRCm39) missense probably damaging 0.98
R1801:Rgs10 UTSW 7 128,006,201 (GRCm39) missense possibly damaging 0.67
R2200:Rgs10 UTSW 7 127,990,761 (GRCm39) missense probably damaging 0.99
R3118:Rgs10 UTSW 7 128,004,955 (GRCm39) missense probably damaging 1.00
R3119:Rgs10 UTSW 7 128,004,955 (GRCm39) missense probably damaging 1.00
R6903:Rgs10 UTSW 7 127,990,797 (GRCm39) missense probably damaging 1.00
R8504:Rgs10 UTSW 7 128,019,793 (GRCm39) missense probably benign 0.38
R8834:Rgs10 UTSW 7 127,990,809 (GRCm39) missense probably damaging 1.00
R9709:Rgs10 UTSW 7 127,975,729 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGGTCTAGCACACTCCAGTC -3'
(R):5'- ACTAGCATGGACTAGTGTGTG -3'

Sequencing Primer
(F):5'- CAAAGAAATGACAGCCTGTACAGTC -3'
(R):5'- CATGGACTAGTGTGTGTGCGC -3'
Posted On 2022-01-20