Incidental Mutation 'R9154:Mroh9'
| ID |
695196 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mroh9
|
| Ensembl Gene |
ENSMUSG00000071890 |
| Gene Name |
maestro heat-like repeat family member 9 |
| Synonyms |
4921528O07Rik, Armc11 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9154 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
162851871-162913239 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 162890030 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 236
(M236L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000094365
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096608]
|
| AlphaFold |
G5E8L9 |
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000094365
Gene: ENSMUSG00000071890
AA Change: M236L
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1gw5b_
|
231 |
716 |
2e-8 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930590J08Rik |
T |
C |
6: 91,926,926 (GRCm39) |
V862A |
probably benign |
Het |
| A2m |
A |
T |
6: 121,645,512 (GRCm39) |
K1019M |
probably damaging |
Het |
| Acot6 |
G |
T |
12: 84,147,789 (GRCm39) |
W15L |
possibly damaging |
Het |
| Adam32 |
CCAGCAGCAGCAGCAGCAG |
CCAGCAGCAGCAGCAG |
8: 25,438,769 (GRCm39) |
|
probably benign |
Het |
| Adnp |
C |
A |
2: 168,026,580 (GRCm39) |
Q238H |
possibly damaging |
Het |
| Akap7 |
T |
C |
10: 25,047,053 (GRCm39) |
Y281C |
probably damaging |
Het |
| Ank1 |
A |
G |
8: 23,605,387 (GRCm39) |
E1085G |
probably damaging |
Het |
| Arhgef38 |
A |
T |
3: 132,837,924 (GRCm39) |
S669T |
unknown |
Het |
| Atp8b2 |
A |
T |
3: 89,865,927 (GRCm39) |
S50R |
possibly damaging |
Het |
| Atp8b5 |
T |
C |
4: 43,372,630 (GRCm39) |
I1090T |
probably benign |
Het |
| Ccdc198 |
A |
T |
14: 49,473,367 (GRCm39) |
H129Q |
probably benign |
Het |
| Chrna4 |
G |
A |
2: 180,670,602 (GRCm39) |
R385C |
probably damaging |
Het |
| Col4a1 |
T |
A |
8: 11,267,446 (GRCm39) |
I1105F |
probably damaging |
Het |
| Crybg2 |
G |
A |
4: 133,792,620 (GRCm39) |
R85Q |
probably benign |
Het |
| Cspg4 |
T |
A |
9: 56,798,287 (GRCm39) |
L1434Q |
|
Het |
| Cyp3a13 |
T |
C |
5: 137,919,758 (GRCm39) |
N6S |
probably benign |
Het |
| Dnase2b |
A |
T |
3: 146,299,326 (GRCm39) |
Y42* |
probably null |
Het |
| F11r |
A |
G |
1: 171,289,376 (GRCm39) |
E233G |
probably damaging |
Het |
| Fip1l1 |
T |
C |
5: 74,747,703 (GRCm39) |
I390T |
possibly damaging |
Het |
| Fiz1 |
G |
A |
7: 5,011,280 (GRCm39) |
R413C |
probably damaging |
Het |
| Fus |
G |
A |
7: 127,580,440 (GRCm39) |
G450E |
unknown |
Het |
| Gm11569 |
C |
A |
11: 99,689,267 (GRCm39) |
C144F |
unknown |
Het |
| Gm7298 |
A |
T |
6: 121,756,436 (GRCm39) |
Y1027F |
probably damaging |
Het |
| Grik5 |
C |
A |
7: 24,758,403 (GRCm39) |
W340L |
probably damaging |
Het |
| H1f2 |
A |
G |
13: 23,923,373 (GRCm39) |
K181R |
unknown |
Het |
| Hectd4 |
G |
A |
5: 121,391,967 (GRCm39) |
R77H |
|
Het |
| Ift81 |
C |
A |
5: 122,689,122 (GRCm39) |
V665L |
probably benign |
Het |
| Ints2 |
A |
G |
11: 86,125,524 (GRCm39) |
F559L |
probably damaging |
Het |
| Kdm8 |
G |
A |
7: 125,054,296 (GRCm39) |
V176I |
probably benign |
Het |
| Keap1 |
A |
T |
9: 21,142,121 (GRCm39) |
Y584* |
probably null |
Het |
| Klra1 |
T |
C |
6: 130,357,607 (GRCm39) |
T7A |
|
Het |
| Lmo7 |
T |
A |
14: 102,122,743 (GRCm39) |
W311R |
probably damaging |
Het |
| Lrp6 |
A |
G |
6: 134,518,855 (GRCm39) |
V70A |
probably damaging |
Het |
| Luc7l3 |
A |
T |
11: 94,190,793 (GRCm39) |
S174T |
unknown |
Het |
| Madd |
T |
C |
2: 90,998,162 (GRCm39) |
T653A |
probably damaging |
Het |
| Mlph |
G |
T |
1: 90,855,716 (GRCm39) |
G41V |
probably damaging |
Het |
| Mov10l1 |
A |
G |
15: 88,896,118 (GRCm39) |
E654G |
possibly damaging |
Het |
| Mpp3 |
T |
C |
11: 101,911,328 (GRCm39) |
I165V |
|
Het |
| Mrgpra2a |
T |
G |
7: 47,076,394 (GRCm39) |
Y288S |
probably damaging |
Het |
| Muc5b |
A |
C |
7: 141,417,974 (GRCm39) |
K3640T |
probably damaging |
Het |
| Myh13 |
A |
G |
11: 67,253,318 (GRCm39) |
I1485V |
probably benign |
Het |
| Nf2 |
A |
T |
11: 4,744,873 (GRCm39) |
F285L |
probably damaging |
Het |
| Nfx1 |
T |
A |
4: 40,990,845 (GRCm39) |
C471S |
probably damaging |
Het |
| Nsd1 |
C |
T |
13: 55,361,253 (GRCm39) |
R74W |
probably damaging |
Het |
| Nudt16l1 |
A |
T |
16: 4,758,281 (GRCm39) |
*212C |
probably null |
Het |
| Oaf |
T |
C |
9: 43,133,992 (GRCm39) |
Y243C |
probably damaging |
Het |
| Or51e1 |
T |
C |
7: 102,358,541 (GRCm39) |
V25A |
probably benign |
Het |
| Or6c3 |
T |
C |
10: 129,308,690 (GRCm39) |
I43T |
probably benign |
Het |
| Or7g30 |
T |
A |
9: 19,352,531 (GRCm39) |
F107L |
probably benign |
Het |
| Or7h8 |
A |
G |
9: 20,124,173 (GRCm39) |
H176R |
possibly damaging |
Het |
| Or8b36 |
T |
A |
9: 37,937,690 (GRCm39) |
L196* |
probably null |
Het |
| Parp9 |
T |
C |
16: 35,768,543 (GRCm39) |
I241T |
probably damaging |
Het |
| Phlpp2 |
G |
T |
8: 110,666,590 (GRCm39) |
A1040S |
possibly damaging |
Het |
| Pon2 |
A |
T |
6: 5,265,391 (GRCm39) |
V332E |
possibly damaging |
Het |
| Ptprc |
A |
G |
1: 138,016,302 (GRCm39) |
V544A |
probably damaging |
Het |
| Rfx6 |
A |
G |
10: 51,597,600 (GRCm39) |
S446G |
probably benign |
Het |
| Rnf103 |
T |
A |
6: 71,487,099 (GRCm39) |
C577S |
probably benign |
Het |
| Ros1 |
T |
G |
10: 51,922,301 (GRCm39) |
E2278D |
possibly damaging |
Het |
| Rpl37 |
A |
G |
15: 5,147,109 (GRCm39) |
S50G |
probably benign |
Het |
| Rrad |
C |
T |
8: 105,355,343 (GRCm39) |
V222M |
possibly damaging |
Het |
| Ryr1 |
T |
C |
7: 28,769,283 (GRCm39) |
T2770A |
probably benign |
Het |
| Secisbp2l |
G |
A |
2: 125,617,623 (GRCm39) |
P18L |
probably damaging |
Het |
| Septin2 |
T |
A |
1: 93,429,310 (GRCm39) |
W260R |
probably damaging |
Het |
| Slc35c2 |
A |
G |
2: 165,122,797 (GRCm39) |
M117T |
probably benign |
Het |
| Slc44a5 |
A |
G |
3: 153,953,373 (GRCm39) |
T252A |
probably benign |
Het |
| Speer4f2 |
T |
A |
5: 17,581,610 (GRCm39) |
L184Q |
|
Het |
| Sphkap |
C |
G |
1: 83,234,982 (GRCm39) |
V1615L |
probably damaging |
Het |
| Sult2a3 |
C |
T |
7: 13,806,981 (GRCm39) |
V234I |
probably benign |
Het |
| Tanc1 |
T |
C |
2: 59,630,132 (GRCm39) |
L704P |
probably damaging |
Het |
| Tas2r126 |
T |
C |
6: 42,412,174 (GRCm39) |
S236P |
probably benign |
Het |
| Tnik |
A |
G |
3: 28,704,235 (GRCm39) |
I1020V |
probably damaging |
Het |
| Tomm5 |
T |
C |
4: 45,106,724 (GRCm39) |
Q64R |
unknown |
Het |
| Ttll13 |
A |
G |
7: 79,897,182 (GRCm39) |
E16G |
probably benign |
Het |
| Vmn1r21 |
C |
A |
6: 57,821,348 (GRCm39) |
C32F |
probably benign |
Het |
| Vmn2r51 |
T |
A |
7: 9,839,480 (GRCm39) |
D36V |
probably damaging |
Het |
| Vmn2r63 |
C |
T |
7: 42,576,413 (GRCm39) |
D467N |
probably damaging |
Het |
| Vwce |
A |
G |
19: 10,625,850 (GRCm39) |
N454S |
possibly damaging |
Het |
| Wfdc1 |
A |
C |
8: 120,406,116 (GRCm39) |
D77A |
|
Het |
| Yme1l1 |
T |
A |
2: 23,077,815 (GRCm39) |
I419N |
probably damaging |
Het |
| Zfp106 |
G |
A |
2: 120,364,812 (GRCm39) |
Q555* |
probably null |
Het |
| Zfp773 |
A |
C |
7: 7,138,302 (GRCm39) |
M111R |
probably damaging |
Het |
| Zmat3 |
G |
A |
3: 32,397,767 (GRCm39) |
A165V |
possibly damaging |
Het |
|
| Other mutations in Mroh9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00593:Mroh9
|
APN |
1 |
162,873,350 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL00705:Mroh9
|
APN |
1 |
162,907,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00788:Mroh9
|
APN |
1 |
162,852,227 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL00795:Mroh9
|
APN |
1 |
162,888,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00815:Mroh9
|
APN |
1 |
162,866,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01025:Mroh9
|
APN |
1 |
162,875,435 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL01303:Mroh9
|
APN |
1 |
162,908,144 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01526:Mroh9
|
APN |
1 |
162,883,172 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01680:Mroh9
|
APN |
1 |
162,875,551 (GRCm39) |
splice site |
probably null |
|
|
IGL01823:Mroh9
|
APN |
1 |
162,883,178 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02024:Mroh9
|
APN |
1 |
162,890,071 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02213:Mroh9
|
APN |
1 |
162,885,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02455:Mroh9
|
APN |
1 |
162,903,149 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02546:Mroh9
|
APN |
1 |
162,908,145 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL03059:Mroh9
|
APN |
1 |
162,852,205 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03061:Mroh9
|
APN |
1 |
162,854,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03071:Mroh9
|
APN |
1 |
162,866,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0048:Mroh9
|
UTSW |
1 |
162,890,056 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0048:Mroh9
|
UTSW |
1 |
162,890,056 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0441:Mroh9
|
UTSW |
1 |
162,888,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0506:Mroh9
|
UTSW |
1 |
162,888,205 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0629:Mroh9
|
UTSW |
1 |
162,888,205 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0751:Mroh9
|
UTSW |
1 |
162,893,693 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R1301:Mroh9
|
UTSW |
1 |
162,871,552 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1481:Mroh9
|
UTSW |
1 |
162,854,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1618:Mroh9
|
UTSW |
1 |
162,852,110 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1647:Mroh9
|
UTSW |
1 |
162,873,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1648:Mroh9
|
UTSW |
1 |
162,873,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1668:Mroh9
|
UTSW |
1 |
162,852,161 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1795:Mroh9
|
UTSW |
1 |
162,884,347 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1796:Mroh9
|
UTSW |
1 |
162,873,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1857:Mroh9
|
UTSW |
1 |
162,866,714 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1869:Mroh9
|
UTSW |
1 |
162,854,082 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1923:Mroh9
|
UTSW |
1 |
162,903,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2325:Mroh9
|
UTSW |
1 |
162,854,099 (GRCm39) |
splice site |
probably null |
|
|
R2511:Mroh9
|
UTSW |
1 |
162,866,514 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2912:Mroh9
|
UTSW |
1 |
162,871,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2913:Mroh9
|
UTSW |
1 |
162,871,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2919:Mroh9
|
UTSW |
1 |
162,884,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2973:Mroh9
|
UTSW |
1 |
162,884,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3912:Mroh9
|
UTSW |
1 |
162,893,638 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4034:Mroh9
|
UTSW |
1 |
162,908,122 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4551:Mroh9
|
UTSW |
1 |
162,871,662 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4656:Mroh9
|
UTSW |
1 |
162,893,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4662:Mroh9
|
UTSW |
1 |
162,883,162 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4743:Mroh9
|
UTSW |
1 |
162,852,061 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4890:Mroh9
|
UTSW |
1 |
162,854,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5128:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5129:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5147:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5157:Mroh9
|
UTSW |
1 |
162,871,690 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5324:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5325:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5340:Mroh9
|
UTSW |
1 |
162,908,156 (GRCm39) |
start gained |
probably benign |
|
|
R6005:Mroh9
|
UTSW |
1 |
162,903,246 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6182:Mroh9
|
UTSW |
1 |
162,893,612 (GRCm39) |
nonsense |
probably null |
|
|
R6414:Mroh9
|
UTSW |
1 |
162,902,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6477:Mroh9
|
UTSW |
1 |
162,903,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6540:Mroh9
|
UTSW |
1 |
162,866,541 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6541:Mroh9
|
UTSW |
1 |
162,885,607 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6643:Mroh9
|
UTSW |
1 |
162,903,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6811:Mroh9
|
UTSW |
1 |
162,873,610 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6830:Mroh9
|
UTSW |
1 |
162,903,935 (GRCm39) |
missense |
probably benign |
|
|
R7026:Mroh9
|
UTSW |
1 |
162,888,251 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7052:Mroh9
|
UTSW |
1 |
162,866,525 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7068:Mroh9
|
UTSW |
1 |
162,866,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7350:Mroh9
|
UTSW |
1 |
162,903,858 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7545:Mroh9
|
UTSW |
1 |
162,902,277 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7615:Mroh9
|
UTSW |
1 |
162,873,601 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7743:Mroh9
|
UTSW |
1 |
162,852,122 (GRCm39) |
missense |
probably benign |
|
|
R7808:Mroh9
|
UTSW |
1 |
162,866,678 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8024:Mroh9
|
UTSW |
1 |
162,866,802 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8062:Mroh9
|
UTSW |
1 |
162,866,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8145:Mroh9
|
UTSW |
1 |
162,890,096 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8426:Mroh9
|
UTSW |
1 |
162,852,294 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8458:Mroh9
|
UTSW |
1 |
162,883,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8555:Mroh9
|
UTSW |
1 |
162,899,595 (GRCm39) |
splice site |
probably null |
|
|
R8960:Mroh9
|
UTSW |
1 |
162,883,196 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9040:Mroh9
|
UTSW |
1 |
162,890,069 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9125:Mroh9
|
UTSW |
1 |
162,875,412 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9596:Mroh9
|
UTSW |
1 |
162,893,576 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9612:Mroh9
|
UTSW |
1 |
162,866,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF003:Mroh9
|
UTSW |
1 |
162,885,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATTGGCATAAAATGTTGGGAACC -3'
(R):5'- ACAGTAGGCATCCGGAACTG -3'
Sequencing Primer
(F):5'- ACATGTGTGAGTTATCTAGTCATTTG -3'
(R):5'- GCATCCGGAACTGGGTAG -3'
|
| Posted On |
2022-01-20 |
Incidental Mutation