Incidental Mutation 'R9157:Vmn2r54'
ID 695435
Institutional Source Beutler Lab
Gene Symbol Vmn2r54
Ensembl Gene ENSMUSG00000096593
Gene Name vomeronasal 2, receptor 54
Synonyms
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # R9157 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 12349160-12374167 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 12366055 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 293 (Y293C)
Ref Sequence ENSEMBL: ENSMUSP00000083386 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086210]
AlphaFold A0A3B2W422
Predicted Effect possibly damaging
Transcript: ENSMUST00000086210
AA Change: Y293C

PolyPhen 2 Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000083386
Gene: ENSMUSG00000096593
AA Change: Y293C

DomainStartEndE-ValueType
Pfam:ANF_receptor 5 397 4.3e-58 PFAM
Pfam:NCD3G 442 495 2.2e-19 PFAM
Pfam:7tm_3 526 763 1.2e-54 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik T C 3: 124,207,220 (GRCm39) T324A probably benign Het
Adam9 A T 8: 25,493,331 (GRCm39) F92L probably damaging Het
Adgrb1 A G 15: 74,411,624 (GRCm39) T376A probably damaging Het
Aff3 A C 1: 38,249,559 (GRCm39) I516S probably benign Het
Bdp1 C T 13: 100,186,436 (GRCm39) S1672N probably benign Het
Btc A T 5: 91,513,980 (GRCm39) I94N probably damaging Het
Ccdc168 A G 1: 44,096,520 (GRCm39) V1526A probably benign Het
Ccdc47 A T 11: 106,093,208 (GRCm39) probably null Het
Ceacam5 A T 7: 17,493,419 (GRCm39) Y814F possibly damaging Het
Celsr3 A T 9: 108,707,185 (GRCm39) R1223W probably damaging Het
Cenpc1 A G 5: 86,166,316 (GRCm39) M779T probably benign Het
Cfap20dc T A 14: 8,518,635 (GRCm38) T274S probably benign Het
Depdc5 T C 5: 33,102,452 (GRCm39) I986T probably damaging Het
Dhx40 A T 11: 86,662,050 (GRCm39) I669N probably damaging Het
Dnah1 T A 14: 30,987,970 (GRCm39) I3483F probably damaging Het
Dzip3 C T 16: 48,748,124 (GRCm39) G918D probably benign Het
Fam185a T G 5: 21,660,837 (GRCm39) V284G probably damaging Het
Fhod3 T C 18: 25,218,651 (GRCm39) S805P probably damaging Het
Filip1l A G 16: 57,391,980 (GRCm39) N856S probably benign Het
Gm12887 C T 4: 121,473,701 (GRCm39) V50M probably benign Het
Gm45785 T C 7: 140,398,616 (GRCm39) I94V unknown Het
Gm9195 A G 14: 72,692,038 (GRCm39) I1616T unknown Het
Grm4 T A 17: 27,653,956 (GRCm39) I665F probably benign Het
Hcls1 C T 16: 36,777,000 (GRCm39) A230V probably benign Het
Hic1 A G 11: 75,057,053 (GRCm39) L612P possibly damaging Het
Hmcn1 A C 1: 150,522,343 (GRCm39) V3519G probably benign Het
Hmgcs1 A G 13: 120,165,963 (GRCm39) Y360C probably benign Het
Hspa12a A T 19: 58,789,292 (GRCm39) M448K possibly damaging Het
Htt T G 5: 34,987,171 (GRCm39) I1130S probably null Het
Irx3 A G 8: 92,527,694 (GRCm39) Y59H probably damaging Het
Klc4 A G 17: 46,950,361 (GRCm39) L280P probably damaging Het
Lrp1 G T 10: 127,410,209 (GRCm39) N1512K probably damaging Het
Ltbp2 G A 12: 84,837,864 (GRCm39) P1192L probably benign Het
Marco T C 1: 120,421,814 (GRCm39) E130G probably damaging Het
Mdga1 G A 17: 30,057,491 (GRCm39) T775M probably damaging Het
Ms4a18 A T 19: 10,988,804 (GRCm39) L184Q probably damaging Het
Msi2 A C 11: 88,608,889 (GRCm39) S10A probably benign Het
Muc5ac T C 7: 141,363,529 (GRCm39) I2280T unknown Het
Ngfr AAGCAGCAGCAGCAGCAGCAGCAG AAGCAGCAGCAGCAGCAGCAG 11: 95,478,316 (GRCm39) probably benign Het
Nradd A G 9: 110,451,188 (GRCm39) L60P probably damaging Het
Nup188 A G 2: 30,188,456 (GRCm39) Y39C probably benign Het
Odf2 G T 2: 29,816,815 (GRCm39) G754C probably benign Het
Or10a2 A T 7: 106,673,214 (GRCm39) M60L probably damaging Het
Or12d15 A G 17: 37,694,183 (GRCm39) M242V probably benign Het
Or13d1 A G 4: 52,971,419 (GRCm39) Y266C possibly damaging Het
Or4b1 A G 2: 89,979,522 (GRCm39) I276T possibly damaging Het
Osbpl6 C T 2: 76,382,468 (GRCm39) P222S probably benign Het
Pcdhga3 T C 18: 37,809,229 (GRCm39) Y561H probably benign Het
Phykpl G A 11: 51,490,375 (GRCm39) V419I probably benign Het
Pskh1 A G 8: 106,640,142 (GRCm39) Y274C possibly damaging Het
Rap1gap G T 4: 137,444,742 (GRCm39) V219F probably damaging Het
Rapgef4 C A 2: 72,005,212 (GRCm39) H220N probably benign Het
Rcor3 G T 1: 191,810,181 (GRCm39) H165Q possibly damaging Het
Reg3d T C 6: 78,354,422 (GRCm39) T60A possibly damaging Het
Rgs9 T A 11: 109,116,549 (GRCm39) D644V probably damaging Het
Rhob T A 12: 8,549,319 (GRCm39) H105L probably benign Het
Rph3a T C 5: 121,101,892 (GRCm39) K115E probably damaging Het
Rsf1 GG GGGGACGGCCG 7: 97,229,113 (GRCm39) probably benign Het
Scn4b T A 9: 45,058,013 (GRCm39) V35E probably damaging Het
Serpina3i T C 12: 104,231,672 (GRCm39) I103T probably damaging Het
Sidt2 T C 9: 45,852,658 (GRCm39) T776A possibly damaging Het
Slc15a1 T C 14: 121,702,389 (GRCm39) I586V probably benign Het
Slc15a5 A T 6: 137,961,456 (GRCm39) V213E Het
Stard13 C A 5: 151,157,152 (GRCm39) A10S probably benign Het
Taf6 C A 5: 138,179,221 (GRCm39) V406F possibly damaging Het
Tap2 G T 17: 34,431,004 (GRCm39) R368L possibly damaging Het
Tmem236 T C 2: 14,223,889 (GRCm39) V226A probably benign Het
Tmem87a T A 2: 120,210,093 (GRCm39) I287F possibly damaging Het
Ttll13 A T 7: 79,904,428 (GRCm39) K351I possibly damaging Het
Ttn T A 2: 76,581,245 (GRCm39) Y23216F probably damaging Het
Vmn2r27 T C 6: 124,201,244 (GRCm39) T238A probably benign Het
Vsig10l T C 7: 43,112,948 (GRCm39) S69P Het
Wdr83 G A 8: 85,806,432 (GRCm39) T122I probably damaging Het
Zfp219 A G 14: 52,246,200 (GRCm39) V309A probably damaging Het
Zfp354a C T 11: 50,960,788 (GRCm39) S332F probably damaging Het
Zfp354b T C 11: 50,813,887 (GRCm39) N346S possibly damaging Het
Other mutations in Vmn2r54
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Vmn2r54 APN 7 12,365,840 (GRCm39) splice site probably benign
IGL01778:Vmn2r54 APN 7 12,366,009 (GRCm39) missense probably benign 0.07
IGL01998:Vmn2r54 APN 7 12,349,227 (GRCm39) missense probably benign
IGL02028:Vmn2r54 APN 7 12,366,088 (GRCm39) missense probably damaging 1.00
IGL02064:Vmn2r54 APN 7 12,349,533 (GRCm39) missense probably benign 0.02
IGL02238:Vmn2r54 APN 7 12,369,910 (GRCm39) missense probably damaging 1.00
IGL03062:Vmn2r54 APN 7 12,366,355 (GRCm39) missense probably damaging 0.98
IGL03120:Vmn2r54 APN 7 12,349,314 (GRCm39) missense probably damaging 1.00
PIT4453001:Vmn2r54 UTSW 7 12,363,669 (GRCm39) missense probably benign 0.06
R0212:Vmn2r54 UTSW 7 12,366,424 (GRCm39) missense probably benign
R0360:Vmn2r54 UTSW 7 12,349,576 (GRCm39) missense probably damaging 1.00
R1646:Vmn2r54 UTSW 7 12,366,434 (GRCm39) missense probably damaging 1.00
R1673:Vmn2r54 UTSW 7 12,350,138 (GRCm39) critical splice acceptor site probably null
R1738:Vmn2r54 UTSW 7 12,369,815 (GRCm39) missense probably benign 0.00
R1856:Vmn2r54 UTSW 7 12,366,238 (GRCm39) missense probably benign
R2012:Vmn2r54 UTSW 7 12,349,804 (GRCm39) missense probably damaging 1.00
R2038:Vmn2r54 UTSW 7 12,363,637 (GRCm39) missense possibly damaging 0.94
R2160:Vmn2r54 UTSW 7 12,349,420 (GRCm39) missense probably benign 0.29
R2397:Vmn2r54 UTSW 7 12,349,578 (GRCm39) missense probably damaging 0.98
R2430:Vmn2r54 UTSW 7 12,365,933 (GRCm39) missense probably damaging 0.99
R2829:Vmn2r54 UTSW 7 12,349,617 (GRCm39) missense possibly damaging 0.62
R2975:Vmn2r54 UTSW 7 12,369,919 (GRCm39) missense possibly damaging 0.92
R3005:Vmn2r54 UTSW 7 12,349,221 (GRCm39) missense probably benign 0.28
R3725:Vmn2r54 UTSW 7 12,366,223 (GRCm39) missense probably benign 0.42
R4486:Vmn2r54 UTSW 7 12,366,199 (GRCm39) nonsense probably null
R4881:Vmn2r54 UTSW 7 12,363,598 (GRCm39) missense probably benign 0.00
R4907:Vmn2r54 UTSW 7 12,350,150 (GRCm39) splice site probably null
R5536:Vmn2r54 UTSW 7 12,366,343 (GRCm39) missense probably benign 0.03
R5637:Vmn2r54 UTSW 7 12,349,296 (GRCm39) missense probably benign 0.41
R5703:Vmn2r54 UTSW 7 12,363,594 (GRCm39) missense probably benign 0.22
R5769:Vmn2r54 UTSW 7 12,349,209 (GRCm39) missense possibly damaging 0.73
R5972:Vmn2r54 UTSW 7 12,369,874 (GRCm39) missense probably damaging 1.00
R5972:Vmn2r54 UTSW 7 12,349,279 (GRCm39) missense probably damaging 1.00
R5977:Vmn2r54 UTSW 7 12,366,143 (GRCm39) missense probably damaging 1.00
R6084:Vmn2r54 UTSW 7 12,366,205 (GRCm39) missense probably damaging 0.98
R6176:Vmn2r54 UTSW 7 12,349,908 (GRCm39) missense probably damaging 1.00
R6229:Vmn2r54 UTSW 7 12,365,883 (GRCm39) missense probably benign 0.00
R6371:Vmn2r54 UTSW 7 12,349,362 (GRCm39) missense probably damaging 1.00
R6374:Vmn2r54 UTSW 7 12,349,420 (GRCm39) missense probably damaging 1.00
R6804:Vmn2r54 UTSW 7 12,363,792 (GRCm39) missense probably benign
R6886:Vmn2r54 UTSW 7 12,366,080 (GRCm39) missense probably benign 0.02
R7041:Vmn2r54 UTSW 7 12,363,751 (GRCm39) missense probably damaging 0.99
R7058:Vmn2r54 UTSW 7 12,349,722 (GRCm39) missense possibly damaging 0.70
R7113:Vmn2r54 UTSW 7 12,350,001 (GRCm39) missense probably damaging 1.00
R7124:Vmn2r54 UTSW 7 12,356,078 (GRCm39) missense probably benign 0.00
R7126:Vmn2r54 UTSW 7 12,366,088 (GRCm39) missense possibly damaging 0.91
R7236:Vmn2r54 UTSW 7 12,365,917 (GRCm39) missense possibly damaging 0.84
R7337:Vmn2r54 UTSW 7 12,356,044 (GRCm39) missense probably benign 0.00
R7406:Vmn2r54 UTSW 7 12,350,150 (GRCm39) splice site probably null
R7634:Vmn2r54 UTSW 7 12,349,630 (GRCm39) missense probably damaging 1.00
R7793:Vmn2r54 UTSW 7 12,366,196 (GRCm39) missense probably damaging 0.98
R8139:Vmn2r54 UTSW 7 12,349,743 (GRCm39) missense possibly damaging 0.92
R8158:Vmn2r54 UTSW 7 12,349,888 (GRCm39) missense probably damaging 1.00
R8179:Vmn2r54 UTSW 7 12,366,018 (GRCm39) nonsense probably null
R8440:Vmn2r54 UTSW 7 12,350,013 (GRCm39) missense possibly damaging 0.72
R8712:Vmn2r54 UTSW 7 12,369,877 (GRCm39) missense probably benign 0.22
R8853:Vmn2r54 UTSW 7 12,349,782 (GRCm39) missense probably damaging 1.00
R8859:Vmn2r54 UTSW 7 12,363,702 (GRCm39) missense possibly damaging 0.70
R9146:Vmn2r54 UTSW 7 12,366,647 (GRCm39) missense probably benign 0.05
R9344:Vmn2r54 UTSW 7 12,366,283 (GRCm39) missense probably benign
R9423:Vmn2r54 UTSW 7 12,349,441 (GRCm39) missense probably damaging 1.00
R9534:Vmn2r54 UTSW 7 12,366,093 (GRCm39) missense probably benign 0.03
R9632:Vmn2r54 UTSW 7 12,363,753 (GRCm39) missense possibly damaging 0.74
R9661:Vmn2r54 UTSW 7 12,349,166 (GRCm39) missense probably benign
R9710:Vmn2r54 UTSW 7 12,363,753 (GRCm39) missense possibly damaging 0.74
U24488:Vmn2r54 UTSW 7 12,349,356 (GRCm39) missense possibly damaging 0.84
X0066:Vmn2r54 UTSW 7 12,349,297 (GRCm39) missense probably damaging 1.00
Z1177:Vmn2r54 UTSW 7 12,366,035 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ATTATGGCTGTTCCCCAACC -3'
(R):5'- CATACCAGGCATTTCCCAGG -3'

Sequencing Primer
(F):5'- TCTCTTACCTGCCAGGAATGGAAG -3'
(R):5'- CATTTCCCAGGTGTTGCAAGGC -3'
Posted On 2022-01-20