Incidental Mutation 'R9158:Il31ra'
ID 695532
Institutional Source Beutler Lab
Gene Symbol Il31ra
Ensembl Gene ENSMUSG00000050377
Gene Name interleukin 31 receptor A
Synonyms GLM-R, GPL
MMRRC Submission 068942-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9158 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 112649439-112717266 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 112670394 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Stop codon at position 331 (W331*)
Ref Sequence ENSEMBL: ENSMUSP00000058045 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051756] [ENSMUST00000223752] [ENSMUST00000223819] [ENSMUST00000224510] [ENSMUST00000224576]
AlphaFold Q8K5B1
Predicted Effect probably null
Transcript: ENSMUST00000051756
AA Change: W331*
SMART Domains Protein: ENSMUSP00000058045
Gene: ENSMUSG00000050377
AA Change: W331*

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
FN3 115 198 7.75e0 SMART
Blast:FN3 216 297 1e-40 BLAST
FN3 325 394 1.15e1 SMART
FN3 408 490 7.18e-3 SMART
low complexity region 508 522 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000223752
Predicted Effect probably null
Transcript: ENSMUST00000223819
AA Change: W358*
Predicted Effect probably null
Transcript: ENSMUST00000224510
AA Change: W250*
Predicted Effect probably benign
Transcript: ENSMUST00000224576
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.5%
Validation Efficiency 100% (62/62)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
PHENOTYPE: Homozygous null mice display no apparent abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam25 G A 8: 41,208,645 (GRCm39) C637Y probably damaging Het
Ahdc1 A G 4: 132,792,505 (GRCm39) T1249A possibly damaging Het
Alkbh3 A G 2: 93,835,082 (GRCm39) S88P probably damaging Het
Ankrd17 C A 5: 90,416,575 (GRCm39) A1086S probably damaging Het
Ankzf1 T A 1: 75,173,020 (GRCm39) V372E probably damaging Het
Apbb1ip T C 2: 22,764,951 (GRCm39) V544A probably benign Het
Atp13a2 T C 4: 140,724,112 (GRCm39) probably null Het
Cacna2d1 A G 5: 16,140,039 (GRCm39) T10A probably benign Het
Cadps T C 14: 12,546,356 (GRCm38) N500S probably benign Het
Casp16 A G 17: 23,769,948 (GRCm39) probably benign Het
Cdh22 T A 2: 165,012,627 (GRCm39) I153F probably damaging Het
Clip2 T C 5: 134,521,251 (GRCm39) E964G probably benign Het
Cracdl A T 1: 37,670,442 (GRCm39) M166K probably damaging Het
Cryga T C 1: 65,142,198 (GRCm39) D65G probably benign Het
Dap3 A G 3: 88,832,637 (GRCm39) Y357H probably damaging Het
Eef2 C T 10: 81,014,693 (GRCm39) probably benign Het
Gja4 A G 4: 127,206,466 (GRCm39) L99P probably damaging Het
Glb1l3 A T 9: 26,765,005 (GRCm39) Y135* probably null Het
Gm5114 T G 7: 39,060,486 (GRCm39) D121A probably damaging Het
Gm6525 A G 3: 84,082,255 (GRCm39) K59E probably benign Het
Herc1 C T 9: 66,376,400 (GRCm39) L3407F probably benign Het
Hmgcr G A 13: 96,792,170 (GRCm39) R589* probably null Het
Iglv3 A C 16: 19,060,012 (GRCm39) D105E probably damaging Het
Il1r1 G A 1: 40,332,391 (GRCm39) W60* probably null Het
Inca1 C T 11: 70,581,376 (GRCm39) C16Y probably damaging Het
Inpp4a A G 1: 37,442,552 (GRCm39) T628A possibly damaging Het
Kdm2a C G 19: 4,374,715 (GRCm39) R805S possibly damaging Het
Kel T A 6: 41,664,905 (GRCm39) I620L probably benign Het
Kmt2d C T 15: 98,741,020 (GRCm39) G4638R unknown Het
Lilrb4b T A 10: 51,357,829 (GRCm39) N174K possibly damaging Het
Ltbp2 G A 12: 84,837,864 (GRCm39) P1192L probably benign Het
Ltf T A 9: 110,868,003 (GRCm39) V615E probably damaging Het
Map7d1 G T 4: 126,130,478 (GRCm39) Q443K possibly damaging Het
Mapk9 A G 11: 49,745,095 (GRCm39) D3G probably benign Het
Nktr T G 9: 121,582,154 (GRCm39) S1424A unknown Het
Npas1 A G 7: 16,195,333 (GRCm39) S332P possibly damaging Het
Or13a25 T C 7: 140,247,547 (GRCm39) S109P possibly damaging Het
Or52n2c T C 7: 104,574,086 (GRCm39) Y295C probably damaging Het
Or5ak4 A G 2: 85,161,348 (GRCm39) I298T probably benign Het
Or6d12 T C 6: 116,492,791 (GRCm39) F18L possibly damaging Het
Or8b12b C A 9: 37,684,800 (GRCm39) P282T probably damaging Het
Pcdh8 A G 14: 80,005,182 (GRCm39) W948R probably damaging Het
Pde3a A G 6: 141,195,614 (GRCm39) E100G probably benign Het
Phrf1 T A 7: 140,836,466 (GRCm39) V246D unknown Het
Pitpnb A T 5: 111,530,876 (GRCm39) N223I probably damaging Het
Pkd1l3 A T 8: 110,394,207 (GRCm39) R2065* probably null Het
Prepl T C 17: 85,383,379 (GRCm39) D355G possibly damaging Het
Runx2 A G 17: 45,046,508 (GRCm39) V5A probably benign Het
Sema4g T A 19: 44,986,846 (GRCm39) V433D possibly damaging Het
Sema6a C T 18: 47,431,330 (GRCm39) V123I probably damaging Het
Senp6 A G 9: 79,994,732 (GRCm39) K24E probably benign Het
Slc22a8 T A 19: 8,583,427 (GRCm39) S211T probably damaging Het
Slc34a2 A G 5: 53,221,217 (GRCm39) D221G possibly damaging Het
Tmprss11g A T 5: 86,637,166 (GRCm39) L323Q probably damaging Het
Tpcn1 T C 5: 120,687,988 (GRCm39) probably benign Het
Trim65 G A 11: 116,018,050 (GRCm39) T311I probably benign Het
Tub T C 7: 108,625,962 (GRCm39) F284L possibly damaging Het
Ube2j1 G A 4: 33,036,711 (GRCm39) V12I probably benign Het
Vmn2r101 A T 17: 19,809,161 (GRCm39) N97Y probably benign Het
Vmn2r49 C A 7: 9,722,835 (GRCm39) W146C probably damaging Het
Zfp628 T C 7: 4,922,153 (GRCm39) L125P probably damaging Het
Other mutations in Il31ra
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00095:Il31ra APN 13 112,684,012 (GRCm39) missense possibly damaging 0.94
IGL00639:Il31ra APN 13 112,686,093 (GRCm39) nonsense probably null
IGL01640:Il31ra APN 13 112,668,292 (GRCm39) missense possibly damaging 0.58
IGL02009:Il31ra APN 13 112,670,401 (GRCm39) missense probably damaging 0.98
IGL02431:Il31ra APN 13 112,666,830 (GRCm39) missense probably damaging 1.00
IGL02675:Il31ra APN 13 112,660,886 (GRCm39) missense probably benign 0.00
IGL02718:Il31ra APN 13 112,666,903 (GRCm39) nonsense probably null
IGL03388:Il31ra APN 13 112,682,746 (GRCm39) missense probably damaging 1.00
IGL03408:Il31ra APN 13 112,662,422 (GRCm39) missense probably benign 0.21
R0482:Il31ra UTSW 13 112,664,015 (GRCm39) missense possibly damaging 0.89
R0639:Il31ra UTSW 13 112,662,377 (GRCm39) missense possibly damaging 0.95
R0905:Il31ra UTSW 13 112,668,207 (GRCm39) missense probably damaging 1.00
R0948:Il31ra UTSW 13 112,666,912 (GRCm39) missense possibly damaging 0.81
R1420:Il31ra UTSW 13 112,668,286 (GRCm39) missense probably damaging 1.00
R1538:Il31ra UTSW 13 112,684,000 (GRCm39) missense possibly damaging 0.91
R1776:Il31ra UTSW 13 112,677,773 (GRCm39) missense probably damaging 0.97
R1931:Il31ra UTSW 13 112,677,756 (GRCm39) missense probably damaging 1.00
R2006:Il31ra UTSW 13 112,666,890 (GRCm39) missense probably damaging 1.00
R2134:Il31ra UTSW 13 112,680,422 (GRCm39) missense possibly damaging 0.94
R3103:Il31ra UTSW 13 112,666,885 (GRCm39) missense probably damaging 1.00
R4089:Il31ra UTSW 13 112,688,453 (GRCm39) nonsense probably null
R4742:Il31ra UTSW 13 112,660,501 (GRCm39) nonsense probably null
R4787:Il31ra UTSW 13 112,664,079 (GRCm39) missense possibly damaging 0.82
R5154:Il31ra UTSW 13 112,660,531 (GRCm39) missense possibly damaging 0.87
R5193:Il31ra UTSW 13 112,660,864 (GRCm39) missense probably benign 0.34
R5402:Il31ra UTSW 13 112,660,669 (GRCm39) missense probably benign 0.01
R5743:Il31ra UTSW 13 112,664,021 (GRCm39) missense possibly damaging 0.89
R5917:Il31ra UTSW 13 112,682,846 (GRCm39) missense probably benign
R6126:Il31ra UTSW 13 112,666,908 (GRCm39) missense probably damaging 1.00
R6414:Il31ra UTSW 13 112,660,441 (GRCm39) missense possibly damaging 0.90
R6580:Il31ra UTSW 13 112,688,476 (GRCm39) missense possibly damaging 0.90
R6727:Il31ra UTSW 13 112,683,902 (GRCm39) missense probably damaging 1.00
R6783:Il31ra UTSW 13 112,688,522 (GRCm39) critical splice acceptor site probably null
R6912:Il31ra UTSW 13 112,685,998 (GRCm39) missense probably damaging 0.99
R6925:Il31ra UTSW 13 112,664,063 (GRCm39) missense possibly damaging 0.56
R7187:Il31ra UTSW 13 112,682,845 (GRCm39) missense probably benign 0.04
R7210:Il31ra UTSW 13 112,686,034 (GRCm39) missense possibly damaging 0.95
R7236:Il31ra UTSW 13 112,660,439 (GRCm39) makesense probably null
R7323:Il31ra UTSW 13 112,688,497 (GRCm39) missense probably damaging 1.00
R7618:Il31ra UTSW 13 112,688,514 (GRCm39) missense possibly damaging 0.66
R7783:Il31ra UTSW 13 112,677,785 (GRCm39) missense probably benign
R8353:Il31ra UTSW 13 112,660,717 (GRCm39) missense probably damaging 1.00
R8453:Il31ra UTSW 13 112,660,717 (GRCm39) missense probably damaging 1.00
R8679:Il31ra UTSW 13 112,662,372 (GRCm39) missense possibly damaging 0.81
R8890:Il31ra UTSW 13 112,660,861 (GRCm39) missense possibly damaging 0.95
R9032:Il31ra UTSW 13 112,660,628 (GRCm39) missense
R9077:Il31ra UTSW 13 112,670,361 (GRCm39) missense probably benign 0.00
R9085:Il31ra UTSW 13 112,660,628 (GRCm39) missense
R9147:Il31ra UTSW 13 112,670,276 (GRCm39) missense probably benign 0.01
R9148:Il31ra UTSW 13 112,670,276 (GRCm39) missense probably benign 0.01
R9178:Il31ra UTSW 13 112,677,780 (GRCm39) missense probably damaging 1.00
R9250:Il31ra UTSW 13 112,669,508 (GRCm39) missense probably damaging 1.00
R9260:Il31ra UTSW 13 112,668,202 (GRCm39) missense probably damaging 0.98
R9312:Il31ra UTSW 13 112,686,023 (GRCm39) missense probably benign 0.01
R9381:Il31ra UTSW 13 112,668,253 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- TTCGCCTGGGAAATGCCAAG -3'
(R):5'- CGGAAGGGAAGTTTTCGAGTTAC -3'

Sequencing Primer
(F):5'- GCCTTCAAAGCCGATCTAAGTG -3'
(R):5'- CAATGGAGATCTTGAGCTTTGATCC -3'
Posted On 2022-01-20