Incidental Mutation 'R9159:Vmn2r73'
ID |
695577 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r73
|
Ensembl Gene |
ENSMUSG00000070458 |
Gene Name |
vomeronasal 2, receptor 73 |
Synonyms |
EG620928 |
MMRRC Submission |
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.172)
|
Stock # |
R9159 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
85506755-85525146 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 85521931 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Valine to Glutamic Acid
at position 136
(V136E)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000076687
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077478]
|
AlphaFold |
D3Z7M3 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000077478
AA Change: V136E
PolyPhen 2
Score 0.902 (Sensitivity: 0.82; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000076687 Gene: ENSMUSG00000070458 AA Change: V136E
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
465 |
1.4e-30 |
PFAM |
Pfam:NCD3G
|
508 |
560 |
5.9e-21 |
PFAM |
Pfam:7tm_3
|
590 |
827 |
4.4e-51 |
PFAM |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
Validation Efficiency |
97% (72/74) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 76 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
9930012K11Rik |
A |
T |
14: 70,394,238 (GRCm39) |
M179K |
probably benign |
Het |
A030003K21Rik |
A |
G |
1: 82,920,787 (GRCm39) |
V86A |
unknown |
Het |
AC133488.1 |
A |
T |
16: 18,440,075 (GRCm39) |
V363E |
probably benign |
Het |
Adamts16 |
A |
G |
13: 70,901,408 (GRCm39) |
S890P |
probably benign |
Het |
Adgrf4 |
A |
G |
17: 42,973,293 (GRCm39) |
V685A |
probably benign |
Het |
Aff1 |
T |
A |
5: 103,990,131 (GRCm39) |
M867K |
possibly damaging |
Het |
Apba3 |
T |
A |
10: 81,106,867 (GRCm39) |
S225T |
|
Het |
Aplp1 |
T |
A |
7: 30,141,775 (GRCm39) |
T228S |
probably benign |
Het |
Arhgap18 |
A |
G |
10: 26,730,886 (GRCm39) |
D188G |
probably benign |
Het |
BC024063 |
T |
A |
10: 81,944,906 (GRCm39) |
S175R |
possibly damaging |
Het |
Bloc1s6 |
T |
G |
2: 122,580,548 (GRCm39) |
S2R |
probably damaging |
Het |
Cd209b |
A |
G |
8: 3,974,245 (GRCm39) |
I119T |
possibly damaging |
Het |
Cdk8 |
T |
C |
5: 146,168,549 (GRCm39) |
V16A |
probably damaging |
Het |
Cep295 |
A |
G |
9: 15,252,904 (GRCm39) |
M308T |
probably benign |
Het |
Cfap53 |
T |
A |
18: 74,416,272 (GRCm39) |
Y2N |
probably damaging |
Het |
Col28a1 |
T |
A |
6: 8,014,993 (GRCm39) |
D804V |
probably damaging |
Het |
Csta3 |
G |
A |
16: 36,038,069 (GRCm39) |
V69I |
probably benign |
Het |
Cyp2c40 |
A |
T |
19: 39,762,317 (GRCm39) |
D443E |
probably damaging |
Het |
Cyp2d9 |
A |
G |
15: 82,338,572 (GRCm39) |
D202G |
possibly damaging |
Het |
Dchs1 |
G |
A |
7: 105,415,126 (GRCm39) |
A686V |
probably benign |
Het |
Egf |
A |
T |
3: 129,472,026 (GRCm39) |
N1199K |
probably benign |
Het |
Eva1a |
A |
G |
6: 82,068,855 (GRCm39) |
R61G |
possibly damaging |
Het |
Exoc6 |
T |
A |
19: 37,597,478 (GRCm39) |
D626E |
probably benign |
Het |
Exosc10 |
T |
C |
4: 148,663,916 (GRCm39) |
|
probably null |
Het |
Firrm |
A |
G |
1: 163,814,514 (GRCm39) |
I143T |
probably damaging |
Het |
Gm12888 |
T |
C |
4: 121,176,600 (GRCm39) |
Q67R |
probably null |
Het |
Gm16485 |
A |
G |
9: 8,972,319 (GRCm39) |
S62G |
unknown |
Het |
Gng4 |
T |
C |
13: 13,999,896 (GRCm39) |
I55T |
probably damaging |
Het |
Gpihbp1 |
A |
G |
15: 75,469,830 (GRCm39) |
S182G |
possibly damaging |
Het |
Hax1 |
T |
C |
3: 89,903,127 (GRCm39) |
R251G |
probably damaging |
Het |
Igf2bp2 |
G |
A |
16: 21,900,502 (GRCm39) |
T213I |
probably damaging |
Het |
Il23a |
T |
A |
10: 128,133,427 (GRCm39) |
K66* |
probably null |
Het |
Itga2 |
A |
T |
13: 115,014,298 (GRCm39) |
L210* |
probably null |
Het |
Ltbp2 |
G |
A |
12: 84,837,864 (GRCm39) |
P1192L |
probably benign |
Het |
Matr3 |
T |
A |
18: 35,712,355 (GRCm39) |
M389K |
possibly damaging |
Het |
Mettl15 |
T |
C |
2: 108,923,444 (GRCm39) |
D326G |
probably damaging |
Het |
Mta1 |
T |
A |
12: 113,100,025 (GRCm39) |
V645E |
probably damaging |
Het |
Muc5ac |
T |
C |
7: 141,363,529 (GRCm39) |
I2280T |
unknown |
Het |
Naa15 |
T |
A |
3: 51,358,802 (GRCm39) |
N362K |
probably benign |
Het |
Necab2 |
T |
C |
8: 120,189,303 (GRCm39) |
Y158H |
probably damaging |
Het |
Nphp3 |
T |
A |
9: 103,897,980 (GRCm39) |
L523Q |
probably damaging |
Het |
Nphs1 |
T |
G |
7: 30,165,026 (GRCm39) |
F540V |
possibly damaging |
Het |
Or2av9 |
A |
G |
11: 58,381,350 (GRCm39) |
V77A |
probably damaging |
Het |
Or2k2 |
A |
G |
4: 58,785,320 (GRCm39) |
I134T |
probably benign |
Het |
Or5p55 |
A |
T |
7: 107,567,524 (GRCm39) |
R307* |
probably null |
Het |
Ppa1 |
A |
T |
10: 61,496,784 (GRCm39) |
I91F |
probably damaging |
Het |
Prdm6 |
C |
A |
18: 53,598,019 (GRCm39) |
A127D |
unknown |
Het |
Prdm8 |
T |
C |
5: 98,334,175 (GRCm39) |
F581L |
probably damaging |
Het |
Rbbp6 |
T |
C |
7: 122,589,428 (GRCm39) |
I372T |
probably damaging |
Het |
Rnf144b |
A |
G |
13: 47,396,348 (GRCm39) |
I228M |
probably damaging |
Het |
Rsf1 |
CG |
CGACGGCGGGG |
7: 97,229,115 (GRCm39) |
|
probably benign |
Het |
Setd2 |
T |
C |
9: 110,374,385 (GRCm39) |
|
probably null |
Het |
Sez6l |
T |
C |
5: 112,613,824 (GRCm39) |
H441R |
possibly damaging |
Het |
Shbg |
G |
A |
11: 69,506,430 (GRCm39) |
L327F |
probably benign |
Het |
Sik3 |
C |
T |
9: 46,123,539 (GRCm39) |
Q1113* |
probably null |
Het |
Smad2 |
T |
A |
18: 76,395,573 (GRCm39) |
I4N |
possibly damaging |
Het |
Spata31h1 |
G |
A |
10: 82,118,524 (GRCm39) |
R4829* |
probably null |
Het |
Sult2b1 |
T |
A |
7: 45,391,534 (GRCm39) |
E84V |
probably damaging |
Het |
Tbc1d8 |
A |
G |
1: 39,444,474 (GRCm39) |
Y162H |
|
Het |
Tedc2 |
A |
G |
17: 24,436,705 (GRCm39) |
L308P |
probably damaging |
Het |
Tmc5 |
T |
C |
7: 118,233,264 (GRCm39) |
V26A |
probably benign |
Het |
Tmem120b |
T |
A |
5: 123,242,566 (GRCm39) |
N181K |
possibly damaging |
Het |
Tmem229b |
T |
G |
12: 79,011,448 (GRCm39) |
N161T |
possibly damaging |
Het |
Tmem43 |
A |
C |
6: 91,459,291 (GRCm39) |
D254A |
probably benign |
Het |
Trpv6 |
T |
C |
6: 41,603,074 (GRCm39) |
D266G |
probably benign |
Het |
Tspan9 |
A |
G |
6: 127,943,717 (GRCm39) |
I102T |
possibly damaging |
Het |
Ung |
A |
G |
5: 114,270,166 (GRCm39) |
|
probably benign |
Het |
Upp2 |
C |
T |
2: 58,667,996 (GRCm39) |
H230Y |
probably damaging |
Het |
Vmn1r184 |
G |
A |
7: 25,966,545 (GRCm39) |
S97N |
possibly damaging |
Het |
Wdr20rt |
T |
C |
12: 65,272,918 (GRCm39) |
V127A |
probably damaging |
Het |
Yme1l1 |
T |
A |
2: 23,063,058 (GRCm39) |
F210I |
probably damaging |
Het |
Yrdc |
T |
C |
4: 124,747,811 (GRCm39) |
|
probably null |
Het |
Zfhx4 |
G |
T |
3: 5,464,312 (GRCm39) |
R1515L |
probably damaging |
Het |
Zfhx4 |
C |
T |
3: 5,466,217 (GRCm39) |
P2150L |
probably damaging |
Het |
Zfp267 |
C |
A |
3: 36,219,902 (GRCm39) |
H642N |
possibly damaging |
Het |
Zfp988 |
C |
T |
4: 147,416,450 (GRCm39) |
P295S |
possibly damaging |
Het |
|
Other mutations in Vmn2r73 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00158:Vmn2r73
|
APN |
7 |
85,506,795 (GRCm39) |
missense |
|
|
IGL01151:Vmn2r73
|
APN |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01408:Vmn2r73
|
APN |
7 |
85,521,455 (GRCm39) |
missense |
probably benign |
0.45 |
IGL01505:Vmn2r73
|
APN |
7 |
85,507,267 (GRCm39) |
nonsense |
probably null |
|
IGL01731:Vmn2r73
|
APN |
7 |
85,506,757 (GRCm39) |
makesense |
probably null |
|
IGL01818:Vmn2r73
|
APN |
7 |
85,519,109 (GRCm39) |
splice site |
probably benign |
|
IGL02236:Vmn2r73
|
APN |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02265:Vmn2r73
|
APN |
7 |
85,520,847 (GRCm39) |
missense |
probably benign |
0.02 |
IGL02266:Vmn2r73
|
APN |
7 |
85,525,007 (GRCm39) |
missense |
possibly damaging |
0.52 |
IGL02276:Vmn2r73
|
APN |
7 |
85,518,980 (GRCm39) |
critical splice donor site |
probably null |
|
IGL02284:Vmn2r73
|
APN |
7 |
85,507,123 (GRCm39) |
missense |
possibly damaging |
0.92 |
IGL02380:Vmn2r73
|
APN |
7 |
85,507,383 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02466:Vmn2r73
|
APN |
7 |
85,522,084 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03172:Vmn2r73
|
APN |
7 |
85,507,495 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03179:Vmn2r73
|
APN |
7 |
85,519,468 (GRCm39) |
missense |
probably benign |
0.04 |
G1Funyon:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
R0077:Vmn2r73
|
UTSW |
7 |
85,525,075 (GRCm39) |
missense |
probably benign |
0.00 |
R0311:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
R0413:Vmn2r73
|
UTSW |
7 |
85,521,087 (GRCm39) |
missense |
possibly damaging |
0.68 |
R0494:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
R1523:Vmn2r73
|
UTSW |
7 |
85,519,486 (GRCm39) |
missense |
probably benign |
0.02 |
R1618:Vmn2r73
|
UTSW |
7 |
85,525,120 (GRCm39) |
nonsense |
probably null |
|
R1667:Vmn2r73
|
UTSW |
7 |
85,506,889 (GRCm39) |
missense |
probably benign |
0.00 |
R1728:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
R1729:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
R1747:Vmn2r73
|
UTSW |
7 |
85,507,375 (GRCm39) |
missense |
probably damaging |
1.00 |
R1784:Vmn2r73
|
UTSW |
7 |
85,507,086 (GRCm39) |
missense |
probably damaging |
1.00 |
R2152:Vmn2r73
|
UTSW |
7 |
85,506,936 (GRCm39) |
missense |
probably benign |
0.03 |
R2395:Vmn2r73
|
UTSW |
7 |
85,506,975 (GRCm39) |
missense |
probably damaging |
1.00 |
R2415:Vmn2r73
|
UTSW |
7 |
85,521,431 (GRCm39) |
missense |
probably damaging |
1.00 |
R2926:Vmn2r73
|
UTSW |
7 |
85,520,871 (GRCm39) |
missense |
probably benign |
0.17 |
R3719:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
R3766:Vmn2r73
|
UTSW |
7 |
85,521,198 (GRCm39) |
missense |
probably benign |
|
R3838:Vmn2r73
|
UTSW |
7 |
85,507,258 (GRCm39) |
missense |
probably benign |
0.00 |
R3890:Vmn2r73
|
UTSW |
7 |
85,507,144 (GRCm39) |
missense |
probably benign |
|
R4030:Vmn2r73
|
UTSW |
7 |
85,521,044 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4247:Vmn2r73
|
UTSW |
7 |
85,521,883 (GRCm39) |
missense |
probably damaging |
0.99 |
R4409:Vmn2r73
|
UTSW |
7 |
85,520,768 (GRCm39) |
missense |
probably damaging |
0.97 |
R4427:Vmn2r73
|
UTSW |
7 |
85,506,981 (GRCm39) |
missense |
probably damaging |
1.00 |
R4430:Vmn2r73
|
UTSW |
7 |
85,519,449 (GRCm39) |
missense |
probably benign |
|
R4552:Vmn2r73
|
UTSW |
7 |
85,525,055 (GRCm39) |
missense |
probably benign |
0.12 |
R4779:Vmn2r73
|
UTSW |
7 |
85,520,923 (GRCm39) |
nonsense |
probably null |
|
R4906:Vmn2r73
|
UTSW |
7 |
85,506,829 (GRCm39) |
missense |
probably damaging |
0.99 |
R4942:Vmn2r73
|
UTSW |
7 |
85,519,582 (GRCm39) |
missense |
probably damaging |
1.00 |
R5280:Vmn2r73
|
UTSW |
7 |
85,507,155 (GRCm39) |
missense |
probably damaging |
0.98 |
R5344:Vmn2r73
|
UTSW |
7 |
85,525,046 (GRCm39) |
missense |
probably benign |
0.00 |
R5478:Vmn2r73
|
UTSW |
7 |
85,518,996 (GRCm39) |
missense |
probably damaging |
1.00 |
R5527:Vmn2r73
|
UTSW |
7 |
85,507,575 (GRCm39) |
missense |
possibly damaging |
0.65 |
R5691:Vmn2r73
|
UTSW |
7 |
85,507,299 (GRCm39) |
missense |
probably damaging |
1.00 |
R5826:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
R6018:Vmn2r73
|
UTSW |
7 |
85,521,875 (GRCm39) |
missense |
possibly damaging |
0.48 |
R6082:Vmn2r73
|
UTSW |
7 |
85,507,429 (GRCm39) |
missense |
probably benign |
0.00 |
R6111:Vmn2r73
|
UTSW |
7 |
85,520,997 (GRCm39) |
missense |
probably benign |
|
R6233:Vmn2r73
|
UTSW |
7 |
85,519,099 (GRCm39) |
missense |
probably benign |
0.00 |
R6278:Vmn2r73
|
UTSW |
7 |
85,522,140 (GRCm39) |
missense |
probably benign |
|
R6283:Vmn2r73
|
UTSW |
7 |
85,521,049 (GRCm39) |
missense |
probably benign |
0.00 |
R6307:Vmn2r73
|
UTSW |
7 |
85,506,828 (GRCm39) |
missense |
probably damaging |
1.00 |
R6413:Vmn2r73
|
UTSW |
7 |
85,519,544 (GRCm39) |
nonsense |
probably null |
|
R6782:Vmn2r73
|
UTSW |
7 |
85,519,563 (GRCm39) |
missense |
probably benign |
0.00 |
R6884:Vmn2r73
|
UTSW |
7 |
85,507,213 (GRCm39) |
missense |
probably benign |
0.05 |
R6921:Vmn2r73
|
UTSW |
7 |
85,507,446 (GRCm39) |
missense |
probably benign |
0.27 |
R7169:Vmn2r73
|
UTSW |
7 |
85,507,663 (GRCm39) |
nonsense |
probably null |
|
R7206:Vmn2r73
|
UTSW |
7 |
85,522,075 (GRCm39) |
missense |
probably benign |
0.03 |
R7311:Vmn2r73
|
UTSW |
7 |
85,521,192 (GRCm39) |
missense |
possibly damaging |
0.80 |
R7650:Vmn2r73
|
UTSW |
7 |
85,521,147 (GRCm39) |
missense |
probably benign |
|
R7811:Vmn2r73
|
UTSW |
7 |
85,524,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
R8263:Vmn2r73
|
UTSW |
7 |
85,507,619 (GRCm39) |
missense |
probably benign |
|
R8301:Vmn2r73
|
UTSW |
7 |
85,507,510 (GRCm39) |
missense |
probably benign |
0.00 |
R8341:Vmn2r73
|
UTSW |
7 |
85,507,128 (GRCm39) |
missense |
probably benign |
0.01 |
R8500:Vmn2r73
|
UTSW |
7 |
85,519,638 (GRCm39) |
missense |
probably benign |
0.01 |
R8673:Vmn2r73
|
UTSW |
7 |
85,521,902 (GRCm39) |
missense |
probably benign |
0.01 |
R8719:Vmn2r73
|
UTSW |
7 |
85,521,095 (GRCm39) |
missense |
probably damaging |
0.96 |
R8783:Vmn2r73
|
UTSW |
7 |
85,507,668 (GRCm39) |
missense |
probably damaging |
0.96 |
R8828:Vmn2r73
|
UTSW |
7 |
85,521,179 (GRCm39) |
missense |
probably damaging |
0.98 |
R8860:Vmn2r73
|
UTSW |
7 |
85,522,149 (GRCm39) |
splice site |
probably benign |
|
R9002:Vmn2r73
|
UTSW |
7 |
85,507,284 (GRCm39) |
missense |
probably benign |
0.32 |
R9008:Vmn2r73
|
UTSW |
7 |
85,521,904 (GRCm39) |
missense |
probably damaging |
0.96 |
R9180:Vmn2r73
|
UTSW |
7 |
85,507,123 (GRCm39) |
missense |
probably benign |
0.07 |
R9198:Vmn2r73
|
UTSW |
7 |
85,518,987 (GRCm39) |
missense |
probably benign |
0.01 |
R9329:Vmn2r73
|
UTSW |
7 |
85,519,073 (GRCm39) |
missense |
probably benign |
|
R9448:Vmn2r73
|
UTSW |
7 |
85,522,027 (GRCm39) |
missense |
probably benign |
0.00 |
R9463:Vmn2r73
|
UTSW |
7 |
85,506,795 (GRCm39) |
missense |
|
|
R9589:Vmn2r73
|
UTSW |
7 |
85,519,659 (GRCm39) |
missense |
probably benign |
0.03 |
X0023:Vmn2r73
|
UTSW |
7 |
85,507,664 (GRCm39) |
missense |
probably benign |
0.31 |
Z1176:Vmn2r73
|
UTSW |
7 |
85,521,176 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1177:Vmn2r73
|
UTSW |
7 |
85,521,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- AATACTGCGGATCCCTATTCC -3'
(R):5'- GTTTTCAGCGTGACACCCAAG -3'
Sequencing Primer
(F):5'- GCGGATCCCTATTCCCATTTATG -3'
(R):5'- CAAGACCAACCATTTGATTTTCTCTG -3'
|
Posted On |
2022-01-20 |