Mutagenetix > Incidental Mutation

Incidental Mutation 'R8937:Slc22a26'

695743

Institutional Source

Beutler Lab

Gene Symbol

Slc22a26

Ensembl Gene

ENSMUSG00000053303

Gene Name

solute carrier family 22 (organic cation transporter), member 26

Synonyms

BC014805

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

R8937 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

7781041-7802667 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

C to T at 7791025 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000113607 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065634] [ENSMUST00000120522]

AlphaFold

Q91WJ2

Predicted Effect

probably benign
Transcript: ENSMUST00000065634

SMART Domains

Protein: ENSMUSP00000064809
Gene: ENSMUSG00000053303

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
low complexity region	53	64	N/A	INTRINSIC
Pfam:Sugar_tr	96	528	1.1e-23	PFAM
Pfam:MFS_1	124	370	7.8e-17	PFAM
Pfam:MFS_1	350	547	2.1e-12	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000120522

SMART Domains

Protein: ENSMUSP00000113607
Gene: ENSMUSG00000053303

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
low complexity region	53	64	N/A	INTRINSIC
Pfam:Sugar_tr	94	527	4.9e-23	PFAM
Pfam:MFS_1	124	358	1.2e-15	PFAM
Pfam:MFS_1	349	547	2.4e-12	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

95% (71/75)

Allele List at MGI

Other mutations in this stock

Total: 75 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700074P13Rik	A	T	6: 40,926,065	Y124*	probably null	Het
4930455H04Rik	C	A	3: 116,968,471		probably benign	Het
Actn3	C	T	19: 4,871,770		probably null	Het
Akap13	T	A	7: 75,534,853		probably null	Het
Akap9	A	T	5: 4,044,048	Q2190L	possibly damaging	Het
Ankrd6	A	T	4: 32,823,452	V190D	possibly damaging	Het
Atrn	T	A	2: 130,999,237	D1186E	probably benign	Het
Bank1	A	T	3: 136,284,173	V52E	probably damaging	Het
Blmh	A	G	11: 76,967,057	N342D	probably benign	Het
Card6	TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG	TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG	15: 5,098,691		probably benign	Het
Ces2f	A	G	8: 104,951,037	T225A	probably damaging	Het
Clic6	G	T	16: 92,499,357	D302Y	probably damaging	Het
Clmn	T	A	12: 104,797,082	N95I	probably damaging	Het
Cmya5	A	T	13: 93,096,332	F749L	probably benign	Het
Cramp1l	A	G	17: 24,983,982	F358L	probably damaging	Het
Dhx38	T	C	8: 109,556,466	D573G	probably damaging	Het
Dync1h1	T	C	12: 110,618,037	Y625H	probably damaging	Het
Enpep	A	G	3: 129,321,358		probably null	Het
Fat1	T	C	8: 45,030,313	L3146P	probably damaging	Het
Gal3st2b	G	A	1: 93,940,848	S265N	probably benign	Het
Glis3	G	A	19: 28,665,866	A92V	possibly damaging	Het
Gm13089	T	C	4: 143,696,992	Y409C	probably damaging	Het
Gm266	T	C	12: 111,485,739	D11G	probably benign	Het
Hmcn2	A	T	2: 31,314,415	M1L	probably benign	Het
Kcnj15	G	A	16: 95,296,689		probably benign	Het
Krt27	A	G	11: 99,348,725	S310P	probably damaging	Het
Lama2	A	T	10: 26,986,820	D2982E	probably damaging	Het
Lrfn3	A	G	7: 30,360,026	V258A	probably benign	Het
Lrit3	A	T	3: 129,800,544	M128K	probably damaging	Het
Ltbp3	A	G	19: 5,747,484	T417A	probably benign	Het
Mettl25	T	C	10: 105,765,261	T554A	probably benign	Het
Micall1	A	G	15: 79,126,998	S523G	probably damaging	Het
Mmp21	G	A	7: 133,678,971	A90V	probably benign	Het
Mon2	T	C	10: 123,059,205	N53S	probably benign	Het
Mpp5	T	A	12: 78,819,341	D313E	probably benign	Het
Muc15	T	C	2: 110,731,907		probably null	Het
Myo15b	A	T	11: 115,882,301	M431L	probably benign	Het
Nicn1	C	T	9: 108,294,509	R163C	possibly damaging	Het
Nt5c3	T	C	6: 56,884,716	D195G	probably damaging	Het
Olfr401	T	A	11: 74,122,048	M253K	probably benign	Het
Olfr648	A	G	7: 104,179,742	L222P	possibly damaging	Het
Pgrmc2	A	G	3: 41,082,690	L102P	probably damaging	Het
Plekha1	T	G	7: 130,900,511		probably benign	Het
Ralgapa1	T	G	12: 55,702,560	I1233L	probably damaging	Het
Rb1cc1	T	A	1: 6,263,217	D68E	probably benign	Het
Rere	C	A	4: 150,614,874		probably benign	Het
Rnf213	A	T	11: 119,430,274	H1185L	possibly damaging	Het
Robo2	G	A	16: 73,973,261	P529L	probably damaging	Het
Robo2	G	T	16: 73,973,262	P529T	probably damaging	Het
Shprh	A	G	10: 11,185,437	T1165A	possibly damaging	Het
Slc43a1	T	C	2: 84,860,106	L456P	probably damaging	Het
Slc5a8	T	C	10: 88,905,023	Y267H	probably damaging	Het
Snrnp200	T	C	2: 127,226,982	I927T	probably benign	Het
Sorbs1	T	C	19: 40,373,562	D156G	probably benign	Het
Sox5	A	T	6: 143,907,443	S370T	probably benign	Het
Spen	T	C	4: 141,474,063	T2418A	probably damaging	Het
St8sia6	A	T	2: 13,696,894	L104H	probably damaging	Het
Stox1	T	A	10: 62,664,651	N710I	probably damaging	Het
Syncrip	T	C	9: 88,462,847		probably benign	Het
Syt11	G	A	3: 88,747,744	P417S	probably damaging	Het
Taf2	A	T	15: 55,047,453	N608K	probably benign	Het
Tfcp2l1	G	A	1: 118,668,717	G394E	possibly damaging	Het
Tial1	A	G	7: 128,454,991	I13T	probably damaging	Het
Tmem108	T	C	9: 103,484,782	D535G	probably benign	Het
Tpp1	T	C	7: 105,747,419	M464V	probably benign	Het
Trrap	C	A	5: 144,820,253	N2108K	probably damaging	Het
Tspan3	T	C	9: 56,146,599	D156G	probably benign	Het
Ttn	C	T	2: 76,762,263	V20842I	probably benign	Het
Ubr4	T	A	4: 139,463,575	W4078R	probably damaging	Het
Uts2r	G	A	11: 121,160,969	V220M	possibly damaging	Het
Vmn2r19	G	A	6: 123,316,324		probably null	Het
Vmn2r3	A	T	3: 64,259,252	F819L	probably damaging	Het
Wdtc1	T	C	4: 133,304,159	Y250C	probably damaging	Het
Zan	T	C	5: 137,395,626	H4521R	unknown	Het
Zfp219	A	T	14: 52,006,767	C652S	probably damaging	Het

Other mutations in Slc22a26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00155:Slc22a26	APN	19	7782836	missense	probably damaging	0.99
IGL00338:Slc22a26	APN	19	7782975	missense	probably benign	0.25
IGL00736:Slc22a26	APN	19	7790162	missense	possibly damaging	0.50
IGL01085:Slc22a26	APN	19	7790099	missense	probably benign	0.02
IGL01581:Slc22a26	APN	19	7802184	missense	probably benign	0.15
IGL02502:Slc22a26	APN	19	7790760	critical splice donor site	probably null
IGL02658:Slc22a26	APN	19	7788248	missense	probably benign	0.25
IGL02936:Slc22a26	APN	19	7791105	missense	probably damaging	0.99
IGL03162:Slc22a26	APN	19	7802101	missense	probably benign	0.00
R0034:Slc22a26	UTSW	19	7802253	missense	probably benign	0.03
R0633:Slc22a26	UTSW	19	7788210	critical splice donor site	probably null
R0676:Slc22a26	UTSW	19	7796144	splice site	probably benign
R2156:Slc22a26	UTSW	19	7802115	missense	probably damaging	1.00
R4043:Slc22a26	UTSW	19	7788329	critical splice acceptor site	probably null
R4781:Slc22a26	UTSW	19	7790135	missense	probably benign	0.34
R4896:Slc22a26	UTSW	19	7791054	missense	probably benign	0.14
R4999:Slc22a26	UTSW	19	7802181	missense	probably damaging	1.00
R5125:Slc22a26	UTSW	19	7790175	missense	possibly damaging	0.62
R5178:Slc22a26	UTSW	19	7790175	missense	possibly damaging	0.62
R6161:Slc22a26	UTSW	19	7786447	missense	possibly damaging	0.50
R6494:Slc22a26	UTSW	19	7802286	missense	probably damaging	1.00
R6512:Slc22a26	UTSW	19	7802500	start gained	probably benign
R6724:Slc22a26	UTSW	19	7802361	missense	probably benign	0.14
R7323:Slc22a26	UTSW	19	7790894	missense	probably damaging	0.97
R7375:Slc22a26	UTSW	19	7783144	splice site	probably null
R7558:Slc22a26	UTSW	19	7785286	missense	possibly damaging	0.94
R7634:Slc22a26	UTSW	19	7802587	splice site	probably null
R8772:Slc22a26	UTSW	19	7790112	missense	probably benign	0.27
R8905:Slc22a26	UTSW	19	7782966	missense	probably damaging	0.97
R9059:Slc22a26	UTSW	19	7785194	missense	probably benign	0.01
R9659:Slc22a26	UTSW	19	7786433	missense	probably benign	0.02
R9788:Slc22a26	UTSW	19	7786433	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- AGGCCTCCAAAATGATGAGAAC -3'
(R):5'- GATGAGACAAACTGCTGCCTG -3'

Sequencing Primer
(F):5'- GAACTCATTGACAGTGTGGTCACC -3'
(R):5'- ATGGAATCATTGTCTTTTCCTCAGG -3'

Posted On

2022-01-27