Incidental Mutation 'R9163:Or4c11'
ID 695820
Institutional Source Beutler Lab
Gene Symbol Or4c11
Ensembl Gene ENSMUSG00000062757
Gene Name olfactory receptor family 4 subfamily C member 11
Synonyms GA_x6K02T2Q125-50339974-50340609, Olfr1207, Olfr1206, MOR230-3, GA_x6K02T2Q125-50338497-50339264
MMRRC Submission 068975-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R9163 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 88694951-88695874 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 88695795 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 282 (P282L)
Ref Sequence ENSEMBL: ENSMUSP00000149929 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077302] [ENSMUST00000216950]
AlphaFold A2ATJ9
Predicted Effect possibly damaging
Transcript: ENSMUST00000077302
AA Change: P282L

PolyPhen 2 Score 0.634 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000076532
Gene: ENSMUSG00000062757
AA Change: P282L

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 3.2e-48 PFAM
Pfam:7tm_1 39 285 1.4e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216950
AA Change: P282L

PolyPhen 2 Score 0.634 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 99% (69/70)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik T C 13: 77,393,400 (GRCm39) S351P possibly damaging Het
4930558K02Rik A G 1: 161,777,174 (GRCm39) S128P probably benign Het
Adam17 C T 12: 21,401,588 (GRCm39) V136I probably benign Het
Adam19 A G 11: 46,018,176 (GRCm39) T413A probably benign Het
Adam28 T C 14: 68,866,531 (GRCm39) K443E probably damaging Het
Adgrv1 T A 13: 81,567,541 (GRCm39) T5211S probably benign Het
Adnp2 A T 18: 80,172,200 (GRCm39) N736K possibly damaging Het
Agtpbp1 C T 13: 59,609,884 (GRCm39) W1082* probably null Het
Ap3b2 T G 7: 81,113,546 (GRCm39) M888L unknown Het
Arhgap35 C A 7: 16,295,549 (GRCm39) R1172L possibly damaging Het
Arrdc3 T A 13: 81,041,506 (GRCm39) D402E probably benign Het
Ccdc14 T C 16: 34,511,118 (GRCm39) F31L possibly damaging Het
Cd5l T G 3: 87,274,932 (GRCm39) L157R probably benign Het
Cdc14a G T 3: 116,122,213 (GRCm39) D251E possibly damaging Het
Cfap210 A T 2: 69,606,510 (GRCm39) I302K probably benign Het
Chmp2a T A 7: 12,766,645 (GRCm39) Q91L possibly damaging Het
Col12a1 A G 9: 79,548,729 (GRCm39) probably null Het
Ctdsp1 G T 1: 74,434,126 (GRCm39) R201L possibly damaging Het
Dhx15 C T 5: 52,342,198 (GRCm39) R40H probably damaging Het
Dnph1 A G 17: 46,809,860 (GRCm39) Y134C probably damaging Het
Foxo1 T A 3: 52,253,301 (GRCm39) V488D probably benign Het
Gcn1 C A 5: 115,742,944 (GRCm39) N1538K probably benign Het
Gldc T A 19: 30,111,686 (GRCm39) E500V probably benign Het
Hhip G A 8: 80,701,743 (GRCm39) T597I probably benign Het
Hmgn1 A G 16: 95,928,509 (GRCm39) probably null Het
Ifi205 A T 1: 173,844,988 (GRCm39) S265T possibly damaging Het
Igkv1-131 T C 6: 67,743,753 (GRCm39) M2V probably benign Het
Irgm2 T G 11: 58,111,280 (GRCm39) S324A probably damaging Het
Jarid2 C G 13: 45,064,727 (GRCm39) D937E possibly damaging Het
Jrkl A T 9: 13,245,404 (GRCm39) W86R probably damaging Het
Kbtbd3 A G 9: 4,330,584 (GRCm39) I319M probably benign Het
Klhl7 T C 5: 24,364,465 (GRCm39) Y500H probably damaging Het
Lats1 C T 10: 7,578,052 (GRCm39) A392V probably benign Het
Llgl1 G T 11: 60,600,402 (GRCm39) A584S probably benign Het
Macf1 G T 4: 123,403,686 (GRCm39) S560Y probably damaging Het
Or8c10 T A 9: 38,279,378 (GRCm39) C169S probably damaging Het
Pde10a G A 17: 9,181,791 (GRCm39) C498Y possibly damaging Het
Pde4dip A G 3: 97,659,123 (GRCm39) probably null Het
Pdhx G A 2: 102,852,561 (GRCm39) P434L probably damaging Het
Pdlim3 T C 8: 46,338,711 (GRCm39) probably null Het
Pik3c3 T C 18: 30,427,483 (GRCm39) probably null Het
Prkag1 T C 15: 98,711,900 (GRCm39) K242R possibly damaging Het
Rap1b A G 10: 117,654,391 (GRCm39) S150P possibly damaging Het
Scn4a A G 11: 106,217,076 (GRCm39) S1102P probably damaging Het
Scrib A G 15: 75,921,108 (GRCm39) Y1332H probably damaging Het
Sim1 A G 10: 50,772,165 (GRCm39) E58G probably benign Het
Slc13a1 C T 6: 24,097,578 (GRCm39) probably null Het
Slc17a8 A G 10: 89,425,444 (GRCm39) V380A probably damaging Het
Slc5a4b G T 10: 75,917,165 (GRCm39) Y290* probably null Het
Slco4c1 A G 1: 96,764,633 (GRCm39) F480L probably damaging Het
Srcap T C 7: 127,121,162 (GRCm39) V146A unknown Het
Ssc5d T A 7: 4,936,432 (GRCm39) D559E probably damaging Het
Sstr5 A C 17: 25,710,584 (GRCm39) I215S probably damaging Het
Stambpl1 G A 19: 34,212,634 (GRCm39) C268Y probably benign Het
Stard3nl C A 13: 19,560,809 (GRCm39) probably benign Het
Sycp3 T C 10: 88,299,734 (GRCm39) probably null Het
Syne2 A T 12: 76,009,349 (GRCm39) M2417L possibly damaging Het
Tenm4 T G 7: 96,473,080 (GRCm39) Y959D probably damaging Het
Tmem132d T A 5: 127,869,570 (GRCm39) D588V possibly damaging Het
Tnfrsf26 T C 7: 143,172,130 (GRCm39) E60G possibly damaging Het
Topbp1 A G 9: 103,205,767 (GRCm39) R802G probably benign Het
Trmu T C 15: 85,781,096 (GRCm39) V360A probably benign Het
Tshz2 G A 2: 169,726,562 (GRCm39) C386Y probably damaging Het
Ttn A T 2: 76,700,771 (GRCm39) D61E Het
Upf1 T C 8: 70,792,674 (GRCm39) T345A probably benign Het
Vmn2r23 T A 6: 123,718,782 (GRCm39) C712S probably damaging Het
Vmn2r44 C T 7: 8,371,091 (GRCm39) V652I probably benign Het
Wfdc1 T C 8: 120,393,302 (GRCm39) V8A probably benign Het
Xrn1 A G 9: 95,880,274 (GRCm39) Y738C probably benign Het
Zfp618 T G 4: 63,051,511 (GRCm39) V764G probably damaging Het
Znfx1 A T 2: 166,898,261 (GRCm39) M221K probably damaging Het
Other mutations in Or4c11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01410:Or4c11 APN 2 88,695,864 (GRCm39) missense probably benign 0.00
IGL01415:Or4c11 APN 2 88,695,864 (GRCm39) missense probably benign 0.00
IGL01783:Or4c11 APN 2 88,695,186 (GRCm39) missense probably damaging 0.98
PIT4812001:Or4c11 UTSW 2 88,695,314 (GRCm39) missense probably benign 0.27
R0437:Or4c11 UTSW 2 88,695,229 (GRCm39) missense probably benign 0.01
R0561:Or4c11 UTSW 2 88,695,024 (GRCm39) missense possibly damaging 0.68
R0669:Or4c11 UTSW 2 88,695,272 (GRCm39) missense probably benign
R0835:Or4c11 UTSW 2 88,695,345 (GRCm39) missense probably benign
R0987:Or4c11 UTSW 2 88,695,527 (GRCm39) missense probably benign 0.00
R1271:Or4c11 UTSW 2 88,695,475 (GRCm39) nonsense probably null
R1386:Or4c11 UTSW 2 88,695,697 (GRCm39) missense probably benign 0.14
R1618:Or4c11 UTSW 2 88,695,871 (GRCm39) splice site probably null
R1935:Or4c11 UTSW 2 88,695,524 (GRCm39) missense probably benign
R2098:Or4c11 UTSW 2 88,695,215 (GRCm39) missense probably benign 0.43
R2112:Or4c11 UTSW 2 88,695,545 (GRCm39) missense possibly damaging 0.67
R2157:Or4c11 UTSW 2 88,695,213 (GRCm39) missense probably benign
R2912:Or4c11 UTSW 2 88,695,458 (GRCm39) missense probably benign 0.17
R2913:Or4c11 UTSW 2 88,695,458 (GRCm39) missense probably benign 0.17
R4583:Or4c11 UTSW 2 88,695,838 (GRCm39) missense probably benign 0.07
R4631:Or4c11 UTSW 2 88,695,174 (GRCm39) missense probably benign 0.00
R7707:Or4c11 UTSW 2 88,695,153 (GRCm39) missense possibly damaging 0.78
R8559:Or4c11 UTSW 2 88,695,527 (GRCm39) missense probably benign 0.00
R9164:Or4c11 UTSW 2 88,695,795 (GRCm39) missense possibly damaging 0.63
R9468:Or4c11 UTSW 2 88,695,795 (GRCm39) missense possibly damaging 0.63
Predicted Primers PCR Primer
(F):5'- CGAAACCACAGTGCTGAAGG -3'
(R):5'- CTGACAGTATTGGACTATCTGCC -3'

Sequencing Primer
(F):5'- ACGGCCACCAACTACTTT -3'
(R):5'- GGACTATCTGCCAGATTATATTTAAT -3'
Posted On 2022-02-07