Mutagenetix > Incidental Mutation

Incidental Mutation 'R9164:Vwf'

695917

Institutional Source

Beutler Lab

Gene Symbol

Vwf

Ensembl Gene

ENSMUSG00000001930

Gene Name

Von Willebrand factor

Synonyms

6820430P06Rik, B130011O06Rik

MMRRC Submission

068944-MU

Accession Numbers

Genbank: NM_011708; MGI: 98941

Essential gene?

Probably non essential (E-score: 0.165) question?

Stock #

R9164 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

125546774-125686679 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 125565843 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 94 (I94N)

Ref Sequence

ENSEMBL: ENSMUSP00000107873 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000100941] [ENSMUST00000112253] [ENSMUST00000112254]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000100941
AA Change: I112N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000098502
Gene: ENSMUSG00000001930
AA Change: I112N

Domain	Start	End	E-Value	Type
VWD	38	196	3.43e-35	SMART
C8	236	310	1.11e-21	SMART
Pfam:TIL	313	366	2.8e-15	PFAM
Blast:VWC	368	404	6e-18	BLAST

Predicted Effect

probably damaging
Transcript: ENSMUST00000112253
AA Change: I97N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000107872
Gene: ENSMUSG00000001930
AA Change: I97N

Domain	Start	End	E-Value	Type
VWD	23	181	3.43e-35	SMART
C8	221	295	1.11e-21	SMART
Pfam:TIL	298	351	2.7e-15	PFAM
Blast:VWC	353	389	6e-18	BLAST

Predicted Effect

SMART Domains

Protein: ENSMUSP00000107873
Gene: ENSMUSG00000001930
AA Change: I94N

Domain	Start	End	E-Value	Type
VWD	23	181	3.43e-35	SMART
C8	221	295	1.11e-21	SMART
Pfam:TIL	298	351	6.9e-15	PFAM
VWC	353	413	8.71e-1	SMART
VWD	380	543	2.93e-52	SMART
C8	580	652	3.82e-25	SMART
Pfam:TIL	655	710	4.1e-14	PFAM
EGF_like	790	825	4.37e1	SMART
VWC	832	901	3.29e-3	SMART
VWD	859	1015	5.15e-39	SMART
C8	1056	1130	1.01e-33	SMART
Pfam:TIL	1144	1199	1.3e-9	PFAM
VWA	1278	1461	1.81e-20	SMART
low complexity region	1464	1477	N/A	INTRINSIC
VWA	1499	1672	8.43e-39	SMART
VWA	1692	1875	2.83e-31	SMART
VWC	1882	1949	2.99e0	SMART
VWD	1941	2104	5.03e-42	SMART
C8	2135	2203	1.29e-13	SMART
Pfam:TIL	2206	2257	8.3e-8	PFAM
VWC	2260	2328	3.16e-16	SMART
low complexity region	2417	2428	N/A	INTRINSIC
VWC	2434	2497	2.61e-17	SMART
VWC	2513	2577	3.37e0	SMART
VWC	2585	2647	2.55e-11	SMART
CT	2730	2815	1.37e-31	SMART

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

97% (63/65)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015]
PHENOTYPE: Homozygous null mutants exhibit hemostatic and thrombotic defects similar to human von Willebrand disease. Mutants have prolonged bleeding time, newborns occasionally show fatal intra-abdominal bleeding and some adults have detectable fecal occult blood. [provided by MGI curators]

Allele List at MGI

All alleles(33) : Targeted, knock-out(1) Gene trapped(32)

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	C	11: 9,328,157 (GRCm38)	E3112D	probably damaging	Het
Abtb2	C	T	2: 103,711,484 (GRCm38)	T847I	possibly damaging	Het
Acox1	A	T	11: 116,198,347 (GRCm38)	H48Q	probably benign	Het
Adam9	A	G	8: 24,996,779 (GRCm38)	I161T	possibly damaging	Het
Ankrd50	A	G	3: 38,457,055 (GRCm38)	Y388H	probably damaging	Het
Arap1	A	T	7: 101,391,883 (GRCm38)	K593*	probably null	Het
Bicc1	G	A	10: 70,945,264 (GRCm38)	T661M	probably damaging	Het
Cela1	A	G	15: 100,682,885 (GRCm38)		probably null	Het
Celf1	T	A	2: 91,001,081 (GRCm38)	L85H	probably damaging	Het
Cep120	A	T	18: 53,719,246 (GRCm38)	M520K	probably benign	Het
Chd1l	C	T	3: 97,594,040 (GRCm38)	R230H	probably benign	Het
Cyp2c55	A	T	19: 39,007,127 (GRCm38)	K28*	probably null	Het
D930048N14Rik	A	T	11: 51,654,782 (GRCm38)	H167L	unknown	Het
Ddx58	T	A	4: 40,208,827 (GRCm38)	M762L	probably damaging	Het
Dnah11	C	T	12: 118,027,516 (GRCm38)	E2372K	probably damaging	Het
Dock4	T	A	12: 40,704,338 (GRCm38)	I442N	probably damaging	Het
Dpp6	T	C	5: 27,451,288 (GRCm38)		probably null	Het
Dysf	T	C	6: 84,203,326 (GRCm38)	C1960R	probably damaging	Het
Gm13941	T	C	2: 111,105,979 (GRCm38)	S2G	unknown	Het
Gm37240	T	C	3: 84,509,941 (GRCm38)	N157S	possibly damaging	Het
Gp1ba	A	G	11: 70,640,457 (GRCm38)	I350V	unknown	Het
Gtf3c4	A	G	2: 28,834,649 (GRCm38)	V357A	probably benign	Het
Hemgn	T	C	4: 46,396,106 (GRCm38)	I377V	probably benign	Het
Hsd3b3	T	C	3: 98,753,373 (GRCm38)	D28G	probably benign	Het
Intu	A	T	3: 40,690,703 (GRCm38)	D508V	probably damaging	Het
Kif28	A	T	1: 179,705,768 (GRCm38)	M604K	probably damaging	Het
Klra6	T	A	6: 130,016,724 (GRCm38)	I195F	possibly damaging	Het
Lhfp	G	A	3: 53,043,466 (GRCm38)	V54I	probably benign	Het
Lrpap1	T	C	5: 35,105,579 (GRCm38)	Y38C	probably damaging	Het
Maats1	A	G	16: 38,335,598 (GRCm38)	Y88H	possibly damaging	Het
Map1b	C	A	13: 99,432,308 (GRCm38)	E1302*	probably null	Het
Map1b	T	A	13: 99,425,843 (GRCm38)	Q2453L	unknown	Het
Map7	C	T	10: 20,246,664 (GRCm38)	R159C	probably benign	Het
Mov10l1	C	T	15: 89,012,158 (GRCm38)	T735I	probably benign	Het
Nfasc	C	A	1: 132,634,806 (GRCm38)	R77L	probably damaging	Het
Nipsnap1	T	C	11: 4,889,969 (GRCm38)	V230A	probably benign	Het
Olfr1206	C	T	2: 88,865,451 (GRCm38)	P282L	possibly damaging	Het
Olfr857	T	A	9: 19,713,658 (GRCm38)	M277K	probably benign	Het
Olfr860	T	A	9: 19,846,208 (GRCm38)	N137I	possibly damaging	Het
Orm3	T	C	4: 63,356,572 (GRCm38)	L39P	probably damaging	Het
Pcdhb19	T	A	18: 37,498,799 (GRCm38)	V549E	probably damaging	Het
Pclo	T	A	5: 14,681,685 (GRCm38)	S274R		Het
Phactr1	A	G	13: 42,682,702 (GRCm38)	D2G	possibly damaging	Het
Phtf2	G	A	5: 20,803,192 (GRCm38)	R164*	probably null	Het
Prkcq	A	G	2: 11,226,905 (GRCm38)	D13G	probably damaging	Het
Proser1	A	T	3: 53,472,073 (GRCm38)	N156I	probably benign	Het
Prss51	T	C	14: 64,097,509 (GRCm38)	I171T	probably damaging	Het
Ptbp2	G	A	3: 119,752,991 (GRCm38)	P81S	probably damaging	Het
Ptk2b	T	C	14: 66,166,773 (GRCm38)	D681G	possibly damaging	Het
Slc7a12	A	T	3: 14,499,300 (GRCm38)	I349F	probably damaging	Het
Sorcs2	G	T	5: 36,077,968 (GRCm38)	T240K	possibly damaging	Het
Sowahc	C	A	10: 59,222,075 (GRCm38)	A11E	probably benign	Het
Spag1	A	T	15: 36,216,253 (GRCm38)	Y526F	probably damaging	Het
Stim1	A	G	7: 102,435,419 (GRCm38)	H526R	probably benign	Het
Stx1b	T	C	7: 127,814,987 (GRCm38)	K69R	probably benign	Het
Tal1	T	C	4: 115,063,449 (GRCm38)	S107P	probably benign	Het
Tas2r130	T	C	6: 131,630,012 (GRCm38)	I273M	probably damaging	Het
Ttc24	A	T	3: 88,072,988 (GRCm38)	Y135*	probably null	Het
Ttn	G	A	2: 76,753,512 (GRCm38)	P22384S	probably damaging	Het
Vmn2r14	T	G	5: 109,216,221 (GRCm38)	T610P	probably damaging	Het
Vmn2r84	T	A	10: 130,385,800 (GRCm38)	*850C	probably null	Het
Zan	A	T	5: 137,424,071 (GRCm38)	S2762T	unknown	Het
Zbtb20	A	G	16: 43,610,401 (GRCm38)	Q352R	probably benign	Het
Zfc3h1	T	C	10: 115,423,469 (GRCm38)	Y1649H	probably benign	Het
Zfp397	A	T	18: 23,956,771 (GRCm38)	Q111L	probably damaging	Het
Zfp616	T	A	11: 74,084,999 (GRCm38)	I698N	probably damaging	Het

Other mutations in Vwf

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00489:Vwf	APN	6	125,658,872 (GRCm38)	missense	unknown
IGL00561:Vwf	APN	6	125,642,721 (GRCm38)	missense	possibly damaging	0.88
IGL01104:Vwf	APN	6	125,683,556 (GRCm38)	missense	probably damaging	1.00
IGL01404:Vwf	APN	6	125,677,970 (GRCm38)	missense	probably damaging	1.00
IGL01539:Vwf	APN	6	125,590,262 (GRCm38)	missense	possibly damaging	0.85
IGL01550:Vwf	APN	6	125,679,289 (GRCm38)	missense	probably benign	0.00
IGL01563:Vwf	APN	6	125,591,165 (GRCm38)	missense	probably damaging	1.00
IGL01637:Vwf	APN	6	125,645,736 (GRCm38)	missense	probably damaging	1.00
IGL01720:Vwf	APN	6	125,642,835 (GRCm38)	missense	possibly damaging	0.69
IGL01834:Vwf	APN	6	125,590,170 (GRCm38)	splice site	probably benign
IGL02103:Vwf	APN	6	125,646,355 (GRCm38)	missense	probably damaging	1.00
IGL02120:Vwf	APN	6	125,616,034 (GRCm38)	missense	probably benign	0.26
IGL02174:Vwf	APN	6	125,555,395 (GRCm38)	missense	probably damaging	1.00
IGL02203:Vwf	APN	6	125,642,406 (GRCm38)	missense	probably damaging	1.00
IGL02420:Vwf	APN	6	125,677,916 (GRCm38)	missense	probably benign	0.00
IGL02723:Vwf	APN	6	125,642,930 (GRCm38)	missense	possibly damaging	0.85
IGL02818:Vwf	APN	6	125,663,548 (GRCm38)	missense	probably benign
IGL02931:Vwf	APN	6	125,615,968 (GRCm38)	missense	possibly damaging	0.68
IGL03015:Vwf	APN	6	125,684,138 (GRCm38)	splice site	probably benign
IGL03038:Vwf	APN	6	125,604,157 (GRCm38)	missense	possibly damaging	0.92
IGL03060:Vwf	APN	6	125,663,560 (GRCm38)	missense	probably damaging	1.00
IGL03114:Vwf	APN	6	125,599,363 (GRCm38)	nonsense	probably null
IGL03266:Vwf	APN	6	125,678,077 (GRCm38)	splice site	probably benign
gingerman	UTSW	6	125,662,963 (GRCm38)	critical splice acceptor site	probably null
R0605_vwf_644	UTSW	6	125,685,837 (GRCm38)	missense	probably benign	0.02
R1575_Vwf_091	UTSW	6	125,663,571 (GRCm38)	nonsense	probably null
R1628_Vwf_608	UTSW	6	125,647,738 (GRCm38)	unclassified	probably benign
R1669_Vwf_448	UTSW	6	125,647,906 (GRCm38)	missense	possibly damaging	0.92
R1833_Vwf_948	UTSW	6	125,642,037 (GRCm38)	missense	probably benign	0.14
R2130_vwf_946	UTSW	6	125,657,057 (GRCm38)	missense	probably damaging	1.00
R6360_Vwf_065	UTSW	6	125,683,526 (GRCm38)	missense	probably benign	0.13
R7900_Vwf_938	UTSW	6	125,628,476 (GRCm38)	critical splice donor site	probably null
Russiahouse	UTSW	6	125,639,341 (GRCm38)	nonsense	probably null
B5639:Vwf	UTSW	6	125,642,984 (GRCm38)	missense	probably damaging	1.00
R0025:Vwf	UTSW	6	125,682,812 (GRCm38)	missense	probably benign	0.05
R0025:Vwf	UTSW	6	125,682,812 (GRCm38)	missense	probably benign	0.05
R0087:Vwf	UTSW	6	125,645,954 (GRCm38)	missense	probably benign	0.03
R0194:Vwf	UTSW	6	125,643,297 (GRCm38)	missense	probably benign
R0206:Vwf	UTSW	6	125,637,456 (GRCm38)	missense	probably damaging	1.00
R0233:Vwf	UTSW	6	125,686,510 (GRCm38)	missense	possibly damaging	0.91
R0233:Vwf	UTSW	6	125,686,510 (GRCm38)	missense	possibly damaging	0.91
R0390:Vwf	UTSW	6	125,626,361 (GRCm38)	nonsense	probably null
R0427:Vwf	UTSW	6	125,673,939 (GRCm38)	missense	probably benign
R0437:Vwf	UTSW	6	125,566,318 (GRCm38)	missense	probably damaging	1.00
R0470:Vwf	UTSW	6	125,628,428 (GRCm38)	missense	possibly damaging	0.70
R0499:Vwf	UTSW	6	125,638,114 (GRCm38)	missense	probably benign	0.10
R0554:Vwf	UTSW	6	125,642,781 (GRCm38)	missense	probably benign	0.13
R0605:Vwf	UTSW	6	125,685,837 (GRCm38)	missense	probably benign	0.02
R0711:Vwf	UTSW	6	125,626,271 (GRCm38)	missense	probably benign	0.01
R0723:Vwf	UTSW	6	125,566,262 (GRCm38)	missense	probably benign	0.01
R0973:Vwf	UTSW	6	125,643,006 (GRCm38)	missense	probably damaging	1.00
R1054:Vwf	UTSW	6	125,590,227 (GRCm38)	missense	probably damaging	1.00
R1115:Vwf	UTSW	6	125,655,065 (GRCm38)	missense	unknown
R1156:Vwf	UTSW	6	125,637,488 (GRCm38)	missense	probably damaging	1.00
R1191:Vwf	UTSW	6	125,599,252 (GRCm38)	missense	probably damaging	1.00
R1240:Vwf	UTSW	6	125,603,308 (GRCm38)	splice site	probably null
R1398:Vwf	UTSW	6	125,603,457 (GRCm38)	missense	probably benign	0.02
R1435:Vwf	UTSW	6	125,642,249 (GRCm38)	nonsense	probably null
R1528:Vwf	UTSW	6	125,608,291 (GRCm38)	missense	possibly damaging	0.69
R1575:Vwf	UTSW	6	125,663,571 (GRCm38)	nonsense	probably null
R1575:Vwf	UTSW	6	125,655,251 (GRCm38)	missense	unknown
R1628:Vwf	UTSW	6	125,647,738 (GRCm38)	unclassified	probably benign
R1669:Vwf	UTSW	6	125,647,906 (GRCm38)	missense	possibly damaging	0.92
R1699:Vwf	UTSW	6	125,685,900 (GRCm38)	missense	possibly damaging	0.74
R1699:Vwf	UTSW	6	125,643,069 (GRCm38)	missense	probably damaging	1.00
R1725:Vwf	UTSW	6	125,646,282 (GRCm38)	missense	probably benign	0.05
R1742:Vwf	UTSW	6	125,667,550 (GRCm38)	missense	probably benign	0.02
R1809:Vwf	UTSW	6	125,590,175 (GRCm38)	splice site	probably benign
R1833:Vwf	UTSW	6	125,642,037 (GRCm38)	missense	probably benign	0.14
R1866:Vwf	UTSW	6	125,667,529 (GRCm38)	missense	possibly damaging	0.62
R1870:Vwf	UTSW	6	125,642,939 (GRCm38)	missense	probably damaging	1.00
R1874:Vwf	UTSW	6	125,628,372 (GRCm38)	missense	probably benign	0.00
R1941:Vwf	UTSW	6	125,639,279 (GRCm38)	missense	possibly damaging	0.64
R2061:Vwf	UTSW	6	125,591,188 (GRCm38)	missense	probably damaging	0.98
R2103:Vwf	UTSW	6	125,646,330 (GRCm38)	missense	probably benign	0.31
R2104:Vwf	UTSW	6	125,646,330 (GRCm38)	missense	probably benign	0.31
R2130:Vwf	UTSW	6	125,657,057 (GRCm38)	missense	probably damaging	1.00
R2159:Vwf	UTSW	6	125,626,341 (GRCm38)	missense	probably damaging	0.99
R2178:Vwf	UTSW	6	125,642,132 (GRCm38)	missense	possibly damaging	0.90
R2656:Vwf	UTSW	6	125,555,361 (GRCm38)	missense	probably benign	0.00
R2913:Vwf	UTSW	6	125,685,846 (GRCm38)	missense	probably benign	0.08
R2917:Vwf	UTSW	6	125,608,143 (GRCm38)	missense	probably benign	0.07
R3726:Vwf	UTSW	6	125,677,948 (GRCm38)	utr 3 prime	probably benign
R3735:Vwf	UTSW	6	125,588,613 (GRCm38)	missense	probably damaging	1.00
R3774:Vwf	UTSW	6	125,649,099 (GRCm38)	splice site	probably null
R3934:Vwf	UTSW	6	125,555,499 (GRCm38)	missense	probably damaging	1.00
R4291:Vwf	UTSW	6	125,642,322 (GRCm38)	missense	probably damaging	1.00
R4384:Vwf	UTSW	6	125,655,116 (GRCm38)	missense	unknown
R4743:Vwf	UTSW	6	125,684,091 (GRCm38)	critical splice acceptor site	probably null
R4760:Vwf	UTSW	6	125,570,604 (GRCm38)	missense	probably damaging	1.00
R4776:Vwf	UTSW	6	125,566,305 (GRCm38)	missense	possibly damaging	0.53
R4791:Vwf	UTSW	6	125,643,363 (GRCm38)	missense
R4871:Vwf	UTSW	6	125,686,462 (GRCm38)	missense	probably benign	0.25
R4894:Vwf	UTSW	6	125,645,934 (GRCm38)	nonsense	probably null
R4963:Vwf	UTSW	6	125,667,483 (GRCm38)	nonsense	probably null
R5010:Vwf	UTSW	6	125,566,257 (GRCm38)	missense	probably benign	0.15
R5289:Vwf	UTSW	6	125,667,510 (GRCm38)	utr 3 prime	probably benign
R5512:Vwf	UTSW	6	125,673,887 (GRCm38)	utr 3 prime	probably benign
R5523:Vwf	UTSW	6	125,643,042 (GRCm38)	missense
R5642:Vwf	UTSW	6	125,603,418 (GRCm38)	missense
R5860:Vwf	UTSW	6	125,679,265 (GRCm38)	utr 3 prime	probably benign
R5860:Vwf	UTSW	6	125,643,090 (GRCm38)	missense
R5896:Vwf	UTSW	6	125,678,762 (GRCm38)	critical splice acceptor site	probably null
R5926:Vwf	UTSW	6	125,604,174 (GRCm38)	missense	probably damaging	1.00
R5976:Vwf	UTSW	6	125,603,463 (GRCm38)	missense
R6053:Vwf	UTSW	6	125,600,665 (GRCm38)	missense	probably benign	0.21
R6151:Vwf	UTSW	6	125,657,065 (GRCm38)	missense	unknown
R6179:Vwf	UTSW	6	125,649,289 (GRCm38)	missense	unknown
R6181:Vwf	UTSW	6	125,566,146 (GRCm38)	missense	probably damaging	0.98
R6234:Vwf	UTSW	6	125,657,165 (GRCm38)	missense	unknown
R6360:Vwf	UTSW	6	125,683,526 (GRCm38)	missense	probably benign	0.13
R6412:Vwf	UTSW	6	125,679,316 (GRCm38)	missense	probably benign	0.00
R6464:Vwf	UTSW	6	125,639,400 (GRCm38)	critical splice donor site	probably null
R6522:Vwf	UTSW	6	125,662,963 (GRCm38)	critical splice acceptor site	probably null
R6766:Vwf	UTSW	6	125,639,376 (GRCm38)	missense	unknown
R6856:Vwf	UTSW	6	125,642,150 (GRCm38)	nonsense	probably null
R6877:Vwf	UTSW	6	125,657,201 (GRCm38)	missense	possibly damaging	0.48
R6896:Vwf	UTSW	6	125,566,194 (GRCm38)	missense	probably damaging	1.00
R7113:Vwf	UTSW	6	125,655,044 (GRCm38)	missense
R7287:Vwf	UTSW	6	125,637,467 (GRCm38)	missense
R7359:Vwf	UTSW	6	125,566,257 (GRCm38)	missense
R7509:Vwf	UTSW	6	125,642,169 (GRCm38)	missense
R7519:Vwf	UTSW	6	125,667,543 (GRCm38)	missense
R7545:Vwf	UTSW	6	125,614,097 (GRCm38)	missense
R7549:Vwf	UTSW	6	125,626,267 (GRCm38)	missense
R7593:Vwf	UTSW	6	125,647,768 (GRCm38)	missense
R7635:Vwf	UTSW	6	125,682,734 (GRCm38)	missense
R7793:Vwf	UTSW	6	125,686,520 (GRCm38)	missense
R7802:Vwf	UTSW	6	125,666,677 (GRCm38)	missense
R7824:Vwf	UTSW	6	125,658,815 (GRCm38)	missense
R7849:Vwf	UTSW	6	125,656,803 (GRCm38)	missense
R7900:Vwf	UTSW	6	125,628,476 (GRCm38)	critical splice donor site	probably null
R7919:Vwf	UTSW	6	125,647,859 (GRCm38)	missense
R7966:Vwf	UTSW	6	125,639,341 (GRCm38)	nonsense	probably null
R8101:Vwf	UTSW	6	125,570,559 (GRCm38)	nonsense	probably null
R8162:Vwf	UTSW	6	125,645,836 (GRCm38)	splice site	probably null
R8345:Vwf	UTSW	6	125,679,302 (GRCm38)	missense
R8853:Vwf	UTSW	6	125,657,264 (GRCm38)	missense
R9027:Vwf	UTSW	6	125,666,663 (GRCm38)	missense
R9065:Vwf	UTSW	6	125,646,299 (GRCm38)	missense
R9068:Vwf	UTSW	6	125,648,829 (GRCm38)	unclassified	probably benign
R9128:Vwf	UTSW	6	125,642,730 (GRCm38)	missense
R9136:Vwf	UTSW	6	125,599,393 (GRCm38)	splice site	probably benign
R9177:Vwf	UTSW	6	125,604,291 (GRCm38)	missense
R9334:Vwf	UTSW	6	125,677,946 (GRCm38)	missense
R9508:Vwf	UTSW	6	125,555,508 (GRCm38)	missense
R9553:Vwf	UTSW	6	125,600,699 (GRCm38)	missense
R9660:Vwf	UTSW	6	125,591,707 (GRCm38)	missense	possibly damaging	0.61
R9706:Vwf	UTSW	6	125,624,573 (GRCm38)	missense
R9708:Vwf	UTSW	6	125,657,090 (GRCm38)	missense
R9712:Vwf	UTSW	6	125,624,573 (GRCm38)	missense
R9714:Vwf	UTSW	6	125,624,573 (GRCm38)	missense
R9728:Vwf	UTSW	6	125,591,707 (GRCm38)	missense	possibly damaging	0.61
R9758:Vwf	UTSW	6	125,626,267 (GRCm38)	missense
X0021:Vwf	UTSW	6	125,646,331 (GRCm38)	missense	probably damaging	1.00
X0065:Vwf	UTSW	6	125,603,433 (GRCm38)	missense	probably null	0.05
Z1176:Vwf	UTSW	6	125,603,308 (GRCm38)	splice site	probably null
Z1176:Vwf	UTSW	6	125,591,231 (GRCm38)	missense

Predicted Primers

PCR Primer
(F):5'- GCTATGCATCAGCCCTTAGTAC -3'
(R):5'- ACAGTGGTCAAGGTTCTGGAC -3'

Sequencing Primer
(F):5'- TGCATCAGCCCTTAGTACTTACAAAG -3'
(R):5'- TTCTGGACCAGCGCTGCAG -3'

Posted On

2022-02-07