Incidental Mutation 'R9165:Acoxl'
ID 695962
Institutional Source Beutler Lab
Gene Symbol Acoxl
Ensembl Gene ENSMUSG00000027380
Gene Name acyl-Coenzyme A oxidase-like
Synonyms 1200014P05Rik
MMRRC Submission 068945-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9165 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 127680796-127965793 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 127726432 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 269 (T269A)
Ref Sequence ENSEMBL: ENSMUSP00000028859 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028859]
AlphaFold Q9DBS4
Predicted Effect probably benign
Transcript: ENSMUST00000028859
AA Change: T269A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000028859
Gene: ENSMUSG00000027380
AA Change: T269A

DomainStartEndE-ValueType
Pfam:Acyl-CoA_dh_M 115 223 7.2e-19 PFAM
Pfam:Acyl-CoA_dh_1 254 416 1.8e-14 PFAM
Pfam:ACOX 458 599 6.8e-21 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700122O11Rik T C 17: 48,348,357 (GRCm39) I27V probably benign Het
A2ml1 T A 6: 128,537,632 (GRCm39) H693L probably benign Het
Acacb A G 5: 114,354,744 (GRCm39) E1206G probably benign Het
Ak9 A G 10: 41,309,235 (GRCm39) K1879R unknown Het
Amot A T X: 144,244,745 (GRCm39) L435H Het
Bnc2 A T 4: 84,329,731 (GRCm39) L95Q Het
Bpifa2 G T 2: 153,851,741 (GRCm39) W59L probably benign Het
Cd209a T A 8: 3,795,602 (GRCm39) Q156H probably damaging Het
Cep104 T A 4: 154,078,971 (GRCm39) probably null Het
Cpt1c A G 7: 44,608,925 (GRCm39) *799R probably null Het
Csn2 A T 5: 87,842,418 (GRCm39) M203K possibly damaging Het
Dclre1a C G 19: 56,526,801 (GRCm39) A872P probably damaging Het
Dlg5 C A 14: 24,196,309 (GRCm39) L1629F probably damaging Het
Dmxl1 A G 18: 50,011,992 (GRCm39) D1383G probably damaging Het
Dnah6 A G 6: 73,121,924 (GRCm39) V1381A probably damaging Het
Dnttip2 G T 3: 122,070,355 (GRCm39) E523D probably benign Het
Dync2h1 A T 9: 7,114,883 (GRCm39) V2425D probably damaging Het
Eif1ad11 A G 12: 87,994,077 (GRCm39) S102G possibly damaging Het
Eif2a G A 3: 58,452,695 (GRCm39) R199Q probably damaging Het
F10 T C 8: 13,089,564 (GRCm39) F60L probably benign Het
Faf2 A G 13: 54,799,951 (GRCm39) I253V probably benign Het
Flt1 T A 5: 147,552,047 (GRCm39) S715C probably damaging Het
Garin4 A G 1: 190,895,258 (GRCm39) S462P probably benign Het
Gm5150 G T 3: 16,045,060 (GRCm39) T55K probably damaging Het
Gria1 T C 11: 57,076,759 (GRCm39) F121L possibly damaging Het
Gucy2d A G 7: 98,103,271 (GRCm39) Q505R probably benign Het
Gzma A T 13: 113,237,455 (GRCm39) S11T probably benign Het
Hoxa6 G A 6: 52,185,535 (GRCm39) Q24* probably null Het
Kcnj14 T A 7: 45,469,068 (GRCm39) I146L possibly damaging Het
Kiss1r G A 10: 79,756,605 (GRCm39) R149H probably damaging Het
Lama2 A G 10: 26,929,022 (GRCm39) probably null Het
Lama5 C A 2: 179,821,286 (GRCm39) R3092L probably damaging Het
Lca5l T A 16: 95,977,218 (GRCm39) N196I probably damaging Het
Lig4 A G 8: 10,022,394 (GRCm39) L462S probably damaging Het
Nbea A T 3: 55,912,289 (GRCm39) V1166E probably benign Het
Nr2c1 T A 10: 94,017,465 (GRCm39) F401Y probably benign Het
Or10ak12 T A 4: 118,666,195 (GRCm39) R289* probably null Het
Or14c43 A T 7: 86,114,825 (GRCm39) M69L probably benign Het
Or4e5 A G 14: 52,727,830 (GRCm39) I197T possibly damaging Het
Or5an9 A T 19: 12,187,286 (GRCm39) M119L probably damaging Het
Otop3 A C 11: 115,235,424 (GRCm39) Y352S possibly damaging Het
Plekha6 T G 1: 133,200,375 (GRCm39) L318R probably damaging Het
Pm20d1 G T 1: 131,743,825 (GRCm39) V497F possibly damaging Het
Pnma2 G A 14: 67,154,572 (GRCm39) R332H probably damaging Het
Ppip5k1 C A 2: 121,162,045 (GRCm39) G1013C probably damaging Het
Prdm13 C G 4: 21,679,659 (GRCm39) R277P unknown Het
Prdm2 A G 4: 142,858,674 (GRCm39) S1539P possibly damaging Het
Ptger2 A G 14: 45,227,235 (GRCm39) T272A probably damaging Het
Qser1 T C 2: 104,618,815 (GRCm39) T576A probably benign Het
Rest GGGGGCCTGCCCCTCCCACGGGGCCTGCCCCTCCCACGGGGCCTGCCCCTCCCACGGAGCCTGCCCCTCCCACGGGGC GGGGGCCTGCCCCTCCCACGGGGCCTGCCCCTCCCACGGAGCCTGCCCCTCCCACGGGGC 5: 77,429,651 (GRCm39) probably benign Het
Sacm1l G T 9: 123,398,021 (GRCm39) V238L probably damaging Het
Sanbr T C 11: 23,565,244 (GRCm39) I248V probably benign Het
Sec16a C T 2: 26,313,645 (GRCm39) G454D Het
Sil1 A G 18: 35,450,899 (GRCm39) S259P possibly damaging Het
Sirpb1b A G 3: 15,639,964 (GRCm39) L16P probably damaging Het
Slc22a20 A T 19: 6,032,879 (GRCm39) V262D probably damaging Het
Slc4a9 G T 18: 36,666,676 (GRCm39) R580L probably benign Het
Ssr3 A G 3: 65,290,521 (GRCm39) V128A probably damaging Het
Stpg2 G T 3: 139,014,993 (GRCm39) S386I possibly damaging Het
Taar8c C A 10: 23,977,500 (GRCm39) C104F probably damaging Het
Tex2 T C 11: 106,458,095 (GRCm39) E445G unknown Het
Tmem253 A C 14: 52,256,099 (GRCm39) D126A probably benign Het
Tox4 A G 14: 52,523,247 (GRCm39) Q69R possibly damaging Het
Tpi1 T A 6: 124,788,501 (GRCm39) S254C probably benign Het
Trmt12 T G 15: 58,745,594 (GRCm39) S331A probably benign Het
Ttn A G 2: 76,543,350 (GRCm39) V33212A probably damaging Het
Tubb4a C T 17: 57,387,734 (GRCm39) E431K unknown Het
Ugt1a10 A T 1: 87,983,509 (GRCm39) E102D probably benign Het
Unc80 A T 1: 66,589,000 (GRCm39) E1055V probably null Het
Vav1 C A 17: 57,618,895 (GRCm39) S708R probably damaging Het
Vmn1r20 A G 6: 57,409,246 (GRCm39) M191V probably damaging Het
Vmn1r37 A T 6: 66,709,054 (GRCm39) T227S probably damaging Het
Vmn1r72 C A 7: 11,412,951 (GRCm39) probably benign Het
Vps33b G A 7: 79,924,434 (GRCm39) probably null Het
Vrtn T A 12: 84,697,251 (GRCm39) L667Q probably benign Het
Xirp1 G A 9: 119,847,302 (GRCm39) T527M probably benign Het
Ylpm1 T A 12: 85,077,342 (GRCm39) Y1356N probably damaging Het
Zfp980 A T 4: 145,428,024 (GRCm39) Y251F possibly damaging Het
Zmym2 A T 14: 57,185,464 (GRCm39) Y1032F probably damaging Het
Other mutations in Acoxl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00417:Acoxl APN 2 127,820,724 (GRCm39) missense probably damaging 1.00
IGL01397:Acoxl APN 2 127,876,811 (GRCm39) missense possibly damaging 0.67
IGL02502:Acoxl APN 2 127,917,804 (GRCm39) missense probably damaging 1.00
gulch UTSW 2 127,964,944 (GRCm39) missense probably benign 0.02
Gully UTSW 2 127,886,311 (GRCm39) missense possibly damaging 0.62
P4748:Acoxl UTSW 2 127,928,264 (GRCm39) splice site probably benign
R0450:Acoxl UTSW 2 127,722,423 (GRCm39) splice site probably null
R0469:Acoxl UTSW 2 127,722,423 (GRCm39) splice site probably null
R0510:Acoxl UTSW 2 127,722,423 (GRCm39) splice site probably null
R1257:Acoxl UTSW 2 127,886,286 (GRCm39) missense probably benign 0.01
R1703:Acoxl UTSW 2 127,820,692 (GRCm39) missense probably damaging 0.99
R1726:Acoxl UTSW 2 127,722,366 (GRCm39) missense probably damaging 1.00
R1867:Acoxl UTSW 2 127,719,707 (GRCm39) missense probably damaging 1.00
R2103:Acoxl UTSW 2 127,814,526 (GRCm39) missense probably damaging 0.97
R2168:Acoxl UTSW 2 127,720,701 (GRCm39) missense probably damaging 1.00
R2761:Acoxl UTSW 2 127,719,733 (GRCm39) missense probably benign 0.01
R3895:Acoxl UTSW 2 127,814,445 (GRCm39) splice site probably benign
R4370:Acoxl UTSW 2 127,720,708 (GRCm39) missense possibly damaging 0.95
R4571:Acoxl UTSW 2 127,719,727 (GRCm39) missense probably damaging 1.00
R4727:Acoxl UTSW 2 127,820,658 (GRCm39) missense probably damaging 1.00
R4851:Acoxl UTSW 2 127,886,311 (GRCm39) missense possibly damaging 0.62
R4962:Acoxl UTSW 2 127,917,810 (GRCm39) missense probably damaging 0.98
R5248:Acoxl UTSW 2 127,917,855 (GRCm39) critical splice donor site probably null
R5392:Acoxl UTSW 2 127,852,088 (GRCm39) critical splice donor site probably null
R5411:Acoxl UTSW 2 127,696,821 (GRCm39) missense probably benign 0.00
R5418:Acoxl UTSW 2 127,719,722 (GRCm39) missense probably benign 0.34
R5507:Acoxl UTSW 2 127,726,394 (GRCm39) missense probably damaging 0.99
R5681:Acoxl UTSW 2 127,814,559 (GRCm39) missense possibly damaging 0.93
R5738:Acoxl UTSW 2 127,719,686 (GRCm39) missense probably benign 0.21
R6325:Acoxl UTSW 2 127,964,944 (GRCm39) missense probably benign 0.02
R6800:Acoxl UTSW 2 127,852,085 (GRCm39) missense probably damaging 1.00
R7027:Acoxl UTSW 2 127,852,003 (GRCm39) missense probably benign
R7098:Acoxl UTSW 2 127,696,835 (GRCm39) nonsense probably null
R7165:Acoxl UTSW 2 127,965,028 (GRCm39) missense probably benign
R7395:Acoxl UTSW 2 127,726,336 (GRCm39) missense probably damaging 1.00
R7697:Acoxl UTSW 2 127,820,702 (GRCm39) missense probably benign 0.01
R9135:Acoxl UTSW 2 127,696,691 (GRCm39) start gained probably benign
R9291:Acoxl UTSW 2 127,814,493 (GRCm39) missense probably damaging 1.00
R9497:Acoxl UTSW 2 127,719,706 (GRCm39) missense probably damaging 1.00
R9527:Acoxl UTSW 2 127,886,284 (GRCm39) missense probably benign 0.01
Z1088:Acoxl UTSW 2 127,714,115 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTTTCAGGATGCTCATTGCTG -3'
(R):5'- ATTGTTAACTGGCCCTCTTCAG -3'

Sequencing Primer
(F):5'- ACATCTAGTAGTGCCATGCTTG -3'
(R):5'- GCATATAACGAATATCTCTGGTCCC -3'
Posted On 2022-02-07