Incidental Mutation 'R9166:Smok3c'
ID 696054
Institutional Source Beutler Lab
Gene Symbol Smok3c
Ensembl Gene ENSMUSG00000075598
Gene Name sperm motility kinase 3C
Synonyms EG622486
MMRRC Submission
Accession Numbers
Essential gene? Possibly essential (E-score: 0.700) question?
Stock # R9166 (G1)
Quality Score 202.009
Status Not validated
Chromosome 5
Chromosomal Location 138051456-138064799 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 138063781 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 423 (T423S)
Ref Sequence ENSEMBL: ENSMUSP00000141020 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110967] [ENSMUST00000178402]
AlphaFold A0A087WSF2
Predicted Effect possibly damaging
Transcript: ENSMUST00000110967
AA Change: T423S

PolyPhen 2 Score 0.606 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000141020
Gene: ENSMUSG00000075598
AA Change: T423S

DomainStartEndE-ValueType
S_TKc 28 276 2.88e-97 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000178402
AA Change: T423S

PolyPhen 2 Score 0.606 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000140749
Gene: ENSMUSG00000075598
AA Change: T423S

DomainStartEndE-ValueType
S_TKc 28 276 2.88e-97 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (70/70)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438H23Rik A G 16: 90,853,046 (GRCm39) L30P possibly damaging Het
Adgrb1 A C 15: 74,420,475 (GRCm39) M875L probably benign Het
Amot A T X: 144,244,745 (GRCm39) L435H Het
Ankrd13c T A 3: 157,705,357 (GRCm39) S427T probably benign Het
Aopep G A 13: 63,318,862 (GRCm39) probably null Het
Ap3b1 A C 13: 94,608,236 (GRCm39) Y569S probably damaging Het
Bco2 A G 9: 50,447,667 (GRCm39) V352A probably benign Het
Bltp1 T A 3: 37,041,516 (GRCm39) N2630K probably damaging Het
Cacnb1 T A 11: 97,910,534 (GRCm39) D48V probably damaging Het
Cdr2l C A 11: 115,283,537 (GRCm39) Q132K probably benign Het
Chrd T C 16: 20,554,572 (GRCm39) M377T probably benign Het
Coq7 T C 7: 118,109,365 (GRCm39) T228A unknown Het
D7Ertd443e G A 7: 133,900,048 (GRCm39) T438I probably benign Het
Dlc1 C T 8: 37,066,589 (GRCm39) E15K probably damaging Het
Dlgap5 C T 14: 47,651,206 (GRCm39) R109Q probably damaging Het
Dysf T C 6: 84,126,959 (GRCm39) V1359A probably damaging Het
E2f7 C T 10: 110,618,085 (GRCm39) P717S probably benign Het
Elmo2 T C 2: 165,132,438 (GRCm39) D669G probably benign Het
Epha6 A G 16: 60,425,238 (GRCm39) V125A probably benign Het
Erg G T 16: 95,190,807 (GRCm39) H119N probably benign Het
Fam13b T C 18: 34,595,252 (GRCm39) S371G probably benign Het
Fancg G C 4: 43,006,800 (GRCm39) Q297E probably benign Het
Gas2 A G 7: 51,586,323 (GRCm39) E145G possibly damaging Het
Gas7 T C 11: 67,561,446 (GRCm39) V218A probably benign Het
Gm9970 A G 5: 31,398,345 (GRCm39) S78P unknown Het
Hectd4 A C 5: 121,446,690 (GRCm39) D259A probably damaging Het
Hoxb2 T G 11: 96,244,339 (GRCm39) S317A probably damaging Het
Hspg2 T C 4: 137,270,185 (GRCm39) L2381P probably damaging Het
Irf4 A T 13: 30,941,484 (GRCm39) H280L probably benign Het
Irf7 A G 7: 140,844,666 (GRCm39) V142A probably benign Het
Kat7 T C 11: 95,190,928 (GRCm39) I94V probably benign Het
Kera T A 10: 97,448,830 (GRCm39) I350K possibly damaging Het
Klf15 T C 6: 90,443,952 (GRCm39) S176P probably benign Het
Lrrc59 C A 11: 94,522,959 (GRCm39) T53N probably benign Het
Morn5 T C 2: 35,945,024 (GRCm39) Y83H probably damaging Het
Myef2l A G 3: 10,153,849 (GRCm39) N206S probably benign Het
Neil3 A C 8: 54,058,722 (GRCm39) M273R probably damaging Het
Ngfr A T 11: 95,465,047 (GRCm39) V267E possibly damaging Het
Nudc T C 4: 133,273,165 (GRCm39) D11G probably damaging Het
Or2t1 A T 14: 14,329,059 (GRCm38) D316V probably benign Het
Or4a81 T A 2: 89,619,291 (GRCm39) N135I probably damaging Het
Pde8a C T 7: 80,982,619 (GRCm39) T746I probably damaging Het
Pik3cg C T 12: 32,242,213 (GRCm39) G966R probably damaging Het
Ppfibp1 A G 6: 146,920,980 (GRCm39) T573A probably damaging Het
Ppp2r5a C A 1: 191,128,504 (GRCm39) R37L probably benign Het
Prpf8 T C 11: 75,387,340 (GRCm39) F1207S possibly damaging Het
Prtg A T 9: 72,764,107 (GRCm39) I527F probably damaging Het
Pspc1 A G 14: 56,999,305 (GRCm39) M317T probably damaging Het
Ptpru C T 4: 131,525,180 (GRCm39) V768I probably benign Het
Ptx4 A G 17: 25,343,546 (GRCm39) probably null Het
Ralgapb T C 2: 158,274,842 (GRCm39) probably null Het
Rhobtb2 C A 14: 70,034,703 (GRCm39) G174V probably damaging Het
Sdad1 G T 5: 92,446,080 (GRCm39) S285* probably null Het
Sema4f G T 6: 82,890,626 (GRCm39) S727* probably null Het
Sik1 A G 17: 32,069,727 (GRCm39) F241L probably damaging Het
Slc8b1 T C 5: 120,662,096 (GRCm39) S279P probably benign Het
Slco4a1 A G 2: 180,106,034 (GRCm39) E72G probably benign Het
Sorcs3 T C 19: 48,784,811 (GRCm39) V1078A probably benign Het
Sptb A G 12: 76,673,776 (GRCm39) V337A probably damaging Het
Tet2 C A 3: 133,173,933 (GRCm39) G1443V probably damaging Het
Ticam2 A T 18: 46,694,048 (GRCm39) L13H probably damaging Het
Tnrc6a A G 7: 122,786,624 (GRCm39) E1562G probably damaging Het
Trim24 A T 6: 37,934,074 (GRCm39) K742N probably damaging Het
Trim56 A T 5: 137,142,751 (GRCm39) V255E probably damaging Het
Trmt12 A G 15: 58,744,608 (GRCm39) E2G probably benign Het
Tubd1 A T 11: 86,452,091 (GRCm39) T353S probably benign Het
Vim T C 2: 13,579,556 (GRCm39) V105A probably benign Het
Vmn2r58 A T 7: 41,513,431 (GRCm39) V404E probably damaging Het
Wdr62 G A 7: 29,941,874 (GRCm39) P1115L probably damaging Het
Wfdc12 G T 2: 164,032,193 (GRCm39) C32* probably null Het
Zfp750 T A 11: 121,403,980 (GRCm39) R298S probably damaging Het
Other mutations in Smok3c
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4440:Smok3c UTSW 5 138,062,866 (GRCm39) missense possibly damaging 0.93
R4560:Smok3c UTSW 5 138,062,746 (GRCm39) missense probably benign 0.42
R4900:Smok3c UTSW 5 138,062,813 (GRCm39) missense probably damaging 1.00
R4924:Smok3c UTSW 5 138,063,844 (GRCm39) nonsense probably null
R5292:Smok3c UTSW 5 138,063,446 (GRCm39) missense probably damaging 1.00
R5446:Smok3c UTSW 5 138,062,895 (GRCm39) missense probably damaging 1.00
R6111:Smok3c UTSW 5 138,063,365 (GRCm39) missense probably damaging 0.98
R6154:Smok3c UTSW 5 138,062,747 (GRCm39) missense probably benign 0.04
R6225:Smok3c UTSW 5 138,063,314 (GRCm39) missense probably benign 0.15
R6759:Smok3c UTSW 5 138,063,699 (GRCm39) missense probably benign 0.04
R6979:Smok3c UTSW 5 138,062,987 (GRCm39) missense probably benign 0.12
R7127:Smok3c UTSW 5 138,062,971 (GRCm39) missense probably damaging 0.96
R7260:Smok3c UTSW 5 138,063,885 (GRCm39) missense possibly damaging 0.84
R7445:Smok3c UTSW 5 138,062,757 (GRCm39) missense probably damaging 1.00
R7962:Smok3c UTSW 5 138,063,341 (GRCm39) missense probably damaging 0.98
R8160:Smok3c UTSW 5 138,063,286 (GRCm39) missense possibly damaging 0.91
R8223:Smok3c UTSW 5 138,063,655 (GRCm39) missense probably benign 0.00
R8381:Smok3c UTSW 5 138,063,824 (GRCm39) missense probably benign
R8841:Smok3c UTSW 5 138,063,537 (GRCm39) missense probably damaging 0.99
R9369:Smok3c UTSW 5 138,063,770 (GRCm39) missense probably damaging 0.98
Z1177:Smok3c UTSW 5 138,062,864 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTGCTACTACCTGTCTCGGAC -3'
(R):5'- CCCAGGTGAGATGTCTCTTTGG -3'

Sequencing Primer
(F):5'- TCTCGGACTTCGCAGGAGAG -3'
(R):5'- CTCTTTGGATGGGATACAGCAAC -3'
Posted On 2022-02-07