Incidental Mutation 'R9167:Kif16b'
ID 696114
Institutional Source Beutler Lab
Gene Symbol Kif16b
Ensembl Gene ENSMUSG00000038844
Gene Name kinesin family member 16B
Synonyms N-3 kinesin, 8430434E15Rik
MMRRC Submission 068946-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9167 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 142460260-142743535 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 142542840 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 152 (L152*)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043589] [ENSMUST00000211861] [ENSMUST00000230763]
AlphaFold B1AVY7
Predicted Effect probably benign
Transcript: ENSMUST00000043589
SMART Domains Protein: ENSMUSP00000042551
Gene: ENSMUSG00000038844

DomainStartEndE-ValueType
KISc 1 366 4.87e-173 SMART
FHA 477 529 1.43e-1 SMART
coiled coil region 597 809 N/A INTRINSIC
coiled coil region 835 858 N/A INTRINSIC
coiled coil region 941 1022 N/A INTRINSIC
PX 1179 1281 1.58e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000211861
Predicted Effect probably null
Transcript: ENSMUST00000212106
AA Change: L152*
Predicted Effect probably benign
Transcript: ENSMUST00000230763
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.8%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
PHENOTYPE: Chimera embryos containing a knock-out allele and derived from tetraploid rescue exhibit lethal growth arrest at the blastocyst stage with abnormal development of the primitive endoderm, epiblast epithelium, and basement membrane. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk C A 11: 119,901,952 (GRCm39) V815F possibly damaging Het
Abcb4 T A 5: 8,986,849 (GRCm39) L756* probably null Het
Acrbp T C 6: 125,039,942 (GRCm39) L515P probably damaging Het
Amot A T X: 144,244,745 (GRCm39) L435H Het
Atic T A 1: 71,604,040 (GRCm39) I201N probably benign Het
Avpr1b T C 1: 131,537,151 (GRCm39) S312P probably damaging Het
Cables1 T C 18: 12,039,029 (GRCm39) V314A possibly damaging Het
Cd22 G A 7: 30,575,430 (GRCm39) T204I probably benign Het
Cep250 A G 2: 155,828,920 (GRCm39) N95D Het
Ctla4 C T 1: 60,951,695 (GRCm39) R75W probably damaging Het
Cul7 A G 17: 46,966,623 (GRCm39) M649V probably benign Het
Ddx46 T A 13: 55,802,915 (GRCm39) V479E probably null Het
Dnah7a T C 1: 53,657,370 (GRCm39) N802S probably benign Het
Fmn2 G T 1: 174,331,056 (GRCm39) R482L unknown Het
Fyn T G 10: 39,402,811 (GRCm39) D194E probably benign Het
Hdac4 G A 1: 91,875,256 (GRCm39) T905M probably benign Het
Herc1 A G 9: 66,411,900 (GRCm39) I4707V possibly damaging Het
Hmgcs2 T C 3: 98,204,430 (GRCm39) I277T possibly damaging Het
Kcnj15 A G 16: 95,096,741 (GRCm39) D121G probably damaging Het
Kcnt2 A G 1: 140,506,200 (GRCm39) E899G probably benign Het
Krt73 A G 15: 101,702,405 (GRCm39) V486A probably benign Het
Lrrc37a T A 11: 103,347,658 (GRCm39) K3012N unknown Het
Musk A T 4: 58,296,687 (GRCm39) I96F probably benign Het
Myrfl A G 10: 116,667,450 (GRCm39) V330A probably damaging Het
Nanp A T 2: 150,872,728 (GRCm39) C67S probably benign Het
Nlrp4e A G 7: 23,039,951 (GRCm39) N758S probably benign Het
Nrxn3 T A 12: 89,154,068 (GRCm39) V345D probably damaging Het
Nsun7 G A 5: 66,435,994 (GRCm39) V289I possibly damaging Het
Or52d1 A G 7: 103,756,426 (GRCm39) *313W probably null Het
Pde4a T C 9: 21,102,798 (GRCm39) S161P probably benign Het
Pom121l2 C T 13: 22,167,160 (GRCm39) A477V probably damaging Het
Rest GGGGGCCTGCCCCTCCCACGGGGCCTGCCCCTCCCACGGGGCCTGCCCCTCCCACGGAGCCTGCCCCTCCCACGGGGC GGGGGCCTGCCCCTCCCACGGGGCCTGCCCCTCCCACGGAGCCTGCCCCTCCCACGGGGC 5: 77,429,651 (GRCm39) probably benign Het
Ryr3 A T 2: 112,664,398 (GRCm39) I1651N probably damaging Het
Serpinb6e A G 13: 34,023,009 (GRCm39) F125L possibly damaging Het
Slc2a9 T A 5: 38,549,092 (GRCm39) T341S probably damaging Het
Taf3 A G 2: 9,945,804 (GRCm39) V600A probably benign Het
Tasor2 A G 13: 3,624,724 (GRCm39) V1742A probably benign Het
Tlx2 T A 6: 83,046,042 (GRCm39) K211* probably null Het
Tmem266 A G 9: 55,322,231 (GRCm39) D174G probably damaging Het
Tpm3 T A 3: 89,994,824 (GRCm39) I147N probably benign Het
Unc93a T C 17: 13,335,108 (GRCm39) K313E possibly damaging Het
Vmn1r9 A C 6: 57,048,138 (GRCm39) E71A probably benign Het
Vwa2 T A 19: 56,899,063 (GRCm39) D754E probably benign Het
Zfp677 T C 17: 21,613,460 (GRCm39) V18A probably damaging Het
Other mutations in Kif16b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00466:Kif16b APN 2 142,689,955 (GRCm39) nonsense probably null
IGL00499:Kif16b APN 2 142,699,244 (GRCm39) missense probably damaging 1.00
IGL00913:Kif16b APN 2 142,545,927 (GRCm39) nonsense probably null
IGL00971:Kif16b APN 2 142,553,664 (GRCm39) missense probably benign 0.01
IGL01712:Kif16b APN 2 142,490,391 (GRCm39) missense probably damaging 1.00
IGL01965:Kif16b APN 2 142,690,325 (GRCm39) missense probably damaging 1.00
IGL02428:Kif16b APN 2 142,514,280 (GRCm39) missense possibly damaging 0.88
IGL02576:Kif16b APN 2 142,704,465 (GRCm39) splice site probably benign
IGL02884:Kif16b APN 2 142,544,534 (GRCm39) splice site probably benign
IGL03065:Kif16b APN 2 142,461,833 (GRCm39) missense probably damaging 1.00
IGL03103:Kif16b APN 2 142,704,408 (GRCm39) missense probably damaging 1.00
IGL03403:Kif16b APN 2 142,553,789 (GRCm39) missense probably damaging 1.00
IGL02835:Kif16b UTSW 2 142,554,133 (GRCm39) missense probably benign 0.00
R0058:Kif16b UTSW 2 142,699,225 (GRCm39) splice site probably null
R0058:Kif16b UTSW 2 142,699,225 (GRCm39) splice site probably null
R0081:Kif16b UTSW 2 142,549,346 (GRCm39) splice site probably benign
R0123:Kif16b UTSW 2 142,514,295 (GRCm39) missense probably benign
R0134:Kif16b UTSW 2 142,514,295 (GRCm39) missense probably benign
R0388:Kif16b UTSW 2 142,582,857 (GRCm39) missense probably damaging 1.00
R0396:Kif16b UTSW 2 142,695,579 (GRCm39) missense probably damaging 1.00
R0502:Kif16b UTSW 2 142,554,075 (GRCm39) missense probably benign 0.00
R1027:Kif16b UTSW 2 142,696,458 (GRCm39) splice site probably benign
R1674:Kif16b UTSW 2 142,554,873 (GRCm39) nonsense probably null
R1752:Kif16b UTSW 2 142,532,586 (GRCm39) missense probably benign 0.01
R2154:Kif16b UTSW 2 142,532,500 (GRCm39) missense probably damaging 1.00
R2262:Kif16b UTSW 2 142,582,837 (GRCm39) missense probably damaging 1.00
R2401:Kif16b UTSW 2 142,598,042 (GRCm39) missense probably benign 0.04
R3951:Kif16b UTSW 2 142,549,279 (GRCm39) missense probably benign 0.01
R4161:Kif16b UTSW 2 142,549,324 (GRCm39) missense probably benign 0.00
R4697:Kif16b UTSW 2 142,532,614 (GRCm39) missense probably benign 0.09
R4747:Kif16b UTSW 2 142,699,346 (GRCm39) missense probably damaging 1.00
R4808:Kif16b UTSW 2 142,699,278 (GRCm39) missense probably damaging 1.00
R4878:Kif16b UTSW 2 142,689,923 (GRCm39) missense probably damaging 1.00
R5068:Kif16b UTSW 2 142,553,627 (GRCm39) missense probably benign
R5120:Kif16b UTSW 2 142,690,259 (GRCm39) missense probably damaging 1.00
R5358:Kif16b UTSW 2 142,582,889 (GRCm39) missense probably damaging 1.00
R5821:Kif16b UTSW 2 142,544,586 (GRCm39) missense probably damaging 1.00
R5833:Kif16b UTSW 2 142,549,287 (GRCm39) missense probably benign
R5882:Kif16b UTSW 2 142,549,178 (GRCm39) critical splice donor site probably null
R5974:Kif16b UTSW 2 142,699,301 (GRCm39) missense probably damaging 1.00
R6043:Kif16b UTSW 2 142,553,820 (GRCm39) missense probably damaging 1.00
R6230:Kif16b UTSW 2 142,691,832 (GRCm39) missense probably damaging 1.00
R6373:Kif16b UTSW 2 142,541,618 (GRCm39) missense possibly damaging 0.91
R6472:Kif16b UTSW 2 142,541,868 (GRCm39) intron probably benign
R6622:Kif16b UTSW 2 142,554,362 (GRCm39) missense probably benign 0.01
R6654:Kif16b UTSW 2 142,543,197 (GRCm39) intron probably benign
R6912:Kif16b UTSW 2 142,542,019 (GRCm39) intron probably benign
R7003:Kif16b UTSW 2 142,600,749 (GRCm39) missense possibly damaging 0.95
R7265:Kif16b UTSW 2 142,556,650 (GRCm39) missense probably damaging 1.00
R7307:Kif16b UTSW 2 142,554,851 (GRCm39) missense probably benign 0.00
R7376:Kif16b UTSW 2 142,553,792 (GRCm39) missense probably damaging 0.99
R7381:Kif16b UTSW 2 142,699,343 (GRCm39) missense probably damaging 1.00
R7558:Kif16b UTSW 2 142,600,746 (GRCm39) missense probably damaging 1.00
R7681:Kif16b UTSW 2 142,598,046 (GRCm39) missense probably damaging 1.00
R7896:Kif16b UTSW 2 142,675,995 (GRCm39) critical splice donor site probably null
R7956:Kif16b UTSW 2 142,704,390 (GRCm39) missense probably benign 0.00
R8053:Kif16b UTSW 2 142,695,634 (GRCm39) missense probably damaging 1.00
R8056:Kif16b UTSW 2 142,554,762 (GRCm39) missense probably damaging 1.00
R8139:Kif16b UTSW 2 142,743,285 (GRCm39) missense probably benign 0.00
R8182:Kif16b UTSW 2 142,554,819 (GRCm39) missense possibly damaging 0.90
R8224:Kif16b UTSW 2 142,676,008 (GRCm39) missense probably benign 0.03
R8357:Kif16b UTSW 2 142,553,828 (GRCm39) missense probably damaging 1.00
R8359:Kif16b UTSW 2 142,553,777 (GRCm39) missense probably benign 0.05
R8360:Kif16b UTSW 2 142,553,777 (GRCm39) missense probably benign 0.05
R8369:Kif16b UTSW 2 142,553,777 (GRCm39) missense probably benign 0.05
R8385:Kif16b UTSW 2 142,554,258 (GRCm39) missense probably benign 0.09
R8457:Kif16b UTSW 2 142,553,828 (GRCm39) missense probably damaging 1.00
R8720:Kif16b UTSW 2 142,691,792 (GRCm39) missense probably damaging 1.00
R8898:Kif16b UTSW 2 142,554,899 (GRCm39) missense possibly damaging 0.81
R8987:Kif16b UTSW 2 142,743,278 (GRCm39) missense probably benign 0.00
R8987:Kif16b UTSW 2 142,691,783 (GRCm39) critical splice donor site probably null
R9022:Kif16b UTSW 2 142,554,537 (GRCm39) missense possibly damaging 0.46
R9040:Kif16b UTSW 2 142,691,798 (GRCm39) missense probably benign 0.02
R9044:Kif16b UTSW 2 142,541,577 (GRCm39) missense possibly damaging 0.91
R9138:Kif16b UTSW 2 142,542,476 (GRCm39) missense
R9218:Kif16b UTSW 2 142,541,583 (GRCm39) missense possibly damaging 0.77
R9283:Kif16b UTSW 2 142,554,900 (GRCm39) missense probably benign 0.00
R9300:Kif16b UTSW 2 142,541,207 (GRCm39) missense probably benign
R9378:Kif16b UTSW 2 142,461,738 (GRCm39) nonsense probably null
R9522:Kif16b UTSW 2 142,691,827 (GRCm39) missense probably damaging 0.96
R9588:Kif16b UTSW 2 142,553,804 (GRCm39) missense possibly damaging 0.82
R9632:Kif16b UTSW 2 142,553,960 (GRCm39) missense probably benign 0.00
R9641:Kif16b UTSW 2 142,542,589 (GRCm39) missense probably benign 0.01
X0058:Kif16b UTSW 2 142,600,781 (GRCm39) missense probably damaging 1.00
Z1177:Kif16b UTSW 2 142,553,744 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGTCCTGATATTGACTAGGGGAGC -3'
(R):5'- TGAGAATTCTGGCCACCTTG -3'

Sequencing Primer
(F):5'- GAATACTAGTGTTTTTAGCATCGGAG -3'
(R):5'- GAACCAAACCGTGCTCATCTTCTTG -3'
Posted On 2022-02-07