Incidental Mutation 'R9168:Ptger3'
ID 696163
Institutional Source Beutler Lab
Gene Symbol Ptger3
Ensembl Gene ENSMUSG00000040016
Gene Name prostaglandin E receptor 3 (subtype EP3)
Synonyms Ptgerep3, EP3, Pgerep3
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R9168 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 157272459-157350392 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 157273424 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 257 (T257K)
Ref Sequence ENSEMBL: ENSMUSP00000134137 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041175] [ENSMUST00000173533]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000041175
AA Change: T257K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000043302
Gene: ENSMUSG00000040016
AA Change: T257K

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srbc 25 171 6e-8 PFAM
Pfam:7tm_1 42 323 9.5e-29 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000173533
AA Change: T257K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000134137
Gene: ENSMUSG00000040016
AA Change: T257K

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srbc 25 171 4.1e-8 PFAM
Pfam:7tm_1 42 323 1.5e-23 PFAM
low complexity region 345 356 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.9%
  • 20x: 99.6%
Validation Efficiency 97% (67/69)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
PHENOTYPE: Homozygotes for targeted null mutations exhibit increased basal renal blood flow, decreased resting renal vascular resistance, impaired duodenal bicarbonate secretion and mucosal integrity, and impaired responses to endotoxin. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alppl2 T C 1: 87,015,050 (GRCm39) Y437C probably damaging Het
Arhgef11 T G 3: 87,633,790 (GRCm39) L808R probably damaging Het
Armc7 G A 11: 115,366,724 (GRCm39) probably benign Het
Ascl1 T C 10: 87,328,361 (GRCm39) N197S probably benign Het
Cdc42bpb T G 12: 111,286,517 (GRCm39) E630D possibly damaging Het
Cep128 T C 12: 91,233,794 (GRCm39) I425V probably damaging Het
Ces4a T A 8: 105,876,050 (GRCm39) D530E probably benign Het
Ch25h T C 19: 34,451,905 (GRCm39) I208V probably benign Het
Cnpy3 A C 17: 47,063,019 (GRCm39) C11G unknown Het
Col12a1 A C 9: 79,548,783 (GRCm39) Y2187* probably null Het
Cyp2c40 C T 19: 39,755,819 (GRCm39) M498I probably benign Het
D630039A03Rik T A 4: 57,910,113 (GRCm39) Y233F probably damaging Het
Dffa A T 4: 149,192,226 (GRCm39) D100V probably damaging Het
Dock7 A T 4: 98,953,643 (GRCm39) M363K Het
Dscam A G 16: 96,420,768 (GRCm39) V1706A possibly damaging Het
En1 A G 1: 120,530,892 (GRCm39) D44G unknown Het
Enpp4 T A 17: 44,413,141 (GRCm39) N131I probably damaging Het
Ezh1 T C 11: 101,086,433 (GRCm39) D587G probably damaging Het
Gm21149 G T 5: 15,677,132 (GRCm39) H241N possibly damaging Het
Gna15 T C 10: 81,350,192 (GRCm39) Y70C probably damaging Het
Gucy1a1 T G 3: 82,009,353 (GRCm39) M552L probably damaging Het
Herc2 G A 7: 55,802,208 (GRCm39) V2017M probably damaging Het
Hsf4 C T 8: 105,999,373 (GRCm39) A297V probably benign Het
Ighd T A 12: 113,379,203 (GRCm39) T122S Het
Iqca1 C T 1: 90,065,937 (GRCm39) R218Q probably damaging Het
Isl2 C A 9: 55,452,227 (GRCm39) S266R probably benign Het
Itpkb A C 1: 180,160,028 (GRCm39) R51S probably benign Het
Jup A T 11: 100,274,219 (GRCm39) probably null Het
Kbtbd6 T C 14: 79,690,553 (GRCm39) V416A possibly damaging Het
Klhl22 T A 16: 17,602,068 (GRCm39) Y372N probably damaging Het
Klrc3 T C 6: 129,616,142 (GRCm39) E191G probably damaging Het
Lhx5 A G 5: 120,570,410 (GRCm39) D22G probably benign Het
Marchf9 GGGCGGCGGCGGCGGCG GGGCGGCGGCGGCG 10: 126,895,360 (GRCm39) probably benign Het
Mbtps1 A G 8: 120,248,602 (GRCm39) I707T probably benign Het
Nbeal1 T A 1: 60,331,047 (GRCm39) Y2219N probably damaging Het
Neb A G 2: 52,085,696 (GRCm39) I5513T probably damaging Het
Nkx1-1 C T 5: 33,591,131 (GRCm39) V64M unknown Het
Nme4 G T 17: 26,314,389 (GRCm39) A13E probably benign Het
Or2g25 T C 17: 37,971,047 (GRCm39) Y59C probably damaging Het
Or52e18 A G 7: 104,609,001 (GRCm39) *313R probably null Het
Or7e173 T C 9: 19,938,818 (GRCm39) M139V probably benign Het
Osbpl3 A T 6: 50,329,762 (GRCm39) probably null Het
Phc3 T A 3: 30,961,544 (GRCm39) M963L probably benign Het
Phf20 C T 2: 156,109,234 (GRCm39) P194S probably benign Het
Pou1f1 C T 16: 65,317,427 (GRCm39) probably benign Het
Pramel46 T A 5: 95,418,133 (GRCm39) M288L probably benign Het
Prdm13 C G 4: 21,679,659 (GRCm39) R277P unknown Het
Prelid1 A G 13: 55,470,010 (GRCm39) K3R possibly damaging Het
Psd C A 19: 46,309,233 (GRCm39) D575Y probably damaging Het
Pth1r T C 9: 110,556,204 (GRCm39) H223R probably benign Het
Ptk2b C T 14: 66,424,899 (GRCm39) E182K probably damaging Het
Ptprj T C 2: 90,294,916 (GRCm39) T431A possibly damaging Het
Rbbp5 T A 1: 132,417,464 (GRCm39) D119E probably benign Het
Rest GGGGGCCTGCCCCTCCCACGGGGCCTGCCCCTCCCACGGGGCCTGCCCCTCCCACGGAGCCTGCCCCTCCCACGGGGC GGGGGCCTGCCCCTCCCACGGGGCCTGCCCCTCCCACGGAGCCTGCCCCTCCCACGGGGC 5: 77,429,651 (GRCm39) probably benign Het
Rinl T G 7: 28,490,084 (GRCm39) L41R possibly damaging Het
Rrp12 A G 19: 41,865,603 (GRCm39) V730A probably benign Het
Saraf G T 8: 34,632,343 (GRCm39) V141L possibly damaging Het
Slc6a13 T C 6: 121,302,042 (GRCm39) L208P probably damaging Het
Slc9a9 C A 9: 94,595,000 (GRCm39) T170K probably damaging Het
Spata31f1e T C 4: 42,793,380 (GRCm39) T251A probably benign Het
Stk33 T C 7: 108,928,747 (GRCm39) N255S probably damaging Het
Tenm2 C T 11: 35,930,722 (GRCm39) V1769M probably damaging Het
Themis C A 10: 28,658,233 (GRCm39) T420N probably benign Het
Tmem116 T C 5: 121,605,975 (GRCm39) V109A Het
Tnfaip2 T A 12: 111,411,382 (GRCm39) L2Q probably damaging Het
Trub1 T C 19: 57,452,859 (GRCm39) probably null Het
Ttn C T 2: 76,679,260 (GRCm39) V10821I unknown Het
Ube2j1 C A 4: 33,045,111 (GRCm39) A197D probably benign Het
Vmn2r101 T A 17: 19,809,138 (GRCm39) I89N probably damaging Het
Wfikkn1 T C 17: 26,097,145 (GRCm39) Y393C probably damaging Het
Zfp729b C A 13: 67,741,942 (GRCm39) E108* probably null Het
Zfp976 A T 7: 42,263,011 (GRCm39) C276* probably null Het
Other mutations in Ptger3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02389:Ptger3 APN 3 157,272,808 (GRCm39) missense probably damaging 1.00
R1371:Ptger3 UTSW 3 157,273,365 (GRCm39) nonsense probably null
R2437:Ptger3 UTSW 3 157,273,207 (GRCm39) missense probably damaging 1.00
R4616:Ptger3 UTSW 3 157,272,931 (GRCm39) missense probably damaging 1.00
R6526:Ptger3 UTSW 3 157,273,139 (GRCm39) missense probably damaging 0.99
R7360:Ptger3 UTSW 3 157,272,764 (GRCm39) missense probably benign 0.18
R7571:Ptger3 UTSW 3 157,347,412 (GRCm39) missense probably benign 0.01
R8433:Ptger3 UTSW 3 157,349,592 (GRCm39) makesense probably null
R8829:Ptger3 UTSW 3 157,273,423 (GRCm39) missense probably damaging 1.00
R9281:Ptger3 UTSW 3 157,273,090 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TGCCAGCCACATGAAGACTC -3'
(R):5'- GACCGACTTGACTAGCTCTTGTAAG -3'

Sequencing Primer
(F):5'- ATGAAGACTCGCGCCACG -3'
(R):5'- GCTCTTGTAAGCTCCGCAAG -3'
Posted On 2022-02-07